| 1 | // =============================================================== // |
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| 2 | // // |
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| 3 | // File : ad_transpro.cxx // |
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| 4 | // Purpose : // |
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| 5 | // // |
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| 6 | // Institute of Microbiology (Technical University Munich) // |
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| 7 | // http://www.arb-home.de/ // |
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| 8 | // // |
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| 9 | // =============================================================== // |
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| 10 | |
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| 11 | #include "NT_local.h" |
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| 12 | |
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| 13 | #include <TranslateRealign.h> |
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| 14 | #include <awt_sel_boxes.hxx> |
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| 15 | #include <AP_codon_table.hxx> |
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| 16 | #include <AP_pro_a_nucs.hxx> |
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| 17 | #include <aw_awars.hxx> |
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| 18 | #include <aw_root.hxx> |
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| 19 | #include <aw_msg.hxx> |
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| 20 | #include <arbdbt.h> |
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| 21 | #include <arb_defs.h> |
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| 22 | |
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| 23 | #define AWAR_TRANSPRO_PREFIX "transpro/" |
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| 24 | #define AWAR_TRANSPRO_SOURCE AWAR_TRANSPRO_PREFIX "source" |
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| 25 | #define AWAR_TRANSPRO_DEST AWAR_TRANSPRO_PREFIX "dest" |
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| 26 | |
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| 27 | // translator only: |
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| 28 | #define AWAR_TRANSPRO_POS AWAR_TRANSPRO_PREFIX "pos" // [0..3]: 0-2 = reading frame; 3 = autodetect |
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| 29 | #define AWAR_TRANSPRO_MODE AWAR_TRANSPRO_PREFIX "mode" |
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| 30 | #define AWAR_TRANSPRO_XSTART AWAR_TRANSPRO_PREFIX "xstart" |
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| 31 | #define AWAR_TRANSPRO_WRITE AWAR_TRANSPRO_PREFIX "write" |
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| 32 | |
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| 33 | // realigner only: |
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| 34 | #define AWAR_REALIGN_INCALI AWAR_TRANSPRO_PREFIX "incali" |
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| 35 | #define AWAR_REALIGN_UNMARK AWAR_TRANSPRO_PREFIX "unmark" |
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| 36 | #define AWAR_REALIGN_CUTOFF "tmp/" AWAR_TRANSPRO_PREFIX "cutoff" // dangerous -> do not save |
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| 37 | |
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| 38 | static void transpro_event(AW_window *aww) { |
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| 39 | GB_ERROR error = GB_begin_transaction(GLOBAL.gb_main); |
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| 40 | if (!error) { |
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| 41 | #if defined(DEBUG) && 0 |
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| 42 | test_AWT_get_codons(); |
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| 43 | #endif |
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| 44 | AW_root *aw_root = aww->get_root(); |
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| 45 | char *ali_source = aw_root->awar(AWAR_TRANSPRO_SOURCE)->read_string(); |
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| 46 | char *ali_dest = aw_root->awar(AWAR_TRANSPRO_DEST)->read_string(); |
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| 47 | char *mode = aw_root->awar(AWAR_TRANSPRO_MODE)->read_string(); |
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| 48 | int startpos = aw_root->awar(AWAR_TRANSPRO_POS)->read_int(); |
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| 49 | bool save2fields = aw_root->awar(AWAR_TRANSPRO_WRITE)->read_int(); |
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| 50 | bool translate_all = aw_root->awar(AWAR_TRANSPRO_XSTART)->read_int(); |
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| 51 | |
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| 52 | error = ALI_translate_marked(GLOBAL.gb_main, strcmp(mode, "fields") == 0, save2fields, startpos, translate_all, ali_source, ali_dest); |
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| 53 | if (!error) error = GBT_check_data(GLOBAL.gb_main, NULp); |
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| 54 | |
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| 55 | free(mode); |
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| 56 | free(ali_dest); |
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| 57 | free(ali_source); |
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| 58 | } |
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| 59 | GB_end_transaction_show_error(GLOBAL.gb_main, error, aw_message); |
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| 60 | } |
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| 61 | |
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| 62 | static void nt_trans_cursorpos_changed(AW_root *awr) { |
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| 63 | AW_awar *awar_startpos = awr->awar(AWAR_TRANSPRO_POS); |
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| 64 | |
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| 65 | if (awar_startpos->read_int() != AUTODETECT_STARTPOS) { |
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| 66 | int pos = bio2info(awr->awar(AWAR_CURSOR_POSITION)->read_int()); |
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| 67 | pos = pos % 3; |
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| 68 | awar_startpos->write_int(pos); |
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| 69 | } |
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| 70 | } |
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| 71 | |
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| 72 | AW_window *NT_create_dna_2_pro_window(AW_root *root) { |
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| 73 | GB_transaction ta(GLOBAL.gb_main); |
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| 74 | |
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| 75 | AW_window_simple *aws = new AW_window_simple; |
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| 76 | aws->init(root, "TRANSLATE_DNA_TO_PRO", "TRANSLATE DNA TO PRO"); |
