| 1 | #include <stdio.h> |
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| 2 | #include <stdlib.h> |
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| 3 | // #include <malloc.h> |
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| 4 | #include <string.h> |
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| 5 | |
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| 6 | #include <arbdb.h> |
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| 7 | #include <arbdbt.h> |
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| 8 | #include <aw_root.hxx> |
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| 9 | #include <aw_device.hxx> |
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| 10 | #include <aw_window.hxx> |
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| 11 | #include <awt.hxx> |
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| 12 | |
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| 13 | #include "gde.hxx" |
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| 14 | #include "GDE_def.h" |
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| 15 | #include "GDE_menu.h" |
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| 16 | #include "GDE_extglob.h" |
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| 17 | |
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| 18 | int MAX(int a,int b) |
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| 19 | { |
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| 20 | if(a>b) return a; |
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| 21 | return b; |
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| 22 | } |
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| 23 | |
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| 24 | int MIN(int a,int b) |
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| 25 | { |
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| 26 | if(a<b) return a; |
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| 27 | return b; |
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| 28 | } |
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| 29 | |
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| 30 | void Regroup(NA_Alignment *alignment) |
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| 31 | { |
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| 32 | size_t j; |
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| 33 | size_t group; |
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| 34 | int last; |
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| 35 | |
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| 36 | for(j=0;j<alignment->numelements;j++) |
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| 37 | { |
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| 38 | alignment->element[j].groupf = NULL; |
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| 39 | alignment->element[j].groupb = NULL; |
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| 40 | } |
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| 41 | |
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| 42 | for (group = 1;group <= alignment->numgroups;group++) |
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| 43 | { |
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| 44 | last = -1; |
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| 45 | for(j=0;j<alignment->numelements;j++) |
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| 46 | if(alignment->element[j].groupid == group) |
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| 47 | { |
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| 48 | if(last != -1) |
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| 49 | { |
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| 50 | alignment->element[j].groupb = |
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| 51 | &(alignment->element[last]); |
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| 52 | alignment->element[last].groupf = |
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| 53 | &(alignment->element[j]); |
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| 54 | } |
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| 55 | last = j; |
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| 56 | } |
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| 57 | } |
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| 58 | return; |
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| 59 | } |
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| 60 | |
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| 61 | |
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| 62 | /* |
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| 63 | * Print error message, and die |
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| 64 | */ |
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| 65 | void ErrorOut5(int code,const char *string) |
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| 66 | { |
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| 67 | if (code == 0) |
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| 68 | { |
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| 69 | fprintf(stderr,"Error:%s\n",string); |
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| 70 | exit(1); |
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| 71 | } |
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| 72 | return; |
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| 73 | } |
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| 74 | |
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| 75 | |
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| 76 | /* |
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| 77 | * More robust memory management routines |
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| 78 | */ |
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| 79 | char *Calloc(int count,int size) |
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| 80 | { |
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| 81 | char *temp; |
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| 82 | size *= count; |
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| 83 | #ifdef SeeAlloc |
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| 84 | extern int TotalCalloc; |
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| 85 | TotalCalloc += count*size; |
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| 86 | fprintf(stderr,"Calloc %d %d\n",count*size,TotalCalloc); |
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| 87 | #endif |
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| 88 | temp = (char *)malloc(size); |
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| 89 | ErrorOut5(0!= temp,"Cannot allocate memory"); |
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| 90 | memset(temp,0,size); |
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| 91 | return(temp); |
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| 92 | } |
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| 93 | |
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| 94 | char *Realloc(char *block,int size) |
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| 95 | { |
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| 96 | char *temp; |
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| 97 | #ifdef SeeAlloc |
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| 98 | extern int TotalRealloc; |
