source: branches/lib/arb_CHANGES.txt

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1ARB change log
2
3Ticket references
4
5    Referenced ticket numbers are linked when you view this information
6    at http://help.arb-home.de/changes.html
7
8Major changes for next release:
9
10 - split alignments (#846)
11 - detect poorly aligned helical regions in editor (#854)
12 - tweaked 'Helix settings' in EDIT4
13   - defaults changed for GG ('#'->'='), TT + UU ('+'->'#'), ambiguity codes (''->'%')
14   - added several predefined configs (traditional, two handling ambiguity codes)
15   - display in SECEDIT updates after helix changes
16 - tweaked 'Track alignment changes'
17   - automatically adds generated fields to species info.
18   - enhanced documentation (recommended workflow)
19 - tweaked progress
20   - better estimation for NJ, ConsensusTree, matrix calculation + PVP
21     - uses weighted progresses (#789)
22     - also fixes progress overflow (#807)
23   - support for longer periods (weeks, months, ...)
24   - prefer overestimation
25   - log to console (estimates finish)
26 - include SINA (1.7.2 patched)
27   - interface auto-adapts to sina version (still compatible with 1.3; currently needs patched version for 1.7.2)
28   - added script arb_sina_install_from_fat_tarball.sh (allows to install sina from fat-tarballs provided via arb homepage)
29 - improved macro scriptability
30   - now synchronizes external tools (#869)
31   - properly allows quitting arb (#867)
32   - allow to plan user interaction (#856)
33 - append output from external tools to arb logfile.
34 - FastTree
35   - added support for protein sequences.
36   - customizable from GUI (rate categories, NJ, bootstraps).
37   - upgraded to version 2.1.11
38   - arb now provides single+multi processor versions of FastTree
39 - NDS (Node display setup; #841)
40   - specifying a zero WIDTH now means "unlimited" (backward compatible).
41   - avoid unwanted truncation (NDS-export, saved distance matrix).
42   - tree/export (using NDS)
43     - no longer truncates labels.
44     - group-labels are generated by NDS now.
45     - raise an error if non-ASCII characters are used in label (optionally).
46 - import from calcsheet:
47   - support for fuzzy matches (#865)
48   - can handle empty trailing cells
49 - added SAVE button to arb message window (saves pos+size+content)
50 - minor changes:
51   - 'Mark/Unmark listed' buttons in search window
52   - new ACI command 'dupidx' supporting group enumeration (#863)
53 - added
54   - script to analyze database structure (#866; generated reports allow database comparison)
55   - macros to cleanup database ("keep_listed_(trees|SAIs|speciesSelections).amc")
56 - documentation (arb integrated help):
57   - length checked + corrected for preformatted text and titles
58   - minor layout changes
59   - link tickets and URLs (html)
60
61Fixes for arb-7.0.1 (31 Jan 2022):
62
63 - fix perl compatibility for macOS 12
64
65Major changes for arb-7.0 (1 Sep 2021):
66
67 - ARB PARSIMONY
68   * topology optimization
69     - now (by default) strictly restricted to marked/visible parts of the tree (#640)
70     - restriction now customizable (marked/all; visible/all)
71     - tree costs for protein-data were not independent from root-position (as expected by model; #633).
72       Caused infinite running optimization under some circumstances.
73     - optimize-modes now strictly restrict to clicked subtrees. single/repeated optimization possible.
74     - KL-optimizer
75       * static path reduction slightly changed meaning. changed default settings.
76       * removed randomness (was just covering some bugs)
77       * improved general optimization speed
78   * branchlength calculation
79     - "forgot" to recalculate lengths under some conditions. fixed.
80     - is now independent of tree-root position (#641)
81   * adding species
82     - 'add partial species' failed if two partial species had NO overlap (#609). fixed.
83     - in 'add species + NNI' local optimization quality depended on insert position. fixed.
84     - insertion of multiple species is now done independently (=unordered; #643)
85     - performance improved (esp. for many added species/big trees; #643)
86   * generally improved combine performance (using SSE)
87   * generally reduced the number of performed combines (skipping many useless)
88   * added function to randomize (parts of) the tree
89   * warns about insufficient sequence data (e.g. as result of too restrictive filtering; #631)
90   * fixed 'RESTORE' (crashed after deleting species from tree; #528)
91   * corrected handling of dots ('.') while combining ancestor sequences
92   * fixed a bunch of internal bugs (#620, #627, #645, ...)
