1 | |
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2 | #include <stdio.h> |
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3 | #include <stdlib.h> |
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4 | #include <string.h> |
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5 | |
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6 | #include "ali_misc.hxx" |
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7 | #include "ali_global.hxx" |
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8 | |
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9 | #define EXCLUSIVE_FLAG_DEFAULT 1 |
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10 | #define MARK_FAMILY_FLAG_DEFAULT 0 |
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11 | #define MARK_EXTENSION_FLAG_DEFAULT 0 |
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12 | #define FIND_FAMILY_MODE_DEFAULT 1 |
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13 | #define MAX_FAMILY_SIZE_DEFAULT 10 |
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14 | #define MIN_FAMILY_SIZE_DEFAULT 5 |
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15 | #define MIN_WEIGHT_DEFAULT 0.7 |
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16 | #define EXT_MAX_WEIGHT_DEFAULT 0.2 |
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17 | #define MULTI_GAP_FACTOR_DEFAULT 0.1 |
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18 | #define INSERT_FACTOR_DEFAULT 2.0; |
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19 | #define MULTI_INSERT_FACTOR_DEFAULT 0.5; |
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20 | #define COST_LOW_DEFAULT 0.25 |
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21 | #define COST_MIDDLE_DEFAULT 0.5 |
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22 | #define COST_HIGH_DEFAULT 0.8 |
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23 | #define MAX_COST_OF_SUB_PERCENT_DEFAULT 0.5 |
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24 | #define MAX_COST_OF_HELIX 2.0 |
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25 | #define ERROR_COUNT_DEFAULT 2 |
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26 | #define MAX_NUMBER_OF_MAPS_DEFAULT 10 /* 100 */ |
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27 | #define MAX_NUMBER_OF_MAPS_ALIGNER_DEFAULT 2 |
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28 | #define INTERVALL_BORDER_DEFAULT 5 |
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29 | #define INTERVALL_CENTER_DEFAULT 5 |
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30 | |
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31 | /* |
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32 | * ACHTUNG: muss noch durch parameter belegbar sein |
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33 | */ |
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34 | #define MATCHES_MIN_DEFAULT 1000 |
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35 | #define PERCENT_MIN_DEFAULT 0.75 |
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36 | #define FAM_LIST_MAX_DEFAULT 5 |
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37 | #define EXT_LIST_MAX_DEFAULT 10 |
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38 | #define USE_SPECIFIED_FAMILY_DEFAULT 0 |
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39 | |
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40 | |
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41 | double default_substitute_matrix[5][5] = { |
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42 | /* a c g u - */ |
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43 | {0.0, 3.0, 1.0, 3.0, 5.0}, /* a */ |
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44 | {3.0, 0.0, 3.0, 1.0, 5.0}, /* c */ |
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45 | {1.0, 3.0, 0.0, 3.0, 5.0}, /* g */ |
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46 | {3.0, 1.0, 3.0, 0.0, 5.0}, /* u */ |
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47 | {5.0, 5.0, 5.0, 5.0, 0.0} /* - */ |
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48 | }; |
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49 | |
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50 | double default_binding_matrix[5][5] = { |
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51 | /* a c g u - */ |
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52 | {9.9, 9.9, 2.0, 0.9, 9.9}, /* a */ |
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53 | {9.9, 9.9, 0.6, 9.9, 9.9}, /* c */ |
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54 | {2.0, 0.6, 5.0, 1.1, 9.9}, /* g */ |
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55 | {0.9, 9.9, 1.1, 9.9, 9.9}, /* u */ |
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56 | {9.9, 9.9, 9.9, 9.9, 0.0} /* - */ |
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57 | }; |
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58 | |
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59 | |
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60 | void ALI_GLOBAL::init(int *argc, char *argv[]) |
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61 | { |
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62 | int kill, i, h, j, ret; |
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63 | char *pos; |
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64 | struct arb_params *params; |
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65 | float fl; |
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66 | |
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67 | params = arb_trace_argv(argc,argv); |
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68 | |
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69 | prog_name = argv[0]; |
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70 | species_name = params->species_name; |
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71 | default_file = params->default_file; |
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72 | db_server = params->db_server; |
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73 | |
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74 | /* |
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75 | * Set the defaults |
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76 | */ |
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77 | |
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78 | for (i = 0; i < 5; i++) |
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79 | for (j = 0; j < 5; j++) { |
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80 | prof_context.substitute_matrix[i][j] = default_substitute_matrix[i][j]; |
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81 | prof_context.binding_matrix[i][j] = default_binding_matrix[i][j]; |
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82 | } |
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83 | |
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84 | cost_low = COST_LOW_DEFAULT; |
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85 | cost_middle = COST_MIDDLE_DEFAULT; |
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86 | cost_high = COST_HIGH_DEFAULT; |
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87 | preali_context.max_number_of_maps = MAX_NUMBER_OF_MAPS_DEFAULT; |
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88 | preali_context.max_number_of_maps_aligner = |
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89 | MAX_NUMBER_OF_MAPS_ALIGNER_DEFAULT; |
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90 | preali_context.intervall_border = INTERVALL_BORDER_DEFAULT; |
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91 | preali_context.intervall_center = INTERVALL_CENTER_DEFAULT; |
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92 | preali_context.max_cost_of_sub_percent = MAX_COST_OF_SUB_PERCENT_DEFAULT; |
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93 | preali_context.max_cost_of_helix = MAX_COST_OF_HELIX; |
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94 | preali_context.error_count = ERROR_COUNT_DEFAULT; |
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95 | mark_species_flag = 0; |
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96 | |