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| 99 | TotalRealloc += size; |
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| 100 | fprintf(stderr,"Realloc %d\n",TotalRealloc); |
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| 101 | #endif |
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| 102 | temp = (char *)realloc(block,size); |
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| 103 | ErrorOut5(0 != temp,"Cannot change memory size"); |
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| 104 | |
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| 105 | return(temp); |
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| 106 | } |
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| 107 | |
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| 108 | void Cfree(char *block) |
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| 109 | { |
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| 110 | if (block) |
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| 111 | { |
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| 112 | /*if(cfree(block) == 0) |
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| 113 | Warning("Error in Cfree...");*/ |
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| 114 | free(block); |
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| 115 | } |
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| 116 | else |
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| 117 | Warning("Error in Cfree, NULL block"); |
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| 118 | return; |
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| 119 | } |
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| 120 | |
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| 121 | |
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| 122 | static void ReadNA_Flat(char *filename,char *dataset,int type) |
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| 123 | { |
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| 124 | size_t j; |
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| 125 | int i, jj, c, curelem=0,offset; |
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| 126 | char buffer[GBUFSIZ]; |
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| 127 | char in_line[GBUFSIZ]; |
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| 128 | char curname[GBUFSIZ]; |
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| 129 | i=0;c=0;type=0; |
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| 130 | |
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| 131 | NA_Sequence *this_elem; |
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| 132 | NA_Alignment *data; |
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| 133 | |
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| 134 | FILE *file; |
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| 135 | |
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| 136 | curname[0] = '\0'; |
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| 137 | data = (NA_Alignment*)dataset; |
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| 138 | |
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| 139 | file = fopen(filename,"r"); |
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| 140 | if(file == NULL) |
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| 141 | { |
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| 142 | fprintf(stderr,"Cannot open %s.\n",filename); |
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| 143 | return; |
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| 144 | } |
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| 145 | for(;fgets(in_line,GBUFSIZ,file) !=0;) |
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| 146 | { |
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| 147 | if (in_line[0] == '#' || |
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| 148 | in_line[0] == '%' || |
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| 149 | in_line[0] == '"' || |
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| 150 | in_line[0] == '@') |
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| 151 | { |
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| 152 | offset = 0; |
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| 153 | for(j=0;j<strlen(in_line);j++) |
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| 154 | { |
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| 155 | if(in_line[j] == '(') |
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| 156 | { |
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| 157 | sscanf((char*) |
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| 158 | &(in_line[j+1]),"%d",&offset); |
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| 159 | in_line[j] = '\0'; |
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| 160 | } |
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| 161 | } |
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| 162 | |
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| 163 | curelem = data->numelements++; |
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| 164 | if( curelem == 0 ) |
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| 165 | { |
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| 166 | data->element=(NA_Sequence*) |
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| 167 | Calloc(5,sizeof(NA_Sequence)); |
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| 168 | data->maxnumelements = 5; |
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| 169 | } |
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| 170 | else if (curelem==data->maxnumelements) |
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| 171 | { |
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| 172 | (data->maxnumelements) *= 2; |
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| 173 | data->element= |
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| 174 | (NA_Sequence*)Realloc((char*)data->element |
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| 175 | ,data->maxnumelements*sizeof(NA_Sequence)); |
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| 176 | } |
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| 177 | |
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| 178 | InitNASeq(&(data->element[curelem]), |
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| 179 | in_line[0] == '#'?DNA: |
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| 180 | in_line[0] == '%'?PROTEIN: |
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| 181 | in_line[0] == '"'?TEXT: |
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| 182 | in_line[0] == '@'?MASK:TEXT); |
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| 183 | this_elem= &(data->element[curelem]); |
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| 184 | if(in_line[strlen(in_line)-1] == '\n') |
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| 185 | in_line[strlen(in_line)-1] = '\0'; |
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| 186 | strncpy(this_elem->short_name,(char*)&(in_line[1]),31); |
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| 187 | this_elem->offset = offset; |
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| 188 | } |
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| 189 | else if(in_line[0] != '\n') |
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| 190 | { |
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| 191 | size_t strl = strlen(in_line); |
