| 1 | #include "mltaln.h" |
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| 2 | #include "dp.h" |
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| 3 | |
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| 4 | #define MACHIGAI 0 |
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| 5 | #define OUTGAP0TRY 1 |
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| 6 | #define DEBUG 0 |
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| 7 | #define XXXXXXX 0 |
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| 8 | #define USE_PENALTY_EX 0 |
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| 9 | #define FASTMATCHCALC 1 |
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| 10 | |
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| 11 | |
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| 12 | static int impalloclen = 0; |
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| 13 | static float **impmtx = NULL; |
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| 14 | float part_imp_match_out_scQ( int i1, int j1 ) |
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| 15 | { |
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| 16 | // fprintf( stderr, "impalloclen = %d\n", impalloclen ); |
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| 17 | // fprintf( stderr, "i1,j1=%d,%d -> impmtx=%f\n", i1, j1, impmtx[i1][j1] ); |
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| 18 | return( impmtx[i1][j1] ); |
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| 19 | #if 0 |
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| 20 | if( i1 == l1 || j1 == l2 ) return( 0.0 ); |
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| 21 | return( impmtx[i1+start1][j1+start2] ); |
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| 22 | #endif |
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| 23 | } |
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| 24 | static void part_imp_match_out_vead_gapmapQ( float *imp, int i1, int lgth2, int start2, int *gapmap2 ) |
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| 25 | { |
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| 26 | #if FASTMACHCALC |
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| 27 | float *pt = imp; |
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| 28 | int *gapmappt = gapmap2; |
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| 29 | while( lgth2-- ) |
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| 30 | *pt++ += impmtx[i1][start2+*gapmappt++]; |
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| 31 | #else |
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| 32 | int j; |
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| 33 | for( j=0; j<lgth2; j++ ) |
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| 34 | { |
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| 35 | imp[j] += impmtx[i1][start2+gapmap2[j]]; |
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| 36 | } |
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| 37 | #endif |
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| 38 | } |
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| 39 | |
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| 40 | static void part_imp_match_out_vead_tate_gapmapQ( float *imp, int j1, int lgth1, int start1, int *gapmap1 ) |
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| 41 | { |
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| 42 | #if FASTMACHCALC |
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| 43 | float *pt = imp; |
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| 44 | int *gapmappt = gapmap1; |
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| 45 | while( lgth1-- ) |
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| 46 | *pt++ = impmtx[start1+*gapmappt++][j1]; |
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| 47 | #else |
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| 48 | int i; |
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| 49 | for( i=0; i<lgth1; i++ ) |
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| 50 | { |
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| 51 | imp[i] += impmtx[start1+gapmap1[i]][j1]; |
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| 52 | } |
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| 53 | #endif |
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| 54 | } |
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| 55 | |
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| 56 | void part_imp_match_init_strictQ( float *imp, int clus1, int clus2, int lgth1, int lgth2, char **seq1, char **seq2, double *eff1, double *eff2, LocalHom ***localhom, int forscore ) |
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| 57 | { |
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| 58 | int i, j, k1, k2, tmpint, start1, start2, end1, end2; |
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| 59 | double effij, effijx; |
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| 60 | char *pt, *pt1, *pt2; |
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| 61 | LocalHom *tmpptr; |
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| 62 | |
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| 63 | if( impalloclen <= lgth1 + 2 || impalloclen <= lgth2 + 2 ) |
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| 64 | { |
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| 65 | if( impmtx ) FreeFloatMtx( impmtx ); |
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| 66 | impalloclen = MAX( lgth1, lgth2 ) + 2; |
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| 67 | impmtx = AllocateFloatMtx( impalloclen+100, impalloclen+100 ); |
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| 68 | } |
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| 69 | |
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| 70 | |
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| 71 | #if 0 |
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| 72 | fprintf( stderr, "eff1 in _init_strict = \n" ); |
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| 73 | for( i=0; i<clus1; i++ ) |
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| 74 | fprintf( stderr, "eff1[] = %f\n", eff1[i] ); |
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| 75 | for( i=0; i<clus2; i++ ) |
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| 76 | fprintf( stderr, "eff2[] = %f\n", eff2[i] ); |
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| 77 | #endif |
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| 78 | |
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| 79 | for( i=0; i<lgth1; i++ ) for( j=0; j<lgth2; j++ ) |
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| 80 | impmtx[i][j] = 0.0; |
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| 81 | effijx = 1.0 * fastathreshold; |
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| 82 | for( i=0; i<clus1; i++ ) |
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| 83 | { |
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| 84 | for( j=0; j<clus2; j++ ) |
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| 85 | { |
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| 86 | effij = eff1[i] * eff2[j] * effijx; |
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| 87 | tmpptr = localhom[i][j]; |
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| 88 | while( tmpptr ) |
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| 89 | { |
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| 90 | // fprintf( stderr, "start1 = %d\n", tmpptr->start1 ); |
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| 91 | // fprintf( stderr, "end1 = %d\n", tmpptr->end1 ); |
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| 92 | // fprintf( stderr, "i = %d, seq1 = \n%s\n", i, seq1[i] ); |
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| 93 | // fprintf( stderr, "j = %d, seq2 = \n%s\n", j, seq2[j] ); |
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| 94 | pt = seq1[i]; |
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| 95 | tmpint = -1; |
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| 96 | while( *pt != 0 ) |
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| 97 | { |
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| 98 | if( *pt++ != '-' ) tmpint++; |
