source: branches/gcc/arb_CHANGES.txt

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1ARB change log
2
3Ticket references
4
5    Referenced ticket numbers are linked when you view this information
6    at http://help.arb-home.de/changes.html
7
8Major changes for next release:
9
10 - support marking species via selections in merge-tool (#868)
11 - split alignments (#846)
12 - detect poorly aligned helical regions in editor (#854)
13 - tweaked 'Helix settings' in EDIT4
14   - defaults changed for GG ('#'->'='), TT + UU ('+'->'#'), ambiguity codes (''->'%')
15   - added several predefined configs (traditional, two handling ambiguity codes)
16   - display in SECEDIT updates after helix changes
17 - tweaked 'Track alignment changes'
18   - automatically adds generated fields to species info.
19   - enhanced documentation (recommended workflow)
20 - tweaked progress
21   - better estimation for NJ, ConsensusTree, matrix calculation + PVP
22     - uses weighted progresses (#789)
23     - also fixes progress overflow (#807)
24   - support for longer periods (weeks, months, ...)
25   - prefer overestimation
26   - log to console (estimates finish)
27 - include SINA (1.7.2 patched)
28   - interface auto-adapts to sina version (still compatible with 1.3; currently needs patched version for 1.7.2)
29   - added script arb_sina_install_from_fat_tarball.sh (allows to install sina from fat-tarballs provided via arb homepage)
30   - fix missing fields bug in SINA (#875)
31 - improved macro scriptability
32   - now synchronizes external tools (#869)
33   - properly allows quitting arb (#867)
34   - allow to plan user interaction (#856)
35   - mergetool now also supports macro playback from command line (#870)
36 - append output from external tools to arb logfile.
37 - FastTree
38   - added support for protein sequences.
39   - customizable from GUI (rate categories, NJ, bootstraps).
40   - upgraded to version 2.1.11
41   - arb now provides single+multi processor versions of FastTree
42 - NDS (Node display setup; #841)
43   - specifying a zero WIDTH now means "unlimited" (backward compatible).
44   - avoid unwanted truncation (NDS-export, saved distance matrix).
45   - tree/export (using NDS)
46     - no longer truncates labels.
47     - group-labels are generated by NDS now.
48     - raise an error if non-ASCII characters are used in label (optionally).
49 - import from calcsheet:
50   - support for fuzzy matches (#865)
51   - can handle empty trailing cells
52 - added SAVE button to arb message window (saves pos+size+content)
53 - minor changes:
54   - 'Mark/Unmark listed' buttons in search window
55   - new ACI command 'dupidx' supporting group enumeration (#863)
56 - added
57   - script to analyze database structure (#866; generated reports allow database comparison)
58   - macros to cleanup database ("keep_listed_(trees|SAIs|speciesSelections).amc")
59 - documentation (arb integrated help):
60   - length checked + corrected for preformatted text and titles
61   - minor layout changes
62   - link tickets and URLs (html)
63
64Fixes for arb-7.0.1 (31 Jan 2022):
65
66 - fix perl compatibility for macOS 12
67
68Major changes for arb-7.0 (1 Sep 2021):
69
70 - ARB PARSIMONY
71   * topology optimization
72     - now (by default) strictly restricted to marked/visible parts of the tree (#640)
73     - restriction now customizable (marked/all; visible/all)
74     - tree costs for protein-data were not independent from root-position (as expected by model; #633).
75       Caused infinite running optimization under some circumstances.
76     - optimize-modes now strictly restrict to clicked subtrees. single/repeated optimization possible.
77     - KL-optimizer
78       * static path reduction slightly changed meaning. changed default settings.
79       * removed randomness (was just covering some bugs)
80       * improved general optimization speed
81   * branchlength calculation
82     - "forgot" to recalculate lengths under some conditions. fixed.
83     - is now independent of tree-root position (#641)
84   * adding species
85     - 'add partial species' failed if two partial species had NO overlap (#609). fixed.
86     - in 'add species + NNI' local optimization quality depended on insert position. fixed.