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| 192 | for(j=0,jj=0;j<strl;j++) |
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| 193 | if(in_line[j] != ' ' && in_line[j] != '\n' && |
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| 194 | in_line[j] != '\t') |
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| 195 | buffer[jj++] = in_line[j]; |
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| 196 | |
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| 197 | if(data->element[curelem].rmatrix) |
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| 198 | Ascii2NA(buffer,jj,data->element[curelem].rmatrix); |
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| 199 | AppendNA((NA_Base*)buffer,jj,&(data->element[curelem])); |
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| 200 | } |
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| 201 | } |
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| 202 | |
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| 203 | for(j=0;j<data->numelements;j++) |
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| 204 | data->maxlen = MAX(data->maxlen,data->element[j].seqlen + |
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| 205 | data->element[j].offset); |
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| 206 | |
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| 207 | for(j=0;j<data->numelements;j++) |
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| 208 | if(data->element[j].seqlen==0) |
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| 209 | data->element[j].protect = |
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| 210 | PROT_BASE_CHANGES+ PROT_GREY_SPACE+ |
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| 211 | PROT_WHITE_SPACE+ PROT_TRANSLATION; |
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| 212 | |
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| 213 | NormalizeOffset(data); |
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| 214 | Regroup(data); |
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| 215 | return; |
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| 216 | } |
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| 217 | |
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| 218 | /* |
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| 219 | LoadFile(): |
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| 220 | Load the given filename into the given dataset. Handle any |
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| 221 | type conversion needed to get the data into the specified data type. |
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| 222 | This routine is used in situations where the format and datatype is known. |
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| 223 | |
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| 224 | Copyright (c) 1989-1990, University of Illinois board of trustees. All |
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| 225 | rights reserved. Written by Steven Smith at the Center for Prokaryote Genome |
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| 226 | Analysis. Design and implementation guidance by Dr. Gary Olsen and Dr. |
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| 227 | Carl Woese. |
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| 228 | |
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| 229 | Copyright (c) 1990,1991,1992 Steven Smith at the Harvard Genome Laboratory. |
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| 230 | All rights reserved. |
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| 231 | */ |
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| 232 | |
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| 233 | static void LoadFile(char *filename,NA_Alignment *dataset,int type,int format) |
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| 234 | { |
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| 235 | |
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| 236 | if (DataType != type) |
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| 237 | fprintf(stderr,"Warning, datatypes do not match.\n"); |
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| 238 | /* |
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| 239 | Handle the overwrite/create/merge dialog here. |
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| 240 | */ |
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| 241 | switch(format) |
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| 242 | { |
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| 243 | case NA_FLAT: |
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| 244 | ReadNA_Flat(filename,(char*)dataset,type); |
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| 245 | ((NA_Alignment*)dataset)->format = GDE; |
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| 246 | break; |
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| 247 | |
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| 248 | case GENBANK: |
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| 249 | ReadGen(filename,dataset,type); |
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| 250 | ((NA_Alignment*)dataset)->format = GENBANK; |
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| 251 | break; |
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| 252 | |
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| 253 | case ARBDB: |
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| 254 | ReadArbdb_plain(filename,dataset,type); |
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| 255 | ((NA_Alignment*)dataset)->format = ARBDB; |
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| 256 | break; |
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| 257 | |
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| 258 | case GDE: |
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| 259 | ReadGDE(filename,dataset,type); |
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| 260 | ((NA_Alignment*)dataset)->format = GDE; |
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| 261 | break; |
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| 262 | case COLORMASK: |
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| 263 | ReadCMask(filename); |
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| 264 | |
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| 265 | default: |
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| 266 | break; |
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| 267 | } |
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| 268 | return; |
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| 269 | } |
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| 270 | |
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| 271 | static int FindType(char *name,int *dtype,int *ftype) |
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| 272 | { |
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| 273 | FILE *file; |
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| 274 | char in_line[GBUFSIZ]; |
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| 275 | |
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| 276 | file = fopen(name,"r"); |
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| 277 | *dtype=0; |
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| 278 | *ftype=0; |
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| 279 | |
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| 280 | if (file == NULL) |
