| 1 | /* |
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| 2 | |
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| 3 | PhyML: a program that computes maximum likelihood phyLOGenies from |
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| 4 | DNA or AA homoLOGous sequences. |
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| 5 | |
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| 6 | Copyright (C) Stephane Guindon. Oct 2003 onward. |
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| 7 | |
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| 8 | All parts of the source except where indicated are distributed under |
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| 9 | the GNU public licence. See http://www.opensource.org for details. |
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| 10 | |
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| 11 | */ |
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| 12 | |
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| 13 | #include "cl.h" |
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| 14 | |
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| 15 | |
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| 16 | /*********************************************************/ |
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| 17 | /** |
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| 18 | * Fill the Option fields, with the argc array |
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| 19 | */ |
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| 20 | int Read_Command_Line(option *io, int argc, char **argv) |
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| 21 | { |
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| 22 | int c; |
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| 23 | int idx; |
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| 24 | int writemode; |
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| 25 | |
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| 26 | if(argc == 1) Exit("\n. No argument was passed to the program. Please check the documentation. \n"); |
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| 27 | |
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| 28 | struct option longopts[] = |
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| 29 | { |
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| 30 | {"n_rgrft", required_argument,NULL,0}, |
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| 31 | {"n_globl", required_argument,NULL,1}, |
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| 32 | {"max_dist", required_argument,NULL,2}, |
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| 33 | {"n_optim", required_argument,NULL,3}, |
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| 34 | {"n_best", required_argument,NULL,4}, |
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| 35 | {"model", required_argument,NULL,5}, |
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| 36 | {"search", required_argument,NULL,6}, |
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| 37 | {"datatype", required_argument,NULL,7}, |
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| 38 | {"multiple", required_argument,NULL,8}, |
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| 39 | {"input", required_argument,NULL,9}, |
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| 40 | {"bootstrap", required_argument,NULL,10}, |
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| 41 | {"ts/tv", required_argument,NULL,11}, |
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| 42 | {"nclasses", required_argument,NULL,12}, |
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| 43 | {"pinv", required_argument,NULL,13}, |
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| 44 | {"alpha", required_argument,NULL,14}, |
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| 45 | {"inputtree", required_argument,NULL,15}, |
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| 46 | {"min_diff_lk_local", required_argument,NULL,16}, |
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| 47 | {"min_diff_lk_global",required_argument,NULL,17}, |
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| 48 | {"steph_spr", no_argument,NULL,18}, |
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| 49 | {"brent_it_max", required_argument,NULL,19}, |
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| 50 | {"rand_start", no_argument,NULL,20}, |
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| 51 | {"n_rand_starts", required_argument,NULL,21}, |
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| 52 | {"sequential", no_argument,NULL,22}, |
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| 53 | {"inside_opt", no_argument,NULL,23}, |
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| 54 | {"p_moves", required_argument,NULL,24}, |
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| 55 | {"fast_nni", no_argument,NULL,25}, |
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| 56 | {"g_pars", no_argument,NULL,26}, |
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| 57 | {"r_seed", required_argument,NULL,27}, |
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| 58 | {"collapse_boot", required_argument,NULL,28}, |
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| 59 | {"random_boot", required_argument,NULL,29}, |
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| 60 | {"print_trace", no_argument,NULL,30}, |
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| 61 | {"print_site_lnl", no_argument,NULL,31}, |
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| 62 | {"print_site_lk", no_argument,NULL,31}, |
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| 63 | {"cov", no_argument,NULL,32}, |
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| 64 | {"cov_delta", required_argument,NULL,33}, |
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| 65 | {"cov_alpha", required_argument,NULL,34}, |
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| 66 | {"cov_ncats", required_argument,NULL,35}, |
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| 67 | {"ps", no_argument,NULL,36}, |
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| 68 | {"cov_free", no_argument,NULL,37}, |
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| 69 | {"no_gap", no_argument,NULL,38}, |
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| 70 | {"n_rr_branch", required_argument,NULL,39}, |
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| 71 | {"append", no_argument,NULL,40}, |
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| 72 | {"no_five_branch", no_argument,NULL,41}, |
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| 73 | {"pars_thresh", required_argument,NULL,42}, |
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| 74 | {"min_diff_lk_move", required_argument,NULL,43}, |
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| 75 | {"hybrid", no_argument,NULL,44}, |
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| 76 | {"use_median", no_argument,NULL,45}, |
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| 77 | {"run_id", required_argument,NULL,46}, |
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| 78 | {"pars", no_argument,NULL,47}, |
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| 79 | {"quiet", no_argument,NULL,48}, |
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| 80 | {"version", no_argument,NULL,49}, |
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| 81 | {"calibration_file", required_argument,NULL,50}, |
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| 82 | {"calibration", required_argument,NULL,50}, |
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| 83 | {"clade_file", required_argument,NULL,50}, |
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| 84 | {"boot_progress_every", required_argument,NULL,51}, |
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| 85 | {"aa_rate_file", required_argument,NULL,52}, |
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| 86 | {"chain_len", required_argument,NULL,53}, |
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| 87 | {"sample_freq", required_argument,NULL,54}, |
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| 88 | {"burnin", required_argument,NULL,55}, |
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| 89 | {"no_memory_check", no_argument,NULL,56}, |
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| 90 | {"no_colalias", no_argument,NULL,57}, |
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| 91 | {"alias_subpatt", no_argument,NULL,58}, |
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| 92 | {"no_sequences", no_argument,NULL,59}, |
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| 93 | {"prior", no_argument,NULL,59}, |
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| 94 | {"fastlk", no_argument,NULL,60}, |
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| 95 | {"free_rates", no_argument,NULL,61}, |
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| 96 | {"freerates", no_argument,NULL,61}, |
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| 97 | {"is", no_argument,NULL,62}, |
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| 98 | // no 63 since it corresponds to character '?' |