93   * added species-info mode
94 - added missing translation tables (genetic codes 24-31)
95 - added amino acid code Xle(=J), which means Ile(=I) or Leu(=L)
96 - DNA realigner
97   * several unjustified failures will no longer happen (fixes #419 and most likely #145)
98     - correctly re-syncs after 'X' (if possible at all)
99     - no longer fails for 'B', 'J' and 'Z'
100     - accepts 3 or more consecutive IUPAC codes in DNA
101   * added option to cut-off DNA sequence (was done at end of sequence by old version. fixed)
102   * fixed several minor bugs (#563,..)
103 - ARB probeSpec: visualisation of probe set specificity (thanks to Paavo Jumppanen, CSIRO)
104 - species selections (editor configurations):
105   * visualisation of multiple selections in standard tree view (#658; example in database demo.arb)
106   * order can be changed; each configuration has a comment
107 - import/export (species,sequence):
108   * manage/edit/test import-/export-filter-definitions from inside ARB (#691)
109   * import can store configuration of imported species (#607)
110   * field transfer sets (#562) may be used to customize import/export behavior (also usable from arb merge-tool)
111   * corrected EMBL export filter (numbers at seq.data; #638)
112   * detected duplicates no longer abort complete import (#779)
113   * new CLI sequence exporter 'arb_export_seq_filtered' (#743)
114 - Tree shading (#443)
115   * according to values stored in database
116   * according to given topology (useful when comparing topologies)
117   * added customisable color ranges (#682)
118 - support for extra database compression (using gzip, bzip2, xz; #665); databases cannot be opened by versions before arb-7.0
119 - ARB_EDIT4:
120   * display selected database fields as flags (allowing to toggle their value; #261).
121     Example use: easily mark sequence as "curated" after manually checking its alignment.
122   * allow to load missing SAIs
123   * "view differences" to a reference sequence:
124      - customizable:
125        * char used for "equality" (i.e. what is displayed where a sequence is equal to selected sequence)
126        * case-sensitivity
127        * ignore different gap-types
128      - equal data also gets hidden in consensus
129      - refresh differences of all displayed sequences, when data of selected sequences changes
130      - change reference sequence using CTRL-R or automatically let it follow the cursor
131      - added hotkey to toggle mode: CTRL-D
132      - fixed minor bugs
133   * consensus calculation in ARB_EDIT4 and calculation of CONSENSUS SAI
134     - now both calculations are strictly consistent (#663):
135       * gaps are now ignored while deciding whether to simplify using IUPAC ambiguity codes
136       * IUPAC ambiguity codes encountered in sequence data are now counted proportionally (=> fewer 'N's occur in consensus)
137     - added sliders to consensus definition windows
138     - user defined consensus settings exchangable between both consensus setups
139     - fixed and updated documentation
140   * added species-info mode + database save (#52,#362)
141   * predefined SAI color translation for PVP
142 - changes to SAI generation
143   * MAX_FREQUENCY:
144     - considers IUPAC ambiguity codes proportionally
145     - amino acids: if MAX_FREQUENCY is below 10% SAI now shows '1' (prev. it did show '0', i.e. 100%)
146   * POS_VAR_BY_PARSIMONY (PVP):
147     - now (again) works with amino acid data (#782)
148     - added CLI tool 'arb_calc_pvp' (#701)
149   * implemented a SAI calculator (allows to modify or combine multiple SAIs)
150 - expand zombies in tree (unfold groups; #22)
151 - compare taxonomy (and mark differences; #651)
152 - search&query for taxonomic groups (#652)
153   - many search criteria (name, size, marked, nesting-level, ingroup-distance (#653), ...)
