| 1 | #include <stdio.h> |
|---|
| 2 | #include <stdlib.h> |
|---|
| 3 | #include <string.h> |
|---|
| 4 | #include <ctype.h> |
|---|
| 5 | #include <malloc.h> |
|---|
| 6 | #include <arbdb.h> |
|---|
| 7 | #include <arbdbt.h> |
|---|
| 8 | |
|---|
| 9 | #ifdef _USE_AW_WINDOW |
|---|
| 10 | #include <aw_root.hxx> |
|---|
| 11 | #include <aw_device.hxx> |
|---|
| 12 | #include <aw_window.hxx> |
|---|
| 13 | #endif |
|---|
| 14 | |
|---|
| 15 | #include "BI_helix.hxx" |
|---|
| 16 | |
|---|
| 17 | #define LEFT_HELIX "{[<(" |
|---|
| 18 | #define RIGHT_HELIX "}]>)" |
|---|
| 19 | #define LEFT_NONS "#*abcdefghij" |
|---|
| 20 | #define RIGHT_NONS "#*ABCDEFGHIJ" |
|---|
| 21 | |
|---|
| 22 | char BI_helix::error[256]; |
|---|
| 23 | |
|---|
| 24 | struct helix_stack { |
|---|
| 25 | struct helix_stack *next; |
|---|
| 26 | long pos; |
|---|
| 27 | BI_PAIR_TYPE type; |
|---|
| 28 | char c; |
|---|
| 29 | }; |
|---|
| 30 | |
|---|
| 31 | struct { |
|---|
| 32 | const char *awar; |
|---|
| 33 | BI_PAIR_TYPE pair_type; |
|---|
| 34 | } helix_awars[] = { |
|---|
| 35 | { "Strong_Pair", HELIX_STRONG_PAIR }, |
|---|
| 36 | { "Normal_Pair", HELIX_PAIR }, |
|---|
| 37 | { "Weak_Pair", HELIX_WEAK_PAIR }, |
|---|
| 38 | { "No_Pair", HELIX_NO_PAIR }, |
|---|
| 39 | { "User_Pair", HELIX_USER0 }, |
|---|
| 40 | { "User_Pair2", HELIX_USER1 }, |
|---|
| 41 | { "User_Pair3", HELIX_USER2 }, |
|---|
| 42 | { "User_Pair4", HELIX_USER3 }, |
|---|
| 43 | { "Default", HELIX_DEFAULT }, |
|---|
| 44 | { "Non_Standart_aA", HELIX_NON_STANDART0 }, |
|---|
| 45 | { "Non_Standart1", HELIX_NON_STANDART1 }, |
|---|
| 46 | { "Non_Standart2", HELIX_NON_STANDART2 }, |
|---|
| 47 | { "Non_Standart3", HELIX_NON_STANDART3 }, |
|---|
| 48 | { "Non_Standart4", HELIX_NON_STANDART4 }, |
|---|
| 49 | { "Non_Standart5", HELIX_NON_STANDART5 }, |
|---|
| 50 | { "Non_Standart6", HELIX_NON_STANDART6 }, |
|---|
| 51 | { "Non_Standart7", HELIX_NON_STANDART7 }, |
|---|
| 52 | { "Non_Standart8", HELIX_NON_STANDART8 }, |
|---|
| 53 | { "Non_Standart9", HELIX_NON_STANDART9 }, |
|---|
| 54 | { "Not_Non_Standart", HELIX_NO_MATCH }, |
|---|
| 55 | { 0, HELIX_NONE }, |
|---|
| 56 | }; |
|---|
| 57 | |
|---|
| 58 | void BI_helix::_init(void) |
|---|
| 59 | { |
|---|
| 60 | int i; |
|---|
| 61 | for (i=0;i<HELIX_MAX; i++) pairs[i] = 0; |
|---|
| 62 | for (i=0;i<HELIX_MAX; i++) char_bind[i] = 0; |
|---|
| 63 | |
|---|
| 64 | entries = 0; |
|---|
| 65 | size = 0; |
|---|
| 66 | |
|---|
| 67 | pairs[HELIX_NONE]=strdup(""); |
|---|
| 68 | char_bind[HELIX_NONE] = strdup(" "); |
|---|
| 69 | |
|---|
| 70 | pairs[HELIX_STRONG_PAIR]=strdup("CG"); |
|---|
| 71 | char_bind[HELIX_STRONG_PAIR] = strdup("-"); |
|---|
| 72 | |
|---|
| 73 | pairs[HELIX_PAIR]=strdup("AU GU"); |
|---|
| 74 | char_bind[HELIX_PAIR] = strdup("-"); |
|---|
| 75 | |
|---|
| 76 | pairs[HELIX_WEAK_PAIR]=strdup("GA GT"); |
|---|
| 77 | char_bind[HELIX_WEAK_PAIR] = strdup("."); |
|---|
| 78 | |
|---|
| 79 | pairs[HELIX_NO_PAIR]=strdup("AA AC CC CT CU TU"); |
|---|