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| 99 | {"rate_model", required_argument,NULL,64}, |
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| 100 | {"ratemodel", required_argument,NULL,64}, |
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| 101 | {"log_l", no_argument,NULL,65}, |
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| 102 | {"gamma_lens", no_argument,NULL,66}, |
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| 103 | {"il", no_argument,NULL,66}, |
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| 104 | {"codpos", required_argument,NULL,67}, |
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| 105 | {"constraint_file", required_argument,NULL,68}, |
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| 106 | {"constraint_tree", required_argument,NULL,68}, |
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| 107 | {"help", no_argument,NULL,69}, |
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| 108 | {"mutmap", no_argument,NULL,70}, |
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| 109 | {"parvals", required_argument,NULL,71}, |
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| 110 | {"constrained_lens", no_argument,NULL,72}, |
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| 111 | {"xml", required_argument,NULL,73}, |
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| 112 | {"l_var", required_argument,NULL,74}, |
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| 113 | {0,0,0,0} |
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| 114 | }; |
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| 115 | |
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| 116 | io->datatype = UNDEFINED; |
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| 117 | |
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| 118 | writemode = 1; |
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| 119 | #ifndef PHYML |
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| 120 | int open_ps_file = 0; |
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| 121 | #endif |
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| 122 | idx=-1; |
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| 123 | |
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| 124 | do |
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| 125 | { |
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| 126 | |
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| 127 | c = getopt_long(argc,argv,"qi:d:m:b:n:t:f:zk:v:c:a:u:ho:s:x:g:l:ep",longopts,&idx); |
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| 128 | |
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| 129 | switch(c) |
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| 130 | { |
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| 131 | case 74: |
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| 132 | { |
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| 133 | io->mod->l_var_sigma = String_To_Dbl(optarg); |
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| 134 | break; |
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| 135 | } |
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| 136 | case 73: |
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| 137 | { |
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| 138 | #ifndef SERGEII |
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| 139 | Free_Optimiz(io->mod->s_opt); |
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| 140 | M4_Free_M4_Model(io->mod->m4mod); |
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| 141 | Free_Model_Basic(io->mod); |
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| 142 | Free_Input(io); |
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| 143 | PhyML_XML(optarg); |
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| 144 | return 0; |
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| 145 | #endif |
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| 146 | |
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| 147 | #ifdef SERGEII |
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| 148 | Free_Optimiz(io->mod->s_opt); |
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| 149 | M4_Free_M4_Model(io->mod->m4mod); |
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| 150 | Free_Model_Basic(io->mod); |
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| 151 | Free_Input(io); |
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| 152 | PhyTime_XML(optarg); |
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| 153 | return 0; |
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| 154 | #endif |
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| 155 | } |
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| 156 | case 72: |
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| 157 | { |
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| 158 | io->mod->s_opt->constrained_br_len = YES; |
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| 159 | break; |
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| 160 | } |
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| 161 | case 71: |
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| 162 | { |
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| 163 | io->mcmc->in_fp_par = fopen(optarg,"r"); |
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| 164 | io->mcmc->randomize = NO; |
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| 165 | break; |
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| 166 | } |
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| 167 | case 70: |
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| 168 | { |
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| 169 | io->mutmap = YES; |
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| 170 | break; |
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| 171 | } |
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| 172 | case 68: |
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| 173 | { |
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| 174 | char *tmp; |
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| 175 | tmp = (char *)mCalloc(T_MAX_FILE, sizeof(char)); |
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| 176 | |
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| 177 | if(strlen(optarg) > T_MAX_FILE -11) |
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| 178 | { |
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| 179 | char choix; |
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| 180 | strcpy (tmp, "\n. The file name'"); |
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| 181 | strcat (tmp, optarg); |
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| 182 | strcat (tmp, "' is too long.\n"); |
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| 183 | PhyML_Printf("%s",tmp); |
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| 184 | PhyML_Printf("\n. Type any key to exit.\n"); |
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| 185 | if(!scanf("%c",&choix)) Exit("\n"); |
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| 186 | Exit("\n"); |
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| 187 | } |
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| 188 | else if (!Filexists (optarg)) |
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| 189 | { |
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| 190 | char choix; |
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| 191 | strcpy (tmp, "\n. The file '"); |
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| 192 | strcat (tmp, optarg); |
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| 193 | strcat (tmp, "' doesn't exist.\n"); |
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| 194 | PhyML_Printf("%s",tmp); |
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| 195 | PhyML_Printf("\n. Type any key to exit.\n"); |
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| 196 | if(!scanf("%c",&choix)) Exit("\n"); |
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| 197 | Exit("\n"); |
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| 198 | } |
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| 199 | else |
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| 200 | { |
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| 201 | strcpy(io->in_constraint_tree_file, optarg); |
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| 202 | io->fp_in_constraint_tree = Openfile(io->in_constraint_tree_file,0); |
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| 203 | } |
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| 204 | Free(tmp); |
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| 205 | break; |
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| 206 | } |
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| 207 | case 67: |
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| 208 | { |
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| 209 | phydbl pos; |
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| 210 | pos = atof(optarg); |
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| 211 | io->codpos = (int)pos; |
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| 212 | if(io->codpos < 1 || io->codpos > 3) |
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| 213 | { |