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97 | prof_context.find_family_mode = FIND_FAMILY_MODE_DEFAULT; |
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98 | prof_context.exclusive_flag = EXCLUSIVE_FLAG_DEFAULT; |
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99 | prof_context.mark_family_flag = MARK_FAMILY_FLAG_DEFAULT; |
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100 | prof_context.mark_family_extension_flag = MARK_EXTENSION_FLAG_DEFAULT; |
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101 | prof_context.max_family_size = MAX_FAMILY_SIZE_DEFAULT; |
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102 | prof_context.min_family_size = MIN_FAMILY_SIZE_DEFAULT; |
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103 | prof_context.min_weight = MIN_WEIGHT_DEFAULT; |
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104 | prof_context.ext_max_weight = EXT_MAX_WEIGHT_DEFAULT; |
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105 | prof_context.multi_gap_factor = MULTI_GAP_FACTOR_DEFAULT; |
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106 | prof_context.insert_factor = INSERT_FACTOR_DEFAULT; |
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107 | prof_context.multi_insert_factor = MULTI_INSERT_FACTOR_DEFAULT; |
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108 | |
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109 | pt_context.matches_min = MATCHES_MIN_DEFAULT; |
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110 | pt_context.percent_min = PERCENT_MIN_DEFAULT; |
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111 | pt_context.fam_list_max = FAM_LIST_MAX_DEFAULT; |
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112 | pt_context.ext_list_max = EXT_LIST_MAX_DEFAULT; |
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113 | pt_context.use_specified_family = USE_SPECIFIED_FAMILY_DEFAULT; |
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114 | |
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115 | /* |
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116 | * evaluate the parameters |
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117 | */ |
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118 | |
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119 | for (i = 1; i < *argc;) { |
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120 | kill = 0; |
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121 | if (strcmp("-nx",argv[i]) == 0 && kill == 0) { |
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122 | prof_context.exclusive_flag = 0; |
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123 | kill = i; |
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124 | } |
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125 | if (strncmp("-f",argv[i],2) == 0 && kill == 0) { |
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126 | pt_context.use_specified_family = strdup(argv[i] + 2); |
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127 | kill = i; |
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128 | } |
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129 | if (strcmp("-ms",argv[i]) == 0 && kill == 0) { |
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130 | mark_species_flag = 1; |
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131 | kill = i; |
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132 | } |
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133 | if (strcmp("-mf",argv[i]) == 0 && kill == 0) { |
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134 | prof_context.mark_family_flag = 1; |
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135 | kill = i; |
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136 | } |
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137 | if (strcmp("-mfe",argv[i]) == 0 && kill == 0) { |
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138 | prof_context.mark_family_extension_flag = 1; |
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139 | kill = i; |
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140 | } |
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141 | if (strncmp("-mgf",argv[i],4) == 0 && kill == 0) { |
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142 | kill = i; |
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143 | pos = argv[i] + 4; |
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144 | ret = sscanf(pos,"%f",&prof_context.multi_gap_factor); |
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145 | if (ret != 1) { |
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146 | ali_warning("Wrong format for -mgf"); |
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147 | break; |
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148 | } |
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149 | } |
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150 | if (strncmp("-if",argv[i],3) == 0 && kill == 0) { |
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151 | kill = i; |
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152 | pos = argv[i] + 3; |
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153 | ret = sscanf(pos,"%f",&prof_context.insert_factor); |
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154 | if (ret != 1) { |
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155 | ali_warning("Wrong format for -if"); |
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156 | break; |
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157 | } |
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158 | } |
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159 | if (strncmp("-mif",argv[i],4) == 0 && kill == 0) { |
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160 | kill = i; |
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161 | pos = argv[i] + 4; |
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162 | ret = sscanf(pos,"%f",&prof_context.multi_insert_factor); |
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163 | if (ret != 1) { |
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164 | ali_warning("Wrong format for -mif"); |
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165 | break; |
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166 | } |
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167 | } |
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168 | if (strcmp("-m",argv[i]) == 0 && kill == 0) { |
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169 | mark_species_flag = 1; |
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170 | prof_context.mark_family_flag = 1; |
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171 | kill = i; |
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172 | } |
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173 | if (strncmp("-msub",argv[i],5) == 0 && kill == 0) { |
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174 | kill = i; |
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175 | pos = argv[i] + 5; |
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176 | for (h = 0; h < 5; h++) |
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177 | for (j = 0; j < 5; j++) { |
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178 | ret = sscanf(pos,"%f",&fl); |
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179 | if (ret != 1) { |
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180 | ali_warning("wrong format for -msub"); |
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181 | break; |
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182 | } |
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183 | else |
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184 | prof_context.substitute_matrix[h][j] = (double) fl; |
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185 | pos = strchr(pos,','); |
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186 | if ((h != 4 || j != 4) && pos == 0) { |
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187 | ali_warning("Not enought values for -msub"); |
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188 | break; |
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189 | } |
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190 | pos++; |
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191 | } |
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192 | } |
