1 | // ---------------------------------------------------------------------------- |
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2 | // probe_collection.hxx |
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3 | // ---------------------------------------------------------------------------- |
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4 | // Declarations of classes used to create and manage probe collections in Arb. |
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5 | // ---------------------------------------------------------------------------- |
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6 | |
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7 | #ifndef PROBE_COLLECTION_HXX |
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8 | #define PROBE_COLLECTION_HXX |
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9 | |
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10 | #ifndef ARB_ASSERT_H |
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11 | #include "arb_assert.h" |
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12 | #endif |
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13 | #ifndef ARBTOOLS_H |
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14 | #include <arbtools.h> |
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15 | #endif |
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16 | #ifndef _GLIBCXX_STRING |
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17 | #include <string> |
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18 | #endif |
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19 | #ifndef _GLIBCXX_ITERATOR |
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20 | #include <iterator> |
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21 | #endif |
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22 | #ifndef _GLIBCXX_LIST |
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23 | #include <list> |
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24 | #endif |
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25 | #ifndef _GLIBCXX_MAP |
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26 | #include <map> |
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27 | #endif |
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28 | #ifndef _GLIBCXX_CERRNO |
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29 | #include <cerrno> |
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30 | #endif |
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31 | #ifndef _GLIBCXX_CSTDLIB |
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32 | #include <cstdlib> |
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33 | #endif |
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34 | #ifndef _GLIBCXX_CSTDIO |
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35 | #include <cstdio> |
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36 | #endif |
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37 | #ifndef _UNISTD_H |
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38 | #include <unistd.h> |
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39 | #endif |
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40 | #ifndef _SYS_STAT_H |
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41 | #include <sys/stat.h> |
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42 | #endif |
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43 | |
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44 | // ---------------------------------------------------------------------------- |
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45 | // struct ArbCachedString |
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46 | // ---------------------------------------------------------------------------- |
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47 | // This structure is a descriptor for a string cache on file by ArbStringCache |
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48 | // ---------------------------------------------------------------------------- |
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49 | struct ArbCachedString { |
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50 | fpos_t Pos; |
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51 | int Len; |
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52 | }; |
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53 | |
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54 | // ---------------------------------------------------------------------------- |
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55 | // class ArbStringCache |
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56 | // ---------------------------------------------------------------------------- |
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57 | // This class is used as a disk based storage of strings (typically result |
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58 | // output) to minimise memory usage. The result string is only used for |
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59 | // display purposes (the Arb results list) so by not storing it in physical |
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60 | // memory in the ArProbeResult class we can reduce our memory consumption |
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61 | // considerably. |
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62 | // ---------------------------------------------------------------------------- |
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63 | class ArbStringCache : virtual Noncopyable { |
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64 | std::string FileName; |
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65 | FILE *WriteCacheFile; |
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66 | mutable FILE *ReadCacheFile; |
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67 | mutable char *ReadBuffer; |
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68 | mutable int ReadBufferLength; |
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69 | bool IsOpen; |
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70 | |
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71 | void open(); |
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72 | void close(); |
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73 | bool allocReadBuffer(int nLength) const; |
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74 | |
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75 | public: |
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76 | ArbStringCache(); |
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77 | virtual ~ArbStringCache(); |
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78 | |
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79 | bool saveString(const char *pString, ArbCachedString& rCachedString); |
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80 | bool saveString(const char *pString, int nLength, ArbCachedString& rCachedString); |
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81 | bool loadString(std::string& rString, const ArbCachedString& rCachedString) const; |
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82 | void flush(); |
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83 | }; |
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84 | |
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85 | |
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86 | // ---------------------------------------------------------------------------- |
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87 | // class ArbRefCount |
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88 | // ---------------------------------------------------------------------------- |
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89 | |
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90 | // WARNING: code uses manual reference counting (most likely not 100% correct) |