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| 99 | if( tmpint == tmpptr->start1 ) break; |
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| 100 | } |
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| 101 | start1 = (int)( pt - seq1[i] ) - 1; |
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| 102 | |
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| 103 | if( tmpptr->start1 == tmpptr->end1 ) end1 = start1; |
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| 104 | else |
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| 105 | { |
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| 106 | #if MACHIGAI |
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| 107 | while( *pt != 0 ) |
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| 108 | { |
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| 109 | if( tmpint == tmpptr->end1 ) break; |
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| 110 | if( *pt++ != '-' ) tmpint++; |
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| 111 | } |
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| 112 | end1 = (int)( pt - seq1[i] ) - 1; |
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| 113 | #else |
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| 114 | while( *pt != 0 ) |
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| 115 | { |
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| 116 | // fprintf( stderr, "tmpint = %d, end1 = %d pos = %d\n", tmpint, tmpptr->end1, pt-seq1[i] ); |
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| 117 | if( *pt++ != '-' ) tmpint++; |
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| 118 | if( tmpint == tmpptr->end1 ) break; |
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| 119 | } |
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| 120 | end1 = (int)( pt - seq1[i] ) - 1; |
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| 121 | #endif |
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| 122 | } |
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| 123 | |
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| 124 | pt = seq2[j]; |
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| 125 | tmpint = -1; |
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| 126 | while( *pt != 0 ) |
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| 127 | { |
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| 128 | if( *pt++ != '-' ) tmpint++; |
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| 129 | if( tmpint == tmpptr->start2 ) break; |
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| 130 | } |
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| 131 | start2 = (int)( pt - seq2[j] ) - 1; |
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| 132 | if( tmpptr->start2 == tmpptr->end2 ) end2 = start2; |
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| 133 | else |
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| 134 | { |
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| 135 | #if MACHIGAI |
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| 136 | while( *pt != 0 ) |
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| 137 | { |
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| 138 | if( tmpint == tmpptr->end2 ) break; |
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| 139 | if( *pt++ != '-' ) tmpint++; |
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| 140 | } |
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| 141 | end2 = (int)( pt - seq2[j] ) - 1; |
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| 142 | #else |
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| 143 | while( *pt != 0 ) |
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| 144 | { |
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| 145 | if( *pt++ != '-' ) tmpint++; |
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| 146 | if( tmpint == tmpptr->end2 ) break; |
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| 147 | } |
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| 148 | end2 = (int)( pt - seq2[j] ) - 1; |
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| 149 | #endif |
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| 150 | } |
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| 151 | // fprintf( stderr, "start1 = %d (%c), end1 = %d (%c), start2 = %d (%c), end2 = %d (%c)\n", start1, seq1[i][start1], end1, seq1[i][end1], start2, seq2[j][start2], end2, seq2[j][end2] ); |
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| 152 | // fprintf( stderr, "step 0\n" ); |
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| 153 | if( end1 - start1 != end2 - start2 ) |
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| 154 | { |
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| 155 | // fprintf( stderr, "CHUUI!!, start1 = %d, end1 = %d, start2 = %d, end2 = %d\n", start1, end1, start2, end2 ); |
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| 156 | } |
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| 157 | |
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| 158 | k1 = start1; k2 = start2; |
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| 159 | pt1 = seq1[i] + k1; |
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| 160 | pt2 = seq2[j] + k2; |
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| 161 | while( *pt1 && *pt2 ) |
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| 162 | { |
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| 163 | if( *pt1 != '-' && *pt2 != '-' ) |
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| 164 | { |
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| 165 | // œÅ€ß€òÆóœÅ€Ë€«€±€Ê€€€è€Š€ËÃí°Õ€·€Æ²Œ€µ€€¡£ |
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| 166 | // impmtx[k1][k2] += tmpptr->wimportance * fastathreshold; |
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| 167 | // impmtx[k1][k2] += tmpptr->importance * effij; |
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| 168 | impmtx[k1][k2] += tmpptr->fimportance * effij; |
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| 169 | // fprintf( stderr, "k1=%d, k2=%d, impalloclen=%d\n", k1, k2, impalloclen ); |
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| 170 | // fprintf( stderr, "mark, %d (%c) - %d (%c) \n", k1, *pt1, k2, *pt2 ); |
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| 171 | k1++; k2++; |
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| 172 | pt1++; pt2++; |
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| 173 | } |
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| 174 | else if( *pt1 != '-' && *pt2 == '-' ) |
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| 175 | { |
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| 176 | // fprintf( stderr, "skip, %d (%c) - %d (%c) \n", k1, *pt1, k2, *pt2 ); |
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| 177 | k2++; pt2++; |
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| 178 | } |
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| 179 | else if( *pt1 == '-' && *pt2 != '-' ) |
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| 180 | { |
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| 181 | // fprintf( stderr, "skip, %d (%c) - %d (%c) \n", k1, *pt1, k2, *pt2 ); |
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| 182 | k1++; pt1++; |
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| 183 | } |
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| 184 | else if( *pt1 == '-' && *pt2 == '-' ) |
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| 185 | { |
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| 186 | // fprintf( stderr, "skip, %d (%c) - %d (%c) \n", k1, *pt1, k2, *pt2 ); |
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| 187 | k1++; pt1++; |
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| 188 | k2++; pt2++; |
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| 189 | } |
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| 190 | if( k1 > end1 || k2 > end2 ) break; |
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| 191 | } |
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| 192 | tmpptr = tmpptr->next; |
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| 193 | } |
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| 194 | } |