154   - search multiple trees, detect duplicate and missing groups
155   - operations on found groups (delete, rename, fold, mark)
156 - added concept of "inverse groups" (aka "keeled groups"; #735)
157 - group transfer between trees (#780):
158   - penalties can be customized in detail
159   - quality reports (to log and optionally to target name)
160 - synchronize positions of roots of multiple trees (#449)
161 - external (command line) aligners (#504):
162   * fixed incorrect handling of 'T' vs 'U': now all aligned sequences will contain the correct base depending on alignment type
163   * preserve gap-type ('-' vs '.') and upper-/lower-case of original alignment
164   * no longer ask what to do with aligned sequence, just overwrite it
165     - only warn about real sequence changes (so please do NOT ignore from now on!)
166 - config-managers:
167   * possibility to restore factory defaults
168   * added comment field for configurations
169   * added them throughout arb (#647)
170 - added slide controls throughout arb (#656)
171 - tree (display) options:
172   * fine grained scaling
173   * group display (shading, customizable counters (#118,#209), triangle clades, name display position)
174   * bootstrap values (filter by upper/lower limits, display position/styles, on/off toggle; #614)
175   * diagonal branch style (#578)
176   * parent branch position
177   * all options are now also supported by ARB_PARSIMONY
178   * improved auto-jump; now also works for groups
179   * added optional auto-unfolding (to selected group/species)
180   * select group on fold/unfold/create/move/..
181   * draw selected group in cursor-color (#709)
182   * added keys for tree-traversal (moving to selected species or group; #687)
183 - synchronized tree scrolling (#683)
184 - colorsets were invalidated by generating new IDs (#660). fixed.
185 - added alternate RAxML (DNA only; version 8.2.8)
186   - multicore support (automatically activates recommended number of threads)
187   - evaluation, optimization and extension of existing trees with RAxML (#681)
188 - fix performance of
189   * "format sequences" (broken in arb-6.0.x series; #702)
190   * nameserver for huge databases (#646)
191   * closing arb (if database uses fastload file; #649)
192 - ACI
193   - added boolean operators, numeric comparisons, floating point arithmetic and several other new commands
194   - allow access to other species via ID or accession number (findspec, ...)
195   - improved ACI debugging: more verbose tracing (console log accessible from inside ARB)
196 - NDS optionally uses only visible definitions
197 - Search&Query:
198   * sort results numerically (#203)
199   * recursive search through all fields (#773)
200 - Species information window: improved detachment, field selection (#695)
201 - improved macro compatibility:
202   * check compatibility with installed perl version during arb startup (#754)
203   * esp. tweaked compatibility of 'Search&Query' and 'Species information window'
204   * fixed a lot of internal names (missing or duplicated) which are used for macros (#429)
205 - improved OSX compatibility (thx to Jan Gerken)
206 - updated integrated documentation (#409)
207
208
209Fixes for arb-6.0.6 (22 Aug 2016):
210
211 - fixes for gcc 6.1.0
212 - tested gcc 4.9.4 + 5.4.0
213
214Fixes for arb-6.0.5 (4 May 2016):
215
216 - fixes for ubuntu 16.04 build
217
218Fixes for arb-6.0.4 (2 May 2016):
219
220 - fixes for OSX build (SIP, accepted compilers)
221
222Fixes for arb-6.0.3 (19 Nov 2015):
223
224 - fixes permission problems when multiple users share databases or ptservers (thx to Alan McCulloch)
225
226Fixes for arb-6.0.2 (8 Aug 2014):
227
228 - compile issues on Snow Leopard (OSX 10.6)
229 - merge Debian security fix for CVE-2008-5378
230 - small changes to build system for Debian
231 - add desktop integration files
232
233Fixes for arb-6.0.1 (22 Jul 2014):
234
235 - arb_parsimony
236   - skip unwanted automatic branchlength recalculations (e.g. by unfolding a group)
237   - corrected branchlength calculation for "Add marked partial species"
238   - dots were treated as gaps for protein sequences (now treated as 'X'; analog to DNA treating gaps as 'N'; #144). thx to Yan Shi for detecting that problem!