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| 214 | char choix; |
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| 215 | PhyML_Printf("\n. Coding position must be set to 1, 2 or 3.\n"); |
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| 216 | PhyML_Printf("\n. Type any key to exit.\n"); |
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| 217 | if(!scanf("%c",&choix)) Exit("\n"); |
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| 218 | Exit("\n"); |
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| 219 | } |
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| 220 | break; |
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| 221 | |
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| 222 | break; |
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| 223 | } |
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| 224 | case 66: |
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| 225 | { |
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| 226 | io->mod->gamma_mgf_bl = YES; |
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| 227 | io->mod->s_opt->opt_gamma_br_len = YES; |
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| 228 | break; |
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| 229 | } |
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| 230 | case 65: |
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| 231 | { |
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| 232 | io->mod->log_l = YES; |
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| 233 | break; |
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| 234 | } |
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| 235 | case 64: |
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| 236 | { |
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| 237 | char *s; |
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| 238 | int i; |
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| 239 | s = (char *)mCalloc(T_MAX_NAME,sizeof(char)); |
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| 240 | i = 0; |
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| 241 | while(optarg[i++]) s[i]=tolower(optarg[i]); |
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| 242 | if(!strcmp(optarg,"gbd")) io->rates->model = THORNE; |
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| 243 | else if(!strcmp(optarg,"gbs")) io->rates->model = GUINDON; |
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| 244 | else if(!strcmp(optarg,"gamma")) io->rates->model = GAMMA; |
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| 245 | else if(!strcmp(optarg,"clock")) io->rates->model = STRICTCLOCK; |
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| 246 | else if(!strcmp(optarg,"strictclock")) io->rates->model = STRICTCLOCK; |
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| 247 | else if(!strcmp(optarg,"strict_clock")) io->rates->model = STRICTCLOCK; |
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| 248 | else |
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| 249 | { |
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| 250 | PhyML_Printf("\n. rate_model should be 'gbs', 'gbd', 'gamma' or 'clock'."); |
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| 251 | Exit("\n"); |
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| 252 | } |
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| 253 | Free(s); |
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| 254 | break; |
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| 255 | } |
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| 256 | |
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| 257 | |
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| 258 | case 62: |
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| 259 | { |
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| 260 | io->mcmc->is = YES; |
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| 261 | break; |
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| 262 | } |
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| 263 | case 61: |
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| 264 | { |
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| 265 | io->mod->ras->free_mixt_rates = YES; |
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| 266 | io->mod->s_opt->opt_free_mixt_rates = YES; |
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| 267 | break; |
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| 268 | } |
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| 269 | case 60: |
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| 270 | { |
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| 271 | io->lk_approx = NORMAL; |
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| 272 | break; |
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| 273 | } |
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| 274 | case 59: |
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| 275 | { |
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| 276 | io->mcmc->use_data = NO; |
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| 277 | break; |
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| 278 | } |
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| 279 | case 58: |
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| 280 | { |
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| 281 | io->do_alias_subpatt = YES; |
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| 282 | break; |
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| 283 | } |
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| 284 | case 57: |
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| 285 | { |
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| 286 | io->colalias = NO; |
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| 287 | break; |
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| 288 | } |
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| 289 | case 56: |
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| 290 | { |
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| 291 | io->mem_question = NO; |
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| 292 | break; |
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| 293 | } |
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| 294 | case 55: |
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| 295 | { |
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| 296 | phydbl len; |
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| 297 | len = atof(optarg); |
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| 298 | io->mcmc->chain_len_burnin = (int)len; |
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| 299 | if(io->mcmc->chain_len_burnin < 1) |
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| 300 | { |
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| 301 | char choix; |
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| 302 | PhyML_Printf("\n. chain_len_burnin must be an integer greater than 0.\n"); |
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| 303 | PhyML_Printf("\n. Type any key to exit.\n"); |
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| 304 | if(!scanf("%c",&choix)) Exit("\n"); |
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| 305 | Exit("\n"); |
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| 306 | } |
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| 307 | break; |
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| 308 | } |
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| 309 | case 54: |
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| 310 | { |
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| 311 | phydbl len; |
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| 312 | len = atof(optarg); |
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| 313 | io->mcmc->sample_interval = (int)len; |
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| 314 | if(io->mcmc->sample_interval < 1) |
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| 315 | { |
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| 316 | char choix; |
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| 317 | PhyML_Printf("\n. sample_interval must be an integer greater than 0.\n"); |
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| 318 | PhyML_Printf("\n. Type any key to exit.\n"); |
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| 319 | if(!scanf("%c",&choix)) Exit("\n"); |
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| 320 | Exit("\n"); |
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| 321 | } |
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| 322 | break; |
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| 323 | } |
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| 324 | case 53: |
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| 325 | { |
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| 326 | phydbl len; |
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| 327 | len = atof(optarg); |
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| 328 | io->mcmc->chain_len = (int)len; |
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| 329 | if(io->mcmc->chain_len < 1) |
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| 330 | { |