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| 195 | } |
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| 196 | #if 0 |
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| 197 | fprintf( stderr, "impmtx = \n" ); |
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| 198 | for( k2=0; k2<lgth2; k2++ ) |
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| 199 | fprintf( stderr, "%6.3f ", (double)k2 ); |
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| 200 | fprintf( stderr, "\n" ); |
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| 201 | for( k1=0; k1<lgth1; k1++ ) |
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| 202 | { |
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| 203 | fprintf( stderr, "%d", k1 ); |
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| 204 | for( k2=0; k2<lgth2; k2++ ) |
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| 205 | fprintf( stderr, "%2.1f ", impmtx[k1][k2] ); |
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| 206 | fprintf( stderr, "\n" ); |
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| 207 | } |
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| 208 | exit( 1 ); |
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| 209 | #endif |
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| 210 | } |
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| 211 | |
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| 212 | |
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| 213 | void part_imp_rnaQ( int nseq1, int nseq2, char **seq1, char **seq2, double *eff1, double *eff2, RNApair ***grouprna1, RNApair ***grouprna2, int *gapmap1, int *gapmap2, RNApair *additionalpair ) |
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| 214 | { |
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| 215 | foldrna( nseq1, nseq2, seq1, seq2, eff1, eff2, grouprna1, grouprna2, impmtx, gapmap1, gapmap2, additionalpair ); |
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| 216 | } |
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| 217 | |
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| 218 | |
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| 219 | void part_imp_match_initQ( float *imp, int clus1, int clus2, int lgth1, int lgth2, char **seq1, char **seq2, double *eff1, double *eff2, LocalHom ***localhom ) |
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| 220 | { |
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| 221 | int dif, i, j, k1, k2, tmpint, start1, start2, end1, end2; |
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| 222 | static int impalloclen = 0; |
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| 223 | char *pt; |
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| 224 | static char *nocount1 = NULL; |
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| 225 | static char *nocount2 = NULL; |
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| 226 | |
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| 227 | if( impalloclen < lgth1 || impalloclen < lgth2 ) |
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| 228 | { |
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| 229 | if( impmtx ) FreeFloatMtx( impmtx ); |
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| 230 | if( nocount1 ) free( nocount1 ); |
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| 231 | if( nocount2 ) free( nocount2 ); |
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| 232 | impalloclen = MAX( lgth1, lgth2 ) + 2; |
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| 233 | impmtx = AllocateFloatMtx( impalloclen, impalloclen ); |
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| 234 | nocount1 = AllocateCharVec( impalloclen ); |
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| 235 | nocount2 = AllocateCharVec( impalloclen ); |
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| 236 | impalloclen -= 2; |
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| 237 | } |
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| 238 | |
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| 239 | for( i=0; i<lgth1; i++ ) |
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| 240 | { |
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| 241 | for( j=0; j<clus1; j++ ) |
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| 242 | if( seq1[j][i] == '-' ) break; |
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| 243 | if( j != clus1 ) nocount1[i] = 1; |
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| 244 | else nocount1[i] = 0; |
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| 245 | } |
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| 246 | for( i=0; i<lgth2; i++ ) |
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| 247 | { |
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| 248 | for( j=0; j<clus2; j++ ) |
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| 249 | if( seq2[j][i] == '-' ) break; |
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| 250 | if( j != clus2 ) nocount2[i] = 1; |
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| 251 | else nocount2[i] = 0; |
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| 252 | } |
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| 253 | |
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| 254 | #if 0 |
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| 255 | fprintf( stderr, "nocount2 =\n" ); |
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| 256 | for( i = 0; i<impalloclen; i++ ) |
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| 257 | { |
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| 258 | fprintf( stderr, "nocount2[%d] = %d (%c)\n", i, nocount2[i], seq2[0][i] ); |
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| 259 | } |
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| 260 | #endif |
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| 261 | |
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| 262 | for( i=0; i<lgth1; i++ ) for( j=0; j<lgth2; j++ ) |
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| 263 | impmtx[i][j] = 0.0; |
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| 264 | for( i=0; i<clus1; i++ ) |
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| 265 | { |
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| 266 | fprintf( stderr, "i = %d, seq1 = %s\n", i, seq1[i] ); |
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| 267 | for( j=0; j<clus2; j++ ) |
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| 268 | { |
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| 269 | fprintf( stderr, "start1 = %d\n", localhom[i][j]->start1 ); |
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| 270 | fprintf( stderr, "end1 = %d\n", localhom[i][j]->end1 ); |
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| 271 | fprintf( stderr, "j = %d, seq2 = %s\n", j, seq2[j] ); |
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| 272 | pt = seq1[i]; |
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| 273 | tmpint = -1; |
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| 274 | while( *pt != 0 ) |
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| 275 | { |
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| 276 | if( *pt++ != '-' ) tmpint++; |
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| 277 | if( tmpint == localhom[i][j]->start1 ) break; |
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| 278 | } |
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| 279 | start1 = pt - seq1[i] - 1; |
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| 280 | |
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| 281 | while( *pt != 0 ) |
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| 282 | { |
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| 283 | // fprintf( stderr, "tmpint = %d, end1 = %d pos = %d\n", tmpint, localhom[i][j].end1, pt-seq1[i] ); |
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| 284 | if( *pt++ != '-' ) tmpint++; |
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| 285 | if( tmpint == localhom[i][j]->end1 ) break; |
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| 286 | } |
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| 287 | end1 = pt - seq1[i] - 1; |
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| 288 | |