239 - print
240   - preview failed (showed empty postscript file)
241   - print to file now always saves in user home
242 - raxml (import tree with bootstrap values)
243
244Major changes for arb-6.0 (4 Jun 2014):
245
246 - merge databases allows to
247   - merge from an existing database into the database loaded in ARB_NT
248   - merge to existing databases from the database loaded in ARB_NT
249 - ARB can now
250   - be restarted with another database and
251   - a second instance of ARB can be opened
252 - ARB_DIST
253   - Detect clusters of species with similar sequences (OTUs)
254   - allow automatic recalculation of matrix and/or tree whenever some parameter or
255     data changes (only makes sense for smaller species sets)
256   - extract distance matrix from tree
257 - Rewrote chimera check. Allows filtering
258 - added RNACMA (computes clusters of correlated positions)
259 - PT-Server
260   - changed behavior
261     - no longer report less hits for a part of a probe than for the probe itself (occurred at 3'-end of alignment)
262     - reports previously missing hits in joined genes
263     - reports more hits at 3'-end of alignment (when using mismatches the PT-server now reports possible
264       matches that go beyond the end of the sequence)
265     - dots in the middle of the alignment act like the sequence ends there
266     - minimum probe length reduced to 2 (was 6)
267     - allow up to 50% of probe to mismatch
268   - performance
269     - optimized memory-estimation (will build in fewer passes)
270     - uses any number of passes (not only 1, 5, 25, ...)
271     - allows to define used memory by setting environment variable ARB_MEMORY
272     - reduced memory needed to build/run ptserver (approx. 50%)
273     - reduced size of indexfile (.pt) to ~50%
274     - fast startup of existing ptservers
275   - probe design
276     - faster in many cases
277     - allow to design probes of length 8 (previously 10)
278     - allow to design probes with different lengths (specifying min/max length)
279     - fixed number of outgroup hits reported when decreasing temperature
280       (now each outgroup member only occurs once)
281     - show possible reasons why no probes could be designed
282   - probe match (allow any number of mismatches)
283   - next relative search
284     - can be restricted to column ranges (needs a PT-Server calculated from aligned sequences)
285     - corrected and improved scaling of relative scores
286     - more accurate scores (due to fixes in PT-Server; see below)
287     - faster in many cases
288   - show errors from ptserver build in ARB
289 - fast-aligner
290   - searches next-relatives based on selected column-block
291   - align multiple column-blocks based on SAI
292 - Rewrote alignment adaption during merge
293 - Insert/delete columns using a SAI to define affected columns
294 - ARB_EDIT4
295   - improved support for using multiple edit-windows
296   - smoother refreshes
297   - tweaked ORF display
298 - tree importer/exporter
299   - ARBs extended newick format (with bootstrap values) handled more restrictive now
300   - fixed several bugs; improved errors/warnings
301 - consensus trees
302   - calculate from multiple existing trees (also allows to merge not completely overlapping trees)
303   - fixed NJ-bootstrapping (no longer drops species)
304 - tree display
305   - Show brackets on open groups (dendrogram tree only)
306   - rewrote IRS (folded) display
307   - fixed tree key-bindings (mark, fold, ...)
308   - improved several tree-commands (move, rotate, spread, length, width)
309 - added a branch analysis tool
310   - groups several functions previously available via menuitems (e.g. mark long branches, etc.)
311   - added leaf-distance analysis
312 - other tree functionality
313   - treelist sortable now
314   - new beautify-tree modes (radial tree / according to other tree)
315   - function to remove marked/zombies from ALL trees
316   - create multifurcations (by branchlength/bootstrap limit)
317   - toggle 100% bootstrap values
318 - tweaked printing (interface, overlapping)
319 - if YOU edit a helpfile it will be automatically packed into an archive ready to be sent to ARB developers
320 - probe design:
321   - added LOAD to result window
322 - automation
323   - macro recording works in ARB client applications (ARB_EDIT4, ARB_PARS, ARB_MERGE, ..)