| 80 | char_bind[HELIX_NO_PAIR] = strdup("#"); |
|---|
| 81 | |
|---|
| 82 | pairs[HELIX_USER0]=strdup(".A .C .G .T .U"); |
|---|
| 83 | char_bind[HELIX_USER0] = strdup("?"); |
|---|
| 84 | |
|---|
| 85 | pairs[HELIX_USER1]=strdup("-A -C -G -T -U"); |
|---|
| 86 | char_bind[HELIX_USER1] = strdup("#"); |
|---|
| 87 | |
|---|
| 88 | pairs[HELIX_USER2]=strdup(".. --"); |
|---|
| 89 | char_bind[HELIX_USER2] = strdup(" "); |
|---|
| 90 | |
|---|
| 91 | pairs[HELIX_USER3]=strdup(".-"); |
|---|
| 92 | char_bind[HELIX_USER3] = strdup(" "); |
|---|
| 93 | |
|---|
| 94 | pairs[HELIX_DEFAULT]=strdup(""); |
|---|
| 95 | char_bind[HELIX_DEFAULT] = strdup("?"); |
|---|
| 96 | |
|---|
| 97 | for (i=HELIX_NON_STANDART0;i<=HELIX_NON_STANDART9;i++){ |
|---|
| 98 | pairs[i] = strdup(""); |
|---|
| 99 | char_bind[i] = strdup(""); |
|---|
| 100 | } |
|---|
| 101 | |
|---|
| 102 | pairs[HELIX_NO_MATCH]=strdup(""); |
|---|
| 103 | char_bind[HELIX_NO_MATCH] = strdup("|"); |
|---|
| 104 | |
|---|
| 105 | deleteable = 1; |
|---|
| 106 | } |
|---|
| 107 | |
|---|
| 108 | BI_helix::BI_helix(void) |
|---|
| 109 | { _init(); } |
|---|
| 110 | |
|---|
| 111 | #ifdef _USE_AW_WINDOW |
|---|
| 112 | BI_helix::BI_helix(AW_root * aw_root) |
|---|
| 113 | { |
|---|
| 114 | int i; |
|---|
| 115 | char awar[256]; |
|---|
| 116 | |
|---|
| 117 | _init(); |
|---|
| 118 | int j; |
|---|
| 119 | for (j=0; helix_awars[j].awar; j++){ |
|---|
| 120 | i = helix_awars[j].pair_type; |
|---|
| 121 | sprintf(awar,HELIX_AWAR_PAIR_TEMPLATE, helix_awars[j].awar); |
|---|
| 122 | aw_root->awar_string( awar,pairs[i])->add_target_var(&pairs[i]); |
|---|
| 123 | sprintf(awar,HELIX_AWAR_SYMBOL_TEMPLATE, helix_awars[j].awar); |
|---|
| 124 | aw_root->awar_string( awar, char_bind[i])->add_target_var(&char_bind[i]); |
|---|
| 125 | } |
|---|
| 126 | deleteable = 0; |
|---|
| 127 | } |
|---|
| 128 | #endif |
|---|
| 129 | |
|---|
| 130 | BI_helix::~BI_helix(void){ |
|---|
| 131 | if (!deleteable){ |
|---|
| 132 | GB_warning("Internal Programm Error: You cannot delete BI_helix !!"); |
|---|
| 133 | } |
|---|
| 134 | int i; |
|---|
| 135 | for (i=0;i<HELIX_MAX; i++) delete pairs[i]; |
|---|
| 136 | for (i=0;i<HELIX_MAX; i++) delete char_bind[i]; |
|---|
| 137 | |
|---|
| 138 | delete entries; |
|---|
| 139 | } |
|---|
| 140 | |
|---|
| 141 | extern "C" long BI_helix_check_error(const char *key, long val) |
|---|
| 142 | { |
|---|
| 143 | struct helix_stack *stack = (struct helix_stack *)val; |
|---|
| 144 | if (BI_helix::error[0]) return val; |
|---|
| 145 | if (stack) { |
|---|
| 146 | sprintf(BI_helix::error,"Too many '%c' in Helix '%s' pos %li", |
|---|
| 147 | stack->c, key, stack->pos); |
|---|
| 148 | } |
|---|
| 149 | return val; |
|---|
| 150 | } |
|---|
| 151 | |
|---|
| 152 | |
|---|
| 153 | extern "C" long BI_helix_free_hash(const char *key, long val) |
|---|
| 154 | { |
|---|
| 155 | key = key; |
|---|
| 156 | struct helix_stack *stack = (struct helix_stack *)val; |
|---|
| 157 | struct helix_stack *next; |