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| 289 | pt = seq2[j]; |
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| 290 | tmpint = -1; |
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| 291 | while( *pt != 0 ) |
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| 292 | { |
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| 293 | if( *pt++ != '-' ) tmpint++; |
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| 294 | if( tmpint == localhom[i][j]->start2 ) break; |
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| 295 | } |
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| 296 | start2 = pt - seq2[j] - 1; |
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| 297 | while( *pt != 0 ) |
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| 298 | { |
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| 299 | if( *pt++ != '-' ) tmpint++; |
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| 300 | if( tmpint == localhom[i][j]->end2 ) break; |
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| 301 | } |
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| 302 | end2 = pt - seq2[j] - 1; |
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| 303 | // fprintf( stderr, "start1 = %d, end1 = %d, start2 = %d, end2 = %d\n", start1, end1, start2, end2 ); |
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| 304 | k1 = start1; |
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| 305 | k2 = start2; |
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| 306 | fprintf( stderr, "step 0\n" ); |
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| 307 | while( k1 <= end1 && k2 <= end2 ) |
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| 308 | { |
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| 309 | #if 0 |
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| 310 | if( !nocount1[k1] && !nocount2[k2] ) |
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| 311 | impmtx[k1][k2] += localhom[i][j].wimportance * eff1[i] * eff2[j]; |
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| 312 | k1++; k2++; |
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| 313 | #else |
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| 314 | if( !nocount1[k1] && !nocount2[k2] ) |
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| 315 | impmtx[k1][k2] += localhom[i][j]->wimportance * eff1[i] * eff2[j]; |
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| 316 | k1++; k2++; |
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| 317 | #endif |
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| 318 | } |
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| 319 | |
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| 320 | dif = ( end1 - start1 ) - ( end2 - start2 ); |
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| 321 | fprintf( stderr, "dif = %d\n", dif ); |
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| 322 | if( dif > 0 ) |
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| 323 | { |
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| 324 | do |
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| 325 | { |
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| 326 | fprintf( stderr, "dif = %d\n", dif ); |
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| 327 | k1 = start1; |
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| 328 | k2 = start2 - dif; |
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| 329 | while( k1 <= end1 && k2 <= end2 ) |
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| 330 | { |
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| 331 | if( 0 <= k2 && start2 <= k2 && !nocount1[k1] && !nocount2[k2] ) |
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| 332 | impmtx[k1][k2] = localhom[i][j]->wimportance * eff1[i] * eff2[j]; |
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| 333 | k1++; k2++; |
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| 334 | } |
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| 335 | } |
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| 336 | while( dif-- ); |
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| 337 | } |
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| 338 | else |
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| 339 | { |
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| 340 | do |
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| 341 | { |
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| 342 | k1 = start1 + dif; |
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| 343 | k2 = start2; |
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| 344 | while( k1 <= end1 ) |
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| 345 | { |
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| 346 | if( k1 >= 0 && k1 >= start1 && !nocount1[k1] && !nocount2[k2] ) |
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| 347 | impmtx[k1][k2] = localhom[i][j]->wimportance * eff1[i] * eff2[j]; |
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| 348 | k1++; k2++; |
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| 349 | } |
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| 350 | } |
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| 351 | while( dif++ ); |
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| 352 | } |
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| 353 | } |
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| 354 | } |
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| 355 | #if 0 |
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| 356 | fprintf( stderr, "impmtx = \n" ); |
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| 357 | for( k2=0; k2<lgth2; k2++ ) |
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| 358 | fprintf( stderr, "%6.3f ", (double)k2 ); |
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| 359 | fprintf( stderr, "\n" ); |
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| 360 | for( k1=0; k1<lgth1; k1++ ) |
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| 361 | { |
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| 362 | fprintf( stderr, "%d", k1 ); |
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| 363 | for( k2=0; k2<lgth2; k2++ ) |
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| 364 | fprintf( stderr, "%6.3f ", impmtx[k1][k2] ); |
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| 365 | fprintf( stderr, "\n" ); |
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| 366 | } |
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| 367 | exit( 1 ); |
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| 368 | #endif |
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| 369 | } |
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| 370 | |
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| 371 | static void match_calc( float *match, float **cpmx1, float **cpmx2, int i1, int lgth2, float **floatwork, int **intwork, int initialize ) |
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| 372 | { |
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| 373 | #if FASTMATCHCALC |
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| 374 | int j, l; |
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| 375 | float scarr[26]; |
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| 376 | float **cpmxpd = floatwork; |
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| 377 | int **cpmxpdn = intwork; |
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| 378 | float *matchpt, *cpmxpdpt, **cpmxpdptpt; |
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| 379 | int *cpmxpdnpt, **cpmxpdnptpt; |
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| 380 | if( initialize ) |
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| 381 | { |
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| 382 | int count = 0; |
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| 383 | for( j=0; j<lgth2; j++ ) |
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| 384 | { |
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| 385 | count = 0; |
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| 386 | for( l=0; l<26; l++ ) |
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| 387 | { |
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| 388 | if( cpmx2[l][j] ) |
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| 389 | { |