324   - arb_ntree can execute macro from command line
325   - added "Never ask again" to modal question boxes (for better compatibility with macros)
326   - a macro can be called for all marked species (once for each)
327   - macros can be nested (i.e. can call other macros)
328 - support for user-specific customization:
329   - of GDE menus (in ~/.arb_prop/gde)
330   - of import/export filters (in ~/.arb_prop/filter)
331 - ACI (some new commands, bugfixes)
332 - updated/added external tools:
333   - added FastTree (version 2.1.7)
334   - added MAFFT (version 7.055)
335   - added MrBayes (version 3.2.1)
336   - added MUSCLE (version 3.8.31)
337   - added PHYML (2013/07/08; also kept old version 2.4.5)
338   - added PROBCONS (version 1.12)
339   - updated RAxML (version 7.7.2)
340 - load/save for window specific settings (e.g. allows to share parts of configuration with other users)
341 - Support for mouse-wheel
342 - many unlisted bugfixes
343 - many internal refactorings
344
345
346Fixes for arb_5.5 (15 Nov 2012):
347
348 * arb_5.4 was broken (several external tools missing)
349
350
351Fixes for arb_5.4 (14 Nov 2012):
352
353 * make it obvious when probe matches are truncated. Truncate all hits beyond 1 million (was 100000)
354 * fixed realigner (better interaction with fields 'transl_table' and 'codon_start'; improved error handling)
355 * fixed several compilation issues (OSX; recent distro releases)
356
357
358Fixes for arb_5.3 (10 Nov 2011):
359
360 - bugfixes
361   - fixed wrong absolute/ecoli position reported for some designed probes
362   - decompression error handling (pt-server build issues)
363   - fixed 'codon_start' generated with wrong type
364   - fixed a buffer overflow in ACI
365   - report failures to write to /tmp
366 - changes
367   - markSpecies.pl:
368     mark by accession number
369     partial/ambiguous matches
370 - internal fixes
371   - compilation fixes for OSX
372   - some patches for debian version (removed refs to xview, textedit, removed molphy(protml))
373   - removed obsolete dependency from libXp
374
375
376Fixes for arb_5.2 (5 Sep 2010):
377
378 - bugfixes
379   - quicksave did silently do nothing (especially not save anything) if an error occurred
380   - ARB_EDIT4: crashed when using config with MANY unknown species
381   - ARB_SECEDIT: crashed when trying to paint strand w/o any base
382   - ARB_NTREE/ARB_PARS: crashed when clicking on inner tree node w/o groupinfo
383 - changes
384   - ARB uses xdg-open to display web-pages
385 - internal fixes
386   - karmic koala (gcc 4.4.1)
387   - installation script
388   - arb build process uses xsltproc instead of sablotron
389
390
391Fixes for arb_5.1 (1 Oct 2009):
392
393 - fixed a bug in 'Create species from consensus' (created sequence was corrupted)
394 - fixed 2 bugs in optimize DB (alignment w/o data, missing transaction)
395 - updated installation instructions, fixed install script, added OSX instruction (thx to Matt Cottrell)
396 - fixed broken demo.arb
397
398
399Major changes for arb_5.00 (4 Sep 2009):
400
401 - ARB 64bit version
402 - new genome importer
403 - search for next relatives improved (normal search and fast-aligner)
404   - new parameters to precise search
405   - improved speed
406   - partial sequence reach normal scores
407 - search&query
408   - supports regular expressions and ACI
409   - track hit information
410   - result sorting
411 - Nameservers with add.field have to be started with default value
412   You need to correct parameter -f in lib/arb_tcp.dat (according to lib/arb_tcp_org.dat)
413 - multiple PT-servers may be used in parallel
414 - fixed multiprobe
415 - type-conversion for DB fields
416 - SILVA compatible import filters
417 - Newick tree export:
418   - optionally save in human-readable format (big)
419   - closer to newick standard format (quoting style, comment, special chars in data)
420 - Upgraded RAxML to 7.0.3 (many features now usable from ARB interface)
421 - Fixed sequence quality calculation
422 - Secondary structures for proteins (DSSP)
423 - Distance matrix (arb_dist): mark by distance to selected
424 - ARB core
425   - many bugfixes and improvements to reliability
426   - faster sorting (general speedup)
427   - improved sequence compression (avoid worse trees, better ratio)
428   - improved handling of temporary files (permission/removal)
429   - prints backtraces in userland
430   - regular expression are POSIX standard now
431 - macro record/playback
432   - fixed several bugs
433   - you need to re-record your old macros!
