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14/08/09 16:29:27 (3 years ago)
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westram
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  • trunk/HELP_SOURCE/oldhelp/awt_csp.hlp

    r2986 r6141  
    99 
    1010#************* Title of helpfile !! and start of real helpfile strunk******** 
    11 TITLE           Estimate Parameters from Coloumn Statistics 
     11TITLE           Estimate Parameters from Column Statistics 
    1212 
    1313OCCURRENCE      ARB_DIST 
    1414 
    15 DESCRIPTION     In a standart RNA, base frequencies are not equally 
     15DESCRIPTION     In a standard RNA, base frequencies are not equally 
    1616                distributed. Especially in the archea subclass we find 
    1717                extremely G+C rich sequences. 
     
    2626                parts have a significant higher G+C content than non 
    2727                helical parts. 
    28                 One strait forward algorhythm would calculate each frequency 
    29                 independently for each coloumn. 
     28                One strait forward algorithm would calculate each frequency 
     29                independently for each column. 
    3030                Especially for small datasets the resulting frequencies would 
    3131                look like random data, as too few examples are analyzed. 
     
    3333                In ARB we implemented a combination of the 2 approaches. 
    3434                        Lets say we want to estimate a Parameter 'P' with 
    35                         a maximum variance 'maxvar', so we need a minumum 
     35                        a maximum variance 'maxvar', so we need a minimum 
    3636                        samples 'minsap'. 
    3737 
     
    4545                          minimum of independent events. 
    4646 
    47                         - The final parameter estimate for a coloumn is a 
     47                        - The final parameter estimate for a column is a 
    4848                          weighted sum between the estimate for the 
    4949                          cluster and the estimate for the single position. 
    5050 
    51                 You can give your favourite method a higher weight by 
    52                 controlling the smothing parameter: 
     51                You can give your favorite method a higher weight by 
     52                controlling the smoothing parameter: 
    5353 
    5454                        Less smoothing -> independent parameter estimates 
     
    7171 
    7272                         1. Much smoothing of parameters is selected and 
    73                          2. your are anlazing ribosomal RNA and 
     73                         2. you are analyzing ribosomal RNA and 
    7474                         3. 'Use Helix Information' is turned off 
    7575