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193 | if (strncmp("-mbind",argv[i],6) == 0 && kill == 0) { |
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194 | kill = i; |
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195 | pos = argv[i] + 6; |
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196 | for (h = 0; h < 5; h++) |
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197 | for (j = 0; j < 5; j++) { |
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198 | ret = sscanf(pos,"%f",&fl); |
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199 | if (ret != 1) { |
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200 | ali_warning("Wrong format for -mbind"); |
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201 | break; |
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202 | } |
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203 | else |
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204 | prof_context.binding_matrix[h][j] = (double) fl; |
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205 | pos = strchr(pos,','); |
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206 | if ((h != 4 || j != 4) && pos == 0) { |
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207 | ali_warning("Not enought values for -mbind"); |
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208 | break; |
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209 | } |
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210 | pos++; |
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211 | } |
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212 | } |
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213 | if (strncmp("-maxf",argv[i],5) == 0 && kill == 0) { |
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214 | kill = i; |
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215 | pos = argv[i] + 5; |
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216 | ret = sscanf(pos,"%d",&prof_context.max_family_size); |
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217 | if (ret != 1) { |
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218 | ali_warning("Wrong format for -maxf"); |
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219 | break; |
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220 | } |
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221 | } |
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222 | if (strncmp("-minf",argv[i],5) == 0 && kill == 0) { |
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223 | kill = i; |
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224 | pos = argv[i] + 5; |
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225 | ret = sscanf(pos,"%d",&prof_context.min_family_size); |
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226 | if (ret != 1) { |
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227 | ali_warning("Wrong format for -minf"); |
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228 | break; |
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229 | } |
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230 | } |
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231 | if (strncmp("-minw",argv[i],5) == 0 && kill == 0) { |
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232 | kill = i; |
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233 | pos = argv[i] + 5; |
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234 | ret = sscanf(pos,"%f",&prof_context.min_weight); |
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235 | if (ret != 1) { |
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236 | ali_warning("Wrong format for -minw"); |
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237 | break; |
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238 | } |
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239 | } |
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240 | if (strncmp("-maxew",argv[i],6) == 0 && kill == 0) { |
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241 | kill = i; |
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242 | pos = argv[i] + 6; |
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243 | ret = sscanf(pos,"%f",&prof_context.ext_max_weight); |
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244 | if (ret != 1) { |
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245 | ali_warning("Wrong format for -minw"); |
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246 | break; |
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247 | } |
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248 | } |
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249 | |
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250 | /* |
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251 | * ACHTUNG: Unused BEGIN |
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252 | */ |
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253 | if (strncmp("-cl",argv[i],3) == 0 && kill == 0) { |
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254 | kill = i; |
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255 | pos = argv[i] + 3; |
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256 | ret = sscanf(pos,"%f",&cost_low); |
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257 | if (ret != 1) { |
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258 | ali_warning("Wrong format for -cl"); |
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259 | break; |
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260 | } |
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261 | } |
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262 | if (strncmp("-cm",argv[i],3) == 0 && kill == 0) { |
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263 | kill = i; |
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264 | pos = argv[i] + 3; |
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265 | ret = sscanf(pos,"%f",&cost_middle); |
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266 | if (ret != 1) { |
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267 | ali_warning("Wrong format for -cm"); |
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268 | break; |
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269 | } |
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270 | } |
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271 | if (strncmp("-ch",argv[i],3) == 0 && kill == 0) { |
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272 | kill = i; |
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273 | pos = argv[i] + 3; |
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274 | ret = sscanf(pos,"%f",&cost_high); |
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275 | if (ret != 1) { |
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276 | ali_warning("Wrong format for -ch"); |
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277 | break; |
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278 | } |
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279 | } |
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280 | /* |
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281 | * ACHTUNG: Unused END |
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282 | */ |
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283 | |
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284 | if (strncmp("-csub",argv[i],5) == 0 && kill == 0) { |
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285 | kill = i; |
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286 | pos = argv[i] + 5; |
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287 | ret = sscanf(pos,"%f",&preali_context.max_cost_of_sub_percent); |
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288 | if (ret != 1) { |
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289 | ali_warning("Wrong format for -csub"); |
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290 | break; |
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291 | } |
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292 | } |
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293 | if (strncmp("-chel",argv[i],5) == 0 && kill == 0) { |
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294 | kill = i; |