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| 281 | return(1); |
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| 282 | |
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| 283 | /* |
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| 284 | * Is this a flat file? |
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| 285 | * Get the first non blank line, see if a type marker shows up. |
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| 286 | */ |
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| 287 | if (fgets(in_line,GBUFSIZ,file) == 0) { |
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| 288 | return 1; |
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| 289 | } |
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| 290 | for(;strlen(in_line)<2 && fgets(in_line,GBUFSIZ,file) != NULL;) ; |
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| 291 | |
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| 292 | if (in_line[0] == '#' || in_line[0] == '%' || |
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| 293 | in_line[0] == '"' || in_line[0] == '@' ) |
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| 294 | { |
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| 295 | *dtype=NASEQ_ALIGN; |
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| 296 | *ftype=NA_FLAT; |
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| 297 | } |
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| 298 | |
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| 299 | /* |
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| 300 | * Else, try genbank |
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| 301 | */ |
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| 302 | else |
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| 303 | { |
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| 304 | fclose(file); |
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| 305 | file = fopen(name,"r"); |
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| 306 | *dtype=0; |
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| 307 | *ftype=0; |
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| 308 | |
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| 309 | if (file == NULL) |
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| 310 | return(1); |
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| 311 | |
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| 312 | for(;fgets(in_line,GBUFSIZ,file) != NULL;) |
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| 313 | if(Find(in_line,"LOCUS")) |
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| 314 | { |
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| 315 | *dtype=NASEQ_ALIGN; |
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| 316 | *ftype=GENBANK; |
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| 317 | fclose(file); |
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| 318 | return(0); |
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| 319 | } |
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| 320 | /* |
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| 321 | * and last, try GDE |
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| 322 | */ |
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| 323 | else if(Find(in_line,"sequence")) |
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| 324 | { |
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| 325 | *dtype = NASEQ_ALIGN; |
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| 326 | *ftype = GDE; |
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| 327 | fclose(file); |
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| 328 | return(0); |
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| 329 | } |
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| 330 | else if(Find(in_line,"start:")) |
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| 331 | { |
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| 332 | *dtype = NASEQ_ALIGN; |
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| 333 | *ftype = COLORMASK; |
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| 334 | fclose(file); |
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| 335 | return(0); |
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| 336 | } |
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| 337 | } |
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| 338 | |
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| 339 | fclose(file); |
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| 340 | return(0); |
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| 341 | } |
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| 342 | |
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| 343 | /* |
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| 344 | LoadData(): |
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| 345 | Load a data set from the command line argument. |
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| 346 | |
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| 347 | Copyright (c) 1989, University of Illinois board of trustees. All rights |
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| 348 | reserved. Written by Steven Smith at the Center for Prokaryote Genome |
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| 349 | Analysis. Design and implementation guidance by Dr. Gary Olsen and Dr. |
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| 350 | Carl Woese. |
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| 351 | |
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| 352 | Copyright (c) 1990,1991,1992 Steven Smith at the Harvard Genome Laboratory. |
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| 353 | All rights reserved. |
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| 354 | |
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| 355 | */ |
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| 356 | |
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| 357 | void LoadData(char *filen) |
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| 358 | { |
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| 359 | |
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| 360 | FILE *file; |
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| 361 | NA_Alignment *DataNaAln; |
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| 362 | char temp[1024]; |
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| 363 | /* |
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| 364 | * Get file name, determine the file type, and away we go.. |
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| 365 | */ |
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| 366 | if(Find2(filen,"gde")!=0) |
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| 367 | strcpy(FileName,filen); |
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| 368 | |
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| 369 | if (strstr(filen,".arb") || strchr(filen, ':')) { /* ARBDB TYPE */ |
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| 370 | if (DataSet == NULL) { |
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| 371 | DataSet = (NA_Alignment *) Calloc(1, |
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| 372 | sizeof(NA_Alignment)); |
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| 373 | DataNaAln = (NA_Alignment *) DataSet; |
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| 374 | DataSet->rel_offset = 0; |
