1 | // ----------------------------------------------------------------------------- |
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2 | // Include-Dateien |
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3 | // ----------------------------------------------------------------------------- |
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4 | |
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5 | #include <iostream> |
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6 | #include <fstream> |
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7 | #include <cstdlib> |
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8 | |
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9 | #include "a3_basen.h" |
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10 | #include "a3_ptree.hxx" |
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11 | |
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12 | #include <inline.h> |
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13 | |
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14 | using std::cout; |
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15 | |
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16 | // ----------------------------------------------------------------------------- |
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17 | static int int_compare ( const void *a, |
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18 | const void *b ) |
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19 | // ----------------------------------------------------------------------------- |
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20 | { |
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21 | int result = 0, |
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22 | diff = *(int*)a - *(int*)b; |
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23 | |
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24 | if (diff < 0) result = -1; |
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25 | else if (diff > 0) result = 1; |
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26 | |
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27 | return result; |
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28 | } |
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29 | |
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30 | // ----------------------------------------------------------------------------- |
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31 | static void SortIntArray ( int *array, |
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32 | int *anz ) |
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33 | // ----------------------------------------------------------------------------- |
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34 | { |
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35 | qsort(array,*anz,sizeof(int),int_compare); |
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36 | |
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37 | int source; |
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38 | int dest = 1; |
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39 | int lastelem = array[0]; |
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40 | |
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41 | for (source = 1; source < *anz; source++) { |
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42 | if (array[source] != lastelem){ |
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43 | array[dest++] = lastelem = array[source]; |
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44 | } |
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45 | } |
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46 | *anz = dest; |
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47 | } |
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48 | |
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49 | // ----------------------------------------------------------------------------- |
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50 | // Liefert die Anzahl aller Positionen unterhalb eines bestimmten Knotens |
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51 | // ----------------------------------------------------------------------------- |
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52 | static int CountLeaves ( PtNode &node ) |
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53 | // ----------------------------------------------------------------------------- |
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54 | { |
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55 | int panz = node.NumOfPos(), |
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56 | nanz = node.NumOfNext(); |
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57 | |
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58 | while (nanz--) panz += CountLeaves(*node.next[nanz]); |
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59 | |
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60 | return panz; |
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61 | } |
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62 | |
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63 | // ----------------------------------------------------------------------------- |
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64 | // Sucht alle Positionen unterhalb eines bestimmten Knotens |
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65 | // ----------------------------------------------------------------------------- |
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66 | static int GetLeaves ( PtNode &node, |
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67 | int *field ) |
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68 | // ----------------------------------------------------------------------------- |
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69 | { |
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70 | int panz = node.NumOfPos(), |
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71 | nanz = node.NumOfNext(), |
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72 | count = 0; |
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73 | |
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74 | while (count < panz) { |
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75 | field[count] = node.position[count]; |
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76 | count++; |
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77 | } |
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78 | |
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79 | while (nanz--) panz += GetLeaves(*node.next[nanz],&field[panz]); |
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80 | |
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81 | return panz; |
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82 | } |
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83 | |
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84 | // ----------------------------------------------------------------------------- |
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85 | // Sucht alle Positionen unterhalb eines bestimmten Knotens |
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86 | // ----------------------------------------------------------------------------- |
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87 | static int *FindLeaves ( PtNode &node, |
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88 | int *anz ) |
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89 | // ----------------------------------------------------------------------------- |
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90 | { |
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91 | int *field = NULL; |
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92 | |
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93 | if (((*anz = CountLeaves(node)) > 0) && |
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94 | ((field = new int [*anz]) != NULL)) GetLeaves(node,field); |
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95 | |
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96 | return field; |
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97 | } |
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98 | |
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99 | // ----------------------------------------------------------------------------- |
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100 | // Konstruktor zum Erzeugen einer leeren Instanz der Klasse Postree |
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101 | // ----------------------------------------------------------------------------- |
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102 | Postree::Postree ( void ) : sequence () |
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103 | // ----------------------------------------------------------------------------- |
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104 | { |
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105 | topnode = NULL; |
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106 | } |
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107 | |
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108 | // ----------------------------------------------------------------------------- |
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109 | // Konstruktor zum Erzeugen einer Instanz der |
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110 | // Klasse Postree aus einer vorgegebenen Sequenz |
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111 | // ----------------------------------------------------------------------------- |
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112 | Postree::Postree ( str seq2 ) : sequence ( seq2 ) |
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113 | // ----------------------------------------------------------------------------- |
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114 | { |