87     - insertion of multiple species is now done independently (=unordered; #643)
88     - performance improved (esp. for many added species/big trees; #643)
89   * generally improved combine performance (using SSE)
90   * generally reduced the number of performed combines (skipping many useless)
91   * added function to randomize (parts of) the tree
92   * warns about insufficient sequence data (e.g. as result of too restrictive filtering; #631)
93   * fixed 'RESTORE' (crashed after deleting species from tree; #528)
94   * corrected handling of dots ('.') while combining ancestor sequences
95   * fixed a bunch of internal bugs (#620, #627, #645, ...)
96   * added species-info mode
97 - added missing translation tables (genetic codes 24-31)
98 - added amino acid code Xle(=J), which means Ile(=I) or Leu(=L)
99 - DNA realigner
100   * several unjustified failures will no longer happen (fixes #419 and most likely #145)
101     - correctly re-syncs after 'X' (if possible at all)
102     - no longer fails for 'B', 'J' and 'Z'
103     - accepts 3 or more consecutive IUPAC codes in DNA
104   * added option to cut-off DNA sequence (was done at end of sequence by old version. fixed)
105   * fixed several minor bugs (#563,..)
106 - ARB probeSpec: visualisation of probe set specificity (thanks to Paavo Jumppanen, CSIRO)
107 - species selections (editor configurations):
108   * visualisation of multiple selections in standard tree view (#658; example in database demo.arb)
109   * order can be changed; each configuration has a comment
110 - import/export (species,sequence):
111   * manage/edit/test import-/export-filter-definitions from inside ARB (#691)
112   * import can store configuration of imported species (#607)
113   * field transfer sets (#562) may be used to customize import/export behavior (also usable from arb merge-tool)
114   * corrected EMBL export filter (numbers at seq.data; #638)
115   * detected duplicates no longer abort complete import (#779)
116   * new CLI sequence exporter 'arb_export_seq_filtered' (#743)
117 - Tree shading (#443)
118   * according to values stored in database
119   * according to given topology (useful when comparing topologies)
120   * added customisable color ranges (#682)
121 - support for extra database compression (using gzip, bzip2, xz; #665); databases cannot be opened by versions before arb-7.0
122 - ARB_EDIT4:
123   * display selected database fields as flags (allowing to toggle their value; #261).
124     Example use: easily mark sequence as "curated" after manually checking its alignment.
125   * allow to load missing SAIs
126   * "view differences" to a reference sequence:
127      - customizable:
128        * char used for "equality" (i.e. what is displayed where a sequence is equal to selected sequence)
129        * case-sensitivity
130        * ignore different gap-types
131      - equal data also gets hidden in consensus
132      - refresh differences of all displayed sequences, when data of selected sequences changes
133      - change reference sequence using CTRL-R or automatically let it follow the cursor
134      - added hotkey to toggle mode: CTRL-D
135      - fixed minor bugs
136   * consensus calculation in ARB_EDIT4 and calculation of CONSENSUS SAI
137     - now both calculations are strictly consistent (#663):
138       * gaps are now ignored while deciding whether to simplify using IUPAC ambiguity codes
139       * IUPAC ambiguity codes encountered in sequence data are now counted proportionally (=> fewer 'N's occur in consensus)
140     - added sliders to consensus definition windows
141     - user defined consensus settings exchangable between both consensus setups
142     - fixed and updated documentation
143   * added species-info mode + database save (#52,#362)
144   * predefined SAI color translation for PVP
145 - changes to SAI generation
146   * MAX_FREQUENCY:
147     - considers IUPAC ambiguity codes proportionally
148     - amino acids: if MAX_FREQUENCY is below 10% SAI now shows '1' (prev. it did show '0', i.e. 100%)
149   * POS_VAR_BY_PARSIMONY (PVP):
150     - now (again) works with amino acid data (#782)
151     - added CLI tool 'arb_calc_pvp' (#701)
152   * implemented a SAI calculator (allows to modify or combine multiple SAIs)
153 - expand zombies in tree (unfold groups; #22)
154 - compare taxonomy (and mark differences; #651)
155 - search&query for taxonomic groups (#652)
156   - many search criteria (name, size, marked, nesting-level, ingroup-distance (#653), ...)