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| 331 | char choix; |
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| 332 | PhyML_Printf("\n. chain_len must be an integer greater than 0.\n"); |
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| 333 | PhyML_Printf("\n. Type any key to exit.\n"); |
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| 334 | if(!scanf("%c",&choix)) Exit("\n"); |
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| 335 | Exit("\n"); |
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| 336 | } |
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| 337 | break; |
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| 338 | } |
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| 339 | case 52: |
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| 340 | { |
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| 341 | char *s; |
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| 342 | s = (char *)mCalloc(T_MAX_FILE, sizeof(char)); |
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| 343 | strcpy(s,optarg); |
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| 344 | io->mod->fp_aa_rate_mat = Openfile(s,0); |
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| 345 | strcpy(io->mod->aa_rate_mat_file->s,s); |
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| 346 | Free(s); |
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| 347 | break; |
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| 348 | } |
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| 349 | case 51: |
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| 350 | { |
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| 351 | io->boot_prog_every = atoi(optarg); |
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| 352 | if(io->boot_prog_every < 1) |
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| 353 | { |
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| 354 | char choix; |
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| 355 | PhyML_Printf("\n. boot_progress_every must be an integer greater than 0.\n"); |
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| 356 | PhyML_Printf("\n. Type any key to exit.\n"); |
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| 357 | if(!scanf("%c",&choix)) Exit("\n"); |
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| 358 | Exit("\n"); |
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| 359 | } |
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| 360 | break; |
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| 361 | } |
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| 362 | case 50: |
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| 363 | { |
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| 364 | strcpy(io->clade_list_file,optarg); |
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| 365 | break; |
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| 366 | } |
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| 367 | case 49: |
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| 368 | { |
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| 369 | PhyML_Printf("\n. This is PhyML version %s.\n\n",VERSION); |
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| 370 | Exit(""); |
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| 371 | break; |
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| 372 | } |
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| 373 | case 48 : |
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| 374 | { |
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| 375 | io->quiet = 1; |
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| 376 | break; |
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| 377 | } |
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| 378 | case 'p' : case 47 : |
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| 379 | { |
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| 380 | io->in_tree = 1; |
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| 381 | break; |
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| 382 | } |
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| 383 | case 46 : |
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| 384 | { |
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| 385 | io->append_run_ID = YES; |
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| 386 | strcpy(io->run_id_string,optarg); |
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| 387 | break; |
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| 388 | } |
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| 389 | case 45 : |
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| 390 | { |
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| 391 | io->mod->ras->gamma_median = 1; |
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| 392 | break; |
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| 393 | } |
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| 394 | case 44 : |
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| 395 | { |
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| 396 | io->mod->s_opt->hybrid_thresh = 0; |
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| 397 | break; |
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| 398 | } |
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| 399 | case 43 : |
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| 400 | { |
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| 401 | io->mod->s_opt->min_diff_lk_move = atof(optarg); |
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| 402 | if(io->mod->s_opt->min_diff_lk_move < 0) |
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| 403 | { |
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| 404 | char choix; |
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| 405 | PhyML_Printf("\n. Min_diff_lk_move must be a double greater than 0.\n"); |
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| 406 | PhyML_Printf("\n. Type any key to exit.\n"); |
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| 407 | if(!scanf("%c",&choix)) Exit("\n"); |
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| 408 | Exit("\n"); |
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| 409 | } |
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| 410 | break; |
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| 411 | } |
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| 412 | case 42 : |
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| 413 | { |
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| 414 | io->mod->s_opt->pars_thresh = (int)atoi(optarg); |
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| 415 | if(io->mod->s_opt->pars_thresh < 0) |
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| 416 | { |
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| 417 | PhyML_Printf("\n. The parsimony threshold must be an integer greater than 0.\n"); |
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| 418 | PhyML_Printf("\n. Type any key to exit.\n"); |
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| 419 | Exit("\n"); |
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| 420 | } |
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| 421 | break; |
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| 422 | } |
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| 423 | case 41 : |
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| 424 | { |
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| 425 | io->mod->s_opt->opt_five_branch = 0; |
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| 426 | break; |
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| 427 | } |
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| 428 | case 40 : |
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| 429 | { |
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| 430 | writemode = 2; |
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| 431 | break; |
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| 432 | } |
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| 433 | case 39 : |
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| 434 | { |
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| 435 | break; |
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| 436 | } |
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| 437 | case 38 : |
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| 438 | { |
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| 439 | io->rm_ambigu = 1; |
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| 440 | break; |
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| 441 | } |
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| 442 | case 37 : |
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| 443 | { |
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| 444 | io->mod->s_opt->opt_cov_free_rates = YES; |
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| 445 | io->mod->m4mod->use_cov_alpha = NO; |
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| 446 | io->mod->m4mod->use_cov_free = YES; |
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| 447 | break; |
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| 448 | } |
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| 449 | case 36 : |