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115 | str seq = sequence.Compressed(); |
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116 | |
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117 | if (seq) topnode = new PtNode(seq,NULL,0,0), delete seq; |
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118 | } |
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119 | |
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120 | // ----------------------------------------------------------------------------- |
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121 | // Konstruktor zum Erzeugen einer Instanz der Klasse Postree aus einer |
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122 | // zufaellig besetzten Instanz der Klasse Sequenz mit vorgebener Sequenzlaenge |
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123 | // ----------------------------------------------------------------------------- |
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124 | Postree::Postree ( UINT len ) : sequence ( len ) |
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125 | // ----------------------------------------------------------------------------- |
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126 | { |
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127 | str seq = sequence.Compressed(); |
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128 | |
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129 | if (seq) topnode = new PtNode(seq,NULL,0,0), delete seq; |
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130 | } |
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131 | |
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132 | // ----------------------------------------------------------------------------- |
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133 | // Konstruktor zum Erzeugen einer leeren Instanz der Klasse Postree |
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134 | // aus einer Instanz der Klasse Sequenz aus ein vorgebener Datei mit |
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135 | // vorgegebener Zeilennummer |
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136 | // ----------------------------------------------------------------------------- |
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137 | Postree::Postree ( str file, |
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138 | UINT line ) : sequence ( file, line ) |
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139 | // ----------------------------------------------------------------------------- |
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140 | { |
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141 | str seq = sequence.Compressed(); |
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142 | |
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143 | if (seq) topnode = new PtNode(seq,NULL,0,0), delete seq; |
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144 | } |
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145 | |
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146 | // ----------------------------------------------------------------------------- |
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147 | // Kopierkonstruktor |
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148 | // ----------------------------------------------------------------------------- |
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149 | Postree::Postree ( Postree &postree ) : sequence ( postree.sequence ) |
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150 | // ----------------------------------------------------------------------------- |
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151 | { |
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152 | cout << "\nKopierkonstruktor(Postree)\n"; |
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153 | |
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154 | if (!postree.topnode) topnode = NULL; |
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155 | else topnode = new PtNode(*postree.topnode); |
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156 | } |
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157 | |
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158 | // ----------------------------------------------------------------------------- |
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159 | // Destruktor |
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160 | // ----------------------------------------------------------------------------- |
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161 | Postree::~Postree ( void ) |
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162 | // ----------------------------------------------------------------------------- |
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163 | { |
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164 | if (topnode) delete topnode; |
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165 | } |
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166 | |
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167 | // ----------------------------------------------------------------------------- |
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168 | // Liefert Laenge der kompremierten Sequenz |
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169 | // ----------------------------------------------------------------------------- |
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170 | int Postree::SeqLen ( void ) |
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171 | // ----------------------------------------------------------------------------- |
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172 | { |
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173 | return sequence.CompressedLen(); |
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174 | } |
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175 | |
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176 | // ----------------------------------------------------------------------------- |
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177 | // Positionsbaum fuer neue Sequenz aufbauen |
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178 | // ----------------------------------------------------------------------------- |
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179 | void Postree::Set ( str seq ) |
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180 | // ----------------------------------------------------------------------------- |
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181 | { |
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182 | if (seq && *seq) |
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183 | { |
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184 | str tmp; |
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185 | |
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186 | sequence.Set(seq); |
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187 | |
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188 | if (topnode) delete topnode, topnode = NULL; |
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189 | |
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190 | tmp = sequence.Compressed(); |
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191 | |
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192 | if (tmp) topnode = new PtNode(tmp,NULL,0,0), delete tmp; |
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193 | } |
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194 | } |
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195 | |
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196 | // ----------------------------------------------------------------------------- |
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197 | // Exakte Suche nach den Vorkommen einer Teilsequenz |
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198 | // ----------------------------------------------------------------------------- |
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199 | int Postree::Find ( str seq, |
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200 | int **pos, |
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201 | int *anz, |
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202 | int *len, |
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203 | int sort ) |
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204 | // ----------------------------------------------------------------------------- |
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205 | { |
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206 | int result = INVALID; |
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207 | |
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208 | *pos = NULL; |
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209 | *anz = 0; |
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210 | *len = 0; |
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211 | |
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212 | if (seq && *seq && pos && anz && len) |
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213 | { |
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214 | PtNode *node = topnode; |
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215 | |
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216 | result = 0; |
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217 | |
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218 | while (!result && *seq) |
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219 | { |
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220 | int base = BIndex[safeCharIndex(*seq++)]; |
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221 | |
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222 | if ((base < ADENIN) || |
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223 | (base > URACIL)) result = INVALID; |
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224 | else |
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225 | { |
