| 1 | #include <stdio.h> |
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| 2 | #include <stdlib.h> |
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| 3 | #include <string.h> |
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| 4 | // #include <malloc.h> |
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| 5 | |
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| 6 | #include <PT_server.h> |
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| 7 | #include <PT_server_prototypes.h> |
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| 8 | #include "probe.h" |
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| 9 | #include "probe_tree.hxx" |
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| 10 | #include "pt_prototypes.h" |
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| 11 | |
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| 12 | static bool findLeftmostProbe(POS_TREE *node, char *probe, int restlen, int height) { |
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| 13 | if (restlen==0) return true; |
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| 14 | |
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| 15 | switch (PT_read_type(node)) { |
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| 16 | case PT_NT_NODE: { |
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| 17 | for (int i=PT_A; i<PT_B_MAX; ++i) { |
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| 18 | POS_TREE *son = PT_read_son(psg.ptmain, node, PT_BASES(i)); |
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| 19 | if (son) { |
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| 20 | probe[0] = PT_BASES(i); // write leftmost probe into result |
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| 21 | bool found = findLeftmostProbe(son, probe+1, restlen-1, height+1); |
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| 22 | pt_assert(!found || (strlen(probe) == (size_t)restlen)); |
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| 23 | if (found) return true; |
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| 24 | } |
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| 25 | } |
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| 26 | break; |
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| 27 | } |
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| 28 | case PT_NT_CHAIN: { |
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| 29 | // fprintf(stdout, "Reached chain in findLeftmostProbe() (restlen=%i)\n", restlen); |
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| 30 | pt_assert(0); // unhandled yet |
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| 31 | break; |
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| 32 | } |
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| 33 | case PT_NT_LEAF: { |
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| 34 | // here the probe-tree is cut off, because only one species matches |
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| 35 | int pos = PT_read_rpos(psg.ptmain, node) + height; |
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| 36 | int name = PT_read_name(psg.ptmain, node); |
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| 37 | if (pos + restlen >= psg.data[name].size) |
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| 38 | break; // at end-of-sequence -> no probe with wanted length here |
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| 39 | |
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| 40 | pt_assert(probe[restlen] == 0); |
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| 41 | const char *seq_data = psg.data[name].data; |
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| 42 | for (int r = 0; r<restlen; ++r) { |
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| 43 | int data = seq_data[pos+r]; |
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| 44 | if (data == PT_QU || data == PT_N) return false; // ignore probes that contain 'N' or '.' |
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| 45 | probe[r] = data; |
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| 46 | } |
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| 47 | pt_assert(probe[restlen] == 0); |
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| 48 | pt_assert(strlen(probe) == (size_t)restlen); |
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| 49 | return true; |
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| 50 | } |
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| 51 | default : pt_assert(0); break; // oops |
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| 52 | } |
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| 53 | |
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| 54 | return false; |
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| 55 | } |
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| 56 | // --------------------------------------------------------------------- |
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| 57 | // static bool findNextProbe(POS_TREE *node, char *probe, int restlen) |
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| 58 | // --------------------------------------------------------------------- |
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| 59 | // searches next probe after 'probe' ('probe' itself may not exist) |
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| 60 | // returns: true if next probe was found |
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| 61 | // 'probe' is modified to next probe |
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| 62 | static bool findNextProbe(POS_TREE *node, char *probe, int restlen, int height) { |
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| 63 | if (restlen==0) return false; // in this case we found the recent probe |
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| 64 | // returning false upwards takes the next after |
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| 65 | |
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| 66 | switch (PT_read_type(node)) { |
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| 67 | case PT_NT_NODE: { |
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| 68 | POS_TREE *son = PT_read_son(psg.ptmain, node, PT_BASES(probe[0])); |
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| 69 | bool found = (son != 0) && findNextProbe(son, probe+1, restlen-1, height+1); |
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| 70 | |
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| 71 | pt_assert(!found || (strlen(probe) == (size_t)restlen)); |
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| 72 | |
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| 73 | if (!found) { |
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| 74 | for (int i=probe[0]+1; !found && i<PT_B_MAX; ++i) { |
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| 75 | son = PT_read_son(psg.ptmain, node, PT_BASES(i)); |
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| 76 | if (son) { |
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| 77 | probe[0] = PT_BASES(i); // change probe |
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| 78 | found = findLeftmostProbe(son, probe+1, restlen-1, height+1); |
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| 79 | pt_assert(!found || (strlen(probe) == (size_t)restlen)); |
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| 80 | } |
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| 81 | } |
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| 82 | } |
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| 83 | return found; |
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| 84 | } |
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| 85 | case PT_NT_CHAIN: |
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| 86 | case PT_NT_LEAF: { |
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| 87 | // species list or single species reached |
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| 88 | // fprintf(stdout, "Reached chain or leaf in findNextProbe() (restlen=%i)\n", restlen); |
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| 89 | return false; |
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| 90 | } |
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| 91 | default : pt_assert(0); break; // oops |
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| 92 | } |
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| 93 | |
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| 94 | pt_assert(0); |
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| 95 | return false; |
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| 96 | } |
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| 97 | |
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| 98 | // ------------------------------------------------------ |
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| 99 | // extern "C" int PT_find_exProb(PT_exProb *pep) |
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| 100 | // ------------------------------------------------------ |
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| 101 | extern "C" int PT_find_exProb(PT_exProb *pep) { |
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| 102 | POS_TREE *pt = psg.pt; // start search at root |
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| 103 | GBS_strstruct *gbs_str = GBS_stropen(pep->numget*(pep->plength+1)+1); |
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| 104 | bool first = true; |
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| 105 | |
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| 106 | for (int c=0; c<pep->numget; ++c) { |
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| 107 | bool found = false; |
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| 108 | |
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| 109 | if (pep->restart) { |
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| 110 | pep->restart = 0; |
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| 111 | |
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| 112 | char *probe = (char*)malloc(pep->plength+1); |
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| 113 | memset(probe, 'N', pep->plength); |
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| 114 | probe[pep->plength] = 0; // EOS marker |
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| 115 | |
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| 116 | compress_data(probe); |
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| 117 | |
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| 118 | pep->next_probe.data = probe; |
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| 119 | pep->next_probe.size = pep->plength+1; |
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| 120 | |
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| 121 | found = findLeftmostProbe(pt, pep->next_probe.data, pep->plength, 0); |
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| 122 | |
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| 123 | pt_assert(pep->next_probe.data[pep->plength] == 0); |
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| 124 | pt_assert(strlen(pep->next_probe.data) == (size_t)pep->plength); |
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| 125 | } |
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| 126 | |
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| 127 | if (!found) { |
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| 128 | found = findNextProbe(pt, pep->next_probe.data, pep->plength, 0); |
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| 129 | |
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| 130 | pt_assert(pep->next_probe.data[pep->plength] == 0); |
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| 131 | pt_assert(strlen(pep->next_probe.data) == (size_t)pep->plength); |
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| 132 | } |
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| 133 | if (!found) break; |
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| 134 | |
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| 135 | // append the probe to the probe list |
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| 136 | |
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| 137 | if (!first) GBS_strcat(gbs_str, ";"); |
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| 138 | first = false; |
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| 139 | GBS_strcat(gbs_str, pep->next_probe.data); |
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| 140 | } |
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| 141 | |
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| 142 | pep->result = GBS_strclose(gbs_str); |
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| 143 | |
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| 144 | return 0; |
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| 145 | } |
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| 146 | |
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