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| 450 | { |
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| 451 | #ifndef PHYML |
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| 452 | open_ps_file = 1; |
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| 453 | #endif |
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| 454 | break; |
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| 455 | } |
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| 456 | case 35 : |
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| 457 | { |
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| 458 | io->mod->m4mod->n_h = (int)atoi(optarg); |
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| 459 | |
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| 460 | if(io->mod->m4mod->n_h < 1) |
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| 461 | { |
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| 462 | char choix; |
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| 463 | PhyML_Printf("\n. The number of classes must be greater than 0.\n"); |
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| 464 | PhyML_Printf("\n. Type any key to exit.\n"); |
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| 465 | if(!scanf("%c",&choix)) Exit("\n"); |
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| 466 | Exit("\n"); |
|---|
| 467 | } |
|---|
| 468 | break; |
|---|
| 469 | } |
|---|
| 470 | case 34 : |
|---|
| 471 | { |
|---|
| 472 | io->mod->m4mod->use_cov_alpha = 1; |
|---|
| 473 | io->mod->m4mod->use_cov_free = 0; |
|---|
| 474 | |
|---|
| 475 | if(!strcmp(optarg,"e") || !strcmp(optarg,"E") || |
|---|
| 476 | !strcmp(optarg,"estimated") || !strcmp(optarg,"ESTIMATED")) |
|---|
| 477 | { |
|---|
| 478 | io->mod->s_opt->opt_cov_alpha = 1; |
|---|
| 479 | io->mod->m4mod->alpha = 1.0; |
|---|
| 480 | } |
|---|
| 481 | else |
|---|
| 482 | { |
|---|
| 483 | io->mod->m4mod->alpha = (phydbl)atof(optarg); |
|---|
| 484 | |
|---|
| 485 | if(io->mod->m4mod->alpha < 1.E-5) |
|---|
| 486 | { |
|---|
| 487 | char choix; |
|---|
| 488 | PhyML_Printf("\n. The value of alpha must be greater than 1.E-5.\n"); |
|---|
| 489 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 490 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 491 | Exit("\n"); |
|---|
| 492 | } |
|---|
| 493 | } |
|---|
| 494 | break; |
|---|
| 495 | } |
|---|
| 496 | case 33 : |
|---|
| 497 | { |
|---|
| 498 | if(!strcmp(optarg,"e") || !strcmp(optarg,"E") || |
|---|
| 499 | !strcmp(optarg,"estimated") || !strcmp(optarg,"ESTIMATED")) |
|---|
| 500 | { |
|---|
| 501 | io->mod->s_opt->opt_cov_delta = YES; |
|---|
| 502 | io->mod->m4mod->delta = 1.0; |
|---|
| 503 | } |
|---|
| 504 | else |
|---|
| 505 | { |
|---|
| 506 | io->mod->m4mod->delta = (phydbl)atof(optarg); |
|---|
| 507 | |
|---|
| 508 | if(atof(optarg) < 1.E-10) |
|---|
| 509 | { |
|---|
| 510 | char choix; |
|---|
| 511 | PhyML_Printf("\n. The value of delta must be larger than 1.E-10.\n"); |
|---|
| 512 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 513 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 514 | Exit("\n"); |
|---|
| 515 | } |
|---|
| 516 | } |
|---|
| 517 | break; |
|---|
| 518 | } |
|---|
| 519 | case 32 : |
|---|
| 520 | { |
|---|
| 521 | io->mod->use_m4mod = YES; |
|---|
| 522 | break; |
|---|
| 523 | } |
|---|
| 524 | case 31 : |
|---|
| 525 | { |
|---|
| 526 | io->print_site_lnl = YES; |
|---|
| 527 | break; |
|---|
| 528 | } |
|---|
| 529 | case 30 : |
|---|
| 530 | { |
|---|
| 531 | io->print_trace = YES; |
|---|
| 532 | break; |
|---|
| 533 | } |
|---|
| 534 | case 29 : |
|---|
| 535 | { |
|---|
| 536 | io->random_boot_seq_order = (int)atoi(optarg); |
|---|
| 537 | break; |
|---|
| 538 | } |
|---|
| 539 | case 28 : |
|---|
| 540 | { |
|---|
| 541 | io->collapse_boot = (int)atoi(optarg); |
|---|
| 542 | break; |
|---|
| 543 | } |
|---|
| 544 | case 27 : |
|---|
| 545 | { |
|---|
| 546 | io->r_seed = (int)atoi(optarg); |
|---|
| 547 | break; |
|---|
| 548 | } |
|---|
| 549 | case 26 : |
|---|
| 550 | { |
|---|
| 551 | io->mod->s_opt->general_pars = YES; |
|---|
| 552 | break; |
|---|
| 553 | } |
|---|
| 554 | case 25 : |
|---|
| 555 | { |
|---|
| 556 | io->mod->s_opt->fast_nni = YES; |
|---|
| 557 | break; |
|---|
| 558 | } |
|---|
| 559 | case 24 : |
|---|
| 560 | { |
|---|
| 561 | io->mod->s_opt->p_moves_to_examine = (phydbl)atof(optarg); |
|---|
| 562 | break; |
|---|
| 563 | } |
|---|
| 564 | case 23 : |
|---|
| 565 | { |
|---|
| 566 | io->mod->s_opt->wim_inside_opt = 1; |
|---|
| 567 | break; |
|---|
| 568 | } |
|---|
| 569 | case 0 : |
|---|
| 570 | { |
|---|
| 571 | io->mod->s_opt->wim_n_rgrft = atoi(optarg); |
|---|
| 572 | break; |
|---|
| 573 | } |
|---|
| 574 | case 1 : |
|---|
| 575 | { |
|---|
| 576 | io->mod->s_opt->wim_n_globl = atoi(optarg); |
|---|
| 577 | break; |
|---|
| 578 | } |
|---|
| 579 | case 2 : |
|---|
| 580 | { |
|---|
| 581 | io->mod->s_opt->wim_max_dist = atoi(optarg); |
|---|
| 582 | break; |
|---|
| 583 | } |
|---|
| 584 | case 3 : |
|---|
| 585 | { |
|---|
| 586 | io->mod->s_opt->wim_n_optim = atoi(optarg); |
|---|
| 587 | break; |
|---|
| 588 | } |
|---|
| 589 | case 4 : |
|---|
| 590 | { |
|---|
| 591 | io->mod->s_opt->wim_n_best = atoi(optarg); |
|---|
| 592 | break; |
|---|
| 593 | } |
|---|
| 594 | case 16 : |
|---|
| 595 | { |
|---|
| 596 | io->mod->s_opt->min_diff_lk_local = atof(optarg); |
|---|
| 597 | break; |
|---|
| 598 | } |
|---|
| 599 | case 17 : |
|---|
| 600 | { |
|---|
| 601 | io->mod->s_opt->min_diff_lk_global = atof(optarg); |
|---|
| 602 | break; |
|---|
| 603 | } |
|---|
| 604 | case 18 : |
|---|
| 605 | { |
|---|
| 606 | io->mod->s_opt->steph_spr = 0; |
|---|
| 607 | io->mod->s_opt->greedy = 1; |
|---|
| 608 | break; |
|---|
| 609 | } |
|---|
| 610 | case 19 : |
|---|
| 611 | { |
|---|
| 612 | io->mod->s_opt->brent_it_max = atoi(optarg); |
|---|
| 613 | break; |
|---|
| 614 | } |
|---|
| 615 | case 20 : |
|---|
| 616 | { |
|---|
| 617 | io->mod->s_opt->random_input_tree = 1; |
|---|
| 618 | break; |
|---|
| 619 | } |
|---|
| 620 | case 21 : |
|---|
| 621 | { |
|---|
| 622 | io->mod->s_opt->random_input_tree = 1; |
|---|
| 623 | io->mod->s_opt->n_rand_starts = atoi(optarg); |
|---|
| 624 | if(io->mod->s_opt->n_rand_starts < 1) Exit("\n== Number of random starting trees must be > 0.\n\n"); |
|---|
| 625 | } |
|---|
| 626 | case 's':case 6: |
|---|
| 627 | { |
|---|
| 628 | if((!strcmp(optarg,"spr")) || (!strcmp(optarg,"SPR"))) |
|---|
| 629 | { |
|---|
| 630 | io->mod->s_opt->topo_search = SPR_MOVE; |
|---|
| 631 | io->mod->s_opt->greedy = (io->mod->s_opt->steph_spr)?(0):(1); |
|---|
| 632 | } |
|---|
| 633 | else if((!strcmp(optarg,"nni")) || (!strcmp(optarg,"NNI"))) |
|---|
| 634 | { |
|---|
| 635 | io->mod->s_opt->topo_search = NNI_MOVE; |
|---|
| 636 | io->mod->s_opt->random_input_tree = 0; |
|---|
| 637 | } |
|---|
| 638 | else if((!strcmp(optarg,"best")) || (!strcmp(optarg,"BEST"))) |
|---|
| 639 | { |
|---|
| 640 | io->mod->s_opt->topo_search = BEST_OF_NNI_AND_SPR; |
|---|
| 641 | io->mod->s_opt->greedy = (io->mod->s_opt->steph_spr)?(0):(1); |
|---|
| 642 | } |
|---|
| 643 | break; |
|---|
| 644 | } |
|---|
| 645 | |
|---|
| 646 | case 'd':case 7: |
|---|
| 647 | { |
|---|
| 648 | if(!strcmp(optarg,"nt")) |
|---|
| 649 | { |
|---|
| 650 | io->datatype = NT; |
|---|
| 651 | io->mod->ns = 4; |
|---|
| 652 | io->mod->m4mod->n_o = 4; |
|---|
| 653 | |
|---|
| 654 | if( |
|---|
| 655 | (io->mod->whichmodel == LG) || |
|---|
| 656 | (io->mod->whichmodel == WAG) || |
|---|
| 657 | (io->mod->whichmodel == DAYHOFF) || |
|---|
| 658 | (io->mod->whichmodel == JTT) || |
|---|
| 659 | (io->mod->whichmodel == BLOSUM62) || |
|---|
| 660 | (io->mod->whichmodel == MTREV) || |
|---|
| 661 | (io->mod->whichmodel == RTREV) || |
|---|
| 662 | (io->mod->whichmodel == CPREV) || |
|---|
| 663 | (io->mod->whichmodel == DCMUT) || |
|---|
| 664 | (io->mod->whichmodel == VT) || |
|---|
| 665 | (io->mod->whichmodel == MTMAM) || |
|---|
| 666 | (io->mod->whichmodel == MTART) || |
|---|
| 667 | (io->mod->whichmodel == HIVW) || |
|---|
| 668 | (io->mod->whichmodel == HIVB) || |
|---|
| 669 | (io->mod->whichmodel == CUSTOMAA) |
|---|
| 670 | ) |
|---|
| 671 | { |
|---|
| 672 | io->mod->whichmodel = HKY85; |
|---|
| 673 | strcpy(io->mod->modelname->s, "HKY85\0"); |
|---|
| 674 | } |
|---|
| 675 | } |
|---|
| 676 | else if (!strcmp(optarg,"aa")) |
|---|
| 677 | { |
|---|
| 678 | io->datatype = AA; |
|---|
| 679 | io->mod->s_opt->opt_kappa = NO; |
|---|
| 680 | io->mod->ns = 20; |
|---|
| 681 | io->mod->m4mod->n_o = 20; |
|---|
| 682 | |
|---|
| 683 | if( |
|---|
| 684 | (io->mod->whichmodel == JC69) || |
|---|
| 685 | (io->mod->whichmodel == K80) || |
|---|
| 686 | (io->mod->whichmodel == F81) || |
|---|
| 687 | (io->mod->whichmodel == HKY85) || |
|---|
| 688 | (io->mod->whichmodel == F84) || |
|---|
| 689 | (io->mod->whichmodel == TN93) || |
|---|
| 690 | (io->mod->whichmodel == GTR) || |
|---|
| 691 | (io->mod->whichmodel == CUSTOM) |
|---|
| 692 | ) |
|---|
| 693 | { |
|---|
| 694 | io->mod->whichmodel = LG; |
|---|
| 695 | strcpy(io->mod->modelname->s, "LG\0"); |
|---|
| 696 | } |
|---|
| 697 | } |
|---|
| 698 | else if ((!strcmp(optarg,"generic")) || (!strcmp(optarg,"gen"))) |
|---|
| 699 | { |
|---|
| 700 | io->datatype = GENERIC; |
|---|
| 701 | } |
|---|
| 702 | else |