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226 | Mask pmask = P_ADENIN, |
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227 | nmask = N_ADENIN; |
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228 | |
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229 | while (base--) |
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230 | { |
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231 | pmask = (Mask)(pmask * 2); |
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232 | nmask = (Mask)(nmask * 2); |
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233 | } |
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234 | |
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235 | if (node->mask & pmask) // Position gefunden |
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236 | { |
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237 | (*len)++; |
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238 | |
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239 | *anz = 1; |
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240 | *pos = new int [1]; |
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241 | |
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242 | if (!*pos) result = INVALID; // Speicher |
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243 | else |
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244 | { |
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245 | *pos[0] = node->position[node->IndexOfPos(pmask)]; |
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246 | |
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247 | if (*seq) // Gesuchte Sequenz ist laenger als Baum tief |
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248 | { |
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249 | str org = sequence.Compressed(); |
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250 | |
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251 | if (!org) result = INVALID; // Speicher |
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252 | else |
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253 | { |
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254 | str ptr = &org[*pos[0] + *len]; |
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255 | |
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256 | while (*ptr && *seq && (*seq == *ptr)) |
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257 | { |
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258 | (*len)++; |
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259 | seq++; |
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260 | ptr++; |
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261 | } |
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262 | |
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263 | if (*seq && *ptr) result = 1; // Unterschied |
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264 | |
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265 | delete org; |
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266 | } |
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267 | } |
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268 | } |
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269 | } |
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270 | else if (node->mask & nmask) // Verzweigung existiert |
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271 | { |
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272 | (*len)++; |
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273 | |
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274 | node = node->next[node->IndexOfNext(nmask)]; |
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275 | } |
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276 | else // Unterschied => alle Moeglichkeiten suchen |
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277 | { |
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278 | result = 1; |
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279 | |
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280 | *pos = FindLeaves(*node,anz); |
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281 | } |
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282 | } |
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283 | } |
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284 | |
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285 | if (!result && !*seq && !*pos) // Sequenz ist kuerzer als Baum tief |
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286 | { |
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287 | *pos = FindLeaves(*node,anz); |
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288 | |
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289 | if (!*pos) result = INVALID; // Speicher |
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290 | } |
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291 | } |
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292 | |
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293 | if (sort && *pos && (*anz > 1)) SortIntArray(*pos,anz); |
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294 | |
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295 | return result; |
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296 | } |
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297 | |
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298 | // ----------------------------------------------------------------------------- |
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299 | // Suche nach den Vorkommen einer Teilsequenz mit bis zu einer Substitution |
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300 | // ----------------------------------------------------------------------------- |
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301 | int Postree::OneSubstitution ( str seq, |
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302 | int **pos, |
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303 | int *anz, |
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304 | int *len ) |
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305 | // ----------------------------------------------------------------------------- |
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306 | { |
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307 | int result = INVALID, |
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308 | seqlen = strlen(seq), |
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309 | *lpos = NULL, |
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310 | lanz = 0, |
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311 | llen = 0, |
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312 | res, |
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313 | count; |
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314 | str search = new char [seqlen + 1]; |
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315 | |
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316 | for (count = 0;count < seqlen;count++) |
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317 | { |
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318 | int base; |
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319 | |
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320 | strcpy(search,seq); |
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321 | |
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322 | for (base = ADENIN;base <= URACIL;base++) |
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323 | { |
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324 | if (search[count] == BCharacter[base]) continue; |
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325 | |
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326 | search[count] = BCharacter[base]; |
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327 | |
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328 | res = Find(search,&lpos,&lanz,&llen,0); |
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329 | |
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330 | if (res >= 0) |
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331 | { |
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332 | if (llen > *len) |
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333 | { |
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334 | if (*pos) delete *pos; |
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335 | |
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336 | *pos = lpos; |
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337 | *len = llen; |
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338 | *anz = lanz; |
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339 | result = res; |
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340 | } |
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341 | else if (llen == *len) |
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342 | { |
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343 | int *tmp = new int [*anz + lanz]; |
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344 | |
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345 | if (*anz) memcpy(tmp,*pos,*anz * sizeof(int)); |
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346 | |
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347 | memcpy(&tmp[*anz],lpos,lanz * sizeof(int)); |
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348 | |
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349 | if (*pos) delete *pos; |
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350 | |
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351 | *pos = tmp; |
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352 | *anz += lanz; |
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353 | result = res; |
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354 | } |
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355 | } |
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356 | |
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357 | search[count] = seq[count]; |