|---|
| 158 | for ( ; stack; stack = next) { |
|---|
| 159 | next = stack->next; |
|---|
| 160 | delete stack; |
|---|
| 161 | } |
|---|
| 162 | return 0; |
|---|
| 163 | } |
|---|
| 164 | |
|---|
| 165 | const char *BI_helix::init(char *helix_nr, char *helix, size_t sizei) |
|---|
| 166 | /* helix_nr string of helix identifiers |
|---|
| 167 | helix helix |
|---|
| 168 | size alignment len |
|---|
| 169 | */ |
|---|
| 170 | { |
|---|
| 171 | GB_HASH *hash = GBS_create_hash(256,1); |
|---|
| 172 | size_t pos; |
|---|
| 173 | char c; |
|---|
| 174 | char ident[256]; |
|---|
| 175 | char *sident; |
|---|
| 176 | struct helix_stack *laststack = 0,*stack; |
|---|
| 177 | |
|---|
| 178 | size = sizei; |
|---|
| 179 | |
|---|
| 180 | { |
|---|
| 181 | size_t len = strlen(helix); |
|---|
| 182 | if (len > size) len = size; |
|---|
| 183 | char *h = (char *)malloc(size+1); |
|---|
| 184 | h[size] = 0; |
|---|
| 185 | if (len<size) memset(h+len,'.', size-len); |
|---|
| 186 | memcpy(h,helix,len); |
|---|
| 187 | helix = h; |
|---|
| 188 | } |
|---|
| 189 | |
|---|
| 190 | if (helix_nr) { |
|---|
| 191 | size_t len = strlen(helix_nr); |
|---|
| 192 | if (len > size) len = (int)size; |
|---|
| 193 | char *h = (char *)malloc((int)size+1); |
|---|
| 194 | h[size] = 0; |
|---|
| 195 | if (len<size) memset(h+len,'.',(int)(size-len)); |
|---|
| 196 | memcpy(h,helix_nr,len); |
|---|
| 197 | helix_nr = h; |
|---|
| 198 | } |
|---|
| 199 | |
|---|
| 200 | error[0] = 0; |
|---|
| 201 | |
|---|
| 202 | strcpy(ident,"0"); |
|---|
| 203 | entries = (struct BI_helix_entry *)GB_calloc(sizeof(struct BI_helix_entry),(size_t)size); |
|---|
| 204 | sident = strdup("-"); |
|---|
| 205 | for (pos = 0; pos < size; pos ++ ) { |
|---|
| 206 | if (helix_nr) { |
|---|
| 207 | if ( isdigit(helix_nr[pos])) { |
|---|
| 208 | int j; |
|---|
| 209 | for (j=0;j<3 && pos+j<size;j++) { |
|---|
| 210 | c = helix_nr[pos+j]; |
|---|
| 211 | helix_nr[pos+j] = ' '; |
|---|
| 212 | if ( isalnum(c) ) { |
|---|
| 213 | ident[j] = c; |
|---|
| 214 | ident[j+1] = 0; |
|---|
| 215 | if ( isdigit(c) ) continue; |
|---|
| 216 | } |
|---|
| 217 | break; |
|---|
| 218 | } |
|---|
| 219 | } |
|---|
| 220 | } |
|---|
| 221 | c = helix[pos]; |
|---|
| 222 | if (strchr(LEFT_HELIX,c) || strchr(LEFT_NONS,c) ){ // push |
|---|
| 223 | laststack = (struct helix_stack *)GBS_read_hash(hash,ident); |
|---|
| 224 | stack = new helix_stack; |
|---|
| 225 | stack->next = laststack; |
|---|
| 226 | stack->pos = pos; |
|---|
| 227 | stack->c = c; |
|---|
| 228 | GBS_write_hash(hash,ident,(long)stack); |
|---|
| 229 | } |
|---|
| 230 | else if (strchr(RIGHT_HELIX,c) || strchr(RIGHT_NONS,c) ){ // pop |
|---|
| 231 | stack = (struct helix_stack *)GBS_read_hash(hash,ident); |
|---|
| 232 | if (!stack) { |
|---|
| 233 | sprintf(error,"Too many '%c' in Helix '%s' pos %i",c,ident,pos); |
|---|
| 234 | goto helix_end; |
|---|
| 235 | } |
|---|
| 236 | if (strchr(RIGHT_HELIX,c)) { |
|---|
| 237 | entries[pos].pair_type = HELIX_PAIR; |