|---|
| 703 | { |
|---|
| 704 | char choix; |
|---|
| 705 | PhyML_Printf("\n. Unknown argument to -d option: please use `nt' for DNA or `aa' for Amino-Acids\n"); |
|---|
| 706 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 707 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 708 | Exit("\n"); |
|---|
| 709 | } |
|---|
| 710 | |
|---|
| 711 | break; |
|---|
| 712 | } |
|---|
| 713 | case 'm': case 5 : |
|---|
| 714 | { |
|---|
| 715 | int i; |
|---|
| 716 | |
|---|
| 717 | For(i,strlen(optarg)) Uppercase(optarg+i); |
|---|
| 718 | |
|---|
| 719 | if(!isalpha(optarg[0])) |
|---|
| 720 | { |
|---|
| 721 | strcpy(io->mod->custom_mod_string->s,optarg); |
|---|
| 722 | |
|---|
| 723 | if(strlen(io->mod->custom_mod_string->s) != 6) |
|---|
| 724 | { |
|---|
| 725 | Warn_And_Exit("\n. The string should be of length 6.\n"); |
|---|
| 726 | } |
|---|
| 727 | else |
|---|
| 728 | { |
|---|
| 729 | /* Make_Custom_Model(io->mod); */ |
|---|
| 730 | /* Translate_Custom_Mod_String(io->mod); */ |
|---|
| 731 | } |
|---|
| 732 | |
|---|
| 733 | io->datatype = NT; |
|---|
| 734 | io->mod->whichmodel = CUSTOM; |
|---|
| 735 | strcpy(io->mod->modelname->s, "custom"); |
|---|
| 736 | io->mod->s_opt->opt_kappa = NO; |
|---|
| 737 | io->mod->s_opt->opt_rr = YES; |
|---|
| 738 | } |
|---|
| 739 | |
|---|
| 740 | else if (strcmp(optarg, "JC69") == 0) |
|---|
| 741 | { |
|---|
| 742 | io->datatype = NT; |
|---|
| 743 | io->mod->whichmodel = JC69; |
|---|
| 744 | } |
|---|
| 745 | else if(strcmp(optarg, "K80") == 0) |
|---|
| 746 | { |
|---|
| 747 | io->datatype = NT; |
|---|
| 748 | io->mod->whichmodel = K80; |
|---|
| 749 | } |
|---|
| 750 | else if(strcmp(optarg, "F81") == 0) |
|---|
| 751 | { |
|---|
| 752 | io->datatype = NT; |
|---|
| 753 | io->mod->whichmodel = F81; |
|---|
| 754 | } |
|---|
| 755 | else if (strcmp(optarg, "HKY85") == 0) |
|---|
| 756 | { |
|---|
| 757 | io->datatype = NT; |
|---|
| 758 | io->mod->whichmodel = HKY85; |
|---|
| 759 | } |
|---|
| 760 | else if(strcmp(optarg, "F84") == 0) |
|---|
| 761 | { |
|---|
| 762 | io->datatype = NT; |
|---|
| 763 | io->mod->whichmodel = F84; |
|---|
| 764 | } |
|---|
| 765 | else if (strcmp (optarg,"TN93") == 0) |
|---|
| 766 | { |
|---|
| 767 | io->datatype = NT; |
|---|
| 768 | io->mod->whichmodel = TN93; |
|---|
| 769 | } |
|---|
| 770 | else if(strcmp (optarg, "GTR") == 0) |
|---|
| 771 | { |
|---|
| 772 | io->datatype = NT; |
|---|
| 773 | io->mod->whichmodel = GTR; |
|---|
| 774 | } |
|---|
| 775 | else if(strcmp(optarg, "DAYHOFF") == 0) |
|---|
| 776 | { |
|---|
| 777 | io->datatype = AA; |
|---|
| 778 | io->mod->whichmodel = DAYHOFF; |
|---|
| 779 | } |
|---|
| 780 | else if(strcmp (optarg, "JTT") == 0) |
|---|
| 781 | { |
|---|
| 782 | io->datatype = AA; |
|---|
| 783 | io->mod->whichmodel = JTT; |
|---|
| 784 | } |
|---|
| 785 | else if(strcmp(optarg, "MTREV") == 0) |
|---|
| 786 | { |
|---|
| 787 | io->datatype = AA; |
|---|
| 788 | io->mod->whichmodel = MTREV; |
|---|
| 789 | } |
|---|
| 790 | else if(strcmp (optarg, "LG") == 0) |
|---|
| 791 | { |
|---|
| 792 | io->datatype = AA; |
|---|
| 793 | io->mod->whichmodel = LG; |
|---|
| 794 | } |
|---|
| 795 | else if(strcmp (optarg, "WAG") == 0) |
|---|
| 796 | { |
|---|
| 797 | io->datatype = AA; |
|---|
| 798 | io->mod->whichmodel = WAG; |
|---|
| 799 | } |
|---|
| 800 | else if(strcmp(optarg, "DCMUT") == 0) |
|---|
| 801 | { |
|---|
| 802 | io->datatype = AA; |
|---|
| 803 | io->mod->whichmodel = DCMUT; |
|---|
| 804 | } |
|---|
| 805 | else if(strcmp (optarg, "RTREV") == 0) |
|---|
| 806 | { |
|---|
| 807 | io->datatype = AA; |
|---|
| 808 | io->mod->whichmodel = RTREV; |
|---|
| 809 | } |
|---|
| 810 | else if(strcmp(optarg, "CPREV") == 0) |
|---|
| 811 | { |
|---|
| 812 | io->datatype = AA; |
|---|
| 813 | io->mod->whichmodel = CPREV; |
|---|
| 814 | } |
|---|
| 815 | else if(strcmp(optarg, "VT") == 0) |
|---|
| 816 | { |
|---|
| 817 | io->datatype = AA; |
|---|
| 818 | io->mod->whichmodel = VT; |
|---|
| 819 | } |
|---|
| 820 | else if(strcmp(optarg, "BLOSUM62") == 0) |
|---|
| 821 | { |
|---|
| 822 | io->datatype = AA; |
|---|
| 823 | io->mod->whichmodel = BLOSUM62; |
|---|
| 824 | } |
|---|
| 825 | else if(strcmp(optarg, "MTMAM") == 0) |
|---|
| 826 | { |
|---|
| 827 | io->datatype = AA; |
|---|
| 828 | io->mod->whichmodel = MTMAM; |
|---|
| 829 | } |
|---|
| 830 | else if (strcmp(optarg,"MTART") == 0) |
|---|
| 831 | { |
|---|
| 832 | io->datatype = AA; |
|---|
| 833 | io->mod->whichmodel = MTART; |
|---|
| 834 | } |
|---|
| 835 | else if (strcmp(optarg,"HIVW") == 0) |
|---|
| 836 | { |
|---|
| 837 | io->datatype = AA; |
|---|
| 838 | io->mod->whichmodel = HIVW; |
|---|
| 839 | } |
|---|
| 840 | else if(strcmp(optarg, "HIVB") == 0) |
|---|
| 841 | { |
|---|
| 842 | io->datatype = AA; |
|---|
| 843 | io->mod->whichmodel = HIVB; |
|---|
| 844 | } |
|---|
| 845 | else if (strcmp(optarg, "CUSTOM") == 0) |
|---|
| 846 | { |
|---|
| 847 | io->datatype = AA; |
|---|
| 848 | io->mod->whichmodel = CUSTOMAA; |
|---|
| 849 | } |
|---|
| 850 | else |
|---|
| 851 | { |
|---|
| 852 | PhyML_Printf("\n. The model name is incorrect. Please see the documentation.\n"); |
|---|
| 853 | Exit("\n"); |
|---|
| 854 | } |
|---|
| 855 | |
|---|
| 856 | Set_Model_Name(io->mod); |
|---|
| 857 | |
|---|
| 858 | break; |
|---|
| 859 | } |
|---|
| 860 | |
|---|
| 861 | case 'a':case 14 : |
|---|
| 862 | { |
|---|
| 863 | if ((strcmp (optarg, "e") == 0) || |
|---|
| 864 | (strcmp (optarg, "E") == 0) || |
|---|
| 865 | (strcmp (optarg, "estimated") == 0) || |
|---|
| 866 | (strcmp (optarg, "ESTIMATED") == 0)) |
|---|
| 867 | { |
|---|
| 868 | io->mod->s_opt->opt_alpha = YES; |
|---|
| 869 | } |
|---|
| 870 | else if (atof(optarg) < 1.E-10) |
|---|
| 871 | { |
|---|
| 872 | char choix; |
|---|
| 873 | PhyML_Printf("\n. Alpha must be > 1.E-10.\n"); |
|---|
| 874 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 875 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 876 | Exit("\n"); |
|---|
| 877 | } |
|---|
| 878 | else |
|---|
| 879 | { |
|---|
| 880 | io->mod->ras->alpha->v = (phydbl)atof(optarg); |
|---|
| 881 | io->mod->s_opt->opt_alpha = 0; |
|---|
| 882 | } |
|---|
| 883 | break; |
|---|
| 884 | } |
|---|
| 885 | case 'b':case 10: |
|---|
| 886 | { |
|---|
| 887 | if ((int)String_To_Dbl(optarg) < -5) |
|---|
| 888 | { |
|---|
| 889 | char choix; |
|---|
| 890 | PhyML_Printf("\n. Branch test value must be a positive integer for bootstrap, or between -1 and -4 for aLRT branch test\n"); |
|---|
| 891 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 892 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 893 | Exit("\n"); |
|---|
| 894 | } |
|---|
| 895 | else |
|---|
| 896 | { |
|---|
| 897 | if((int)String_To_Dbl(optarg) > 0) |
|---|
| 898 | { |
|---|
| 899 | io->ratio_test = 0; |
|---|
| 900 | io->mod->bootstrap = (int)atoi(optarg); |
|---|
| 901 | io->print_boot_trees = 1; |
|---|
| 902 | |
|---|
| 903 | if(io->n_data_sets > 1) |
|---|
| 904 | { |
|---|
| 905 | char choix; |
|---|
| 906 | PhyML_Printf("\n. Bootstrap option is not allowed with multiple data sets\n"); |
|---|
| 907 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 908 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 909 | Exit("\n"); |
|---|
| 910 | } |
|---|
| 911 | } |
|---|
| 912 | else if (atoi(optarg)==0) |
|---|
| 913 | { |
|---|
| 914 | io->mod->bootstrap = 0; |
|---|
| 915 | io->ratio_test = 0; |
|---|
| 916 | } |
|---|
| 917 | else |
|---|
| 918 | { |
|---|
| 919 | io->mod->bootstrap = 0; |
|---|
| 920 | io->ratio_test = -(int)atoi(optarg); |
|---|
| 921 | } |
|---|
| 922 | } |
|---|
| 923 | break; |
|---|
| 924 | } |
|---|
| 925 | case 'c':case 12: |
|---|
| 926 | { |
|---|
| 927 | if ((!atoi(optarg)) || (atoi(optarg) < 0)) |
|---|
| 928 | { |
|---|
| 929 | char choix; |
|---|
| 930 | PhyML_Printf("\n. Unknown argument to -c option: the number of rate categories must be a positive integer\n"); |
|---|
| 931 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 932 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 933 | Exit("\n"); |
|---|
| 934 | } |
|---|
| 935 | else |
|---|
| 936 | { |
|---|
| 937 | io->mod->ras->n_catg = atoi(optarg); |
|---|
| 938 | if(io->mod->ras->n_catg < 1) |
|---|
| 939 | { |
|---|
| 940 | PhyML_Printf("\n. The number of rate categories must be a positive integer\n"); |
|---|
| 941 | Exit("\n"); |
|---|
| 942 | } |
|---|
| 943 | } |
|---|
| 944 | break; |
|---|
| 945 | } |
|---|
| 946 | case 'f': |
|---|
| 947 | { |
|---|
| 948 | if(!strcmp(optarg,"e")) |
|---|
| 949 | { |
|---|
| 950 | if(io->datatype == NT) |
|---|
| 951 | io->mod->s_opt->opt_state_freq = NO; |
|---|
| 952 | else if (io->datatype == AA) |
|---|
| 953 | io->mod->s_opt->opt_state_freq = YES; |
|---|
| 954 | else |
|---|
| 955 | { |
|---|
| 956 | PhyML_Printf("\n. Please define the data type (nt or aa) before setting the -f option\n"); |
|---|
| 957 | Exit("\n"); |
|---|
| 958 | } |
|---|
| 959 | } |
|---|
| 960 | else if(!strcmp(optarg,"m")) |
|---|
| 961 | { |
|---|
| 962 | if (io->datatype == NT) |
|---|
| 963 | io->mod->s_opt->opt_state_freq = YES; |
|---|
| 964 | else if (io->datatype == AA) |
|---|
| 965 | io->mod->s_opt->opt_state_freq = NO; |
|---|
| 966 | else |
|---|
| 967 | { |
|---|
| 968 | PhyML_Printf("\n. Please define the data type (nt or aa) before setting the -f option\n"); |
|---|
| 969 | Exit("\n"); |
|---|