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91 | // @@@ consider using SmartPtr<myclass> instead of deriving myclass from ArbRefCount |
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92 | // see also: comments about errors supposed in std::string (grep for REFCOUNT_HACK) |
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93 | |
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94 | class ArbRefCount { |
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95 | mutable int RefCount; |
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96 | |
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97 | public: |
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98 | ArbRefCount() : RefCount(1) {} |
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99 | ArbRefCount(const ArbRefCount&) : RefCount(1) {} |
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100 | virtual ~ArbRefCount() {} |
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101 | |
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102 | void lock() const { |
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103 | RefCount++; |
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104 | } |
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105 | bool unlock() const { |
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106 | RefCount--; |
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107 | return RefCount == 0; |
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108 | } |
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109 | void free() const { |
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110 | if (unlock()) { |
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111 | delete this; |
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112 | } |
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113 | } |
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114 | }; |
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115 | |
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116 | // ---------------------------------------------------------------------------- |
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117 | // class ArbProbeMatchWeighting |
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118 | // ---------------------------------------------------------------------------- |
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119 | // This class defines the match weighting algorithm and parameterisation for |
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120 | // the weighting applied to a match. |
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121 | // ---------------------------------------------------------------------------- |
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122 | class ArbProbeMatchWeighting : public ArbRefCount { |
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123 | float PenaltyMatrix[4][4]; |
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124 | float Width; |
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125 | float Bias; |
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126 | |
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127 | int toIndex(char nC) const; |
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128 | double positionalWeight(int nPos, int nLength) const; |
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129 | void copy(const ArbProbeMatchWeighting& rCopy); |
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130 | |
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131 | public: |
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132 | ArbProbeMatchWeighting(); |
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133 | ArbProbeMatchWeighting(const float aValues[16], float dWidth, float dBias); |
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134 | |
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135 | ArbProbeMatchWeighting(const ArbProbeMatchWeighting& rCopy); |
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136 | virtual ~ArbProbeMatchWeighting(); |
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137 | |
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138 | ArbProbeMatchWeighting& operator = (const ArbProbeMatchWeighting& rCopy); |
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139 | |
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140 | void initialise(const float aValues[16], float dWidth, float dBias); |
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141 | bool initialise(const char *pCSValues, const char *pCSWidth, const char *pCSBias); |
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142 | |
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143 | void setParameters(const float aValues[16], float dWidth, float dBias) { |
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144 | initialise(aValues, dWidth, dBias); |
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145 | } |
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146 | void getParameters(float aValues[16], float& dWidth, float& dBias) const; |
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147 | |
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148 | void writeXML(FILE *hFile, const char *pPrefix) const; |
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149 | |
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150 | double matchWeight(const char *pSequenceA, const char *pSequenceB) const; |
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151 | double matchWeightResult(const char *pProbeSequence, const char *pMatchResult) const; |
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152 | }; |
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153 | |
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154 | // ---------------------------------------------------------------------------- |
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155 | // class ArbProbe |
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156 | // ---------------------------------------------------------------------------- |
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157 | // This class is an abstraction of a probe used in the probe matching with |
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158 | // specificity feature in Arb. |
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159 | // ---------------------------------------------------------------------------- |
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160 | class ArbProbe : public ArbRefCount { |
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161 | std::string Name; |
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162 | std::string Sequence; |
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163 | std::string DisplayName; |
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164 | |
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165 | public: |
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166 | ArbProbe(); |
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167 | ArbProbe(const char *pName, const char *pSequence); |
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168 | ArbProbe(const ArbProbe& rCopy); |
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169 | virtual ~ArbProbe(); |
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170 | |
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171 | void writeXML(FILE *hFile, const char *pPrefix) const; |
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172 | |
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173 | void nameAndSequence(const char* pName, const char* pSequence); |
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174 | |
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175 | const std::string& name() const { return Name; } |
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176 | const std::string& sequence() const { return Sequence; } |