157   - search multiple trees, detect duplicate and missing groups
158   - operations on found groups (delete, rename, fold, mark)
159 - added concept of "inverse groups" (aka "keeled groups"; #735)
160 - group transfer between trees (#780):
161   - penalties can be customized in detail
162   - quality reports (to log and optionally to target name)
163 - synchronize positions of roots of multiple trees (#449)
164 - external (command line) aligners (#504):
165   * fixed incorrect handling of 'T' vs 'U': now all aligned sequences will contain the correct base depending on alignment type
166   * preserve gap-type ('-' vs '.') and upper-/lower-case of original alignment
167   * no longer ask what to do with aligned sequence, just overwrite it
168     - only warn about real sequence changes (so please do NOT ignore from now on!)
169 - config-managers:
170   * possibility to restore factory defaults
171   * added comment field for configurations
172   * added them throughout arb (#647)
173 - added slide controls throughout arb (#656)
174 - tree (display) options:
175   * fine grained scaling
176   * group display (shading, customizable counters (#118,#209), triangle clades, name display position)
177   * bootstrap values (filter by upper/lower limits, display position/styles, on/off toggle; #614)
178   * diagonal branch style (#578)
179   * parent branch position
180   * all options are now also supported by ARB_PARSIMONY
181   * improved auto-jump; now also works for groups
182   * added optional auto-unfolding (to selected group/species)
183   * select group on fold/unfold/create/move/..
184   * draw selected group in cursor-color (#709)
185   * added keys for tree-traversal (moving to selected species or group; #687)
186 - synchronized tree scrolling (#683)
187 - colorsets were invalidated by generating new IDs (#660). fixed.
188 - added alternate RAxML (DNA only; version 8.2.8)
189   - multicore support (automatically activates recommended number of threads)
190   - evaluation, optimization and extension of existing trees with RAxML (#681)
191 - fix performance of
192   * "format sequences" (broken in arb-6.0.x series; #702)
193   * nameserver for huge databases (#646)
194   * closing arb (if database uses fastload file; #649)
195 - ACI
196   - added boolean operators, numeric comparisons, floating point arithmetic and several other new commands
197   - allow access to other species via ID or accession number (findspec, ...)
198   - improved ACI debugging: more verbose tracing (console log accessible from inside ARB)
199 - NDS optionally uses only visible definitions
200 - Search&Query:
201   * sort results numerically (#203)
202   * recursive search through all fields (#773)
203 - Species information window: improved detachment, field selection (#695)
204 - improved macro compatibility:
205   * check compatibility with installed perl version during arb startup (#754)
206   * esp. tweaked compatibility of 'Search&Query' and 'Species information window'
207   * fixed a lot of internal names (missing or duplicated) which are used for macros (#429)
208 - improved OSX compatibility (thx to Jan Gerken)
209 - updated integrated documentation (#409)
210
211
212Fixes for arb-6.0.6 (22 Aug 2016):
213
214 - fixes for gcc 6.1.0
215 - tested gcc 4.9.4 + 5.4.0
216
217Fixes for arb-6.0.5 (4 May 2016):
218
219 - fixes for ubuntu 16.04 build
220
221Fixes for arb-6.0.4 (2 May 2016):
222
223 - fixes for OSX build (SIP, accepted compilers)
224
225Fixes for arb-6.0.3 (19 Nov 2015):
226
227 - fixes permission problems when multiple users share databases or ptservers (thx to Alan McCulloch)
228
229Fixes for arb-6.0.2 (8 Aug 2014):
230
231 - compile issues on Snow Leopard (OSX 10.6)
232 - merge Debian security fix for CVE-2008-5378
233 - small changes to build system for Debian
234 - add desktop integration files
235
236Fixes for arb-6.0.1 (22 Jul 2014):
237
238 - arb_parsimony
239   - skip unwanted automatic branchlength recalculations (e.g. by unfolding a group)
240   - corrected branchlength calculation for "Add marked partial species"
241   - dots were treated as gaps for protein sequences (now treated as 'X'; analog to DNA treating gaps as 'N'; #144). thx to Yan Shi for detecting that problem!