| 970 | } |
|---|
| 971 | } |
|---|
| 972 | else if(!isalpha(optarg[0])) |
|---|
| 973 | { |
|---|
| 974 | phydbl sum; |
|---|
| 975 | double val1,val2,val3,val4; |
|---|
| 976 | |
|---|
| 977 | io->mod->s_opt->opt_state_freq = 0; |
|---|
| 978 | io->mod->s_opt->user_state_freq = 1; |
|---|
| 979 | |
|---|
| 980 | /* sscanf(optarg,"%lf,%lf,%lf,%lf", */ |
|---|
| 981 | /* io->mod->user_b_freq, */ |
|---|
| 982 | /* io->mod->user_b_freq+1, */ |
|---|
| 983 | /* io->mod->user_b_freq+2, */ |
|---|
| 984 | /* io->mod->user_b_freq+3); */ |
|---|
| 985 | sscanf(optarg,"%lf,%lf,%lf,%lf",&val1,&val2,&val3,&val4); |
|---|
| 986 | io->mod->user_b_freq->v[0] = (phydbl)val1; |
|---|
| 987 | io->mod->user_b_freq->v[1] = (phydbl)val2; |
|---|
| 988 | io->mod->user_b_freq->v[2] = (phydbl)val3; |
|---|
| 989 | io->mod->user_b_freq->v[3] = (phydbl)val4; |
|---|
| 990 | |
|---|
| 991 | sum = |
|---|
| 992 | (io->mod->user_b_freq->v[0] + |
|---|
| 993 | io->mod->user_b_freq->v[1] + |
|---|
| 994 | io->mod->user_b_freq->v[2] + |
|---|
| 995 | io->mod->user_b_freq->v[3]); |
|---|
| 996 | |
|---|
| 997 | io->mod->user_b_freq->v[0] /= sum; |
|---|
| 998 | io->mod->user_b_freq->v[1] /= sum; |
|---|
| 999 | io->mod->user_b_freq->v[2] /= sum; |
|---|
| 1000 | io->mod->user_b_freq->v[3] /= sum; |
|---|
| 1001 | |
|---|
| 1002 | |
|---|
| 1003 | if(io->mod->user_b_freq->v[0] < .0 || |
|---|
| 1004 | io->mod->user_b_freq->v[1] < .0 || |
|---|
| 1005 | io->mod->user_b_freq->v[2] < .0 || |
|---|
| 1006 | io->mod->user_b_freq->v[3] < .0 || |
|---|
| 1007 | io->mod->user_b_freq->v[0] > 1. || |
|---|
| 1008 | io->mod->user_b_freq->v[1] > 1. || |
|---|
| 1009 | io->mod->user_b_freq->v[2] > 1. || |
|---|
| 1010 | io->mod->user_b_freq->v[3] > 1.) |
|---|
| 1011 | { |
|---|
| 1012 | Warn_And_Exit("\n. Invalid base frequencies.\n"); |
|---|
| 1013 | } |
|---|
| 1014 | } |
|---|
| 1015 | break; |
|---|
| 1016 | } |
|---|
| 1017 | |
|---|
| 1018 | case 'h':case 69: |
|---|
| 1019 | { |
|---|
| 1020 | Usage(); |
|---|
| 1021 | break; |
|---|
| 1022 | } |
|---|
| 1023 | |
|---|
| 1024 | case 'i':case 9: |
|---|
| 1025 | { |
|---|
| 1026 | char *tmp; |
|---|
| 1027 | tmp = (char *) mCalloc (T_MAX_FILE, sizeof(char)); |
|---|
| 1028 | if (strlen (optarg) > T_MAX_FILE -16) |
|---|
| 1029 | { |
|---|
| 1030 | char choix; |
|---|
| 1031 | strcpy (tmp, "\n. The file name'"); |
|---|
| 1032 | strcat (tmp, optarg); |
|---|
| 1033 | strcat (tmp, "' is too long.\n"); |
|---|
| 1034 | PhyML_Printf("%s",tmp); |
|---|
| 1035 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 1036 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 1037 | Exit("\n"); |
|---|
| 1038 | } |
|---|
| 1039 | |
|---|
| 1040 | else if (!Filexists (optarg)) |
|---|
| 1041 | { |
|---|
| 1042 | char choix; |
|---|
| 1043 | strcpy (tmp, "\n. The file '"); |
|---|
| 1044 | strcat (tmp, optarg); |
|---|
| 1045 | strcat (tmp, "' does not exist.\n"); |
|---|
| 1046 | PhyML_Printf("%s",tmp); |
|---|
| 1047 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 1048 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 1049 | Exit("\n"); |
|---|
| 1050 | } |
|---|
| 1051 | else |
|---|
| 1052 | { |
|---|
| 1053 | strcpy(io->in_align_file, optarg); |
|---|
| 1054 | io->fp_in_align = Openfile(io->in_align_file,0); |
|---|
| 1055 | |
|---|
| 1056 | strcpy(io->out_tree_file,optarg); |
|---|
| 1057 | #ifdef PHYML |
|---|
| 1058 | strcat(io->out_tree_file,"_phyml_tree"); |
|---|
| 1059 | #elif(MC) |
|---|
| 1060 | strcat(io->out_tree_file,"_mc_tree"); |
|---|
| 1061 | #elif(M4) |
|---|
| 1062 | strcat(io->out_tree_file,"_m4_tree"); |
|---|
| 1063 | #endif |
|---|
| 1064 | |
|---|
| 1065 | strcpy(io->out_stats_file,optarg); |
|---|
| 1066 | #ifdef PHYML |
|---|
| 1067 | strcat(io->out_stats_file,"_phyml_stats"); |
|---|
| 1068 | #elif(MC) |
|---|
| 1069 | strcat(io->out_stats_file,"_mc_stats"); |
|---|
| 1070 | #elif(M4) |
|---|
| 1071 | strcat(io->out_stats_file,"_m4_stats"); |
|---|
| 1072 | #endif |
|---|
| 1073 | } |
|---|
| 1074 | Free (tmp); |
|---|
| 1075 | break; |
|---|
| 1076 | } |
|---|
| 1077 | |
|---|
| 1078 | case 't':case 11: |
|---|
| 1079 | { |
|---|
| 1080 | if ((io->mod->whichmodel != JC69) && |
|---|
| 1081 | (io->mod->whichmodel != F81) && |
|---|
| 1082 | (io->mod->whichmodel != GTR)) |
|---|
| 1083 | { |
|---|
| 1084 | if ((strcmp(optarg, "e") == 0) || |
|---|
| 1085 | (strcmp(optarg, "E") == 0) || |
|---|
| 1086 | (strcmp(optarg, "estimated") == 0) || |
|---|
| 1087 | (strcmp(optarg, "ESTIMATED") == 0)) |
|---|
| 1088 | { |
|---|
| 1089 | io->mod->kappa->v = 4.0; |
|---|
| 1090 | io->mod->s_opt->opt_kappa = YES; |
|---|
| 1091 | if (io->mod->whichmodel == TN93) |
|---|
| 1092 | io->mod->s_opt->opt_lambda = YES; |
|---|
| 1093 | } |
|---|
| 1094 | else |
|---|
| 1095 | { |
|---|
| 1096 | if (atof(optarg) < .0) |
|---|
| 1097 | { |
|---|
| 1098 | char choix; |
|---|
| 1099 | PhyML_Printf("\n. The ts/tv ratio must be a positive number\n"); |
|---|
| 1100 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 1101 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 1102 | Exit("\n"); |
|---|
| 1103 | } |
|---|
| 1104 | else |
|---|
| 1105 | { |
|---|
| 1106 | io->mod->kappa->v = (phydbl)atof(optarg); |
|---|
| 1107 | io->mod->s_opt->opt_kappa = 0; |
|---|
| 1108 | io->mod->s_opt->opt_lambda = 0; |
|---|
| 1109 | } |
|---|
| 1110 | } |
|---|
| 1111 | } |
|---|
| 1112 | break; |
|---|
| 1113 | } |
|---|
| 1114 | case 'n':case 8: |
|---|
| 1115 | { |
|---|
| 1116 | if ((!atoi(optarg)) || (atoi(optarg) < 0)) |
|---|
| 1117 | { |
|---|
| 1118 | char choix; |
|---|
| 1119 | PhyML_Printf("\n. The number of alignments must be a positive integer\n"); |
|---|
| 1120 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 1121 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 1122 | Exit("\n"); |
|---|
| 1123 | } |
|---|
| 1124 | else io->n_data_sets = atoi (optarg); |
|---|
| 1125 | break; |
|---|
| 1126 | } |
|---|
| 1127 | case 'q':case 22: |
|---|
| 1128 | { |
|---|
| 1129 | io->interleaved = NO; |
|---|
| 1130 | break; |
|---|
| 1131 | } |
|---|
| 1132 | case 'u':case 15: |
|---|
| 1133 | { |
|---|
| 1134 | char *tmp; |
|---|
| 1135 | tmp = (char *)mCalloc(T_MAX_FILE, sizeof(char)); |
|---|
| 1136 | if(strlen(optarg) > T_MAX_FILE -11) |
|---|
| 1137 | { |
|---|
| 1138 | char choix; |
|---|
| 1139 | strcpy (tmp, "\n. The file name'"); |
|---|
| 1140 | strcat (tmp, optarg); |
|---|
| 1141 | strcat (tmp, "' is too long.\n"); |
|---|
| 1142 | PhyML_Printf("%s",tmp); |
|---|
| 1143 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 1144 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 1145 | Exit("\n"); |
|---|
| 1146 | } |
|---|
| 1147 | else if (! Filexists (optarg)) |
|---|
| 1148 | { |
|---|
| 1149 | char choix; |
|---|
| 1150 | strcpy (tmp, "\n. The file '"); |
|---|
| 1151 | strcat (tmp, optarg); |
|---|
| 1152 | strcat (tmp, "' doesn't exist.\n"); |
|---|
| 1153 | PhyML_Printf("%s",tmp); |
|---|
| 1154 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 1155 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 1156 | Exit("\n"); |
|---|
| 1157 | } |
|---|
| 1158 | else |
|---|
| 1159 | { |
|---|
| 1160 | strcpy(io->in_tree_file, optarg); |
|---|
| 1161 | io->in_tree = 2; |
|---|
| 1162 | io->fp_in_tree = Openfile(io->in_tree_file,READ); |
|---|
| 1163 | } |
|---|
| 1164 | Free(tmp); |
|---|
| 1165 | break; |
|---|
| 1166 | } |
|---|
| 1167 | |
|---|
| 1168 | case 'v':case 13: |
|---|
| 1169 | { |
|---|
| 1170 | if ((strcmp (optarg, "e") == 0) || |
|---|
| 1171 | (strcmp (optarg, "E") == 0) || |
|---|
| 1172 | (strcmp (optarg, "estimated") == 0) || |
|---|
| 1173 | (strcmp (optarg, "ESTIMATED") == 0)) |
|---|
| 1174 | { |
|---|
| 1175 | io->mod->s_opt->opt_pinvar = YES; |
|---|
| 1176 | io->mod->ras->invar = YES; |
|---|
| 1177 | } |
|---|
| 1178 | |
|---|
| 1179 | else if ((atof(optarg) < 0.0) || (atof(optarg) > 1.0)) |
|---|
| 1180 | { |
|---|
| 1181 | char choix; |
|---|
| 1182 | PhyML_Printf("\n. The proportion of invariable site must be a number between 0.0 and 1.0\n"); |
|---|
| 1183 | PhyML_Printf("\n. Type any key to exit."); |
|---|
| 1184 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 1185 | Exit("\n"); |
|---|
| 1186 | } |
|---|
| 1187 | else |
|---|
| 1188 | { |
|---|
| 1189 | io->mod->ras->pinvar->v = (phydbl)atof(optarg); |
|---|
| 1190 | if (io->mod->ras->pinvar->v > 0.0+SMALL) |
|---|
| 1191 | io->mod->ras->invar = 1; |
|---|
| 1192 | else |
|---|
| 1193 | io->mod->ras->invar = 0; |
|---|
| 1194 | io->mod->s_opt->opt_pinvar = 0; |
|---|
| 1195 | } |
|---|
| 1196 | break; |
|---|
| 1197 | } |
|---|
| 1198 | case 'o': |
|---|
| 1199 | { |
|---|
| 1200 | if(!strcmp(optarg,"tlr")) |
|---|
| 1201 | { |
|---|
| 1202 | io->mod->s_opt->opt_topo = YES; |
|---|
| 1203 | io->mod->s_opt->opt_bl = YES; |
|---|
| 1204 | io->mod->s_opt->opt_subst_param = YES; |
|---|
| 1205 | } |
|---|
| 1206 | else if(!strcmp(optarg,"tl")) |
|---|
| 1207 | { |
|---|
| 1208 | io->mod->s_opt->opt_topo = YES; |
|---|
| 1209 | io->mod->s_opt->opt_bl = YES; |
|---|
| 1210 | io->mod->s_opt->opt_subst_param = NO; |
|---|
| 1211 | } |
|---|
| 1212 | else if(!strcmp(optarg,"t")) |
|---|
| 1213 | { |
|---|
| 1214 | Warn_And_Exit("\n. You can't optimize the topology without adjusting branch length too...\n"); |
|---|
| 1215 | } |
|---|
| 1216 | else if(!strcmp(optarg,"lr")) |
|---|
| 1217 | { |