|---|
| 238 | entries[stack->pos].pair_type = HELIX_PAIR; |
|---|
| 239 | }else{ |
|---|
| 240 | c = tolower(c); |
|---|
| 241 | if (stack->c != c) { |
|---|
| 242 | sprintf(error,"Character '%c' pos %li don't mach character '%c' pos %i in Helix '%s'", |
|---|
| 243 | stack->c,stack->pos,c,pos,ident); |
|---|
| 244 | goto helix_end; |
|---|
| 245 | } |
|---|
| 246 | if (isalpha(c)) { |
|---|
| 247 | entries[pos].pair_type = (BI_PAIR_TYPE)(HELIX_NON_STANDART0+c-'a'); |
|---|
| 248 | entries[stack->pos].pair_type = (BI_PAIR_TYPE)(HELIX_NON_STANDART0+c-'a'); |
|---|
| 249 | }else{ |
|---|
| 250 | entries[pos].pair_type = HELIX_NO_PAIR; |
|---|
| 251 | entries[stack->pos].pair_type = HELIX_NO_PAIR; |
|---|
| 252 | } |
|---|
| 253 | } |
|---|
| 254 | entries[pos].pair_pos = stack->pos; |
|---|
| 255 | entries[stack->pos].pair_pos = pos; |
|---|
| 256 | GBS_write_hash(hash,ident,(long)stack->next); |
|---|
| 257 | |
|---|
| 258 | if (strcmp(sident+1,ident)) { |
|---|
| 259 | //free(sident); |
|---|
| 260 | sident = new char[strlen(ident)+2]; |
|---|
| 261 | sprintf(sident,"-%s",ident); |
|---|
| 262 | } |
|---|
| 263 | entries[pos].helix_nr = sident+1; |
|---|
| 264 | entries[stack->pos].helix_nr = sident; |
|---|
| 265 | |
|---|
| 266 | delete stack; |
|---|
| 267 | } |
|---|
| 268 | } |
|---|
| 269 | |
|---|
| 270 | GBS_hash_do_loop(hash,BI_helix_check_error); |
|---|
| 271 | |
|---|
| 272 | helix_end:; |
|---|
| 273 | GBS_hash_do_loop(hash,BI_helix_free_hash); |
|---|
| 274 | GBS_free_hash(hash); |
|---|
| 275 | delete helix_nr; |
|---|
| 276 | delete helix; |
|---|
| 277 | if (error[0]) return error; |
|---|
| 278 | return 0; |
|---|
| 279 | } |
|---|
| 280 | |
|---|
| 281 | |
|---|
| 282 | const char *BI_helix::init(GBDATA *gb_helix_nr,GBDATA *gb_helix,size_t sizei) |
|---|
| 283 | { |
|---|
| 284 | if (gb_helix) GB_push_transaction(gb_helix); |
|---|
| 285 | char *helix_nr = 0; |
|---|
| 286 | char *helix = 0; |
|---|
| 287 | const char *err = 0; |
|---|
| 288 | if (!gb_helix) err = "Cannot find the helix"; |
|---|
| 289 | else if (gb_helix_nr) helix_nr = GB_read_string(gb_helix_nr); |
|---|
| 290 | if (!err) { |
|---|
| 291 | helix = GB_read_string(gb_helix); |
|---|
| 292 | err = init(helix_nr,helix,sizei); |
|---|
| 293 | } |
|---|
| 294 | delete helix_nr; |
|---|
| 295 | delete helix; |
|---|
| 296 | if (gb_helix) GB_pop_transaction(gb_helix); |
|---|
| 297 | return err; |
|---|
| 298 | } |
|---|
| 299 | |
|---|
| 300 | const char *BI_helix::init(GBDATA *gb_main, const char *alignment_name, const char *helix_nr_name, const char *helix_name) |
|---|
| 301 | { |
|---|
| 302 | const char *err = 0; |
|---|
| 303 | GB_push_transaction(gb_main); |
|---|
| 304 | GBDATA *gb_extended_data = GB_search(gb_main,"extended_data",GB_CREATE_CONTAINER); |
|---|
| 305 | long size2 = GBT_get_alignment_len(gb_main,alignment_name); |
|---|
| 306 | if (size2<=0) err = (char *)GB_get_error(); |
|---|
| 307 | if (!err) { |
|---|
| 308 | GBDATA *gb_helix_nr_con = GBT_find_SAI_rel_exdata(gb_extended_data, helix_nr_name); |