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| 390 | cpmxpd[j][count] = cpmx2[l][j]; |
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| 391 | cpmxpdn[j][count] = l; |
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| 392 | count++; |
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| 393 | } |
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| 394 | } |
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| 395 | cpmxpdn[j][count] = -1; |
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| 396 | } |
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| 397 | } |
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| 398 | |
|---|
| 399 | { |
|---|
| 400 | for( l=0; l<26; l++ ) |
|---|
| 401 | { |
|---|
| 402 | scarr[l] = 0.0; |
|---|
| 403 | for( j=0; j<26; j++ ) |
|---|
| 404 | // scarr[l] += n_dis[j][l] * cpmx1[j][i1]; |
|---|
| 405 | scarr[l] += n_dis_consweight_multi[j][l] * cpmx1[j][i1]; |
|---|
| 406 | } |
|---|
| 407 | matchpt = match; |
|---|
| 408 | cpmxpdnptpt = cpmxpdn; |
|---|
| 409 | cpmxpdptpt = cpmxpd; |
|---|
| 410 | while( lgth2-- ) |
|---|
| 411 | { |
|---|
| 412 | *matchpt = 0.0; |
|---|
| 413 | cpmxpdnpt = *cpmxpdnptpt++; |
|---|
| 414 | cpmxpdpt = *cpmxpdptpt++; |
|---|
| 415 | while( *cpmxpdnpt>-1 ) |
|---|
| 416 | *matchpt += scarr[*cpmxpdnpt++] * *cpmxpdpt++; |
|---|
| 417 | matchpt++; |
|---|
| 418 | } |
|---|
| 419 | } |
|---|
| 420 | #else |
|---|
| 421 | int j, k, l; |
|---|
| 422 | float scarr[26]; |
|---|
| 423 | float **cpmxpd = floatwork; |
|---|
| 424 | int **cpmxpdn = intwork; |
|---|
| 425 | // simple |
|---|
| 426 | if( initialize ) |
|---|
| 427 | { |
|---|
| 428 | int count = 0; |
|---|
| 429 | for( j=0; j<lgth2; j++ ) |
|---|
| 430 | { |
|---|
| 431 | count = 0; |
|---|
| 432 | for( l=0; l<26; l++ ) |
|---|
| 433 | { |
|---|
| 434 | if( cpmx2[l][j] ) |
|---|
| 435 | { |
|---|
| 436 | cpmxpd[count][j] = cpmx2[l][j]; |
|---|
| 437 | cpmxpdn[count][j] = l; |
|---|
| 438 | count++; |
|---|
| 439 | } |
|---|
| 440 | } |
|---|
| 441 | cpmxpdn[count][j] = -1; |
|---|
| 442 | } |
|---|
| 443 | } |
|---|
| 444 | for( l=0; l<26; l++ ) |
|---|
| 445 | { |
|---|
| 446 | scarr[l] = 0.0; |
|---|
| 447 | for( k=0; k<26; k++ ) |
|---|
| 448 | // scarr[l] += n_dis[k][l] * cpmx1[k][i1]; |
|---|
| 449 | scarr[l] += n_dis_consweight_multi[k][l] * cpmx1[k][i1]; |
|---|
| 450 | } |
|---|
| 451 | for( j=0; j<lgth2; j++ ) |
|---|
| 452 | { |
|---|
| 453 | match[j] = 0.0; |
|---|
| 454 | for( k=0; cpmxpdn[k][j]>-1; k++ ) |
|---|
| 455 | match[j] += scarr[cpmxpdn[k][j]] * cpmxpd[k][j]; |
|---|
| 456 | } |
|---|
| 457 | #endif |
|---|
| 458 | } |
|---|
| 459 | |
|---|
| 460 | static void Atracking_localhom( float *impwmpt, float *lasthorizontalw, float *lastverticalw, |
|---|
| 461 | char **seq1, char **seq2, |
|---|
| 462 | char **mseq1, char **mseq2, |
|---|
| 463 | float **cpmx1, float **cpmx2, |
|---|
| 464 | int **ijp, int icyc, int jcyc, |
|---|
| 465 | int start1, int end1, int start2, int end2, |
|---|
| 466 | int *gapmap1, int *gapmap2 ) |
|---|
| 467 | { |
|---|
| 468 | int i, j, l, iin, jin, ifi, jfi, lgth1, lgth2, k; |
|---|
| 469 | // char gap[] = "-"; |
|---|
| 470 | char *gap; |
|---|
| 471 | float wm; |
|---|
| 472 | gap = newgapstr; |
|---|
| 473 | lgth1 = strlen( seq1[0] ); |
|---|
| 474 | lgth2 = strlen( seq2[0] ); |
|---|
| 475 | |
|---|
| 476 | #if 0 |
|---|
| 477 | for( i=0; i<lgth1; i++ ) |
|---|
| 478 | { |
|---|
| 479 | fprintf( stderr, "lastverticalw[%d] = %f\n", i, lastverticalw[i] ); |
|---|
| 480 | } |
|---|
| 481 | #endif |
|---|
| 482 | |
|---|
| 483 | if( outgap == 1 ) |
|---|
| 484 | ; |
|---|
| 485 | else |
|---|
| 486 | { |
|---|
| 487 | wm = lastverticalw[0]; |
|---|
| 488 | for( i=0; i<lgth1; i++ ) |
|---|
| 489 | { |
|---|
| 490 | if( lastverticalw[i] >= wm ) |
|---|
| 491 | { |
|---|
| 492 | wm = lastverticalw[i]; |
|---|
| 493 | iin = i; jin = lgth2-1; |
|---|
| 494 | ijp[lgth1][lgth2] = +( lgth1 - i ); |
|---|
| 495 | } |
|---|
| 496 | } |
|---|
| 497 | for( j=0; j<lgth2; j++ ) |
|---|
| 498 | { |
|---|
| 499 | if( lasthorizontalw[j] >= wm ) |
|---|
| 500 | { |
|---|
| 501 | wm = lasthorizontalw[j]; |
|---|
| 502 | iin = lgth1-1; jin = j; |
|---|
| 503 | ijp[lgth1][lgth2] = -( lgth2 - j ); |
|---|
| 504 | } |
|---|
| 505 | } |
|---|
| 506 | } |
|---|
| 507 | |
|---|
| 508 | for( i=0; i<lgth1+1; i++ ) |
|---|
| 509 | { |
|---|
| 510 | ijp[i][0] = i + 1; |
|---|
| 511 | } |
|---|
| 512 | for( j=0; j<lgth2+1; j++ ) |
|---|
| 513 | { |
|---|
| 514 | ijp[0][j] = -( j + 1 ); |
|---|
| 515 | } |
|---|
| 516 | |
|---|
| 517 | for( i=0; i<icyc; i++ ) |
|---|
| 518 | { |
|---|
| 519 | mseq1[i] += lgth1+lgth2; |
|---|
| 520 | *mseq1[i] = 0; |
|---|
| 521 | } |
|---|
| 522 | for( j=0; j<jcyc; j++ ) |
|---|
| 523 | { |
|---|
| 524 | mseq2[j] += lgth1+lgth2; |
|---|
| 525 | *mseq2[j] = 0; |
|---|
| 526 | } |
|---|
| 527 | iin = lgth1; jin = lgth2; |
|---|
| 528 | *impwmpt = 0.0; |
|---|
| 529 | for( k=0; k<=lgth1+lgth2; k++ ) |
|---|
| 530 | { |
|---|
| 531 | if( ijp[iin][jin] < 0 ) |
|---|
| 532 | { |
|---|
| 533 | ifi = iin-1; jfi = jin+ijp[iin][jin]; |
|---|
| 534 | } |
|---|
| 535 | else if( ijp[iin][jin] > 0 ) |
|---|
| 536 | { |
|---|
| 537 | ifi = iin-ijp[iin][jin]; jfi = jin-1; |
|---|
| 538 | } |
|---|
| 539 | else |
|---|
| 540 | { |
|---|
| 541 | ifi = iin-1; jfi = jin-1; |
|---|
| 542 | } |
|---|
| 543 | l = iin - ifi; |
|---|
| 544 | while( --l ) |
|---|
| 545 | { |
|---|
| 546 | for( i=0; i<icyc; i++ ) |
|---|
| 547 | *--mseq1[i] = seq1[i][ifi+l]; |
|---|
| 548 | for( j=0; j<jcyc; j++ ) |
|---|
| 549 | *--mseq2[j] = *gap; |
|---|
| 550 | k++; |
|---|
| 551 | } |
|---|
| 552 | l= jin - jfi; |
|---|
| 553 | while( --l ) |
|---|
| 554 | { |
|---|
| 555 | for( i=0; i<icyc; i++ ) |
|---|
| 556 | *--mseq1[i] = *gap; |
|---|
| 557 | for( j=0; j<jcyc; j++ ) |
|---|
| 558 | *--mseq2[j] = seq2[j][jfi+l]; |
|---|
| 559 | k++; |
|---|
| 560 | } |
|---|
| 561 | if( iin != lgth1 && jin != lgth2 ) // ?? |
|---|
| 562 | { |
|---|
| 563 | *impwmpt += part_imp_match_out_scQ( gapmap1[iin]+start1, gapmap2[jin]+start2 ); |
|---|
| 564 | // fprintf( stderr, "impwm = %f (iin=%d, jin=%d) seq1=%c, seq2=%c\n", *impwmpt, iin, jin, seq1[0][iin], seq2[0][jin] ); |
|---|
| 565 | } |
|---|
| 566 | if( iin <= 0 || jin <= 0 ) break; |
|---|
| 567 | for( i=0; i<icyc; i++ ) |
|---|
| 568 | *--mseq1[i] = seq1[i][ifi]; |
|---|
| 569 | for( j=0; j<jcyc; j++ ) |
|---|
| 570 | *--mseq2[j] = seq2[j][jfi]; |
|---|
| 571 | k++; |
|---|
| 572 | iin = ifi; jin = jfi; |
|---|
| 573 | } |
|---|
| 574 | } |
|---|
| 575 | static float Atracking( float *lasthorizontalw, float *lastverticalw, |
|---|
| 576 | char **seq1, char **seq2, |
|---|
| 577 | char **mseq1, char **mseq2, |
|---|
| 578 | float **cpmx1, float **cpmx2, |
|---|
| 579 | int **ijp, int icyc, int jcyc ) |
|---|
| 580 | { |
|---|
| 581 | int i, j, l, iin, jin, ifi, jfi, lgth1, lgth2, k, lastk; |
|---|
| 582 | // char gap[] = "-"; |
|---|
| 583 | char *gap; |
|---|
| 584 | float wm = 0.0; |
|---|
| 585 | gap = newgapstr; |
|---|
| 586 | lgth1 = strlen( seq1[0] ); |
|---|
| 587 | lgth2 = strlen( seq2[0] ); |
|---|
| 588 | |
|---|
| 589 | #if 0 |
|---|
| 590 | for( i=0; i<lgth1; i++ ) |
|---|
| 591 | { |
|---|
| 592 | fprintf( stderr, "lastverticalw[%d] = %f\n", i, lastverticalw[i] ); |
|---|
| 593 | } |
|---|
| 594 | #endif |
|---|
| 595 | |
|---|
| 596 | if( outgap == 1 ) |
|---|
| 597 | ; |
|---|
| 598 | else |
|---|
| 599 | { |
|---|
| 600 | wm = lastverticalw[0]; |
|---|
| 601 | for( i=0; i<lgth1; i++ ) |
|---|
| 602 | { |
|---|
| 603 | if( lastverticalw[i] >= wm ) |
|---|
| 604 | { |
|---|
| 605 | wm = lastverticalw[i]; |
|---|
| 606 | iin = i; jin = lgth2-1; |
|---|
| 607 | ijp[lgth1][lgth2] = +( lgth1 - i ); |
|---|
| 608 | } |
|---|
| 609 | } |
|---|
| 610 | for( j=0; j<lgth2; j++ ) |
|---|
| 611 | { |
|---|
| 612 | if( lasthorizontalw[j] >= wm ) |
|---|
| 613 | { |
|---|
| 614 | wm = lasthorizontalw[j]; |
|---|
| 615 | iin = lgth1-1; jin = j; |
|---|
| 616 | ijp[lgth1][lgth2] = -( lgth2 - j ); |
|---|
| 617 | } |
|---|
| 618 | } |
|---|
| 619 | } |
|---|
| 620 | |
|---|
| 621 | for( i=0; i<lgth1+1; i++ ) |
|---|
| 622 | { |
|---|
| 623 | ijp[i][0] = i + 1; |
|---|
| 624 | } |
|---|
| 625 | for( j=0; j<lgth2+1; j++ ) |
|---|
| 626 | { |
|---|
| 627 | ijp[0][j] = -( j + 1 ); |
|---|
| 628 | } |
|---|
| 629 | |