242 - print
243   - preview failed (showed empty postscript file)
244   - print to file now always saves in user home
245 - raxml (import tree with bootstrap values)
246
247Major changes for arb-6.0 (4 Jun 2014):
248
249 - merge databases allows to
250   - merge from an existing database into the database loaded in ARB
251   - merge to existing databases from the database loaded in ARB
252 - ARB can now
253   - be restarted with another database and
254   - a second instance of ARB can be opened
255 - ARB_DIST
256   - Detect clusters of species with similar sequences (OTUs)
257   - allow automatic recalculation of matrix and/or tree whenever some parameter or
258     data changes (only makes sense for smaller species sets)
259   - extract distance matrix from tree
260 - Rewrote chimera check. Allows filtering
261 - added RNACMA (computes clusters of correlated positions)
262 - PT-Server
263   - changed behavior
264     - no longer report less hits for a part of a probe than for the probe itself (occurred at 3'-end of alignment)
265     - reports previously missing hits in joined genes
266     - reports more hits at 3'-end of alignment (when using mismatches the PT-server now reports possible
267       matches that go beyond the end of the sequence)
268     - dots in the middle of the alignment act like the sequence ends there
269     - minimum probe length reduced to 2 (was 6)
270     - allow up to 50% of probe to mismatch
271   - performance
272     - optimized memory-estimation (will build in fewer passes)
273     - uses any number of passes (not only 1, 5, 25, ...)
274     - allows to define used memory by setting environment variable ARB_MEMORY
275     - reduced memory needed to build/run ptserver (approx. 50%)
276     - reduced size of indexfile (.pt) to ~50%
277     - fast startup of existing ptservers
278   - probe design
279     - faster in many cases
280     - allow to design probes of length 8 (previously 10)
281     - allow to design probes with different lengths (specifying min/max length)
282     - fixed number of outgroup hits reported when decreasing temperature
283       (now each outgroup member only occurs once)
284     - show possible reasons why no probes could be designed
285   - probe match (allow any number of mismatches)
286   - next relative search
287     - can be restricted to column ranges (needs a PT-Server calculated from aligned sequences)
288     - corrected and improved scaling of relative scores
289     - more accurate scores (due to fixes in PT-Server; see below)
290     - faster in many cases
291   - show errors from ptserver build in ARB
292 - fast-aligner
293   - searches next-relatives based on selected column-block
294   - align multiple column-blocks based on SAI
295 - Rewrote alignment adaption during merge
296 - Insert/delete columns using a SAI to define affected columns
297 - ARB_EDIT4
298   - improved support for using multiple edit-windows
299   - smoother refreshes
300   - tweaked ORF display
301 - tree importer/exporter
302   - ARBs extended newick format (with bootstrap values) handled more restrictive now
303   - fixed several bugs; improved errors/warnings
304 - consensus trees
305   - calculate from multiple existing trees (also allows to merge not completely overlapping trees)
306   - fixed NJ-bootstrapping (no longer drops species)
307 - tree display
308   - Show brackets on open groups (dendrogram tree only)
309   - rewrote IRS (folded) display
310   - fixed tree key-bindings (mark, fold, ...)
311   - improved several tree-commands (move, rotate, spread, length, width)
312 - added a branch analysis tool
313   - groups several functions previously available via menuitems (e.g. mark long branches, etc.)
314   - added leaf-distance analysis
315 - other tree functionality
316   - treelist sortable now
317   - new beautify-tree modes (radial tree / according to other tree)
318   - function to remove marked/zombies from ALL trees
319   - create multifurcations (by branchlength/bootstrap limit)
320   - toggle 100% bootstrap values
321 - tweaked printing (interface, overlapping)
322 - if YOU edit a helpfile it will be automatically packed into an archive ready to be sent to ARB developers
323 - probe design:
324   - added LOAD to result window
325 - automation
326   - macro recording works in ARB client applications (ARB_EDIT4, ARB_PARS, ARB_MERGE, ..)