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295 | pos = argv[i] + 5; |
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296 | ret = sscanf(pos,"%f",&preali_context.max_cost_of_helix); |
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297 | if (ret != 1) { |
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298 | ali_warning("Wrong format for -chel"); |
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299 | break; |
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300 | } |
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301 | } |
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302 | if (strncmp("-mma",argv[i],4) == 0 && kill == 0) { |
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303 | kill = i; |
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304 | pos = argv[i] + 4; |
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305 | ret = sscanf(pos,"%ld",&preali_context.max_number_of_maps_aligner); |
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306 | if (ret != 1) { |
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307 | ali_warning("Wrong format for -mma"); |
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308 | break; |
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309 | } |
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310 | } |
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311 | if (strncmp("-mm",argv[i],3) == 0 && kill == 0) { |
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312 | kill = i; |
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313 | pos = argv[i] + 3; |
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314 | ret = sscanf(pos,"%ld",&preali_context.max_number_of_maps); |
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315 | if (ret != 1) { |
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316 | ali_warning("Wrong format for -mm"); |
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317 | break; |
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318 | } |
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319 | } |
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320 | if (strncmp("-ec",argv[i],3) == 0 && kill == 0) { |
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321 | kill = i; |
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322 | pos = argv[i] + 3; |
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323 | ret = sscanf(pos,"%ld",&preali_context.error_count); |
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324 | if (ret != 1) { |
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325 | ali_warning("Wrong format for -ec"); |
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326 | break; |
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327 | } |
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328 | } |
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329 | if (strncmp("-ib",argv[i],3) == 0 && kill == 0) { |
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330 | kill = i; |
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331 | pos = argv[i] + 3; |
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332 | ret = sscanf(pos,"%d",&preali_context.intervall_border); |
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333 | if (ret != 1) { |
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334 | ali_warning("Wrong format for -ib"); |
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335 | break; |
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336 | } |
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337 | } |
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338 | if (strncmp("-ic",argv[i],3) == 0 && kill == 0) { |
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339 | kill = i; |
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340 | pos = argv[i] + 3; |
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341 | ret = sscanf(pos,"%d",&preali_context.intervall_center); |
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342 | if (ret != 1) { |
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343 | ali_warning("Wrong format for -ic"); |
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344 | break; |
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345 | } |
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346 | } |
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347 | |
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348 | if (kill > 0) { |
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349 | for (i++; i < *argc; i++) |
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350 | argv[i-1] = argv[i]; |
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351 | (*argc)--; |
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352 | i = kill; |
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353 | } |
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354 | else |
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355 | i++; |
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356 | } |
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357 | |
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358 | /* |
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359 | * Check for consistency |
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360 | */ |
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361 | |
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362 | if (prof_context.min_family_size > prof_context.max_family_size) { |
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363 | ali_warning("minf <= maxf"); |
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364 | } |
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365 | |
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366 | if (prof_context.ext_max_weight < 0 || prof_context.ext_max_weight > 1.0) { |
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367 | ali_warning("0 <= maxew <= 1.0"); |
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368 | } |
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369 | |
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370 | if (prof_context.min_weight < 0 || prof_context.min_weight > 1.0) { |
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371 | ali_warning("0 <= minw <= 1.0"); |
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372 | } |
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373 | |
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374 | if (cost_low > cost_middle || cost_middle > cost_high || |
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375 | cost_low < 0 || cost_high > 1.0) { |
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376 | ali_warning("0 <= cl <= cm <= ch <= 1.0"); |
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377 | } |
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378 | |
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379 | /* |
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380 | * Open Database and Pt server |
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381 | */ |
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382 | |
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383 | ali_message("Connecting to Database server"); |
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384 | if (arbdb.open(db_server) != 0) { |
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385 | ali_error("Can't connect to Database server"); |
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386 | } |
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387 | ali_message("Connection established"); |
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388 | prof_context.arbdb = &arbdb; |
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389 | |
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390 | pt_context.servername = params->pt_server; |
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391 | pt_context.gb_main = arbdb.gb_main; |
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392 | |
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393 | pt = new ALI_PT(&pt_context); |
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394 | |
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395 | prof_context.pt = pt; |
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396 | } |
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