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358 | } |
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359 | } |
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360 | |
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361 | delete search; |
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362 | |
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363 | return result; |
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364 | } |
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365 | |
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366 | // ----------------------------------------------------------------------------- |
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367 | // Suche nach den Vorkommen einer Teilsequenz mit bis zu einer Deletion |
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368 | // ----------------------------------------------------------------------------- |
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369 | int Postree::OneDeletion ( str seq, |
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370 | int **pos, |
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371 | int *anz, |
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372 | int *len ) |
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373 | // ----------------------------------------------------------------------------- |
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374 | { |
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375 | int result = INVALID, |
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376 | seqlen = strlen(seq), |
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377 | *lpos = NULL, |
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378 | lanz = 0, |
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379 | llen = 0, |
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380 | res, |
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381 | count; |
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382 | str search = new char [seqlen + 1]; |
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383 | |
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384 | for (count = 0;count < seqlen;count++) |
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385 | { |
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386 | if (!count) *search = 0; |
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387 | else strncpy(search,seq,count), search[count] = 0; |
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388 | |
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389 | strcat(search,&seq[count + 1]); |
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390 | |
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391 | res = Find(search,&lpos,&lanz,&llen,0); |
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392 | |
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393 | if (res >= 0) |
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394 | { |
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395 | if (llen > *len) |
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396 | { |
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397 | if (*pos) delete *pos; |
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398 | |
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399 | *pos = lpos; |
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400 | *len = llen; |
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401 | *anz = lanz; |
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402 | result = res; |
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403 | } |
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404 | else if (llen == *len) |
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405 | { |
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406 | int *tmp = new int [*anz + lanz]; |
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407 | |
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408 | if (*anz) memcpy(tmp,*pos,*anz * sizeof(int)); |
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409 | |
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410 | memcpy(&tmp[*anz],lpos,lanz * sizeof(int)); |
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411 | |
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412 | if (*pos) delete *pos; |
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413 | |
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414 | *pos = tmp; |
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415 | *anz += lanz; |
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416 | result = res; |
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417 | } |
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418 | } |
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419 | } |
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420 | |
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421 | delete search; |
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422 | |
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423 | return result; |
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424 | } |
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425 | |
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426 | // ----------------------------------------------------------------------------- |
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427 | // Suche nach den Vorkommen einer Teilsequenz mit bis zu einer Insertion |
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428 | // ----------------------------------------------------------------------------- |
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429 | int Postree::OneInsertion ( str seq, |
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430 | int **pos, |
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431 | int *anz, |
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432 | int *len ) |
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433 | // ----------------------------------------------------------------------------- |
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434 | { |
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435 | int result = INVALID, |
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436 | seqlen = strlen(seq), |
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437 | *lpos = NULL, |
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438 | lanz = 0, |
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439 | llen = 0, |
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440 | res, |
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441 | count; |
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442 | str search = new char [seqlen + 2]; |
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443 | |
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444 | for (count = 0;count <= seqlen;count++) |
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445 | { |
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446 | int base; |
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447 | |
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448 | if (!count) search[0] = ' ', |
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449 | search[1] = 0; |
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450 | else strncpy(search,seq,count), |
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451 | search[count] = ' ', |
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452 | search[count + 1] = 0; |
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453 | |
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454 | strcat(search,&seq[count]); |
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455 | |
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456 | for (base = ADENIN;base <= URACIL;base++) |
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457 | { |
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458 | search[count] = BCharacter[base]; |
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459 | |
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460 | res = Find(search,&lpos,&lanz,&llen,0); |
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461 | |
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462 | if (res >= 0) |
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463 | { |
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464 | if (llen > *len) |
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465 | { |
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466 | if (*pos) delete *pos; |
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467 | |
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468 | *pos = lpos; |
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469 | *len = llen; |
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470 | *anz = lanz; |
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471 | result = res; |
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472 | } |
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473 | else if (llen == *len) |
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474 | { |
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475 | int *tmp = new int [*anz + lanz]; |
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476 | |
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477 | if (*anz) memcpy(tmp,*pos,*anz * sizeof(int)); |
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478 | |
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479 | memcpy(&tmp[*anz],lpos,lanz * sizeof(int)); |
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480 | |
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481 | if (*pos) delete *pos; |
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482 | |
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483 | *pos = tmp; |
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484 | *anz += lanz; |
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485 | result = res; |
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486 | } |
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487 | } |