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| 375 | } else{ |
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| 376 | DataNaAln = (NA_Alignment *) DataSet; |
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| 377 | } |
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| 378 | DataType = NASEQ_ALIGN; |
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| 379 | FileFormat = ARBDB; |
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| 380 | LoadFile(filen, DataNaAln, |
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| 381 | DataType, FileFormat); |
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| 382 | |
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| 383 | sprintf(temp,"Remote ARBDB access (%s)",filen); |
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| 384 | return; |
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| 385 | } |
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| 386 | |
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| 387 | |
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| 388 | if( (file=fopen(filen,"r"))!=0 ) |
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| 389 | { |
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| 390 | FindType(filen,&DataType,&FileFormat); |
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| 391 | switch(DataType) |
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| 392 | { |
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| 393 | case NASEQ_ALIGN: |
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| 394 | if(DataSet == NULL) |
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| 395 | { |
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| 396 | DataSet = (NA_Alignment*)Calloc(1, |
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| 397 | sizeof(NA_Alignment)); |
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| 398 | DataNaAln =(NA_Alignment*)DataSet; |
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| 399 | DataSet->rel_offset = 0; |
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| 400 | }else{ |
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| 401 | DataNaAln = (NA_Alignment*)DataSet; |
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| 402 | } |
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| 403 | |
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| 404 | LoadFile(filen,DataNaAln, |
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| 405 | DataType,FileFormat); |
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| 406 | |
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| 407 | break; |
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| 408 | default: |
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| 409 | aw_message(GBS_global_string("Internal error: unknown file type of file %s",filen)); |
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| 410 | break; |
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| 411 | } |
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| 412 | fclose(file); |
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| 413 | } |
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| 414 | sprintf(temp,"Genetic Data Environment 2.2 (%s)",FileName); |
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| 415 | return; |
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| 416 | } |
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| 417 | |
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| 418 | |
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| 419 | void AppendNA(NA_Base *buffer,int len,NA_Sequence *seq) |
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| 420 | { |
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| 421 | int curlen=0,j; |
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| 422 | NA_Base *temp; |
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| 423 | temp=0; |
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| 424 | if(seq->seqlen+len >= seq->seqmaxlen) |
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| 425 | { |
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| 426 | if(seq->seqlen>0) |
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| 427 | seq->sequence = (NA_Base*)Realloc((char*)seq->sequence, |
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| 428 | (seq->seqlen + len+GBUFSIZ) * sizeof(NA_Base)); |
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| 429 | else |
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| 430 | seq->sequence = (NA_Base*)Calloc(1,(seq->seqlen + |
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| 431 | len+GBUFSIZ) * sizeof(NA_Base)); |
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| 432 | seq->seqmaxlen = seq->seqlen + len+GBUFSIZ; |
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| 433 | } |
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| 434 | /* |
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| 435 | * seqlen is the length, and the index of the next free |
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| 436 | * base |
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| 437 | */ |
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| 438 | curlen = seq->seqlen + seq->offset; |
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| 439 | for(j=0;j<len;j++) |
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| 440 | putelem(seq,j+curlen,buffer[j]); |
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| 441 | |
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| 442 | seq->seqlen += len; |
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| 443 | return; |
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| 444 | } |
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| 445 | |
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| 446 | void Ascii2NA(char *buffer,int len,int matrix[16]) |
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| 447 | { |
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| 448 | /* |
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| 449 | * if the translation matrix exists, use it to |
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| 450 | * encode the buffer. |
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| 451 | */ |
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| 452 | int i; |
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| 453 | if(matrix != NULL) { |
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| 454 | for(i=0;i<len;i++) { |
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| 455 | buffer[i] = matrix[(unsigned char)buffer[i]]; |
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| 456 | } |
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| 457 | } |
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| 458 | return; |
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| 459 | } |
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| 460 | |
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| 461 | int WriteNA_Flat(NA_Alignment *aln,char *filename,int method,int maskable) |
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| 462 | { |
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| 463 | size_t j; |
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| 464 | int kk,mask = -1,k,offset; |
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| 465 | char offset_str[100],buf[100]; |
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| 466 | NA_Sequence *seqs; |