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177 | const std::string& displayName() const { return DisplayName; } |
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178 | |
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179 | int allowedMismatches() const; |
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180 | }; |
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181 | |
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182 | // ---------------------------------------------------------------------------- |
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183 | // List of ArbProbe* objects |
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184 | // ---------------------------------------------------------------------------- |
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185 | typedef std::list<ArbProbe*> ArbProbePtrList; |
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186 | typedef ArbProbePtrList::iterator ArbProbePtrListIter; |
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187 | typedef ArbProbePtrList::const_iterator ArbProbePtrListConstIter; |
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188 | |
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189 | // ---------------------------------------------------------------------------- |
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190 | // class ArbProbeCollection |
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191 | // ---------------------------------------------------------------------------- |
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192 | // This class is a collection of a probes to match against in the probe |
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193 | // matching with specificity feature in Arb. |
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194 | // ---------------------------------------------------------------------------- |
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195 | class ArbProbeCollection : public ArbRefCount { |
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196 | std::string Name; |
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197 | ArbProbePtrList ProbeList; |
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198 | ArbProbeMatchWeighting MatchWeighting; |
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199 | mutable bool HasChanged; |
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200 | |
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201 | void flush(); |
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202 | void copy(const ArbProbePtrList& rList); |
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203 | |
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204 | public: |
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205 | ArbProbeCollection(); |
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206 | ArbProbeCollection(const char *pName); |
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207 | ArbProbeCollection(const ArbProbeCollection& rCopy); |
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208 | virtual ~ArbProbeCollection(); |
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209 | |
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210 | ArbProbeCollection& operator = (const ArbProbeCollection& rCopy); |
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211 | |
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212 | bool openXML(const char *pFileAndPath, std::string& rErrorMessage); |
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213 | bool saveXML(const char *pFileAndPath) const; |
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214 | |
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215 | void setParameters(const float aValues[16], float dWidth, float dBias); |
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216 | void getParameters(float aValues[16], float& dWidth, float& dBias) const; |
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217 | |
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218 | const ArbProbePtrList& probeList() const { return ProbeList; } |
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219 | const ArbProbeMatchWeighting& matchWeighting() const { return MatchWeighting; } |
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220 | |
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221 | const ArbProbe *find(const char *pSequence) const; |
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222 | |
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223 | bool add(const char *pName, const char *pSequence, const ArbProbe **ppProbe = NULp); |
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224 | bool replace(const char *oldSequence, const char *pName, const char *pSequence, const ArbProbe **ppProbe = NULp); |
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225 | bool remove(const char *pSequence); |
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226 | bool clear(); |
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227 | |
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228 | void name(const char *pName); |
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229 | const std::string& name() const { return Name; } |
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230 | |
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231 | bool hasChanged() const { return HasChanged; } |
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232 | bool hasProbes() const { return ProbeList.size() > 0; } |
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233 | }; |
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234 | |
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235 | // ---------------------------------------------------------------------------- |
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236 | // class ArbMatchResult |
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237 | // ---------------------------------------------------------------------------- |
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238 | class ArbMatchResult : public ArbRefCount { |
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239 | const ArbProbe *Probe; |
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240 | ArbCachedString CachedResultA; |
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241 | ArbCachedString CachedResultB; |
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242 | double Weight; |
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243 | mutable int Index; |
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244 | mutable int Padding; |
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245 | |
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246 | public: |
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247 | ArbMatchResult(); |
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248 | ArbMatchResult(const ArbProbe *pProbe, const char *pResult, int nSplitPoint, double dWeight); |
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249 | ArbMatchResult(const ArbMatchResult& rCopy); |
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250 | virtual ~ArbMatchResult(); |
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251 | |
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252 | ArbMatchResult& operator = (const ArbMatchResult& rCopy); |
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253 | |
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254 | static void addedHeadline(std::string& rHeadline); |
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255 | void weightAndResult(std::string& rDest) const; |
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256 | void result(std::string& sResult) const; |
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257 | double weight() const { return Weight; } |
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258 | |
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259 | void padding(int nPadding) const { Padding = nPadding; } |