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| 77 | |
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| 78 | aws->load_xfig("transpro.fig"); |
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| 79 | |
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| 80 | aws->at("close"); |
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| 81 | aws->callback(AW_POPDOWN); |
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| 82 | aws->create_button("CLOSE", "CLOSE", "C"); |
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| 83 | |
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| 84 | aws->callback(makeHelpCallback("translate_dna_2_pro.hlp")); |
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| 85 | aws->at("help"); |
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| 86 | aws->create_button("HELP", "HELP", "H"); |
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| 87 | |
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| 88 | aws->at("source"); |
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| 89 | awt_create_ALI_selection_list(GLOBAL.gb_main, (AW_window *)aws, AWAR_TRANSPRO_SOURCE, "dna=:rna="); |
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| 90 | |
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| 91 | aws->at("dest"); |
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| 92 | awt_create_ALI_selection_list(GLOBAL.gb_main, (AW_window *)aws, AWAR_TRANSPRO_DEST, "pro=:ami="); |
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| 93 | |
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| 94 | root->awar_int(AWAR_PROTEIN_TYPE, AWAR_PROTEIN_TYPE_bacterial_code_index, GLOBAL.gb_main); |
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| 95 | aws->at("table"); |
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| 96 | aws->create_option_menu(AWAR_PROTEIN_TYPE); |
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| 97 | for (int code_nr=0; code_nr<AWT_CODON_TABLES; code_nr++) { |
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| 98 | aws->insert_option(AWT_get_codon_code_name(code_nr), "", code_nr); |
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| 99 | } |
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| 100 | aws->update_option_menu(); |
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| 101 | |
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| 102 | aws->at("mode"); |
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| 103 | aws->create_toggle_field(AWAR_TRANSPRO_MODE); |
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| 104 | aws->insert_toggle("from fields 'codon_start' and 'transl_table'", "", "fields"); |
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| 105 | aws->insert_default_toggle("use settings below (same for all species):", "", "settings"); |
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| 106 | aws->update_toggle_field(); |
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| 107 | |
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| 108 | aws->at("pos"); |
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| 109 | aws->create_option_menu(AWAR_TRANSPRO_POS); |
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| 110 | for (int p = 1; p <= 3; ++p) { |
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| 111 | char label[2] = { char(p+'0'), 0 }; |
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| 112 | aws->insert_option(label, label, bio2info(p)); |
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| 113 | } |
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| 114 | aws->insert_option("choose best", "choose best", AUTODETECT_STARTPOS); |
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| 115 | |
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| 116 | aws->update_option_menu(); |
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| 117 | aws->get_root()->awar_int(AWAR_CURSOR_POSITION)->add_callback(nt_trans_cursorpos_changed); |
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| 118 | |
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| 119 | aws->at("write"); |
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| 120 | aws->label("Save settings (to 'codon_start'+'transl_table')"); |
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| 121 | aws->create_toggle(AWAR_TRANSPRO_WRITE); |
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| 122 | |
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| 123 | aws->at("start"); |
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| 124 | aws->label("Translate all data"); |
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| 125 | aws->create_toggle(AWAR_TRANSPRO_XSTART); |
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| 126 | |
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| 127 | aws->at("translate"); |
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| 128 | aws->callback(transpro_event); |
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| 129 | aws->highlight(); |
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| 130 | aws->create_button("TRANSLATE", "TRANSLATE", "T"); |
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| 131 | |
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| 132 | aws->window_fit(); |
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| 133 | |
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| 134 | return aws; |
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| 135 | } |
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| 136 | |
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| 137 | static void realign_event(AW_window *aww) { |
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| 138 | AW_root *aw_root = aww->get_root(); |
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| 139 | char *ali_source = aw_root->awar(AWAR_TRANSPRO_DEST)->read_string(); |
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| 140 | char *ali_dest = aw_root->awar(AWAR_TRANSPRO_SOURCE)->read_string(); |
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| 141 | bool unmark_succeeded = aw_root->awar(AWAR_REALIGN_UNMARK)->read_int(); |
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| 142 | bool cutoff_dna = aw_root->awar(AWAR_REALIGN_CUTOFF)->read_int(); |
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| 143 | size_t neededLength = 0; |
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| 144 | GBDATA *gb_main = GLOBAL.gb_main; |
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| 145 | GB_ERROR error = ALI_realign_marked(gb_main, ali_source, ali_dest, neededLength, unmark_succeeded, cutoff_dna); |
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| 146 | |
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| 147 | if (!error && neededLength) { |
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| 148 | bool auto_inc_alisize = aw_root->awar(AWAR_REALIGN_INCALI)->read_int(); |
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| 149 | if (auto_inc_alisize) { |
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| 150 | { |
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| 151 | GB_transaction ta(gb_main); |
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| 152 | error = ta.close(GBT_set_alignment_len(gb_main, ali_dest, neededLength)); |