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| 467 | FILE *file; |
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| 468 | if(aln == NULL) |
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| 469 | return(1); |
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| 470 | if(aln->numelements == 0) |
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| 471 | return(1); |
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| 472 | seqs = aln->element; |
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| 473 | |
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| 474 | file = fopen(filename,"w"); |
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| 475 | if(file == NULL) |
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| 476 | { |
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| 477 | Warning("Cannot open file for output"); |
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| 478 | return(1); |
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| 479 | } |
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| 480 | if(maskable && (method != SELECT_REGION)) |
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| 481 | { |
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| 482 | for(j=0;j<aln->numelements;j++) |
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| 483 | if(seqs[j].elementtype == MASK && |
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| 484 | seqs[j].selected) |
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| 485 | mask = j; |
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| 486 | } |
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| 487 | /* Removed by OLIVER |
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| 488 | for(j=0;j<aln->numelements;j++) |
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| 489 | { |
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| 490 | SeqNorm(&(seqs[j])); |
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| 491 | } |
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| 492 | */ |
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| 493 | |
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| 494 | for(j=0;j<aln->numelements;j++) |
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| 495 | { |
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| 496 | if (method != SELECT_REGION) { |
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| 497 | offset = seqs[j].offset; |
|---|
| 498 | } |
|---|
| 499 | else { |
|---|
| 500 | for(offset=seqs[j].offset; aln->selection_mask[offset] == '0'; offset++) ; |
|---|
| 501 | } |
|---|
| 502 | |
|---|
| 503 | if(offset+aln->rel_offset != 0) |
|---|
| 504 | sprintf(offset_str,"(%d)",offset+aln->rel_offset); |
|---|
| 505 | else |
|---|
| 506 | offset_str[0] = '\0'; |
|---|
| 507 | |
|---|
| 508 | if((((int)j!=mask) && (seqs[j].selected) && method != SELECT_REGION) |
|---|
| 509 | || (method == SELECT_REGION && seqs[j].subselected) |
|---|
| 510 | || method == ALL) |
|---|
| 511 | { |
|---|
| 512 | fprintf(file,"%c%s%s\n", |
|---|
| 513 | seqs[j].elementtype == DNA?'#': |
|---|
| 514 | seqs[j].elementtype == RNA?'#': |
|---|
| 515 | seqs[j].elementtype == PROTEIN?'%': |
|---|
| 516 | seqs[j].elementtype == TEXT?'"': |
|---|
| 517 | seqs[j].elementtype == MASK?'@':'"', |
|---|
| 518 | seqs[j].short_name, |
|---|
| 519 | (offset+aln->rel_offset == 0)? "":offset_str); |
|---|
| 520 | if(seqs[j].tmatrix) |
|---|
| 521 | { |
|---|
| 522 | if(mask == -1) |
|---|
| 523 | for(k=0,kk=0;kk<seqs[j].seqlen;kk++) |
|---|
| 524 | { |
|---|
| 525 | if((k)%60 == 0 && k>0) |
|---|
| 526 | { |
|---|
| 527 | buf[60] = '\0'; |
|---|
| 528 | fputs(buf,file); |
|---|
| 529 | putc('\n',file); |
|---|
| 530 | } |
|---|
| 531 | if(method == SELECT_REGION) |
|---|
| 532 | { |
|---|
| 533 | if(aln->selection_mask[kk+offset]=='1') |
|---|
| 534 | { |
|---|
| 535 | buf[k%60] =((char)seqs[j].tmatrix[ |
|---|
| 536 | (int)getelem( &(seqs[j]),kk+offset) ]); |
|---|
| 537 | k++; |
|---|
| 538 | } |
|---|
| 539 | } |
|---|
| 540 | else |
|---|
| 541 | { |
|---|
| 542 | buf[k%60] =((char)seqs[j].tmatrix[ |
|---|
| 543 | (int)getelem( &(seqs[j]),kk+offset) ]); |
|---|
| 544 | k++; |
|---|
| 545 | } |
|---|
| 546 | } |
|---|
| 547 | else |
|---|
| 548 | for(k=0,kk=0;kk<seqs[j].seqlen;kk++) |
|---|
| 549 | { |
|---|
| 550 | if(getelem(&(seqs[mask]),kk+seqs[mask].offset) != '0' |
|---|
| 551 | && (getelem(&(seqs[mask]),kk+seqs[mask].offset) |
|---|
| 552 | != '-')) |
|---|
| 553 | { |
|---|
| 554 | if((k++)%60 == 0 && k>1) |
|---|
| 555 | { |
|---|
| 556 | buf[60] = '\0'; |
|---|
| 557 | fputs(buf,file); |
|---|
| 558 | putc('\n',file); |
|---|
| 559 | } |
|---|
| 560 | buf[k%60] = ((char)seqs[j].tmatrix |
|---|
| 561 | [getelem(&(seqs[j]),kk+offset)]); |
|---|
| 562 | } |
|---|
| 563 | } |
|---|
| 564 | } |
|---|
| 565 | else |
|---|
| 566 | { |
|---|
| 567 | if(mask == -1) |
|---|
| 568 | for(k=0,kk=0;kk<seqs[j].seqlen;kk++) |
|---|
| 569 | { |
|---|
| 570 | if((k)%60 == 0 && k>0) |
|---|
| 571 | { |
|---|
| 572 | buf[60] = '\0'; |
|---|
| 573 | fputs(buf,file); |
|---|
| 574 | putc('\n',file); |
|---|
| 575 | } |
|---|
| 576 | if(method == SELECT_REGION) |
|---|
| 577 | { |
|---|
| 578 | if(aln->selection_mask[kk+offset]=='1') |
|---|
| 579 | { |
|---|
| 580 | buf[k%60] =(getelem( &(seqs[j]),kk+offset)); |
|---|
| 581 | k++; |
|---|
| 582 | } |
|---|
| 583 | } |
|---|
| 584 | else |
|---|
| 585 | { |
|---|
| 586 | buf[k%60] =( getelem( &(seqs[j]),kk+offset) ); |
|---|
| 587 | k++; |
|---|
| 588 | } |
|---|
| 589 | } |
|---|
| 590 | else |
|---|
| 591 | for(k=0,kk=0;kk<seqs[j].seqlen;kk++) |
|---|
| 592 | { |
|---|
| 593 | if(getelem(&(seqs[mask]),kk+offset) == '1') |
|---|
| 594 | { |
|---|
| 595 | if((k++)%60 == 0 && k>1) |
|---|
| 596 | { |
|---|
| 597 | buf[60] = '\0'; |
|---|
| 598 | fputs(buf,file); |
|---|
| 599 | putc('\n',file); |
|---|
| 600 | } |
|---|
| 601 | buf[k%60] =((char)getelem(&(seqs[j]), |
|---|
| 602 | kk+offset)); |
|---|
| 603 | } |
|---|
| 604 | } |
|---|
| 605 | } |
|---|
| 606 | buf[(k%60)>0 ? (k%60):60] = '\0'; |
|---|
| 607 | fputs(buf,file); |
|---|
| 608 | putc('\n',file); |
|---|
| 609 | } |
|---|
| 610 | } |
|---|
| 611 | fclose(file); |
|---|
| 612 | return(0); |
|---|
| 613 | } |
|---|
| 614 | |
|---|
| 615 | |
|---|
| 616 | void Warning(const char *s) |
|---|
| 617 | { |
|---|
| 618 | /*extern Frame frame; |
|---|
| 619 | extern Panel_item left_foot,right_foot; |
|---|
| 620 | Beep(); |
|---|
| 621 | xv_set(frame,FRAME_RIGHT_FOOTER,s,0); |
|---|
| 622 | xv_set(right_foot,PANEL_LABEL_STRING,s,0);*/ |
|---|
| 623 | aw_message(s); |
|---|
| 624 | } |
|---|
| 625 | |
|---|
| 626 | |
|---|
| 627 | void InitNASeq(NA_Sequence *seq,int type) |
|---|
| 628 | { |
|---|
| 629 | |
|---|
| 630 | |
|---|
| 631 | SetTime(&(seq->t_stamp.origin)); |
|---|
| 632 | SetTime(&(seq->t_stamp.modify)); |
|---|
| 633 | strncpy(seq->id,uniqueID(),79); |
|---|
| 634 | seq->seq_name[0] = '\0'; |
|---|
| 635 | seq->barcode[0] = '\0'; |
|---|
| 636 | seq->contig[0] = '\0'; |
|---|
| 637 | seq->membrane[0] = '\0'; |
|---|
| 638 | seq->authority[0] = '\0'; |
|---|
| 639 | seq->short_name[0] = '\0'; |
|---|
| 640 | seq->sequence = NULL; |
|---|
| 641 | seq->offset = 0; |
|---|
| 642 | seq->baggage = NULL; |
|---|
| 643 | seq->baggage_len = 0; |
|---|
| 644 | seq->baggage_maxlen = 0; |
|---|
| 645 | seq->comments = NULL; |
|---|
| 646 | seq->comments_len = 0; |
|---|
| 647 | seq->comments_maxlen = 0; |
|---|
| 648 | seq->description[0] = '\0'; |
|---|
| 649 | seq->mask = NULL; |
|---|
| 650 | seq->seqlen = 0; |