327   - arb can execute macro from command line
328   - added "Never ask again" to modal question boxes (for better compatibility with macros)
329   - a macro can be called for all marked species (once for each)
330   - macros can be nested (i.e. can call other macros)
331 - support for user-specific customization:
332   - of GDE menus (in ~/.arb_prop/gde)
333   - of import/export filters (in ~/.arb_prop/filter)
334 - ACI (some new commands, bugfixes)
335 - updated/added external tools:
336   - added FastTree (version 2.1.7)
337   - added MAFFT (version 7.055)
338   - added MrBayes (version 3.2.1)
339   - added MUSCLE (version 3.8.31)
340   - added PHYML (2013/07/08; also kept old version 2.4.5)
341   - added PROBCONS (version 1.12)
342   - updated RAxML (version 7.7.2)
343 - load/save for window specific settings (e.g. allows to share parts of configuration with other users)
344 - Support for mouse-wheel
345 - many unlisted bugfixes
346 - many internal refactorings
347
348
349Fixes for arb_5.5 (15 Nov 2012):
350
351 * arb_5.4 was broken (several external tools missing)
352
353
354Fixes for arb_5.4 (14 Nov 2012):
355
356 * make it obvious when probe matches are truncated. Truncate all hits beyond 1 million (was 100000)
357 * fixed realigner (better interaction with fields 'transl_table' and 'codon_start'; improved error handling)
358 * fixed several compilation issues (OSX; recent distro releases)
359
360
361Fixes for arb_5.3 (10 Nov 2011):
362
363 - bugfixes
364   - fixed wrong absolute/ecoli position reported for some designed probes
365   - decompression error handling (pt-server build issues)
366   - fixed 'codon_start' generated with wrong type
367   - fixed a buffer overflow in ACI
368   - report failures to write to /tmp
369 - changes
370   - markSpecies.pl:
371     mark by accession number
372     partial/ambiguous matches
373 - internal fixes
374   - compilation fixes for OSX
375   - some patches for debian version (removed refs to xview, textedit, removed molphy(protml))
376   - removed obsolete dependency from libXp
377
378
379Fixes for arb_5.2 (5 Sep 2010):
380
381 - bugfixes
382   - quicksave did silently do nothing (especially not save anything) if an error occurred
383   - ARB_EDIT4: crashed when using config with MANY unknown species
384   - ARB_SECEDIT: crashed when trying to paint strand w/o any base
385   - ARB tree display: crashed when clicking on inner tree node w/o groupinfo
386 - changes
387   - ARB uses xdg-open to display web-pages
388 - internal fixes
389   - karmic koala (gcc 4.4.1)
390   - installation script
391   - arb build process uses xsltproc instead of sablotron
392
393
394Fixes for arb_5.1 (1 Oct 2009):
395
396 - fixed a bug in 'Create species from consensus' (created sequence was corrupted)
397 - fixed 2 bugs in optimize DB (alignment w/o data, missing transaction)
398 - updated installation instructions, fixed install script, added OSX instruction (thx to Matt Cottrell)
399 - fixed broken demo.arb
400
401
402Major changes for arb_5.00 (4 Sep 2009):
403
404 - ARB 64bit version
405 - new genome importer
406 - search for next relatives improved (normal search and fast-aligner)
407   - new parameters to precise search
408   - improved speed
409   - partial sequence reach normal scores
410 - search&query
411   - supports regular expressions and ACI
412   - track hit information
413   - result sorting
414 - Nameservers with add.field have to be started with default value
415   You need to correct parameter -f in lib/arb_tcp.dat (according to lib/arb_tcp_org.dat)
416 - multiple PT-servers may be used in parallel
417 - fixed multiprobe
418 - type-conversion for DB fields
419 - SILVA compatible import filters
420 - Newick tree export:
421   - optionally save in human-readable format (big)
422   - closer to newick standard format (quoting style, comment, special chars in data)
423 - Upgraded RAxML to 7.0.3 (many features now usable from ARB interface)
424 - Fixed sequence quality calculation
425 - Secondary structures for proteins (DSSP)
426 - Distance matrix (arb_dist): mark by distance to selected
427 - ARB core
428   - many bugfixes and improvements to reliability
429   - faster sorting (general speedup)
430   - improved sequence compression (avoid worse trees, better ratio)
431   - improved handling of temporary files (permission/removal)
432   - prints backtraces in userland
433   - regular expression are POSIX standard now
434 - macro record/playback
435   - fixed several bugs
436   - you need to re-record your old macros!