|---|
| 309 | GBDATA *gb_helix_con = GBT_find_SAI_rel_exdata(gb_extended_data, helix_name); |
|---|
| 310 | GBDATA *gb_helix = 0; |
|---|
| 311 | GBDATA *gb_helix_nr = 0; |
|---|
| 312 | |
|---|
| 313 | if (gb_helix_nr_con) gb_helix_nr = GBT_read_sequence(gb_helix_nr_con,alignment_name); |
|---|
| 314 | if (gb_helix_con) gb_helix = GBT_read_sequence(gb_helix_con,alignment_name); |
|---|
| 315 | |
|---|
| 316 | err = init(gb_helix_nr, gb_helix, size2); |
|---|
| 317 | } |
|---|
| 318 | GB_pop_transaction(gb_main); |
|---|
| 319 | return err; |
|---|
| 320 | } |
|---|
| 321 | |
|---|
| 322 | const char *BI_helix::init(GBDATA *gb_main) |
|---|
| 323 | { |
|---|
| 324 | const char *err = 0; |
|---|
| 325 | GB_push_transaction(gb_main); |
|---|
| 326 | char *helix = GBT_get_default_helix(gb_main); |
|---|
| 327 | char *helix_nr = GBT_get_default_helix_nr(gb_main); |
|---|
| 328 | char *use = GBT_get_default_alignment(gb_main); |
|---|
| 329 | err = init(gb_main,use,helix_nr,helix); |
|---|
| 330 | GB_pop_transaction(gb_main); |
|---|
| 331 | delete helix; |
|---|
| 332 | delete helix_nr; |
|---|
| 333 | delete use; |
|---|
| 334 | |
|---|
| 335 | return err; |
|---|
| 336 | |
|---|
| 337 | } |
|---|
| 338 | |
|---|
| 339 | extern "C" { |
|---|
| 340 | char *GB_give_buffer(long size); |
|---|
| 341 | } |
|---|
| 342 | |
|---|
| 343 | int BI_helix::_check_pair(char left, char right, BI_PAIR_TYPE pair_type) |
|---|
| 344 | { |
|---|
| 345 | int i; |
|---|
| 346 | int len = strlen(pairs[pair_type])-1; |
|---|
| 347 | char *pai = pairs[pair_type]; |
|---|
| 348 | for (i=0; i<len;i+=3){ |
|---|
| 349 | if ( pai[i] == left && pai[i+1] == right) return 1; |
|---|
| 350 | if ( pai[i] == right && pai[i+1] == left) return 1; |
|---|
| 351 | } |
|---|
| 352 | return 0; |
|---|
| 353 | } |
|---|
| 354 | |
|---|
| 355 | int BI_helix::check_pair(char left, char right, BI_PAIR_TYPE pair_type) |
|---|
| 356 | // returns 2 helix 1 weak helix 0 no helix -1 nothing |
|---|
| 357 | { |
|---|
| 358 | left = toupper(left); |
|---|
| 359 | right = toupper(right); |
|---|
| 360 | switch(pair_type) { |
|---|
| 361 | case HELIX_PAIR: |
|---|
| 362 | if ( _check_pair(left,right,HELIX_STRONG_PAIR) || |
|---|
| 363 | _check_pair(left,right,HELIX_PAIR) ) return 2; |
|---|
| 364 | if ( _check_pair(left,right,HELIX_WEAK_PAIR) ) return 1; |
|---|
| 365 | return 0; |
|---|
| 366 | case HELIX_NO_PAIR: |
|---|
| 367 | if ( _check_pair(left,right,HELIX_STRONG_PAIR) || |
|---|
| 368 | _check_pair(left,right,HELIX_PAIR) ) return 0; |
|---|
| 369 | return 1; |
|---|
| 370 | default: |
|---|
| 371 | return _check_pair(left,right,pair_type); |
|---|
| 372 | } |
|---|
| 373 | } |
|---|
| 374 | |
|---|
| 375 | |
|---|
| 376 | #ifdef _USE_AW_WINDOW |
|---|
| 377 | |
|---|
| 378 | char BI_helix::get_symbol(char left, char right, BI_PAIR_TYPE pair_type){ |
|---|
| 379 | left = toupper(left); |
|---|
| 380 | right = toupper(right); |
|---|
| 381 | int i; |
|---|