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260 | void index(int nIndex) const { Index = nIndex; } |
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261 | int index() const { return Index; } |
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262 | }; |
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263 | |
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264 | // ---------------------------------------------------------------------------- |
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265 | // multimap of ArbMatchResult* by string |
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266 | // ---------------------------------------------------------------------------- |
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267 | |
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268 | typedef std::multimap<std::string, ArbMatchResult*> ArbMatchResultPtrByStringMultiMap; |
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269 | typedef ArbMatchResultPtrByStringMultiMap::iterator ArbMatchResultPtrByStringMultiMapIter; |
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270 | typedef ArbMatchResultPtrByStringMultiMap::const_iterator ArbMatchResultPtrByStringMultiMapConstIter; |
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271 | |
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272 | // ---------------------------------------------------------------------------- |
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273 | // multimap of ArbMatchResult* by double |
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274 | // ---------------------------------------------------------------------------- |
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275 | // We use this as a means of results sorting by match weight |
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276 | // ---------------------------------------------------------------------------- |
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277 | |
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278 | typedef std::multimap<double, ArbMatchResult*> ArbMatchResultPtrByDoubleMultiMap; |
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279 | typedef ArbMatchResultPtrByDoubleMultiMap::iterator ArbMatchResultPtrByDoubleMultiMapIter; |
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280 | |
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281 | |
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282 | // ---------------------------------------------------------------------------- |
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283 | // List of strings |
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284 | // ---------------------------------------------------------------------------- |
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285 | |
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286 | typedef std::list<std::string> ArbStringList; |
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287 | typedef std::list<std::string>::const_iterator ArbStringListConstIter; |
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288 | |
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289 | // ---------------------------------------------------------------------------- |
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290 | // class ArbMatchResultSet |
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291 | // ---------------------------------------------------------------------------- |
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292 | class ArbMatchResultSet FINAL_TYPE : public ArbRefCount { |
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293 | const ArbProbe *Probe; |
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294 | std::string Headline; |
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295 | ArbMatchResultPtrByStringMultiMap ResultMap; |
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296 | ArbStringList CommentList; |
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297 | int Index; |
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298 | int EndFullName; |
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299 | |
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300 | void flush(); |
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301 | void copy(const ArbMatchResultPtrByStringMultiMap& rMap); |
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302 | |
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303 | public: |
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304 | ArbMatchResultSet(); |
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305 | ArbMatchResultSet(const ArbProbe *pProbe); |
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306 | |
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307 | ArbMatchResultSet(const ArbMatchResultSet& rCopy); |
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308 | DECLARE_ASSIGNMENT_OPERATOR(ArbMatchResultSet); |
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309 | virtual ~ArbMatchResultSet(); |
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310 | |
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311 | void initialise(const ArbProbe *pProbe, int nIndex); |
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312 | |
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313 | bool add(const char *pName, |
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314 | const char *pFullName, |
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315 | const char *pMatchPart, |
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316 | const char *pResult, |
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317 | const ArbProbeMatchWeighting& rMatchWeighting); |
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318 | |
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319 | bool addComment(const char *pComment); |
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320 | |
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321 | void findMaximumWeight(double& dMaximumWeight) const; |
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322 | |
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323 | const ArbMatchResultPtrByStringMultiMap& resultMap() const { return ResultMap; } |
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324 | |
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325 | bool isMatched(const ArbStringList& rCladeList, |
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326 | bool& bPartialMatch, |
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327 | double dThreshold, |
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328 | double dCladeMarkedThreshold, |
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329 | double dCladePartiallyMarkedThreshold) const; |
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330 | |
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331 | bool isMatched(const std::string& rName, double dThreshold) const; |
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332 | const ArbStringList& commentList() const { return CommentList; } |
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333 | |
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334 | bool hasResults() const { |
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335 | return Probe && ResultMap.size() > 0; |
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336 | } |
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337 | |
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338 | const ArbProbe *probe() const { return Probe; } |
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339 | |
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340 | void headline(const char *pHeadline, int nEndFullName) { |
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341 | if (pHeadline) { |
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342 | Headline = pHeadline; |