|---|
| 630 | for( i=0; i<icyc; i++ ) |
|---|
| 631 | { |
|---|
| 632 | mseq1[i] += lgth1+lgth2; |
|---|
| 633 | *mseq1[i] = 0; |
|---|
| 634 | } |
|---|
| 635 | for( j=0; j<jcyc; j++ ) |
|---|
| 636 | { |
|---|
| 637 | mseq2[j] += lgth1+lgth2; |
|---|
| 638 | *mseq2[j] = 0; |
|---|
| 639 | } |
|---|
| 640 | iin = lgth1; jin = lgth2; |
|---|
| 641 | lastk = lgth1+lgth2; |
|---|
| 642 | for( k=0; k<=lastk; k++ ) |
|---|
| 643 | { |
|---|
| 644 | if( ijp[iin][jin] < 0 ) |
|---|
| 645 | { |
|---|
| 646 | ifi = iin-1; jfi = jin+ijp[iin][jin]; |
|---|
| 647 | } |
|---|
| 648 | else if( ijp[iin][jin] > 0 ) |
|---|
| 649 | { |
|---|
| 650 | ifi = iin-ijp[iin][jin]; jfi = jin-1; |
|---|
| 651 | } |
|---|
| 652 | else |
|---|
| 653 | { |
|---|
| 654 | ifi = iin-1; jfi = jin-1; |
|---|
| 655 | } |
|---|
| 656 | l = iin - ifi; |
|---|
| 657 | while( --l ) |
|---|
| 658 | { |
|---|
| 659 | for( i=0; i<icyc; i++ ) |
|---|
| 660 | *--mseq1[i] = seq1[i][ifi+l]; |
|---|
| 661 | for( j=0; j<jcyc; j++ ) |
|---|
| 662 | *--mseq2[j] = *gap; |
|---|
| 663 | k++; |
|---|
| 664 | } |
|---|
| 665 | l= jin - jfi; |
|---|
| 666 | while( --l ) |
|---|
| 667 | { |
|---|
| 668 | for( i=0; i<icyc; i++ ) |
|---|
| 669 | *--mseq1[i] = *gap; |
|---|
| 670 | for( j=0; j<jcyc; j++ ) |
|---|
| 671 | *--mseq2[j] = seq2[j][jfi+l]; |
|---|
| 672 | k++; |
|---|
| 673 | } |
|---|
| 674 | if( iin <= 0 || jin <= 0 ) break; |
|---|
| 675 | for( i=0; i<icyc; i++ ) |
|---|
| 676 | *--mseq1[i] = seq1[i][ifi]; |
|---|
| 677 | for( j=0; j<jcyc; j++ ) |
|---|
| 678 | *--mseq2[j] = seq2[j][jfi]; |
|---|
| 679 | k++; |
|---|
| 680 | iin = ifi; jin = jfi; |
|---|
| 681 | } |
|---|
| 682 | return( 0.0 ); |
|---|
| 683 | } |
|---|
| 684 | |
|---|
| 685 | float partQ__align( char **seq1, char **seq2, double *eff1, double *eff2, int icyc, int jcyc, int alloclen, LocalHom ***localhom, float *impmatch, int start1, int end1, int start2, int end2, int *gapmap1, int *gapmap2, char *sgap1, char *sgap2, char *egap1, char *egap2 ) |
|---|
| 686 | /* score no keisan no sai motokaraaru gap no atukai ni mondai ga aru */ |
|---|
| 687 | { |
|---|
| 688 | // int k; |
|---|
| 689 | register int i, j; |
|---|
| 690 | int lasti, lastj; /* outgap == 0 -> lgth1, outgap == 1 -> lgth1+1 */ |
|---|
| 691 | int lgth1, lgth2; |
|---|
| 692 | int resultlen; |
|---|
| 693 | float wm = 0.0; /* int ?????? */ |
|---|
| 694 | float g; |
|---|
| 695 | float *currentw, *previousw; |
|---|
| 696 | #if 1 |
|---|
| 697 | float *wtmp; |
|---|
| 698 | int *ijppt; |
|---|
| 699 | float *mjpt, *prept, *curpt; |
|---|
| 700 | int *mpjpt; |
|---|
| 701 | #endif |
|---|
| 702 | static float mi, *m; |
|---|
| 703 | static int **ijp; |
|---|
| 704 | static int mpi, *mp; |
|---|
| 705 | static float *w1, *w2; |
|---|
| 706 | static float *match; |
|---|
| 707 | static float *initverticalw; /* kufuu sureba iranai */ |
|---|
| 708 | static float *lastverticalw; /* kufuu sureba iranai */ |
|---|
| 709 | static char **mseq1; |
|---|
| 710 | static char **mseq2; |
|---|
| 711 | static char **mseq; |
|---|
| 712 | static float *digf1; |
|---|
| 713 | static float *digf2; |
|---|
| 714 | static float *diaf1; |
|---|
| 715 | static float *diaf2; |
|---|
| 716 | static float *gapz1; |
|---|
| 717 | static float *gapz2; |
|---|
| 718 | static float *gapf1; |
|---|
| 719 | static float *gapf2; |
|---|
| 720 | static float *ogcp1g; |
|---|
| 721 | static float *ogcp2g; |
|---|
| 722 | static float *fgcp1g; |
|---|
| 723 | static float *fgcp2g; |
|---|
| 724 | static float *og_h_dg_n1_p; |
|---|
| 725 | static float *og_h_dg_n2_p; |
|---|
| 726 | static float *fg_h_dg_n1_p; |
|---|
| 727 | static float *fg_h_dg_n2_p; |
|---|
| 728 | static float *og_t_fg_h_dg_n1_p; |
|---|
| 729 | static float *og_t_fg_h_dg_n2_p; |
|---|
| 730 | static float *fg_t_og_h_dg_n1_p; |
|---|
| 731 | static float *fg_t_og_h_dg_n2_p; |
|---|
| 732 | static float *gapz_n1; |
|---|
| 733 | static float *gapz_n2; |
|---|
| 734 | static float **cpmx1; |
|---|
| 735 | static float **cpmx2; |
|---|
| 736 | static int **intwork; |
|---|
| 737 | static float **floatwork; |
|---|
| 738 | static int orlgth1 = 0, orlgth2 = 0; |
|---|
| 739 | float fpenalty = (float)penalty; |
|---|
| 740 | #if USE_PENALTY_EX |
|---|
| 741 | float fpenalty_ex = (float)penalty_ex; |
|---|
| 742 | #endif |
|---|
| 743 | float tmppenal; |
|---|
| 744 | float *fg_t_og_h_dg_n2_p_pt; |
|---|
| 745 | float *og_t_fg_h_dg_n2_p_pt; |
|---|
| 746 | float *og_h_dg_n2_p_pt; |
|---|
| 747 | float *fg_h_dg_n2_p_pt; |
|---|
| 748 | float *gapz_n2_pt0; |
|---|
| 749 | float *gapz_n2_pt1; |
|---|
| 750 | float *fgcp2pt; |
|---|
| 751 | float *ogcp2pt; |
|---|
| 752 | float fg_t_og_h_dg_n1_p_va; |
|---|
| 753 | float og_t_fg_h_dg_n1_p_va; |
|---|
| 754 | float og_h_dg_n1_p_va; |
|---|
| 755 | float fg_h_dg_n1_p_va; |
|---|
| 756 | float gapz_n1_va0; |
|---|
| 757 | float gapz_n1_va1; |
|---|
| 758 | float fgcp1va; |
|---|
| 759 | float ogcp1va; |
|---|
| 760 | |
|---|
| 761 | |
|---|
| 762 | |
|---|
| 763 | #if 0 |
|---|
| 764 | fprintf( stderr, "eff in SA+++align\n" ); |
|---|
| 765 | for( i=0; i<icyc; i++ ) fprintf( stderr, "eff1[%d] = %f\n", i, eff1[i] ); |
|---|
| 766 | #endif |
|---|
| 767 | if( orlgth1 == 0 ) |
|---|
| 768 | { |
|---|
| 769 | mseq1 = AllocateCharMtx( njob, 0 ); |
|---|
| 770 | mseq2 = AllocateCharMtx( njob, 0 ); |
|---|
| 771 | } |
|---|
| 772 | |
|---|
| 773 | |
|---|
| 774 | lgth1 = strlen( seq1[0] ); |
|---|
| 775 | lgth2 = strlen( seq2[0] ); |
|---|
| 776 | |
|---|
| 777 | if( lgth1 > orlgth1 || lgth2 > orlgth2 ) |
|---|
| 778 | { |
|---|
| 779 | int ll1, ll2; |
|---|
| 780 | |
|---|
| 781 | if( orlgth1 > 0 && orlgth2 > 0 ) |
|---|
| 782 | { |
|---|
| 783 | FreeFloatVec( w1 ); |
|---|
| 784 | FreeFloatVec( w2 ); |
|---|
| 785 | FreeFloatVec( match ); |
|---|
| 786 | FreeFloatVec( initverticalw ); |
|---|
| 787 | FreeFloatVec( lastverticalw ); |
|---|
| 788 | |
|---|
| 789 | FreeFloatVec( m ); |
|---|
| 790 | FreeIntVec( mp ); |
|---|
| 791 | |
|---|
| 792 | FreeCharMtx( mseq ); |
|---|
| 793 | |
|---|
| 794 | FreeFloatVec( digf1 ); |
|---|
| 795 | FreeFloatVec( digf2 ); |
|---|
| 796 | FreeFloatVec( diaf1 ); |
|---|
| 797 | FreeFloatVec( diaf2 ); |
|---|
| 798 | FreeFloatVec( gapz1 ); |
|---|
| 799 | FreeFloatVec( gapz2 ); |
|---|
| 800 | FreeFloatVec( gapf1 ); |
|---|
| 801 | FreeFloatVec( gapf2 ); |
|---|
| 802 | FreeFloatVec( ogcp1g ); |
|---|
| 803 | FreeFloatVec( ogcp2g ); |
|---|
| 804 | FreeFloatVec( fgcp1g ); |
|---|
| 805 | FreeFloatVec( fgcp2g ); |
|---|
| 806 | FreeFloatVec( og_h_dg_n1_p ); |
|---|
| 807 | FreeFloatVec( og_h_dg_n2_p ); |
|---|
| 808 | FreeFloatVec( fg_h_dg_n1_p ); |
|---|
| 809 | FreeFloatVec( fg_h_dg_n2_p ); |
|---|
| 810 | FreeFloatVec( og_t_fg_h_dg_n1_p ); |
|---|
| 811 | FreeFloatVec( og_t_fg_h_dg_n2_p ); |
|---|
| 812 | FreeFloatVec( fg_t_og_h_dg_n1_p ); |
|---|
| 813 | FreeFloatVec( fg_t_og_h_dg_n2_p ); |
|---|
| 814 | FreeFloatVec( gapz_n1 ); |
|---|
| 815 | FreeFloatVec( gapz_n2 ); |
|---|
| 816 | |
|---|
| 817 | FreeFloatMtx( cpmx1 ); |
|---|
| 818 | FreeFloatMtx( cpmx2 ); |
|---|
| 819 | |
|---|
| 820 | FreeFloatMtx( floatwork ); |
|---|
| 821 | FreeIntMtx( intwork ); |
|---|
| 822 | } |
|---|
| 823 | |
|---|
| 824 | ll1 = MAX( (int)(1.3*lgth1), orlgth1 ) + 100; |
|---|
| 825 | ll2 = MAX( (int)(1.3*lgth2), orlgth2 ) + 100; |
|---|
| 826 | |
|---|
| 827 | #if DEBUG |
|---|
| 828 | fprintf( stderr, "\ntrying to allocate (%d+%d)xn matrices ... ", ll1, ll2 ); |
|---|
| 829 | #endif |
|---|
| 830 | |
|---|
| 831 | w1 = AllocateFloatVec( ll2+2 ); |
|---|
| 832 | w2 = AllocateFloatVec( ll2+2 ); |
|---|
| 833 | match = AllocateFloatVec( ll2+2 ); |
|---|
| 834 | |
|---|
| 835 | initverticalw = AllocateFloatVec( ll1+2 ); |
|---|
| 836 | lastverticalw = AllocateFloatVec( ll1+2 ); |
|---|
| 837 | |
|---|
| 838 | m = AllocateFloatVec( ll2+2 ); |
|---|
| 839 | mp = AllocateIntVec( ll2+2 ); |
|---|
| 840 | |
|---|
| 841 | mseq = AllocateCharMtx( njob, ll1+ll2 ); |
|---|
| 842 | |
|---|
| 843 | digf1 = AllocateFloatVec( ll1+2 ); |
|---|
| 844 | digf2 = AllocateFloatVec( ll2+2 ); |
|---|
| 845 | diaf1 = AllocateFloatVec( ll1+2 ); |
|---|
| 846 | diaf2 = AllocateFloatVec( ll2+2 ); |
|---|
| 847 | gapz1 = AllocateFloatVec( ll1+2 ); |
|---|
| 848 | gapz2 = AllocateFloatVec( ll2+2 ); |
|---|
| 849 | gapf1 = AllocateFloatVec( ll1+2 ); |
|---|
| 850 | gapf2 = AllocateFloatVec( ll2+2 ); |