|---|
| 1218 | io->mod->s_opt->opt_topo = NO; |
|---|
| 1219 | io->mod->s_opt->opt_bl = YES; |
|---|
| 1220 | io->mod->s_opt->opt_subst_param = YES; |
|---|
| 1221 | } |
|---|
| 1222 | else if(!strcmp(optarg,"l")) |
|---|
| 1223 | { |
|---|
| 1224 | io->mod->s_opt->opt_topo = NO; |
|---|
| 1225 | io->mod->s_opt->opt_bl = YES; |
|---|
| 1226 | io->mod->s_opt->opt_subst_param = NO; |
|---|
| 1227 | } |
|---|
| 1228 | else if(!strcmp(optarg,"r")) |
|---|
| 1229 | { |
|---|
| 1230 | io->mod->s_opt->opt_topo = NO; |
|---|
| 1231 | io->mod->s_opt->opt_bl = NO; |
|---|
| 1232 | io->mod->s_opt->opt_subst_param = YES; |
|---|
| 1233 | } |
|---|
| 1234 | else if(!strcmp(optarg,"none") || !strcmp(optarg,"n")) |
|---|
| 1235 | { |
|---|
| 1236 | io->mod->s_opt->opt_topo = NO; |
|---|
| 1237 | io->mod->s_opt->opt_bl = NO; |
|---|
| 1238 | io->mod->s_opt->opt_subst_param = NO; |
|---|
| 1239 | } |
|---|
| 1240 | else |
|---|
| 1241 | { |
|---|
| 1242 | char choix; |
|---|
| 1243 | PhyML_Printf ("\n. The optimization parameter must be 'tlr' or 'tl' or 'lr' or 'l' or 'r' or ''."); |
|---|
| 1244 | PhyML_Printf("\n. Type any key to exit.\n"); |
|---|
| 1245 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 1246 | Exit("\n"); |
|---|
| 1247 | } |
|---|
| 1248 | break; |
|---|
| 1249 | } |
|---|
| 1250 | |
|---|
| 1251 | case '?': |
|---|
| 1252 | { |
|---|
| 1253 | Exit("\n"); |
|---|
| 1254 | break; |
|---|
| 1255 | } |
|---|
| 1256 | |
|---|
| 1257 | case -1: |
|---|
| 1258 | { |
|---|
| 1259 | break; |
|---|
| 1260 | } |
|---|
| 1261 | |
|---|
| 1262 | default: |
|---|
| 1263 | { |
|---|
| 1264 | Usage(); |
|---|
| 1265 | break; |
|---|
| 1266 | } |
|---|
| 1267 | } |
|---|
| 1268 | }while(c != -1); |
|---|
| 1269 | |
|---|
| 1270 | |
|---|
| 1271 | /* if((io->mod->whichmodel == K80) || (io->mod->whichmodel == JC69)) */ |
|---|
| 1272 | /* { */ |
|---|
| 1273 | /* if(io->mod->s_opt->opt_state_freq) */ |
|---|
| 1274 | /* { */ |
|---|
| 1275 | /* char c; */ |
|---|
| 1276 | /* PhyML_Printf("\n. WARNING: nucleotide frequencies must be set to 1/4 with this model.\n"); */ |
|---|
| 1277 | /* PhyML_Printf("\n. Type the enter key to resume the analysis.\n"); */ |
|---|
| 1278 | /* scanf("%c",&c); */ |
|---|
| 1279 | /* } */ |
|---|
| 1280 | /* io->mod->s_opt->opt_state_freq = 0; */ |
|---|
| 1281 | /* } */ |
|---|
| 1282 | |
|---|
| 1283 | |
|---|
| 1284 | if(io->mod->s_opt->constrained_br_len == YES) |
|---|
| 1285 | { |
|---|
| 1286 | io->mod->s_opt->opt_topo = NO; |
|---|
| 1287 | /* io->mod->s_opt->opt_bl = NO; */ |
|---|
| 1288 | } |
|---|
| 1289 | |
|---|
| 1290 | #ifndef PHYML |
|---|
| 1291 | if((open_ps_file) || (io->m4_model == YES)) |
|---|
| 1292 | { |
|---|
| 1293 | strcpy(io->out_ps_file,io->in_align_file); |
|---|
| 1294 | strcat(io->out_ps_file, "_mc_tree.ps"); |
|---|
| 1295 | io->fp_out_ps = Openfile(io->out_ps_file,WRITE); |
|---|
| 1296 | } |
|---|
| 1297 | #endif |
|---|
| 1298 | |
|---|
| 1299 | |
|---|
| 1300 | if(io->datatype == UNDEFINED) io->datatype = NT; |
|---|
| 1301 | |
|---|
| 1302 | |
|---|
| 1303 | if((io->mod->s_opt->n_rand_starts) && |
|---|
| 1304 | (io->mod->s_opt->topo_search == NNI_MOVE) && |
|---|
| 1305 | (io->mod->s_opt->random_input_tree)) |
|---|
| 1306 | { |
|---|
| 1307 | Warn_And_Exit("\n== The random starting tree option is only compatible with SPR based search options.\n"); |
|---|
| 1308 | } |
|---|
| 1309 | |
|---|
| 1310 | if ((io->datatype == NT) && (io->mod->whichmodel > 10)) |
|---|
| 1311 | { |
|---|
| 1312 | char choix; |
|---|
| 1313 | PhyML_Printf("\n== Err.: model incompatible with the data type. Please use JC69, K80, F81, HKY, F84, TN93 or GTR\n"); |
|---|
| 1314 | PhyML_Printf("\n== Type any key to exit.\n"); |
|---|
| 1315 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 1316 | Warn_And_Exit("\n"); |
|---|
| 1317 | } |
|---|
| 1318 | else if ((io->datatype == AA) && (io->mod->whichmodel < 11)) |
|---|
| 1319 | { |
|---|
| 1320 | char choix; |
|---|
| 1321 | PhyML_Printf("\n== Err.: model incompatible with the data type. Please use LG, Dayhoff, JTT, MtREV, WAG, DCMut, RtREV, CpREV, VT, Blosum62, MtMam, MtArt, HIVw or HIVb.\n"); |
|---|
| 1322 | PhyML_Printf("\n== Type any key to exit.\n"); |
|---|
| 1323 | if(!scanf("%c",&choix)) Exit("\n"); |
|---|
| 1324 | Exit("\n"); |
|---|
| 1325 | } |
|---|
| 1326 | |
|---|
| 1327 | |
|---|
| 1328 | |
|---|
| 1329 | |
|---|
| 1330 | if(io->mod->use_m4mod == NO) |
|---|
| 1331 | { |
|---|
| 1332 | io->mod->s_opt->opt_cov_delta = 0; |
|---|
| 1333 | io->mod->s_opt->opt_cov_alpha = 0; |
|---|
| 1334 | io->mod->s_opt->opt_cov_free_rates = 0; |
|---|
| 1335 | } |
|---|
| 1336 | |
|---|
| 1337 | if((io->mod->s_opt->opt_cov_free_rates) && (io->mod->s_opt->opt_cov_alpha)) |
|---|
| 1338 | { |
|---|
| 1339 | io->mod->s_opt->opt_cov_free_rates = 1; |
|---|
| 1340 | io->mod->m4mod->use_cov_alpha = 0; |
|---|
| 1341 | io->mod->m4mod->use_cov_free = 1; |
|---|
| 1342 | } |
|---|
| 1343 | |
|---|
| 1344 | if(io->print_site_lnl) |
|---|
| 1345 | { |
|---|
| 1346 | strcpy(io->out_lk_file,io->in_align_file); |
|---|
| 1347 | strcat(io->out_lk_file, "_phyml_lk"); |
|---|
| 1348 | if(io->append_run_ID) { strcat(io->out_lk_file,"_"); strcat(io->out_lk_file,io->run_id_string); } |
|---|
| 1349 | strcat(io->out_lk_file, ".txt"); |
|---|
| 1350 | io->fp_out_lk = Openfile(io->out_lk_file,1); |
|---|
| 1351 | } |
|---|
| 1352 | |
|---|
| 1353 | if(io->print_trace) |
|---|
| 1354 | { |
|---|
| 1355 | strcpy(io->out_trace_file,io->in_align_file); |
|---|
| 1356 | strcat(io->out_trace_file,"_phyml_trace"); |
|---|
| 1357 | if(io->append_run_ID) { strcat(io->out_trace_file,"_"); strcat(io->out_trace_file,io->run_id_string); } |
|---|
| 1358 | strcat(io->out_trace_file,".txt"); |
|---|
| 1359 | io->fp_out_trace = Openfile(io->out_trace_file,1); |
|---|
| 1360 | } |
|---|
| 1361 | |
|---|
| 1362 | if(io->mod->s_opt->random_input_tree) |
|---|
| 1363 | { |
|---|
| 1364 | strcpy(io->out_trees_file,io->in_align_file); |
|---|
| 1365 | strcat(io->out_trees_file,"_phyml_rand_trees"); |
|---|
| 1366 | if(io->append_run_ID) { strcat(io->out_trees_file,"_"); strcat(io->out_trees_file,io->run_id_string); } |
|---|
| 1367 | strcat(io->out_trees_file,".txt"); |
|---|
| 1368 | io->fp_out_trees = Openfile(io->out_trees_file,1); |
|---|
| 1369 | } |
|---|
| 1370 | |
|---|
| 1371 | if((io->print_boot_trees) && (io->mod->bootstrap > 0)) |
|---|
| 1372 | { |
|---|
| 1373 | strcpy(io->out_boot_tree_file,io->in_align_file); |
|---|
| 1374 | strcat(io->out_boot_tree_file,"_phyml_boot_trees"); |
|---|
| 1375 | if(io->append_run_ID) { strcat(io->out_boot_tree_file,"_"); strcat(io->out_boot_tree_file,io->run_id_string); } |
|---|
| 1376 | strcat(io->out_boot_tree_file,".txt"); |
|---|
| 1377 | io->fp_out_boot_tree = Openfile(io->out_boot_tree_file,1); |
|---|
| 1378 | |
|---|
| 1379 | strcpy(io->out_boot_stats_file,io->in_align_file); |
|---|
| 1380 | strcat(io->out_boot_stats_file,"_phyml_boot_stats"); |
|---|
| 1381 | if(io->append_run_ID) { strcat(io->out_boot_stats_file,"_"); strcat(io->out_boot_stats_file,io->run_id_string); } |
|---|
| 1382 | strcat(io->out_boot_stats_file,".txt"); |
|---|
| 1383 | io->fp_out_boot_stats = Openfile(io->out_boot_stats_file,1); |
|---|
| 1384 | } |
|---|
| 1385 | |
|---|
| 1386 | if(io->append_run_ID) |
|---|
| 1387 | { |
|---|
| 1388 | strcat(io->out_tree_file,"_"); |
|---|
| 1389 | strcat(io->out_stats_file,"_"); |
|---|
| 1390 | strcat(io->out_tree_file,io->run_id_string); |
|---|
| 1391 | strcat(io->out_stats_file,io->run_id_string); |
|---|
| 1392 | } |
|---|
| 1393 | strcat(io->out_tree_file,".txt"); |
|---|
| 1394 | strcat(io->out_stats_file,".txt"); |
|---|
| 1395 | |
|---|
| 1396 | if(io->mod->ras->n_catg == 1) io->mod->s_opt->opt_alpha = 0; |
|---|
| 1397 | |
|---|
| 1398 | if(!io->mod->s_opt->opt_subst_param) |
|---|
| 1399 | { |
|---|
| 1400 | io->mod->s_opt->opt_alpha = 0; |
|---|
| 1401 | io->mod->s_opt->opt_kappa = 0; |
|---|
| 1402 | io->mod->s_opt->opt_lambda = 0; |
|---|
| 1403 | io->mod->s_opt->opt_pinvar = 0; |
|---|
| 1404 | io->mod->s_opt->opt_rr = 0; |
|---|
| 1405 | } |
|---|
| 1406 | |
|---|
| 1407 | if(io->mod->whichmodel != K80 && |
|---|
| 1408 | io->mod->whichmodel != HKY85 && |
|---|
| 1409 | io->mod->whichmodel != F84 && |
|---|
| 1410 | io->mod->whichmodel != TN93) |
|---|
| 1411 | { |
|---|
| 1412 | io->mod->s_opt->opt_kappa = 0; |
|---|
| 1413 | } |
|---|
| 1414 | |
|---|
| 1415 | if(io->datatype == AA && io->mod->whichmodel == CUSTOMAA && !io->mod->fp_aa_rate_mat) |
|---|
| 1416 | { |
|---|
| 1417 | PhyML_Printf("\n== Custom model option with amino-acid requires you to specify a rate matrix file through the '--aa_rate_file' option.\n"); |
|---|
| 1418 | Exit("\n"); |
|---|
| 1419 | } |
|---|
| 1420 | |
|---|
| 1421 | io->fp_out_tree = Openfile(io->out_tree_file,writemode); |
|---|
| 1422 | io->fp_out_stats = Openfile(io->out_stats_file,writemode); |
|---|
| 1423 | |
|---|
| 1424 | if(io->mod->whichmodel == GTR) |
|---|
| 1425 | { |
|---|
| 1426 | /* Make_Custom_Model(io->mod); */ |
|---|
| 1427 | io->mod->s_opt->opt_rr = 1; |
|---|
| 1428 | } |
|---|
| 1429 | |
|---|
| 1430 | return 1; |
|---|
| 1431 | } |
|---|
| 1432 | |
|---|
| 1433 | ////////////////////////////////////////////////////////////// |
|---|
| 1434 | ////////////////////////////////////////////////////////////// |
|---|
| 1435 | |
|---|