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343 | EndFullName = nEndFullName; |
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344 | } |
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345 | } |
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346 | const std::string& headline() const { return Headline; } |
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347 | int endFullName() const { return EndFullName; } |
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348 | |
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349 | void enumerateResults(ArbMatchResultPtrByDoubleMultiMap& rMap, int nMaxFullName); |
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350 | |
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351 | int index() const { return Index; } |
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352 | }; |
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353 | |
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354 | // ---------------------------------------------------------------------------- |
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355 | // Map of ArbMatchResultSet objects by string |
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356 | // ---------------------------------------------------------------------------- |
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357 | typedef std::pair<const std::string, ArbMatchResultSet> ArbMatchResultSetStringPair; |
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358 | typedef std::map<std::string, ArbMatchResultSet> ArbMatchResultSetByStringMap; |
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359 | typedef std::map<std::string, ArbMatchResultSet>::iterator ArbMatchResultSetByStringMapIter; |
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360 | typedef std::map<std::string, ArbMatchResultSet>::const_iterator ArbMatchResultSetByStringMapConstIter; |
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361 | typedef std::map<std::string, ArbMatchResultSet>::reverse_iterator ArbMatchResultSetByStringMapRIter; |
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362 | typedef std::map<std::string, ArbMatchResultSet>::const_reverse_iterator ArbMatchResultSetByStringMapConstRIter; |
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363 | |
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364 | |
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365 | // ---------------------------------------------------------------------------- |
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366 | // Map of int by string |
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367 | // ---------------------------------------------------------------------------- |
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368 | typedef std::pair<int, const std::string> ArbStringIntPair; |
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369 | typedef std::map<int, std::string> ArbIntByStringMap; |
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370 | typedef std::map<int, std::string>::iterator ArbIntByStringMapIter; |
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371 | typedef std::map<int, std::string>::const_iterator ArbIntByStringMapConstIter; |
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372 | typedef std::map<int, std::string>::reverse_iterator ArbIntByStringMapRIter; |
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373 | typedef std::map<int, std::string>::const_reverse_iterator ArbIntByStringMapConstRIter; |
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374 | |
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375 | |
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376 | typedef bool (*ArbMatchResultsEnumCallback)(void *pContext, const char *pResult, bool bIsComment, int nItem, int nItems); |
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377 | |
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378 | |
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379 | // ---------------------------------------------------------------------------- |
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380 | // class ArbMatchResultsManager |
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381 | // ---------------------------------------------------------------------------- |
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382 | class ArbMatchResultsManager { |
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383 | ArbMatchResultPtrByStringMultiMap ResultsMap; |
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384 | ArbMatchResultSetByStringMap ResultSetMap; |
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385 | double MaximumWeight; |
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386 | std::string ResultsFileName; |
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387 | |
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388 | void flush(); |
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389 | void initFileName(); |
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390 | |
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391 | public: |
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392 | ArbMatchResultsManager(); |
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393 | ArbMatchResultsManager(const ArbMatchResultsManager& rCopy); |
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394 | virtual ~ArbMatchResultsManager(); |
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395 | |
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396 | void reset(); |
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397 | |
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398 | ArbMatchResultSet *addResultSet(const ArbProbe *pProbe); |
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399 | const ArbMatchResultSet *findResultSet(const char *pProbeSequence) const; |
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400 | void updateResults(); |
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401 | |
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402 | const ArbMatchResultPtrByStringMultiMap& resultsMap() const { return ResultsMap; } |
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403 | const ArbMatchResultSetByStringMap& resultSetMap() const { return ResultSetMap; } |
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404 | |
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405 | double maximumWeight() const { return MaximumWeight; } |
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406 | |
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407 | int enumerate_results(ArbMatchResultsEnumCallback pCallback, void *pContext); |
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408 | |
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409 | const char *resultsFileName() const; |
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410 | void openResultsFile() const; |
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411 | |
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412 | bool hasResults() const { return ResultSetMap.size() > 0; } |
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413 | }; |
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414 | |
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415 | // ---------------------------------------------------------------------------- |
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416 | |
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417 | ArbProbeCollection& get_probe_collection(); |
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418 | ArbMatchResultsManager& get_results_manager(); |
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419 | |
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420 | #else |
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421 | #error probe_collection.hxx included twice |
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422 | #endif // PROBE_COLLECTION_HXX |
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