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| 153 | } |
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| 154 | if (!error) { |
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| 155 | aw_message(GBS_global_string("Alignment length of '%s' has been set to %zu\n" |
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| 156 | "running re-aligner again!", |
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| 157 | ali_dest, neededLength)); |
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| 158 | |
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| 159 | error = ALI_realign_marked(gb_main, ali_source, ali_dest, neededLength, unmark_succeeded, cutoff_dna); |
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| 160 | if (neededLength) { |
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| 161 | error = GBS_global_string("internal error: neededLength=%zu (after autoinc)", neededLength); |
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| 162 | } |
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| 163 | } |
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| 164 | } |
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| 165 | else { |
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| 166 | GB_transaction ta(gb_main); |
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| 167 | long destLen = GBT_get_alignment_len(gb_main, ali_dest); |
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| 168 | nt_assert(destLen>0 && size_t(destLen)<neededLength); |
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| 169 | error = GBS_global_string("Missing %zu columns in alignment '%s' (got=%li, need=%zu)\n" |
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| 170 | "(check toggle to permit auto-increment)", |
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| 171 | size_t(neededLength-destLen), ali_dest, destLen, neededLength); |
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| 172 | } |
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| 173 | } |
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| 174 | |
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| 175 | if (error) aw_message(error); |
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| 176 | free(ali_dest); |
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| 177 | free(ali_source); |
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| 178 | } |
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| 179 | |
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| 180 | AW_window *NT_create_realign_dna_window(AW_root *root) { |
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| 181 | AW_window_simple *aws = new AW_window_simple; |
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| 182 | aws->init(root, "REALIGN_DNA", "Realign DNA"); |
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| 183 | |
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| 184 | aws->load_xfig("realign_dna.fig"); |
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| 185 | |
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| 186 | aws->at("close"); |
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| 187 | aws->callback(AW_POPDOWN); |
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| 188 | aws->create_button("CLOSE", "CLOSE", "C"); |
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| 189 | |
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| 190 | aws->callback(makeHelpCallback("realign_dna.hlp")); |
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| 191 | aws->at("help"); |
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| 192 | aws->create_button("HELP", "HELP", "H"); |
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| 193 | |
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| 194 | aws->at("source"); |
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| 195 | #if defined(DEVEL_RALF) |
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| 196 | awt_create_ALI_selection_button(GLOBAL.gb_main, aws, AWAR_TRANSPRO_SOURCE, "dna=:rna="); // @@@ nonsense here - just testing awt_create_ALI_selection_button somewhere |
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| 197 | #else // !defined(DEVEL_RALF) |
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| 198 | awt_create_ALI_selection_list(GLOBAL.gb_main, aws, AWAR_TRANSPRO_SOURCE, "dna=:rna="); |
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| 199 | #endif |
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| 200 | aws->at("dest"); |
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| 201 | awt_create_ALI_selection_list(GLOBAL.gb_main, aws, AWAR_TRANSPRO_DEST, "pro=:ami="); |
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| 202 | |
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| 203 | aws->at("autolen"); aws->create_toggle(AWAR_REALIGN_INCALI); |
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| 204 | aws->at("unmark"); aws->create_toggle(AWAR_REALIGN_UNMARK); |
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| 205 | aws->at("cutoff"); aws->create_toggle(AWAR_REALIGN_CUTOFF); |
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| 206 | |
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| 207 | aws->at("realign"); |
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| 208 | aws->callback(realign_event); |
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| 209 | aws->create_autosize_button("REALIGN", "Realign marked species", "R"); |
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| 210 | |
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| 211 | return aws; |
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| 212 | } |
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| 213 | |
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| 214 | |
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| 215 | void NT_create_transpro_variables(AW_root *root, AW_default props) { |
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| 216 | root->awar_string(AWAR_TRANSPRO_SOURCE, "", props); |
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| 217 | root->awar_string(AWAR_TRANSPRO_DEST, "", props); |
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| 218 | root->awar_string(AWAR_TRANSPRO_MODE, "settings", props); |
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| 219 | |
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| 220 | root->awar_int(AWAR_TRANSPRO_POS, 0, props); |
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| 221 | root->awar_int(AWAR_TRANSPRO_XSTART, 1, props); |
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| 222 | root->awar_int(AWAR_TRANSPRO_WRITE, 0, props); |
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| 223 | root->awar_int(AWAR_REALIGN_INCALI, 0, props); |
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| 224 | root->awar_int(AWAR_REALIGN_UNMARK, 0, props); |
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| 225 | root->awar_int(AWAR_REALIGN_CUTOFF, 0, props); |
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| 226 | } |
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| 227 | |
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