|---|
| 851 | ogcp1g = AllocateFloatVec( ll1+2 ); |
|---|
| 852 | ogcp2g = AllocateFloatVec( ll2+2 ); |
|---|
| 853 | fgcp1g = AllocateFloatVec( ll1+2 ); |
|---|
| 854 | fgcp2g = AllocateFloatVec( ll2+2 ); |
|---|
| 855 | og_h_dg_n1_p = AllocateFloatVec( ll1 + 2 ); |
|---|
| 856 | og_h_dg_n2_p = AllocateFloatVec( ll2 + 2 ); |
|---|
| 857 | fg_h_dg_n1_p = AllocateFloatVec( ll1 + 2 ); |
|---|
| 858 | fg_h_dg_n2_p = AllocateFloatVec( ll2 + 2 ); |
|---|
| 859 | og_t_fg_h_dg_n1_p = AllocateFloatVec( ll1 + 2 ); |
|---|
| 860 | og_t_fg_h_dg_n2_p = AllocateFloatVec( ll2 + 2 ); |
|---|
| 861 | fg_t_og_h_dg_n1_p = AllocateFloatVec( ll1 + 2 ); |
|---|
| 862 | fg_t_og_h_dg_n2_p = AllocateFloatVec( ll2 + 2 ); |
|---|
| 863 | gapz_n1 = AllocateFloatVec( ll1+2 ); |
|---|
| 864 | gapz_n2 = AllocateFloatVec( ll2+2 ); |
|---|
| 865 | |
|---|
| 866 | cpmx1 = AllocateFloatMtx( 26, ll1+2 ); |
|---|
| 867 | cpmx2 = AllocateFloatMtx( 26, ll2+2 ); |
|---|
| 868 | |
|---|
| 869 | #if FASTMATCHCALC |
|---|
| 870 | floatwork = AllocateFloatMtx( MAX( ll1, ll2 )+2, 26 ); |
|---|
| 871 | intwork = AllocateIntMtx( MAX( ll1, ll2 )+2, 26 ); |
|---|
| 872 | #else |
|---|
| 873 | floatwork = AllocateFloatMtx( 26, MAX( ll1, ll2 )+2 ); |
|---|
| 874 | intwork = AllocateIntMtx( 26, MAX( ll1, ll2 )+2 ); |
|---|
| 875 | #endif |
|---|
| 876 | |
|---|
| 877 | #if DEBUG |
|---|
| 878 | fprintf( stderr, "succeeded\n" ); |
|---|
| 879 | #endif |
|---|
| 880 | |
|---|
| 881 | orlgth1 = ll1 - 100; |
|---|
| 882 | orlgth2 = ll2 - 100; |
|---|
| 883 | } |
|---|
| 884 | |
|---|
| 885 | |
|---|
| 886 | for( i=0; i<icyc; i++ ) mseq1[i] = mseq[i]; |
|---|
| 887 | for( j=0; j<jcyc; j++ ) mseq2[j] = mseq[icyc+j]; |
|---|
| 888 | |
|---|
| 889 | |
|---|
| 890 | if( orlgth1 > commonAlloc1 || orlgth2 > commonAlloc2 ) |
|---|
| 891 | { |
|---|
| 892 | int ll1, ll2; |
|---|
| 893 | |
|---|
| 894 | if( commonAlloc1 && commonAlloc2 ) |
|---|
| 895 | { |
|---|
| 896 | FreeIntMtx( commonIP ); |
|---|
| 897 | } |
|---|
| 898 | |
|---|
| 899 | ll1 = MAX( orlgth1, commonAlloc1 ); |
|---|
| 900 | ll2 = MAX( orlgth2, commonAlloc2 ); |
|---|
| 901 | |
|---|
| 902 | #if DEBUG |
|---|
| 903 | fprintf( stderr, "\n\ntrying to allocate %dx%d matrices ... ", ll1+1, ll2+1 ); |
|---|
| 904 | #endif |
|---|
| 905 | |
|---|
| 906 | commonIP = AllocateIntMtx( ll1+10, ll2+10 ); |
|---|
| 907 | |
|---|
| 908 | #if DEBUG |
|---|
| 909 | fprintf( stderr, "succeeded\n\n" ); |
|---|
| 910 | #endif |
|---|
| 911 | |
|---|
| 912 | commonAlloc1 = ll1; |
|---|
| 913 | commonAlloc2 = ll2; |
|---|
| 914 | } |
|---|
| 915 | ijp = commonIP; |
|---|
| 916 | |
|---|
| 917 | cpmx_calc_new( seq1, cpmx1, eff1, lgth1, icyc ); |
|---|
| 918 | cpmx_calc_new( seq2, cpmx2, eff2, lgth2, jcyc ); |
|---|
| 919 | |
|---|
| 920 | if( sgap1 ) |
|---|
| 921 | { |
|---|
| 922 | new_OpeningGapCount_zure( ogcp1g, icyc, seq1, eff1, lgth1, sgap1, egap1 ); |
|---|
| 923 | new_OpeningGapCount_zure( ogcp2g, jcyc, seq2, eff2, lgth2, sgap2, egap2 ); |
|---|
| 924 | new_FinalGapCount_zure( fgcp1g, icyc, seq1, eff1, lgth1, sgap1, egap1 ); |
|---|
| 925 | new_FinalGapCount_zure( fgcp2g, jcyc, seq2, eff2, lgth2, sgap2, egap2 ); |
|---|
| 926 | getdigapfreq_part( digf1, icyc, seq1, eff1, lgth1, sgap1, egap1 ); |
|---|
| 927 | getdigapfreq_part( digf2, jcyc, seq2, eff2, lgth2, sgap2, egap2 ); |
|---|
| 928 | getdiaminofreq_part( diaf1, icyc, seq1, eff1, lgth1, sgap1, egap1 ); |
|---|
| 929 | getdiaminofreq_part( diaf2, jcyc, seq2, eff2, lgth2, sgap2, egap2 ); |
|---|
| 930 | getgapfreq( gapf1, icyc, seq1, eff1, lgth1 ); |
|---|
| 931 | getgapfreq( gapf2, jcyc, seq2, eff2, lgth2 ); |
|---|
| 932 | getgapfreq_zure_part( gapz1, icyc, seq1, eff1, lgth1, sgap1 ); |
|---|
| 933 | getgapfreq_zure_part( gapz2, jcyc, seq2, eff2, lgth2, sgap1 ); |
|---|
| 934 | } |
|---|
| 935 | else |
|---|
| 936 | { |
|---|
| 937 | st_OpeningGapCount( ogcp1g, icyc, seq1, eff1, lgth1 ); |
|---|
| 938 | st_OpeningGapCount( ogcp2g, jcyc, seq2, eff2, lgth2 ); |
|---|
| 939 | st_FinalGapCount_zure( fgcp1g, icyc, seq1, eff1, lgth1 ); |
|---|
| 940 | st_FinalGapCount_zure( fgcp2g, jcyc, seq2, eff2, lgth2 ); |
|---|
| 941 | getdigapfreq_st( digf1, icyc, seq1, eff1, lgth1 ); |
|---|
| 942 | getdigapfreq_st( digf2, jcyc, seq2, eff2, lgth2 ); |
|---|
| 943 | getdiaminofreq_x( diaf1, icyc, seq1, eff1, lgth1 ); |
|---|
| 944 | getdiaminofreq_x( diaf2, jcyc, seq2, eff2, lgth2 ); |
|---|
| 945 | getgapfreq( gapf1, icyc, seq1, eff1, lgth1 ); |
|---|
| 946 | getgapfreq( gapf2, jcyc, seq2, eff2, lgth2 ); |
|---|
| 947 | getgapfreq_zure( gapz1, icyc, seq1, eff1, lgth1 ); |
|---|
| 948 | getgapfreq_zure( gapz2, jcyc, seq2, eff2, lgth2 ); |
|---|
| 949 | } |
|---|
| 950 | |
|---|
| 951 | #if 1 |
|---|
| 952 | lastj = lgth2+2; |
|---|
| 953 | for( i=0; i<lastj; i++ ) |
|---|
| 954 | { |
|---|
| 955 | og_h_dg_n2_p[i] = ( 1.0-ogcp2g[i]-digf2[i] ) * fpenalty * 0.5; |
|---|
| 956 | fg_h_dg_n2_p[i] = ( 1.0-fgcp2g[i]-digf2[i] ) * fpenalty * 0.5; |
|---|
| 957 | og_t_fg_h_dg_n2_p[i] = (1.0-ogcp2g[i]+fgcp2g[i]-digf2[i]) * 0.5 * fpenalty; |
|---|
| 958 | fg_t_og_h_dg_n2_p[i] = (1.0-fgcp2g[i]+ogcp2g[i]-digf2[i]) * 0.5 * fpenalty; |
|---|
| 959 | gapz_n2[i] = (1.0-gapz2[i]); |
|---|
| 960 | } |
|---|
| 961 | lastj = lgth1+2; |
|---|
| 962 | for( i=0; i<lastj; i++ ) |
|---|
| 963 | { |
|---|
| 964 | og_h_dg_n1_p[i] = ( 1.0-ogcp1g[i]-digf1[i] ) * fpenalty * 0.5; |
|---|
| 965 | fg_h_dg_n1_p[i] = ( 1.0-fgcp1g[i]-digf1[i] ) * fpenalty * 0.5; |
|---|
| 966 | og_t_fg_h_dg_n1_p[i] = (1.0-ogcp1g[i]+fgcp1g[i]-digf1[i]) * 0.5 * fpenalty; |
|---|
| 967 | fg_t_og_h_dg_n1_p[i] = (1.0-fgcp1g[i]+ogcp1g[i]-digf1[i]) * 0.5 * fpenalty; |
|---|
| 968 | gapz_n1[i] = (1.0-gapz1[i]); |
|---|
| 969 | } |
|---|
| 970 | #endif |
|---|
| 971 | |
|---|
| 972 | currentw = w1; |
|---|
| 973 | previousw = w2; |
|---|
| 974 | |
|---|
| 975 | |
|---|
| 976 | match_calc( initverticalw, cpmx2, cpmx1, 0, lgth1, floatwork, intwork, 1 ); |
|---|
| 977 | if( localhom ) |
|---|
| 978 | part_imp_match_out_vead_tate_gapmapQ( initverticalw, gapmap2[0]+start2, lgth1, start1, gapmap1 ); |
|---|
| 979 | |
|---|
| 980 | |
|---|
| 981 | match_calc( currentw, cpmx1, cpmx2, 0, lgth2, floatwork, intwork, 1 ); |
|---|
| 982 | if( localhom ) |
|---|
| 983 | part_imp_match_out_vead_gapmapQ( currentw, gapmap1[0]+start1, lgth2, start2, gapmap2 ); |
|---|
| 984 | #if 0 // -> tbfast.c |
|---|
| 985 | if( localhom ) |
|---|
| 986 | imp_match_calc( currentw, icyc, jcyc, lgth1, lgth2, seq1, seq2, eff1, eff2, localhom, 1, 0 ); |
|---|
| 987 | |
|---|
| 988 | #endif |
|---|
| 989 | |
|---|
| 990 | if( outgap == 1 ) |
|---|
| 991 | { |
|---|
| 992 | g = 0.0; |
|---|
| 993 | |
|---|
| 994 | g += ogcp1g[0] * og_h_dg_n2_p[0]; |
|---|
| 995 | |
|---|
| 996 | g += ogcp2g[0] * og_h_dg_n1_p[0]; |
|---|
| 997 | |
|---|
| 998 | g += fgcp1g[0] * fg_h_dg_n2_p[0]; |
|---|
| 999 | |
|---|
| 1000 | g += fgcp2g[0] * fg_h_dg_n1_p[0]; |
|---|
| 1001 | |
|---|
| 1002 | initverticalw[0] += g; |
|---|
| 1003 | currentw[0] += g; |
|---|
| 1004 | |
|---|
| 1005 | for( i=1; i<lgth1+1; i++ ) |
|---|
| 1006 | { |
|---|
| 1007 | tmppenal = gapz_n2[0]*og_t_fg_h_dg_n1_p[0]; |
|---|
| 1008 | initverticalw[i] += tmppenal; |
|---|
| 1009 | |
|---|
| 1010 | tmppenal = gapz_n2[1]*fg_t_og_h_dg_n1_p[i]; |
|---|
| 1011 | initverticalw[i] += tmppenal; |
|---|
| 1012 | |
|---|
| 1013 | } |
|---|
| 1014 | for( j=1; j<lgth2+1; j++ ) |
|---|
| 1015 | { |
|---|
| 1016 | tmppenal = gapz_n1[0]*og_t_fg_h_dg_n2_p[0]; |
|---|
| 1017 | currentw[j] += tmppenal; |
|---|
| 1018 | |
|---|
| 1019 | tmppenal = gapz_n1[1]*fg_t_og_h_dg_n2_p[j]; |
|---|
| 1020 | currentw[j] += tmppenal; |
|---|
| 1021 | } |
|---|
| 1022 | } |
|---|
| 1023 | #if OUTGAP0TRY |
|---|
| 1024 | else |
|---|
| 1025 | { |
|---|
| 1026 | for( j=1; j<lgth2+1; j++ ) |
|---|
| 1027 | currentw[j] -= offset * j / 2.0; |
|---|
| 1028 | for( i=1; i<lgth1+1; i++ ) |
|---|
| 1029 | initverticalw[i] -= offset * i / 2.0; |
|---|
| 1030 | } |
|---|
| 1031 | #endif |
|---|
| 1032 | |
|---|
| 1033 | m[0] = 0.0; // iranai |
|---|
| 1034 | for( j=1; j<lgth2+1; ++j ) |
|---|
| 1035 | { |
|---|
| 1036 | mp[j] = 0; |
|---|
| 1037 | m[j] = currentw[j-1] + 10000 * fpenalty; //iinoka? |
|---|
| 1038 | } |
|---|
| 1039 | if( lgth2 == 0 ) |
|---|
| 1040 | lastverticalw[0] = 0.0; // Falign kara yobaretatoki kounarukanousei ari |
|---|
| 1041 | else |
|---|