434 - GUI:
435   - disabled auto-focus, you need to click now
436   - auto-raise windows on access
437 - Minor things:
438   - Ubuntu: packet installation for ARB
439   - Fixed novice/expert mode
440   - Mark deep/degenerated branches
441   - Increased NDS entries
442 - up-to-date Mac port (thx to Matt Cottrell)
443
444Major changes in ARB 07.12.07org (7 Dec 2007):
445
446 - rewrote secondary structure editor
447 - Sequence quality check
448 - Nameserver may use one field additional to 'acc' (useful to keep multiple species with same acc)
449 - tweaked base frequency filter generation
450 - Normal export (not using readseq) improved:
451   - supports filters and gap removal
452   - optimized for big amount of data
453   - reworked export filters
454 - Display translation with different ORFs in EDIT4
455 - ARB exports in FIG 3.2 format (optionally in colors). Thanks to Elmar Pruesse.
456 - added PHYML 2.4.5 (thanks to Stephane Guidon for the permission to distribute that great tool)
457 - more compact display in EDIT4
458 - capable to use iso10646 fonts
459 - supports various gcc versions (2.95.3 - 4.1.1)
460 - fixed a bug in DB optimization (occurred when fields had bigger protection than current)
461 - Bootstrap circles may be displayed as ellipses; upper size limit configurable; uses
462   different color for size-limited circles; fixed xfig-export-bug
463 - Allows Branchlength <-> Bootstrap value transfer (lossy!)
464 - fixed several scaling bugs in "folded tree"-mode
465 - improved import-filter error-messages
466 - NDS-display of groups (e.g. in tree) is now handled by ACI-command 'taxonomy'. This gives
467   several new possibilities:
468   - export taxonomy via 'Export NDS list'
469   - display taxonomy in Editor etc.
470   - display of cascaded taxonomies
471   - display taxonomy of tree_1 in tree_2
472   - allows to write taxonomy into database field of species
473   - compare taxonomies of two trees
474   - ...
475 - ACI:
476   - many new ACI commands
477   - unified handling of binary ACI-operators
478   - tracing of ACI actions for debugging purpose
479 - ARB Neighbour joining:
480   - bootstrap limit configurable
481   - bugfix: when aborting bootstrap calculation, sometimes no tree was generated
482 - EDIT4:
483   - added unalign right (block-op)
484   - added 'Save loaded properties'
485 - GENE MAP:
486   - multiple views possible at the same time
487   - origin now at "12 o'clock"
488   - implemented 'jump to gene'
489 - tweaked file selection
490 - Enhanced Search Depth for Probe Match --> max 20 MM
491 - CLUSTALW:
492   - separated menus for fast and slow alignment
493   - most parameters accessible from inside ARB now
494 - upgraded to PHYLIP 3.6 (adds PROML)
495 - external programs may be called parallel (e.g. several treeing programs)
496 - fixed bugs in protml and integration of protml
497 - rewrote ASCII database import
498 - arb_repair for databases of any size (script for database repair)
499 - fixed bug in data compression
500 - increased internal cache size (alignments up to 400.000bp possible w/o performance collapse)
501 - ARBparsimony: increase hardcoded species limit (50.000 -> 250.000)
502 - GDE menus cleanup
503 - translation/re-alignment tweaked
504 - unalign right (EDIT4)
505 - visualization of SAIs in Probe Match Results
506 - changed formatting of probe match results; increase # of allowed matches to 100.000;
507   warn if results are truncated
508 - PT server for genes
509 - Probe design performance optimized
510 - fixed NEXUS export format
511 - exports group names into Newick format
512 - import XML tree files
513 - help for external tools now properly shown inside ARB
514
515Major changes in Beta 2003_08_22 (22 Aug 2003):
516
517 - automatic formatting of alignments
518 - SECEDIT may use EDIT4 colors
519 - fixed bootstrapping (DNAPARS, PROTPARS, PROTML(experimental!))