437 - GUI:
438   - disabled auto-focus, you need to click now
439   - auto-raise windows on access
440 - Minor things:
441   - Ubuntu: packet installation for ARB
442   - Fixed novice/expert mode
443   - Mark deep/degenerated branches
444   - Increased NDS entries
445 - up-to-date Mac port (thx to Matt Cottrell)
446
447Major changes in ARB 07.12.07org (7 Dec 2007):
448
449 - rewrote secondary structure editor
450 - Sequence quality check
451 - Nameserver may use one field additional to 'acc' (useful to keep multiple species with same acc)
452 - tweaked base frequency filter generation
453 - Normal export (not using readseq) improved:
454   - supports filters and gap removal
455   - optimized for big amount of data
456   - reworked export filters
457 - Display translation with different ORFs in EDIT4
458 - ARB exports in FIG 3.2 format (optionally in colors). Thanks to Elmar Pruesse.
459 - added PHYML 2.4.5 (thanks to Stephane Guidon for the permission to distribute that great tool)
460 - more compact display in EDIT4
461 - capable to use iso10646 fonts
462 - supports various gcc versions (2.95.3 - 4.1.1)
463 - fixed a bug in DB optimization (occurred when fields had bigger protection than current)
464 - Bootstrap circles may be displayed as ellipses; upper size limit configurable; uses
465   different color for size-limited circles; fixed xfig-export-bug
466 - Allows Branchlength <-> Bootstrap value transfer (lossy!)
467 - fixed several scaling bugs in "folded tree"-mode
468 - improved import-filter error-messages
469 - NDS-display of groups (e.g. in tree) is now handled by ACI-command 'taxonomy'. This gives
470   several new possibilities:
471   - export taxonomy via 'Export NDS list'
472   - display taxonomy in Editor etc.
473   - display of cascaded taxonomies
474   - display taxonomy of tree_1 in tree_2
475   - allows to write taxonomy into database field of species
476   - compare taxonomies of two trees
477   - ...
478 - ACI:
479   - many new ACI commands
480   - unified handling of binary ACI-operators
481   - tracing of ACI actions for debugging purpose
482 - ARB Neighbour joining:
483   - bootstrap limit configurable
484   - bugfix: when aborting bootstrap calculation, sometimes no tree was generated
485 - EDIT4:
486   - added unalign right (block-op)
487   - added 'Save loaded properties'
488 - GENE MAP:
489   - multiple views possible at the same time
490   - origin now at "12 o'clock"
491   - implemented 'jump to gene'
492 - tweaked file selection
493 - Enhanced Search Depth for Probe Match --> max 20 MM
494 - CLUSTALW:
495   - separated menus for fast and slow alignment
496   - most parameters accessible from inside ARB now
497 - upgraded to PHYLIP 3.6 (adds PROML)
498 - external programs may be called parallel (e.g. several treeing programs)
499 - fixed bugs in protml and integration of protml
500 - rewrote ASCII database import
501 - arb_repair for databases of any size (script for database repair)
502 - fixed bug in data compression
503 - increased internal cache size (alignments up to 400.000bp possible w/o performance collapse)
504 - ARBparsimony: increase hardcoded species limit (50.000 -> 250.000)
505 - GDE menus cleanup
506 - translation/re-alignment tweaked
507 - unalign right (EDIT4)
508 - visualization of SAIs in Probe Match Results
509 - changed formatting of probe match results; increase # of allowed matches to 100.000;
510   warn if results are truncated
511 - PT server for genes
512 - Probe design performance optimized
513 - fixed NEXUS export format
514 - exports group names into Newick format
515 - import XML tree files
516 - help for external tools now properly shown inside ARB
517
518Major changes in Beta 2003_08_22 (22 Aug 2003):
519
520 - automatic formatting of alignments
521 - SECEDIT may use EDIT4 colors
522 - fixed bootstrapping (DNAPARS, PROTPARS, PROTML(experimental!))