|---|
| 651 | seq->seqmaxlen = 0; |
|---|
| 652 | seq->protect = PROT_WHITE_SPACE + PROT_TRANSLATION; |
|---|
| 653 | #ifdef HGL |
|---|
| 654 | seq->attr = 0; |
|---|
| 655 | #else |
|---|
| 656 | seq->attr = IS_5_TO_3 + IS_PRIMARY; |
|---|
| 657 | #endif |
|---|
| 658 | seq->elementtype = type; |
|---|
| 659 | seq->groupid = 0; |
|---|
| 660 | seq->groupb = NULL; |
|---|
| 661 | seq->groupf = NULL; |
|---|
| 662 | seq->cmask = NULL; |
|---|
| 663 | seq->selected = 0; |
|---|
| 664 | seq->subselected = 0; |
|---|
| 665 | |
|---|
| 666 | switch (type) |
|---|
| 667 | { |
|---|
| 668 | case DNA: |
|---|
| 669 | seq->tmatrix = Default_DNA_Trans; |
|---|
| 670 | seq->rmatrix = Default_NA_RTrans; |
|---|
| 671 | seq->col_lut = Default_NAColor_LKUP; |
|---|
| 672 | break; |
|---|
| 673 | case RNA: |
|---|
| 674 | seq->tmatrix = Default_RNA_Trans; |
|---|
| 675 | seq->rmatrix = Default_NA_RTrans; |
|---|
| 676 | seq->col_lut = Default_NAColor_LKUP; |
|---|
| 677 | break; |
|---|
| 678 | case PROTEIN: |
|---|
| 679 | seq->tmatrix = NULL; |
|---|
| 680 | seq->rmatrix = NULL; |
|---|
| 681 | seq->col_lut = Default_PROColor_LKUP; |
|---|
| 682 | break; |
|---|
| 683 | case MASK: |
|---|
| 684 | case TEXT: |
|---|
| 685 | default: |
|---|
| 686 | seq->tmatrix = NULL; |
|---|
| 687 | seq->rmatrix = NULL; |
|---|
| 688 | seq->col_lut = NULL; |
|---|
| 689 | break; |
|---|
| 690 | } |
|---|
| 691 | return; |
|---|
| 692 | } |
|---|
| 693 | |
|---|
| 694 | |
|---|
| 695 | void ReadCMask(const char *filename) |
|---|
| 696 | { |
|---|
| 697 | |
|---|
| 698 | char in_line[GBUFSIZ]; |
|---|
| 699 | char head[GBUFSIZ]; |
|---|
| 700 | char curname[GBUFSIZ]; |
|---|
| 701 | char temp[GBUFSIZ]; |
|---|
| 702 | bool IGNORE_DASH = false; |
|---|
| 703 | int offset; |
|---|
| 704 | |
|---|
| 705 | /*NA_DisplayData *NAdd;*/ |
|---|
| 706 | NA_Alignment *aln; |
|---|
| 707 | |
|---|
| 708 | size_t j; |
|---|
| 709 | size_t curlen = 0; |
|---|
| 710 | int *colors = 0,orig_ctype,jj,indx = 0; |
|---|
| 711 | FILE *file; |
|---|
| 712 | |
|---|
| 713 | if(DataSet == NULL) return; |
|---|
| 714 | |
|---|
| 715 | /*NAdd = (NA_DisplayData*)((NA_Alignment*)DataSet)->na_ddata; |
|---|
| 716 | |
|---|
| 717 | if(NAdd == NULL) |
|---|
| 718 | return; |
|---|
| 719 | */ |
|---|
| 720 | aln = (NA_Alignment*)DataSet; |
|---|
| 721 | |
|---|
| 722 | curname[0] = '\0'; |
|---|
| 723 | orig_ctype = COLOR_MONO; |
|---|
| 724 | file = fopen(filename,"r"); |
|---|
| 725 | if(file == NULL) |
|---|
| 726 | { |
|---|
| 727 | Warning("File not found"); |
|---|
| 728 | Warning(filename); |
|---|
| 729 | return; |
|---|
| 730 | } |
|---|
| 731 | |
|---|
| 732 | /*NAdd->color_type = COLOR_ALN_MASK;*/ |
|---|
| 733 | for(;fgets(in_line,GBUFSIZ,file) !=0;) |
|---|
| 734 | { |
|---|
| 735 | if(Find(in_line,"offset:")) |
|---|
| 736 | { |
|---|
| 737 | crop(in_line,head,temp); |
|---|
| 738 | sscanf(temp,"%d",&(aln->cmask_offset)); |
|---|
| 739 | } |
|---|
| 740 | else if(Find(in_line,"nodash:")) |
|---|
| 741 | IGNORE_DASH = true; |
|---|
| 742 | else if(Find(in_line,"dash:")) |
|---|
| 743 | IGNORE_DASH = true; |
|---|
| 744 | else if(Find(in_line,"name:")) |
|---|
| 745 | { |
|---|
| 746 | crop(in_line,head,curname); |
|---|
| 747 | curname[strlen(curname)-1] = '\0'; |
|---|
| 748 | for(j=0;j<strlen(curname);j++) |
|---|
| 749 | if(curname[j] == '(') |
|---|
| 750 | curname[j] = '\0'; |
|---|
| 751 | } |
|---|
| 752 | else if(Find(in_line,"length:")) |
|---|
| 753 | { |
|---|
| 754 | crop(in_line,head,temp); |
|---|
| 755 | sscanf(temp,"%zu",&curlen); |
|---|
| 756 | } |
|---|
| 757 | else if(Find(in_line,"start:")) |
|---|
| 758 | { |
|---|
| 759 | indx = -1; |
|---|
| 760 | if(curlen == 0) |
|---|
| 761 | { |
|---|
| 762 | Warning("illegal format in colormask"); |
|---|
| 763 | /*NAdd->color_type = orig_ctype;*/ |
|---|
| 764 | return; |
|---|
| 765 | } |
|---|
| 766 | if(strlen(curname) != 0) |
|---|
| 767 | { |
|---|
| 768 | indx = -1; |
|---|
| 769 | for(j=0;j<aln->numelements;j++) |
|---|
| 770 | if(Find(aln->element[j].short_name,curname) |
|---|
| 771 | || Find(aln->element[j].id,curname)) |
|---|
| 772 | { |
|---|
| 773 | if(aln->element[j].cmask != NULL) |
|---|
| 774 | Cfree((char*)aln -> element[j].cmask); |
|---|
| 775 | colors=(int*)Calloc(aln->element[j] |
|---|
| 776 | .seqmaxlen+1+aln->element[j].offset |
|---|
| 777 | ,sizeof(int)); |
|---|
| 778 | aln->element[j].cmask = colors; |
|---|
| 779 | /*NAdd->color_type = COLOR_SEQ_MASK;*/ |
|---|
| 780 | indx = j; |
|---|
| 781 | j = aln->numelements; |
|---|
| 782 | } |
|---|
| 783 | if(indx == -1) |
|---|
| 784 | colors=NULL; |
|---|
| 785 | } |
|---|
| 786 | else |
|---|
| 787 | { |
|---|
| 788 | if(aln->cmask != NULL) Cfree((char*)aln->cmask); |
|---|
| 789 | colors=(int*)Calloc(curlen,sizeof(int)); |
|---|
| 790 | aln->cmask = colors; |
|---|
| 791 | aln->cmask_len = curlen; |
|---|
| 792 | /*NAdd->color_type = COLOR_ALN_MASK;*/ |
|---|
| 793 | for(j=0;j<curlen;j++) |
|---|
| 794 | colors[j] = 12; |
|---|
| 795 | } |
|---|
| 796 | |
|---|
| 797 | if(IGNORE_DASH && (indx != -1)) |
|---|
| 798 | { |
|---|
| 799 | for(jj=0,j=0;(j<curlen) && |
|---|
| 800 | (jj<aln->element[indx].seqlen);j++,jj++) |
|---|
| 801 | { |
|---|
| 802 | offset = aln->element[indx].offset; |
|---|
| 803 | if(fgets(in_line,GBUFSIZ,file)==NULL) |
|---|
| 804 | { |
|---|
| 805 | Warning |
|---|
| 806 | ("illegal format in colormask"); |
|---|
| 807 | /*NAdd->color_type = orig_ctype;*/ |
|---|
| 808 | return; |
|---|
| 809 | } |
|---|
| 810 | /* |
|---|
| 811 | * Fixed so that the keyword nodash causes the colormask to be mapped |
|---|
| 812 | * to the sequence, not the alignment. |
|---|
| 813 | * |
|---|
| 814 | * The allocated space is equal the seqlen of the matched sequence. |
|---|
| 815 | * |
|---|
| 816 | */ |
|---|
| 817 | if(aln->element[indx].tmatrix) |
|---|
| 818 | for(;(getelem(&(aln->element[indx]),jj |
|---|
| 819 | +offset) |
|---|
| 820 | ==(aln->element[indx].tmatrix['-']) |
|---|
| 821 | || (getelem(&(aln->element[indx]),jj |
|---|
| 822 | +offset) |
|---|
| 823 | ==aln->element[indx].tmatrix['~'])) |
|---|
| 824 | && jj < aln->element[indx].seqlen;) |
|---|
| 825 | colors[jj++] = 12; |
|---|
| 826 | else |
|---|
| 827 | for(;getelem(&(aln->element[indx]),jj |
|---|
| 828 | +offset) |
|---|
| 829 | =='-' && jj < aln->element[indx].seqlen;) |
|---|
| 830 | colors[jj++] = 12; |
|---|
| 831 | |
|---|
| 832 | sscanf(in_line,"%d",&(colors[jj])); |
|---|
| 833 | } |
|---|
| 834 | } |
|---|
| 835 | else if((indx == -1) && (strlen(curname) != 0)) |
|---|
| 836 | for(j=0;j<curlen;j++) |
|---|
| 837 | fgets(in_line,GBUFSIZ,file); |
|---|
| 838 | else |
|---|
| 839 | for(j=0;j<curlen;j++) |
|---|
| 840 | { |
|---|
| 841 | if(fgets(in_line,GBUFSIZ,file)==NULL) |
|---|
| 842 | { |
|---|
| 843 | Warning |
|---|
| 844 | ("illegal format in colormask"); |
|---|
| 845 | /*NAdd->color_type = orig_ctype;*/ |
|---|
| 846 | return; |
|---|
| 847 | } |
|---|
| 848 | sscanf(in_line,"%d",&(colors[j])); |
|---|
| 849 | } |
|---|
| 850 | IGNORE_DASH = false; |
|---|
| 851 | curname[0] = '\0'; |
|---|
| 852 | } |
|---|
| 853 | |
|---|
| 854 | } |
|---|
| 855 | /*RepaintAll(true);*/ |
|---|
| 856 | return; |
|---|
| 857 | } |
|---|
| 858 | |
|---|
| 859 | |
|---|
| 860 | int WriteStatus(NA_Alignment *aln,char *filename,int method) |
|---|
| 861 | { |
|---|
| 862 | // extern int EditMode; |
|---|
| 863 | // NA_DisplayData *NAdd; |
|---|
| 864 | NA_Sequence *this_seq; |
|---|
| 865 | int j; |
|---|
| 866 | FILE *file; |
|---|