| 382 | int erg; |
|---|
| 383 | if (pair_type< HELIX_NON_STANDART0) { |
|---|
| 384 | erg = *char_bind[HELIX_DEFAULT]; |
|---|
| 385 | for (i=HELIX_STRONG_PAIR; i< HELIX_NON_STANDART0; i++){ |
|---|
| 386 | if (_check_pair(left,right,(BI_PAIR_TYPE)i)){ |
|---|
| 387 | erg = *char_bind[i]; |
|---|
| 388 | break; |
|---|
| 389 | } |
|---|
| 390 | } |
|---|
| 391 | }else{ |
|---|
| 392 | erg = *char_bind[HELIX_NO_MATCH]; |
|---|
| 393 | if (_check_pair(left,right,pair_type)) erg = *char_bind[pair_type]; |
|---|
| 394 | } |
|---|
| 395 | if (!erg) erg = ' '; |
|---|
| 396 | return erg; |
|---|
| 397 | } |
|---|
| 398 | |
|---|
| 399 | char *BI_helix::seq_2_helix(char *sequence,char undefsymbol){ |
|---|
| 400 | size_t size2 = strlen(sequence); |
|---|
| 401 | bi_assert(size2<=size); // if this fails there is a sequence longer than the alignment |
|---|
| 402 | char *helix = (char *)GB_calloc(sizeof(char),size+1); |
|---|
| 403 | register unsigned long i,j; |
|---|
| 404 | for (i=0; i<size2; i++) { |
|---|
| 405 | if ( i<size && entries[i].pair_type) { |
|---|
| 406 | j = entries[i].pair_pos; |
|---|
| 407 | helix[i] = get_symbol(sequence[i],sequence[j], |
|---|
| 408 | entries[i].pair_type); |
|---|
| 409 | }else{ |
|---|
| 410 | helix[i] = undefsymbol; |
|---|
| 411 | } |
|---|
| 412 | if (helix[i] == ' ') helix[i] = undefsymbol; |
|---|
| 413 | } |
|---|
| 414 | return helix; |
|---|
| 415 | } |
|---|
| 416 | |
|---|
| 417 | int BI_show_helix_on_device(AW_device *device, int gc, const char *opt_string, size_t opt_string_size, size_t start, size_t size, |
|---|
| 418 | AW_pos x,AW_pos y, AW_pos opt_ascent,AW_pos opt_descent, |
|---|
| 419 | AW_CL cduser, AW_CL cd1, AW_CL cd2) |
|---|
| 420 | { |
|---|
| 421 | AWUSE(opt_ascent);AWUSE(opt_descent); |
|---|
| 422 | BI_helix *THIS = (BI_helix *)cduser; |
|---|
| 423 | char *buffer = GB_give_buffer(size+1); |
|---|
| 424 | register unsigned long i,j,k; |
|---|
| 425 | |
|---|
| 426 | for (k=0; k<size; k++) { |
|---|
| 427 | i = k+start; |
|---|
| 428 | if ( i<THIS->size && THIS->entries[i].pair_type) { |
|---|
| 429 | j = THIS->entries[i].pair_pos; |
|---|
| 430 | char pairing_character = '.'; |
|---|
| 431 | if (j < opt_string_size){ |
|---|
| 432 | pairing_character = opt_string[j]; |
|---|
| 433 | } |
|---|
| 434 | buffer[k] = THIS->get_symbol(opt_string[i],pairing_character, |
|---|
| 435 | THIS->entries[i].pair_type); |
|---|
| 436 | }else{ |
|---|
| 437 | buffer[k] = ' '; |
|---|
| 438 | } |
|---|
| 439 | } |
|---|
| 440 | buffer[size] = 0; |
|---|
| 441 | return device->text(gc,buffer,x,y,0.0,(AW_bitset)-1,cd1,cd2); |
|---|
| 442 | } |
|---|
| 443 | |
|---|
| 444 | int BI_helix::show_helix( void *devicei, int gc1 , char *sequence, |
|---|
| 445 | AW_pos x, AW_pos y, |
|---|
| 446 | AW_bitset filter, |
|---|
| 447 | AW_CL cd1, AW_CL cd2){ |
|---|
| 448 | |
|---|
| 449 | if (!entries) return 0; |
|---|
| 450 | AW_device *device = (AW_device *)devicei; |
|---|
| 451 | return device->text_overlay(gc1, sequence, 0, x , y, 0.0 , filter, (AW_CL)this, cd1, cd2, |