| 1042 | lastverticalw[0] = currentw[lgth2-1]; |
|---|
| 1043 | |
|---|
| 1044 | if( outgap ) lasti = lgth1+1; else lasti = lgth1; |
|---|
| 1045 | lastj = lgth2+1; |
|---|
| 1046 | |
|---|
| 1047 | #if XXXXXXX |
|---|
| 1048 | fprintf( stderr, "currentw = \n" ); |
|---|
| 1049 | for( i=0; i<lgth1+1; i++ ) |
|---|
| 1050 | { |
|---|
| 1051 | fprintf( stderr, "%5.2f ", currentw[i] ); |
|---|
| 1052 | } |
|---|
| 1053 | fprintf( stderr, "\n" ); |
|---|
| 1054 | fprintf( stderr, "initverticalw = \n" ); |
|---|
| 1055 | for( i=0; i<lgth2+1; i++ ) |
|---|
| 1056 | { |
|---|
| 1057 | fprintf( stderr, "%5.2f ", initverticalw[i] ); |
|---|
| 1058 | } |
|---|
| 1059 | fprintf( stderr, "\n" ); |
|---|
| 1060 | fprintf( stderr, "fcgp\n" ); |
|---|
| 1061 | for( i=0; i<lgth1; i++ ) |
|---|
| 1062 | fprintf( stderr, "fgcp1[%d]=%f\n", i, ogcp1[i] ); |
|---|
| 1063 | for( i=0; i<lgth2; i++ ) |
|---|
| 1064 | fprintf( stderr, "fgcp2[%d]=%f\n", i, ogcp2[i] ); |
|---|
| 1065 | #endif |
|---|
| 1066 | |
|---|
| 1067 | for( i=1; i<lasti; i++ ) |
|---|
| 1068 | { |
|---|
| 1069 | wtmp = previousw; |
|---|
| 1070 | previousw = currentw; |
|---|
| 1071 | currentw = wtmp; |
|---|
| 1072 | |
|---|
| 1073 | previousw[0] = initverticalw[i-1]; |
|---|
| 1074 | |
|---|
| 1075 | match_calc( currentw, cpmx1, cpmx2, i, lgth2, floatwork, intwork, 0 ); |
|---|
| 1076 | #if XXXXXXX |
|---|
| 1077 | fprintf( stderr, "\n" ); |
|---|
| 1078 | fprintf( stderr, "i=%d\n", i ); |
|---|
| 1079 | fprintf( stderr, "currentw = \n" ); |
|---|
| 1080 | for( j=0; j<lgth2; j++ ) |
|---|
| 1081 | { |
|---|
| 1082 | fprintf( stderr, "%5.2f ", currentw[j] ); |
|---|
| 1083 | } |
|---|
| 1084 | fprintf( stderr, "\n" ); |
|---|
| 1085 | #endif |
|---|
| 1086 | if( localhom ) |
|---|
| 1087 | { |
|---|
| 1088 | // fprintf( stderr, "Calling imp_match_calc (o) lgth = %d, i = %d\n", lgth1, i ); |
|---|
| 1089 | // imp_match_out_vead( currentw, i, lgth2 ); |
|---|
| 1090 | part_imp_match_out_vead_gapmapQ( currentw, gapmap1[i]+start1, lgth2, start2, gapmap2 ); |
|---|
| 1091 | } |
|---|
| 1092 | #if XXXXXXX |
|---|
| 1093 | fprintf( stderr, "\n" ); |
|---|
| 1094 | fprintf( stderr, "i=%d\n", i ); |
|---|
| 1095 | fprintf( stderr, "currentw = \n" ); |
|---|
| 1096 | for( j=0; j<lgth2; j++ ) |
|---|
| 1097 | { |
|---|
| 1098 | fprintf( stderr, "%5.2f ", currentw[j] ); |
|---|
| 1099 | } |
|---|
| 1100 | fprintf( stderr, "\n" ); |
|---|
| 1101 | #endif |
|---|
| 1102 | currentw[0] = initverticalw[i]; |
|---|
| 1103 | |
|---|
| 1104 | mpi = 0; |
|---|
| 1105 | mi = previousw[0] + 10000 * fpenalty; |
|---|
| 1106 | |
|---|
| 1107 | ijppt = ijp[i] + 1; |
|---|
| 1108 | mjpt = m + 1; |
|---|
| 1109 | prept = previousw; |
|---|
| 1110 | curpt = currentw + 1; |
|---|
| 1111 | mpjpt = mp + 1; |
|---|
| 1112 | fg_t_og_h_dg_n2_p_pt = fg_t_og_h_dg_n2_p + 1; |
|---|
| 1113 | og_t_fg_h_dg_n2_p_pt = og_t_fg_h_dg_n2_p + 1; |
|---|
| 1114 | og_h_dg_n2_p_pt = og_h_dg_n2_p + 1; |
|---|
| 1115 | fg_h_dg_n2_p_pt = fg_h_dg_n2_p + 1; |
|---|
| 1116 | gapz_n2_pt0 = gapz_n2 + 1; |
|---|
| 1117 | gapz_n2_pt1 = gapz_n2 + 2; |
|---|
| 1118 | fgcp2pt = fgcp2g + 1; |
|---|
| 1119 | ogcp2pt = ogcp2g + 1; |
|---|
| 1120 | |
|---|
| 1121 | fg_t_og_h_dg_n1_p_va = fg_t_og_h_dg_n1_p[i]; |
|---|
| 1122 | og_t_fg_h_dg_n1_p_va = og_t_fg_h_dg_n1_p[i]; |
|---|
| 1123 | og_h_dg_n1_p_va = og_h_dg_n1_p[i]; |
|---|
| 1124 | fg_h_dg_n1_p_va = fg_h_dg_n1_p[i]; |
|---|
| 1125 | gapz_n1_va0 = gapz_n1[i]; |
|---|
| 1126 | gapz_n1_va1 = gapz_n1[i+1]; |
|---|
| 1127 | fgcp1va = fgcp1g[i]; |
|---|
| 1128 | ogcp1va = ogcp1g[i]; |
|---|
| 1129 | |
|---|
| 1130 | for( j=1; j<lastj; j++ ) |
|---|
| 1131 | { |
|---|
| 1132 | wm = *prept; |
|---|
| 1133 | |
|---|
| 1134 | g = ogcp1va * *og_h_dg_n2_p_pt; |
|---|
| 1135 | wm += g; |
|---|
| 1136 | |
|---|
| 1137 | g = *ogcp2pt * og_h_dg_n1_p_va; |
|---|
| 1138 | wm += g; |
|---|
| 1139 | |
|---|
| 1140 | g = fgcp1va * *fg_h_dg_n2_p_pt; |
|---|
| 1141 | wm += g; |
|---|
| 1142 | |
|---|
| 1143 | g = *fgcp2pt * fg_h_dg_n1_p_va; |
|---|
| 1144 | wm += g; |
|---|
| 1145 | |
|---|
| 1146 | *ijppt = 0; |
|---|
| 1147 | |
|---|
| 1148 | |
|---|
| 1149 | #if 0 |
|---|
| 1150 | fprintf( stderr, "%5.0f->", wm ); |
|---|
| 1151 | #endif |
|---|
| 1152 | tmppenal = gapz_n1_va1 * *fg_t_og_h_dg_n2_p_pt; |
|---|
| 1153 | #if 0 |
|---|
| 1154 | fprintf( stderr, "%5.0f?", g ); |
|---|
| 1155 | #endif |
|---|
| 1156 | if( (g=mi+tmppenal) > wm ) |
|---|
| 1157 | { |
|---|
| 1158 | wm = g; |
|---|
| 1159 | *ijppt = -( j - mpi ); |
|---|
| 1160 | } |
|---|
| 1161 | |
|---|
| 1162 | tmppenal = gapz_n1_va0 * *og_t_fg_h_dg_n2_p_pt; |
|---|
| 1163 | if( (g=*prept+tmppenal) >= mi ) |
|---|
| 1164 | { |
|---|
| 1165 | mi = g; |
|---|
| 1166 | mpi = j-1; |
|---|
| 1167 | } |
|---|
| 1168 | #if USE_PENALTY_EX |
|---|
| 1169 | mi += fpenalty_ex; |
|---|
| 1170 | #endif |
|---|
| 1171 | |
|---|
| 1172 | tmppenal = *gapz_n2_pt1 * fg_t_og_h_dg_n1_p_va; |
|---|
| 1173 | #if 0 |
|---|
| 1174 | fprintf( stderr, "%5.0f?", g ); |
|---|
| 1175 | #endif |
|---|
| 1176 | if( (g=*mjpt+tmppenal) > wm ) |
|---|
| 1177 | { |
|---|
| 1178 | wm = g; |
|---|
| 1179 | *ijppt = +( i - *mpjpt ); |
|---|
| 1180 | } |
|---|
| 1181 | |
|---|
| 1182 | tmppenal = *gapz_n2_pt0 * og_t_fg_h_dg_n1_p_va; |
|---|
| 1183 | if( (g=*prept+tmppenal) >= *mjpt ) |
|---|
| 1184 | { |
|---|
| 1185 | *mjpt = g; |
|---|
| 1186 | *mpjpt = i-1; |
|---|
| 1187 | } |
|---|
| 1188 | #if USE_PENALTY_EX |
|---|
| 1189 | m[j] += fpenalty_ex; |
|---|
| 1190 | #endif |
|---|
| 1191 | |
|---|
| 1192 | #if 0 |
|---|
| 1193 | fprintf( stderr, "%5.0f ", wm ); |
|---|
| 1194 | #endif |
|---|
| 1195 | *curpt++ += wm; |
|---|
| 1196 | ijppt++; |
|---|
| 1197 | mjpt++; |
|---|
| 1198 | prept++; |
|---|
| 1199 | mpjpt++; |
|---|
| 1200 | fg_t_og_h_dg_n2_p_pt++; |
|---|
| 1201 | og_t_fg_h_dg_n2_p_pt++; |
|---|
| 1202 | og_h_dg_n2_p_pt++; |
|---|
| 1203 | fg_h_dg_n2_p_pt++; |
|---|
| 1204 | gapz_n2_pt0++; |
|---|
| 1205 | gapz_n2_pt1++; |
|---|
| 1206 | fgcp2pt++; |
|---|
| 1207 | ogcp2pt++; |
|---|
| 1208 | } |
|---|
| 1209 | lastverticalw[i] = currentw[lgth2-1]; |
|---|
| 1210 | } |
|---|
| 1211 | |
|---|
| 1212 | #if OUTGAP0TRY |
|---|
| 1213 | if( !outgap ) |
|---|
| 1214 | { |
|---|
| 1215 | for( j=1; j<lgth2+1; j++ ) |
|---|
| 1216 | currentw[j] -= offset * ( lgth2 - j ) / 2.0; |
|---|
| 1217 | for( i=1; i<lgth1+1; i++ ) |
|---|
| 1218 | lastverticalw[i] -= offset * ( lgth1 - i / 2.0); |
|---|
| 1219 | } |
|---|
| 1220 | #endif |
|---|
| 1221 | |
|---|
| 1222 | /* |
|---|
| 1223 | fprintf( stderr, "\n" ); |
|---|
| 1224 | for( i=0; i<icyc; i++ ) fprintf( stderr,"%s\n", seq1[i] ); |
|---|
| 1225 | fprintf( stderr, "#####\n" ); |
|---|
| 1226 | for( j=0; j<jcyc; j++ ) fprintf( stderr,"%s\n", seq2[j] ); |
|---|
| 1227 | fprintf( stderr, "====>" ); |
|---|
| 1228 | for( i=0; i<icyc; i++ ) strcpy( mseq1[i], seq1[i] ); |
|---|
| 1229 | for( j=0; j<jcyc; j++ ) strcpy( mseq2[j], seq2[j] ); |
|---|
| 1230 | */ |
|---|
| 1231 | if( localhom ) |
|---|
| 1232 | { |
|---|
| 1233 | Atracking_localhom( impmatch, currentw, lastverticalw, seq1, seq2, mseq1, mseq2, cpmx1, cpmx2, ijp, icyc, jcyc, start1, end1, start2, end2, gapmap1, gapmap2 ); |
|---|
| 1234 | } |
|---|
| 1235 | else |
|---|
| 1236 | Atracking( currentw, lastverticalw, seq1, seq2, mseq1, mseq2, cpmx1, cpmx2, ijp, icyc, jcyc ); |
|---|
| 1237 | |
|---|
| 1238 | // fprintf( stderr, "### impmatch = %f\n", *impmatch ); |
|---|
| 1239 | |
|---|
| 1240 | resultlen = strlen( mseq1[0] ); |
|---|
| 1241 | if( alloclen < resultlen || resultlen > N ) |
|---|
| 1242 | { |
|---|
| 1243 | fprintf( stderr, "alloclen=%d, resultlen=%d, N=%d\n", alloclen, resultlen, N ); |
|---|
| 1244 | ErrorExit( "LENGTH OVER!\n" ); |
|---|
| 1245 | } |
|---|
| 1246 | |
|---|
| 1247 | |
|---|
| 1248 | for( i=0; i<icyc; i++ ) strcpy( seq1[i], mseq1[i] ); |
|---|
| 1249 | for( j=0; j<jcyc; j++ ) strcpy( seq2[j], mseq2[j] ); |
|---|
| 1250 | /* |
|---|
| 1251 | fprintf( stderr, "\n" ); |
|---|
| 1252 | for( i=0; i<icyc; i++ ) fprintf( stderr, "%s\n", mseq1[i] ); |
|---|
| 1253 | fprintf( stderr, "#####\n" ); |
|---|
| 1254 | for( j=0; j<jcyc; j++ ) fprintf( stderr, "%s\n", mseq2[j] ); |
|---|
| 1255 | */ |
|---|
| 1256 | |
|---|
| 1257 | // fprintf( stderr, "wm = %f\n", wm ); |
|---|
| 1258 | |
|---|
| 1259 | |
|---|
| 1260 | return( wm ); |
|---|
| 1261 | } |
|---|
| 1262 | |
|---|