| 867 | method=0;filename=0; |
|---|
| 868 | |
|---|
| 869 | if(DataSet == NULL) |
|---|
| 870 | return(1); |
|---|
| 871 | |
|---|
| 872 | /* |
|---|
| 873 | NAdd = (NA_DisplayData*)((NA_Alignment*)DataSet)->na_ddata; |
|---|
| 874 | if(NAdd == NULL) |
|---|
| 875 | return(1); |
|---|
| 876 | */ |
|---|
| 877 | |
|---|
| 878 | file = fopen(filename,"w"); |
|---|
| 879 | if (file == NULL) |
|---|
| 880 | { |
|---|
| 881 | Warning("Cannot open status file."); |
|---|
| 882 | return(1); |
|---|
| 883 | } |
|---|
| 884 | fprintf(file,"File_format: %s\n",FileFormat==GENBANK?"genbank":"flat"); |
|---|
| 885 | /* |
|---|
| 886 | fprintf(file,"EditMode: %s\n",EditMode==INSERT?"insert": |
|---|
| 887 | "check"); |
|---|
| 888 | */ |
|---|
| 889 | |
|---|
| 890 | this_seq = &(aln->element[1]); /* Nadd->cursor !? */ |
|---|
| 891 | if(this_seq->id != NULL) |
|---|
| 892 | fprintf(file,"sequence-ID %s\n",this_seq->id); |
|---|
| 893 | fprintf(file,"Column: %d\nPos:%d\n",1,1);/*NAdd->cursor_x,NAdd->position*/ |
|---|
| 894 | switch(this_seq->elementtype) |
|---|
| 895 | { |
|---|
| 896 | case DNA: |
|---|
| 897 | case RNA: |
|---|
| 898 | fprintf(file,"#%s\n", |
|---|
| 899 | this_seq->short_name); |
|---|
| 900 | break; |
|---|
| 901 | case PROTEIN: |
|---|
| 902 | fprintf(file,"%%%s\n", |
|---|
| 903 | this_seq->short_name); |
|---|
| 904 | break; |
|---|
| 905 | case MASK: |
|---|
| 906 | fprintf(file,"@%s\n", |
|---|
| 907 | this_seq->short_name); |
|---|
| 908 | break; |
|---|
| 909 | case TEXT: |
|---|
| 910 | fprintf(file,"%c%s\n",'"', |
|---|
| 911 | this_seq->short_name); |
|---|
| 912 | break; |
|---|
| 913 | default: |
|---|
| 914 | break; |
|---|
| 915 | } |
|---|
| 916 | if(this_seq->tmatrix) |
|---|
| 917 | for(j=0;j<this_seq->seqlen;j++) |
|---|
| 918 | putc(this_seq->tmatrix[getelem(this_seq,j)],file); |
|---|
| 919 | else |
|---|
| 920 | for(j=0;j<this_seq->seqlen;j++) |
|---|
| 921 | putc(getelem(this_seq,j),file); |
|---|
| 922 | |
|---|
| 923 | fclose(file); |
|---|
| 924 | return(0); |
|---|
| 925 | } |
|---|
| 926 | |
|---|
| 927 | void ReadStatus(char *filename) |
|---|
| 928 | { |
|---|
| 929 | filename=0; |
|---|
| 930 | /* |
|---|
| 931 | int i,j; |
|---|
| 932 | FILE *file; |
|---|
| 933 | filename=0; |
|---|
| 934 | |
|---|
| 935 | char in_line[GBUFSIZ],head[GBUFSIZ]; |
|---|
| 936 | file = fopen(filename,"r"); |
|---|
| 937 | for(;!DONE;) |
|---|
| 938 | { |
|---|
| 939 | fgets(in_line,GBUFSIZ,file); |
|---|
| 940 | if(strlen(in_line) == 0) |
|---|
| 941 | DONE = true; |
|---|
| 942 | else |
|---|
| 943 | { |
|---|
| 944 | sscanf(in_line,"%s",head); |
|---|
| 945 | if(strncmp(head,"Col",3) != 0) |
|---|
| 946 | { |
|---|
| 947 | sscanf(in_line,"%*s %d",head,&(DataSet->nadd-> |
|---|
| 948 | cursor_x),&(DataSet->nadd->cursory); |
|---|
| 949 | } |
|---|
| 950 | else if(strncmp(head,"Pos",3) != 0) |
|---|
| 951 | { |
|---|
| 952 | } |
|---|
| 953 | } |
|---|
| 954 | } |
|---|
| 955 | |
|---|
| 956 | */ |
|---|
| 957 | } |
|---|
| 958 | |
|---|
| 959 | |
|---|
| 960 | void NormalizeOffset(NA_Alignment *aln) |
|---|
| 961 | { |
|---|
| 962 | int i; |
|---|
| 963 | size_t j; |
|---|
| 964 | int offset = 99999999; |
|---|
| 965 | i=0; |
|---|
| 966 | |
|---|
| 967 | for(j=0;j<aln->numelements;j++) |
|---|
| 968 | offset = MIN(offset,aln->element[j].offset); |
|---|
| 969 | |
|---|
| 970 | for(j=0;j<aln->numelements;j++) |
|---|
| 971 | aln->element[j].offset -= offset; |
|---|
| 972 | |
|---|
| 973 | aln->maxlen = -999999999; |
|---|
| 974 | for(j=0;j<aln->numelements;j++) |
|---|
| 975 | aln->maxlen = MAX(aln->element[j].seqlen+aln->element[j].offset, |
|---|
| 976 | aln->maxlen); |
|---|
| 977 | |
|---|
| 978 | aln->rel_offset += offset; |
|---|
| 979 | |
|---|
| 980 | if(aln->numelements == 0) |
|---|
| 981 | aln->rel_offset = 0; |
|---|
| 982 | |
|---|
| 983 | return; |
|---|
| 984 | } |
|---|
| 985 | |
|---|
| 986 | int WriteCMask(NA_Alignment *aln,char *filename,int method,int maskable) |
|---|
| 987 | { |
|---|
| 988 | size_t j; |
|---|
| 989 | int kk,mask = -1,k,offset; |
|---|
| 990 | char offset_str[100]; |
|---|
| 991 | int *buf; |
|---|
| 992 | NA_Sequence *seqs; |
|---|
| 993 | FILE *file; |
|---|
| 994 | if(aln == NULL) |
|---|
| 995 | return(1); |
|---|
| 996 | |
|---|
| 997 | if(aln->numelements == 0) |
|---|
| 998 | return(1); |
|---|
| 999 | seqs = aln->element; |
|---|
| 1000 | |
|---|
| 1001 | file = fopen(filename,"w"); |
|---|
| 1002 | if(file == NULL) |
|---|
| 1003 | { |
|---|
| 1004 | Warning("Cannot open file for output"); |
|---|
| 1005 | return(1); |
|---|
| 1006 | } |
|---|
| 1007 | if(maskable && (method != SELECT_REGION)) |
|---|
| 1008 | { |
|---|
| 1009 | for(j=0;j<aln->numelements;j++) |
|---|
| 1010 | if(seqs[j].elementtype == MASK && |
|---|
| 1011 | seqs[j].selected) |
|---|
| 1012 | mask = j; |
|---|
| 1013 | } |
|---|
| 1014 | for(j=0;j<aln->numelements;j++) |
|---|
| 1015 | { |
|---|
| 1016 | SeqNorm(&(seqs[j])); |
|---|
| 1017 | } |
|---|
| 1018 | |
|---|
| 1019 | for(j=0;j<aln->numelements;j++) |
|---|
| 1020 | { |
|---|
| 1021 | if(method != SELECT_REGION) { |
|---|
| 1022 | offset = seqs[j].offset; |
|---|
| 1023 | } |
|---|
| 1024 | else { |
|---|
| 1025 | for(offset=seqs[j].offset; aln->selection_mask[offset] == '0'; offset++) ; |
|---|
| 1026 | } |
|---|
| 1027 | |
|---|
| 1028 | if(offset+aln->rel_offset != 0) { |
|---|
| 1029 | sprintf(offset_str,"(%d)",offset+aln->rel_offset); |
|---|
| 1030 | } |
|---|
| 1031 | else { |
|---|
| 1032 | offset_str[0] = '\0'; |
|---|
| 1033 | } |
|---|
| 1034 | |
|---|
| 1035 | if((((int)j!=mask) && (seqs[j].selected) && method != SELECT_REGION) |
|---|
| 1036 | || (method == SELECT_REGION && seqs[j].subselected) |
|---|
| 1037 | || method == ALL) |
|---|
| 1038 | { |
|---|
| 1039 | fprintf(file,"%c%s%s\n", |
|---|
| 1040 | seqs[j].elementtype == DNA?'#': |
|---|
| 1041 | seqs[j].elementtype == RNA?'#': |
|---|
| 1042 | seqs[j].elementtype == PROTEIN?'%': |
|---|
| 1043 | seqs[j].elementtype == TEXT?'"': |
|---|
| 1044 | seqs[j].elementtype == MASK?'@':'"', |
|---|
| 1045 | seqs[j].short_name, |
|---|
| 1046 | (offset+aln->rel_offset == 0)? "":offset_str); |
|---|
| 1047 | |
|---|
| 1048 | if(seqs[j].cmask != NULL) |
|---|
| 1049 | { |
|---|
| 1050 | |
|---|
| 1051 | buf =(int*) Calloc(seqs[j].seqlen,sizeof(int) ); |
|---|
| 1052 | |
|---|
| 1053 | if(mask == -1) |
|---|
| 1054 | { |
|---|
| 1055 | for(k=0,kk=0;kk<seqs[j].seqlen;kk++) |
|---|
| 1056 | { |
|---|
| 1057 | if(method == SELECT_REGION) |
|---|
| 1058 | { |
|---|
| 1059 | if(aln->selection_mask[kk+offset]=='1') |
|---|
| 1060 | buf[k++] = (getcmask( &(seqs[j]),kk+offset)); |
|---|
| 1061 | } |
|---|
| 1062 | |
|---|
| 1063 | else |
|---|
| 1064 | buf[k++] =( getcmask( &(seqs[j]),kk+offset) ); |
|---|
| 1065 | } |
|---|
| 1066 | } |
|---|
| 1067 | else |
|---|
| 1068 | { |
|---|
| 1069 | for(k=0,kk=0;kk<seqs[j].seqlen;kk++) |
|---|
| 1070 | if(getelem(&(seqs[mask]),kk+offset) == '1') |
|---|
| 1071 | buf[k++] =(getcmask(&(seqs[j]), kk+offset)); |
|---|
| 1072 | /* |
|---|
| 1073 | * Looks like k might be one behind? |
|---|
| 1074 | */ |
|---|
| 1075 | } |
|---|
| 1076 | fprintf(file,"name:%s\noffset:%d\nlength:%d\nstart:\n", |
|---|
| 1077 | seqs[j].short_name,seqs[j].offset,k); |
|---|
| 1078 | |
|---|
| 1079 | for(kk = 0; kk < k; kk++) |
|---|
| 1080 | fprintf(file, "%d\n", buf[kk]); |
|---|
| 1081 | |
|---|
| 1082 | Cfree((char*)buf); |
|---|
| 1083 | } |
|---|
| 1084 | } |
|---|
| 1085 | } |
|---|
| 1086 | fclose(file); |
|---|
| 1087 | return(0); |
|---|
| 1088 | } |
|---|