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488 | |
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489 | search[count] = seq[count]; |
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490 | } |
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491 | } |
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492 | |
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493 | delete search; |
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494 | |
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495 | return result; |
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496 | } |
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497 | |
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498 | // ----------------------------------------------------------------------------- |
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499 | // Suche nach den Vorkommen einer Teilsequenz mit bis zu einem Fehler |
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500 | // ----------------------------------------------------------------------------- |
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501 | int Postree::OneMismatch ( str seq, |
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502 | int **pos, |
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503 | int *anz, |
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504 | int *len ) |
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505 | // ----------------------------------------------------------------------------- |
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506 | { |
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507 | int result = Find(seq,pos,anz,len,0); |
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508 | |
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509 | if (result >= 0) |
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510 | { |
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511 | int *lpos[3] = { NULL, NULL, NULL }, |
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512 | lanz[3] = { 0, 0, 0 }, |
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513 | llen[3], |
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514 | res [3] = { INVALID, INVALID, INVALID }, |
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515 | count; |
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516 | |
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517 | llen[0] = llen[2] = *len; |
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518 | llen[1] = 0; |
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519 | res[0] = OneSubstitution(seq,&lpos[0],&lanz[0],&llen[0]); |
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520 | res[1] = OneDeletion (seq,&lpos[1],&lanz[1],&llen[1]); |
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521 | res[2] = OneInsertion (seq,&lpos[2],&lanz[2],&llen[2]); |
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522 | |
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523 | for (count = 0; count < 3;count++) |
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524 | { |
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525 | if (res[count] >= 0) |
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526 | { |
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527 | result = 1; |
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528 | |
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529 | if (llen[count] > *len) |
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530 | { |
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531 | if (*pos) delete *pos; |
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532 | |
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533 | *pos = lpos[count]; |
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534 | *len = llen[count]; |
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535 | *anz = lanz[count]; |
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536 | result = res [count]; |
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537 | |
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538 | lpos[count] = NULL; |
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539 | } |
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540 | else if (llen[count] == *len) |
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541 | { |
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542 | int *tmp = new int [*anz + lanz[count]]; |
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543 | |
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544 | if (*anz) memcpy(tmp,*pos,*anz * sizeof(int)); |
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545 | |
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546 | memcpy(&tmp[*anz],lpos[count],lanz[count] * sizeof(int)); |
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547 | |
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548 | if (*pos) delete *pos; |
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549 | |
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550 | *pos = tmp; |
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551 | *anz += lanz[count]; |
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552 | } |
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553 | } |
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554 | |
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555 | if (lpos[count]) delete lpos[count]; |
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556 | } |
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557 | |
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558 | if (*pos && (*anz > 1)) SortIntArray(*pos,anz); |
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559 | } |
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560 | |
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561 | return result; |
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562 | } |
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563 | |
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564 | // ----------------------------------------------------------------------------- |
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565 | // Ausgabefunktion fur eine Instanz der Klasse Postree zu debug-Zwecken |
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566 | // ----------------------------------------------------------------------------- |
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567 | void Postree::Dump ( void ) |
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568 | // ----------------------------------------------------------------------------- |
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569 | { |
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570 | cout << "\nsequence :\n"; |
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571 | |
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572 | sequence.Dump(); |
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573 | |
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574 | cout << "topnode :\n"; |
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575 | |
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576 | if (topnode) topnode->Dump(), cout << "\n"; |
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577 | } |
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578 | |
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579 | // ----------------------------------------------------------------------------- |
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580 | // Ausgabefunktion fur eine Instanz der Klasse Postree |
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581 | // ----------------------------------------------------------------------------- |
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582 | void Postree::Show ( int mode ) |
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583 | // ----------------------------------------------------------------------------- |
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584 | { |
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585 | switch (mode) |
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586 | { |
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587 | case 0: cout << "\npostree:\n\n"; |
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588 | if (topnode) topnode->Show(0,NULL), cout << "\n"; |
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589 | break; |
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590 | case 1: |
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591 | { |
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592 | str seq = sequence.Compressed(); |
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593 | |
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594 | cout << "\nsequence:\n\n"; |
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595 | |
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596 | if (seq) |
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597 | { |
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598 | cout << "Laenge: " << strlen(seq) << "\n"; |
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599 | cout << seq << "\n"; |
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600 | delete seq; |
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601 | } |
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602 | |
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603 | break; |
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604 | } |
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605 | case 2: cout << "\nsequence :\n"; |
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606 | sequence.Dump(); |
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607 | cout << "\npostree :\n\n"; |
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608 | if (topnode) topnode->Show(0,NULL), cout << "\n"; |
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609 | break; |
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610 | } |
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611 | } |
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