|---|
| 452 | 1.0,1.0, BI_show_helix_on_device); |
|---|
| 453 | } |
|---|
| 454 | |
|---|
| 455 | |
|---|
| 456 | |
|---|
| 457 | AW_window *create_helix_props_window(AW_root *awr, AW_cb_struct * /*owner*/awcbs){ |
|---|
| 458 | AW_window_simple *aws = new AW_window_simple; |
|---|
| 459 | aws->init( awr, "HELIX_PROPS", "HELIX_PROPERTIES",400, 300 ); |
|---|
| 460 | |
|---|
| 461 | aws->at ( 10,10 ); |
|---|
| 462 | aws->auto_space(3,3); |
|---|
| 463 | aws->callback ( AW_POPDOWN ); |
|---|
| 464 | aws->create_button( "CLOSE", "CLOSE", "C" ); |
|---|
| 465 | aws->at_newline(); |
|---|
| 466 | |
|---|
| 467 | aws->label_length( 18 ); |
|---|
| 468 | int i; |
|---|
| 469 | int j; |
|---|
| 470 | int ex= 0,ey = 0; |
|---|
| 471 | char awar[256]; |
|---|
| 472 | for (j=0; helix_awars[j].awar; j++){ |
|---|
| 473 | |
|---|
| 474 | aws->label_length( 25 ); |
|---|
| 475 | i = helix_awars[j].pair_type; |
|---|
| 476 | |
|---|
| 477 | if (i != HELIX_DEFAULT && i!= HELIX_NO_MATCH ) { |
|---|
| 478 | sprintf(awar,HELIX_AWAR_PAIR_TEMPLATE, helix_awars[j].awar); |
|---|
| 479 | aws->label(helix_awars[j].awar); |
|---|
| 480 | aws->callback(awcbs); |
|---|
| 481 | aws->create_input_field(awar,20); |
|---|
| 482 | }else{ |
|---|
| 483 | aws->create_button(0,helix_awars[j].awar); |
|---|
| 484 | aws->at_x(ex); |
|---|
| 485 | } |
|---|
| 486 | if (!j) aws->get_at_position(&ex,&ey); |
|---|
| 487 | |
|---|
| 488 | sprintf(awar,HELIX_AWAR_SYMBOL_TEMPLATE, helix_awars[j].awar); |
|---|
| 489 | aws->callback(awcbs); |
|---|
| 490 | aws->create_input_field(awar,3); |
|---|
| 491 | aws->at_newline(); |
|---|
| 492 | } |
|---|
| 493 | aws->window_fit(); |
|---|
| 494 | return (AW_window *)aws; |
|---|
| 495 | } |
|---|
| 496 | #endif |
|---|
| 497 | |
|---|
| 498 | /*************************************************************************************** |
|---|
| 499 | ******* Reference to abs pos ******** |
|---|
| 500 | ****************************************************************************************/ |
|---|
| 501 | void BI_ecoli_ref::exit(void){ |
|---|
| 502 | delete _abs_2_rel1; |
|---|
| 503 | delete _abs_2_rel2; |
|---|
| 504 | delete _rel_2_abs; |
|---|
| 505 | _abs_2_rel1 = 0; |
|---|
| 506 | _abs_2_rel2 = 0; |
|---|
| 507 | _rel_2_abs = 0; |
|---|
| 508 | } |
|---|
| 509 | |
|---|
| 510 | BI_ecoli_ref::BI_ecoli_ref(void) |
|---|
| 511 | { |
|---|
| 512 | memset((char *)this,0,sizeof(BI_ecoli_ref)); |
|---|
| 513 | } |
|---|
| 514 | |
|---|
| 515 | BI_ecoli_ref::~BI_ecoli_ref(void){ |
|---|
| 516 | exit(); |
|---|
| 517 | } |
|---|
| 518 | |
|---|
| 519 | const char *BI_ecoli_ref::init(char *seq,long size) |
|---|
| 520 | { |
|---|
| 521 | exit(); |
|---|
| 522 | _abs_2_rel1 = new long[size]; |
|---|
| 523 | _abs_2_rel2 = new long[size]; |
|---|
| 524 | _rel_2_abs = new long[size]; |
|---|
| 525 | memset((char *)_rel_2_abs,0,(size_t)(sizeof(long)*size)); |
|---|
| 526 | |
|---|
| 527 | _rel_len = 0; |
|---|