523 - updated clustalw to version 1.83
524 - Restore window sizes for ALL windows (too small sizes are ignored)
525 - new algorithm to add partial sequences to an existing tree
526 - PROT-parsimony was completely redesigned and works now most similar to DNA/RNA-parsimony
527 - ARB_EDIT4 top area may be reduced to maximize display area
528 - All arb menus may be detached (click dashed line at top of menu)
529 - visualization of SAIs (as background color behind Sequences)
530 - ARB_EDIT4 may save/use alignment-specific and alignment-type-specific properties
531 - PT-server occupies more memory => does less passes; more diagnostic output
532 - small changes to status window (unhide behavior/time estimation)
533 - menus and menu-hotkeys reorganized
534 - colored buttons in color config windows
535 - alignment concatenation (e.g. several different genes)
536 - merging data of similar species (according selected database field)
537 - keyboard commands for tree display (mark/unmark/invert, collapse/expand)
538 - expanded sellists
539 - save/load fixed for multi probes
540 - Binary SAIs are editable in ARB_EDIT4
541 - Information windows are detachable (allows to have multiple windows showing different items)
542 - Scanning for hidden/unknown database fields improved and separated;
543   possibility to remove unused fields.
544 - new tabbed format in 'Export NDS' and 'Export matrix' (useful for star-calc/excel/etc.)
545 - updated fastDNAml to 1.2.2
546 - added AxML (accelerated fastDNAml 1.2.2)
547 - Field transfer definitions for exporting gene-species
548 - File Selection: - recursive search available
549 - macro recording/execution has been fixed
550 - Colorize species (see demo.arb)
551 - Fixed missing-character-bug in Xfig, Print and Edit4-Info-Display
552 - 'IslandHopper' -- a new integrated aligner (beta)
553 - Many improvements and bugfixes to secondary structure editor:
554   - highlighting of search (i.e for probes) like in EDIT4
555   - interactive constraint editing (stretch/compress)
556   - probe info
557   - editing secondary structure in XFIG now possible
558   - visualization of SAIs
559 - import reads Unix, DOS, and MAC linefeeds
560 - NTREE/SAI/Etc/GnuPlot: calls gnuplot directly; more plotting features; basic help
561 - tree and sequence export to XML ( DTDs are provided in ./lib/dtd )
562   (reloading of these XML files is planned for the future)
563 - fixed problems with phylip-tree import/export (bootstrap values,comments,...)
564 - search in all database fields possible ('[all fields]')
565 - up to 10 quicksaves are kept
566 - new ACI functions: upper, lower, caps, eval
567 - variables for import filter programming
568 - extract gene-species: creates acc; extraction to existing alignments
569 - sequence of selected gene is mirrored in ARB_EDIT4/local_signature
570   (=> selected gene can be highlighted in primary editor)
571 - PCR primer-design for single genes
572 - when selecting a gene, the corresponding gene-species is selected (if found)
573 - save configuration for several windows (e.g. Search&Query, WWW, NDS, ...)
574 - file selection box in import window
575 - mark item with double click works in all search&query windows
576 - User masks: create new; 'edit enable' and 'marked' toggles (like in info window)
577 - Fixed command line help for all Arb-modules
578 - Fixed problem parsing fonts (should fix display problems with default fonts)
579 - Mark mode now also works in list-view of tree-display
580 - Fixed appearance of 'tiny little boxes' (everywhere)
581 - Redesign of ARB help:
582     - a HTML version is in $ARBHOME/lib/help_html
583     - a text version is in $ARBHOME/lib/help (like before, but now generated)
584
585Major changes in Beta 2001_11_07 (7 Nov 2001):
586
587 - design probes to maximum length of 60 nucleotides
588 - fastAligner1.03 bug fixed (chooses best match now in 'auto search' mode)
589 - import default changed to foreign data format, ali name '16s'
590 - printing of multi-page-trees works again
591 - implemented user defineable masks to access database fields
592 - fixed bugs in pt-server (lockup, unknown species just after building pt-server)
593 - improved performance during pt-server-build
594 - several programs coming along with ARB where updated (PHYLIP,...)
595 - reads EMBL genom files
596 - support for experiments (genom databases only)
597
598Major changes in Beta 2001_07_24 (24 Jul 2001):
599
600 - basic support for genoms (Gene Map, reads Genebank files)
601 - ported to libc6
602
603Changes in ancient versions (last century):
604
605 - see http://help.arb-home.de/version.html
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