520 - updated clustalw to version 1.83
521 - Restore window sizes for ALL windows (too small sizes are ignored)
522 - new algorithm to add partial sequences to an existing tree
523 - PROT-parsimony was completely redesigned and works now most similar to DNA/RNA-parsimony
524 - Top area of ARB_NTREE may be reduced to maximize display area
525 - All arb menus may be detached (click dashed line at top of menu)
526 - visualization of SAIs (as background color behind Sequences)
527 - ARB_EDIT4 may save/use alignment-specific and alignment-type-specific properties
528 - PT-server occupies more memory => does less passes; more diagnostic output
529 - small changes to status window (unhide behavior/time estimation)
530 - menus and menu-hotkeys reorganized
531 - colored buttons in color config windows
532 - alignment concatenation (e.g. several different genes)
533 - merging data of similar species (according selected database field)
534 - keyboard commands for ARB_NTREE (mark/unmark/invert, collapse/expand)
535 - expanded sellists
536 - save/load fixed for multi probes
537 - Binary SAIs are editable in ARB_EDIT4
538 - Information windows are detachable (allows to have multiple windows showing different items)
539 - Scanning for hidden/unknown database fields improved and separated;
540   possibility to remove unused fields.
541 - new tabbed format in 'Export NDS' and 'Export matrix' (useful for star-calc/excel/etc.)
542 - updated fastDNAml to 1.2.2
543 - added AxML (accelerated fastDNAml 1.2.2)
544 - Field transfer definitions for exporting gene-species
545 - File Selection: - recursive search available
546 - The ARB_NTREE macro recording/execution has been fixed
547 - Colorize species (see demo.arb)
548 - Fixed missing-character-bug in Xfig, Print and Edit4-Info-Display
549 - 'IslandHopper' -- a new integrated aligner (beta)
550 - Many improvements and bugfixes to secondary structure editor:
551   - highlighting of search (i.e for probes) like in EDIT4
552   - interactive constraint editing (stretch/compress)
553   - probe info
554   - editing secondary structure in XFIG now possible
555   - visualization of SAIs
556 - import reads Unix, DOS, and MAC linefeeds
557 - NTREE/SAI/Etc/GnuPlot: calls gnuplot directly; more plotting features; basic help
558 - tree and sequence export to XML ( DTDs are provided in ./lib/dtd )
559   (reloading of these XML files is planned for the future)
560 - fixed problems with phylip-tree import/export (bootstrap values,comments,...)
561 - search in all database fields possible ('[all fields]')
562 - up to 10 quicksaves are kept
563 - new ACI functions: upper, lower, caps, eval
564 - variables for import filter programming
565 - extract gene-species: creates acc; extraction to existing alignments
566 - sequence of selected gene is mirrored in ARB_EDIT4/local_signature
567   (=> selected gene can be highlighted in primary editor)
568 - PCR primer-design for single genes
569 - when selecting a gene, the corresponding gene-species is selected (if found)
570 - save configuration for several windows (e.g. Search&Query, WWW, NDS, ...)
571 - file selection box in import window
572 - mark item with double click works in all search&query windows
573 - User masks: create new; 'edit enable' and 'marked' toggles (like in info window)
574 - Fixed command line help for all Arb-modules
575 - Fixed problem parsing fonts (should fix display problems with default fonts)
576 - Mark mode now works in list-view as well (ARB_NTREE)
577 - Fixed appearance of 'tiny little boxes' (everywhere)
578 - Redesign of ARB help:
579     - a HTML version is in $ARBHOME/lib/help_html
580     - a text version is in $ARBHOME/lib/help (like before, but now generated)
581
582Major changes in Beta 2001_11_07 (7 Nov 2001):
583
584 - design probes to maximum length of 60 nucleotides
585 - fastAligner1.03 bug fixed (chooses best match now in 'auto search' mode)
586 - import default changed to foreign data format, ali name '16s'
587 - printing of multi-page-trees works again
588 - implemented user defineable masks to access database fields
589 - fixed bugs in pt-server (lockup, unknown species just after building pt-server)
590 - improved performance during pt-server-build
591 - several programs coming along with ARB where updated (PHYLIP,...)
592 - reads EMBL genom files
593 - support for experiments (genom databases only)
594
595Major changes in Beta 2001_07_24 (24 Jul 2001):
596
597 - basic support for genoms (Gene Map, reads Genebank files)
598 - ported to libc6
599
600Changes in ancient versions (last century):
601
602 - see http://help.arb-home.de/version.html
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