| 528 | _abs_len = size; |
|---|
| 529 | long rel_len2 = 0; |
|---|
| 530 | long i; |
|---|
| 531 | long sl = strlen(seq); |
|---|
| 532 | for (i= 0;i<size;i++) { |
|---|
| 533 | _abs_2_rel1[i] = _rel_len; |
|---|
| 534 | _abs_2_rel2[i] = rel_len2; |
|---|
| 535 | _rel_2_abs[_rel_len] = i; |
|---|
| 536 | if (i>=sl || seq[i] == '.' || seq[i] == '-') { |
|---|
| 537 | rel_len2++; |
|---|
| 538 | }else{ |
|---|
| 539 | rel_len2 = 0; |
|---|
| 540 | _rel_len ++; |
|---|
| 541 | } |
|---|
| 542 | } |
|---|
| 543 | return 0; |
|---|
| 544 | } |
|---|
| 545 | |
|---|
| 546 | const char *BI_ecoli_ref::init(GBDATA *gb_main,char *alignment_name, char *ref_name) |
|---|
| 547 | { |
|---|
| 548 | const char *err = 0; |
|---|
| 549 | GB_transaction dummy(gb_main); |
|---|
| 550 | long size = GBT_get_alignment_len(gb_main,alignment_name); |
|---|
| 551 | if (size<=0) err = (char*)GB_get_error(); |
|---|
| 552 | if (!err) { |
|---|
| 553 | GBDATA *gb_ref_con = |
|---|
| 554 | GBT_find_SAI(gb_main, ref_name); |
|---|
| 555 | GBDATA *gb_ref = 0; |
|---|
| 556 | if (gb_ref_con){ |
|---|
| 557 | gb_ref = GBT_read_sequence(gb_ref_con,alignment_name); |
|---|
| 558 | if (gb_ref){ |
|---|
| 559 | err = init(GB_read_char_pntr(gb_ref), size); |
|---|
| 560 | }else{ |
|---|
| 561 | err = (char *)GB_export_error("Your SAI '%s' has no sequence '%s/data'", |
|---|
| 562 | ref_name,alignment_name); |
|---|
| 563 | } |
|---|
| 564 | }else{ |
|---|
| 565 | err = (char *)GB_export_error("I cannot find the SAI '%s'",ref_name); |
|---|
| 566 | } |
|---|
| 567 | } |
|---|
| 568 | return err; |
|---|
| 569 | } |
|---|
| 570 | |
|---|
| 571 | const char *BI_ecoli_ref::init(GBDATA *gb_main) |
|---|
| 572 | { |
|---|
| 573 | const char *err = 0; |
|---|
| 574 | GB_transaction dummy(gb_main); |
|---|
| 575 | char *ref = GBT_get_default_ref(gb_main); |
|---|
| 576 | char *use = GBT_get_default_alignment(gb_main); |
|---|
| 577 | err = init(gb_main,use,ref); |
|---|
| 578 | delete ref; |
|---|
| 579 | delete use; |
|---|
| 580 | |
|---|
| 581 | return err; |
|---|
| 582 | |
|---|
| 583 | } |
|---|
| 584 | |
|---|
| 585 | |
|---|
| 586 | const char *BI_ecoli_ref::abs_2_rel(long in,long &out,long &add){ |
|---|
| 587 | if (!_abs_2_rel1) { |
|---|
| 588 | out = in; |
|---|
| 589 | add = 0; |
|---|
| 590 | return "BI_ecoli_ref is not correctly initialized"; |
|---|
| 591 | } |
|---|
| 592 | if (in >= _abs_len) in = _abs_len -1; |
|---|
| 593 | if (in < 0 ) in = 0; |
|---|
| 594 | out = _abs_2_rel1[in]; |
|---|
| 595 | add = _abs_2_rel2[in]; |
|---|
| 596 | return 0; |
|---|
| 597 | } |
|---|
| 598 | |
|---|
| 599 | const char *BI_ecoli_ref::rel_2_abs(long in,long add,long &out){ |
|---|
| 600 | if (!_abs_2_rel1) { |
|---|
| 601 | out = in; |
|---|
| 602 | return ("BI_ecoli_ref is not correctly initialized"); |
|---|
| 603 | } |
|---|
| 604 | if (in >= _rel_len) in = _rel_len -1; |
|---|
| 605 | if (in < 0 ) in = 0; |
|---|
| 606 | out = _rel_2_abs[in]+add; |
|---|
| 607 | return 0; |
|---|
| 608 | } |
|---|