1 | #include "phylip.h" |
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2 | |
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3 | #define maxcategories 5 /* maximum number of site types */ |
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4 | #define smoothings 2 /* number of passes through smoothing algorithm */ |
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5 | #define iterations 10 /* number of iterates for each branch */ |
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6 | #define nmlngth 10 /* number of characters max. in species name */ |
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7 | |
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8 | #define epsilon 0.0001 /* used in makenewv, getthree, update */ |
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9 | |
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10 | #define point '.' |
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11 | |
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12 | #define ibmpc0 false |
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13 | #define ansi0 true |
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14 | #define vt520 false |
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15 | |
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16 | |
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17 | typedef enum { |
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18 | A, C, G, T |
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19 | } base; |
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20 | typedef double sitelike[(short)T - (short)A + 1]; |
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21 | typedef sitelike **phenotype; |
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22 | typedef double *contribarr; |
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23 | typedef char **sequence; |
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24 | |
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25 | |
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26 | typedef short longer[6]; |
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27 | |
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28 | typedef struct node { |
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29 | struct node *next, *back; |
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30 | phenotype x; |
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31 | double tyme, v; |
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32 | short number, xcoord, ycoord, ymin, ymax; |
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33 | boolean tip, haslength, initialized; |
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34 | } node; |
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35 | |
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36 | |
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37 | typedef struct tree { |
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38 | node **nodep; |
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39 | double likelihood; |
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40 | node *root; |
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41 | } tree; |
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42 | |
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43 | |
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44 | extern short categs,spp,endsite,sites,nonodes,weightsum,datasets, |
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45 | njumble,jumb; |
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46 | extern double rate[maxcategories]; |
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47 | extern double xi,xv,freqa,freqc,freqg,freqt,freqr,freqy,freqar,freqcy, |
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48 | freqgr,freqty,lambda,lambda1,fracchange; |
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49 | extern boolean usertree,globle,jumble,lengths,trout,weights,ctgry,auto_, |
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50 | printdata,progress,treeprint; |
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51 | extern tree curtree,bestree,bestree2; |
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52 | extern contribarr probcat; |
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53 | extern double **contribution; |
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54 | extern short *alias,*ally,*location,*aliasweight; |
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55 | extern FILE *infile,*outfile,*treefile; |
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56 | extern Char **naym; |
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57 | extern short *enterorder; |
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58 | extern longer seed; |
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59 | |
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60 | /* end pseudo-include file */ |
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61 | |
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62 | #define down 2 |
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63 | #define over 60 |
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64 | |
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65 | |
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66 | /* Local variables for maketree, propagated globally for C version: */ |
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67 | short k, which, maxwhich,col; |
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68 | double like, bestyet, tdelta, lnlike, slope, curv, maxlogl; |
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69 | boolean lastrearr, smoothed; |
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70 | double *l0gl; |
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71 | double x[3], lnl[3]; |
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72 | double expon1i[maxcategories], expon1v[maxcategories], |
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73 | expon2i[maxcategories], expon2v[maxcategories]; |
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74 | node *there; |
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75 | double **l0gf; |
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76 | Char ch; |
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77 | |
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78 | double randum(seed) |
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79 | short *seed; |
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80 | { |
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81 | /* random number generator -- slow but machine independent */ |
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82 | short i, j, k, sum; |
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83 | longer mult, newseed; |
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84 | double x; |
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85 | |
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86 | mult[0] = 13; |
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87 | mult[1] = 24; |
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88 | mult[2] = 22; |
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89 | mult[3] = 6; |
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90 | for (i = 0; i <= 5; i++) |
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91 | newseed[i] = 0; |
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92 | for (i = 0; i <= 5; i++) { |
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93 | sum = newseed[i]; |
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94 | k = i; |
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95 | if (i > 3) |
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96 | k = 3; |
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97 | for (j = 0; j <= k; j++) |
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98 | sum += mult[j] * seed[i - j]; |
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99 | newseed[i] = sum; |
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100 | for (j = i; j <= 4; j++) { |
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101 | newseed[j + 1] += newseed[j] / 64; |
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102 | newseed[j] &= 63; |
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103 | } |
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104 | } |
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105 | memcpy(seed, newseed, sizeof(longer)); |
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106 | seed[5] &= 3; |
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107 | x = 0.0; |
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108 | for (i = 0; i <= 5; i++) |
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109 | x = x / 64.0 + seed[i]; |
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110 | x /= 4.0; |
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111 | return x; |
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112 | } /* randum */ |
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113 | |
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114 | |
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115 | void exmake(lz, n) |
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116 | double lz; |
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117 | short n; |
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118 | { |
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119 | /* pretabulate tables of exponentials so need not do for each site */ |
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120 | short i; |
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121 | double rat; |
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122 | |
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123 | for (i = 0; i < categs; i++) { |
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124 | rat = rate[i]; |
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125 | switch (n) { |
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126 | |
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127 | case 1: |
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128 | expon1i[i] = exp(rat * xi * lz); |
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129 | expon1v[i] = exp(rat * xv * lz); |
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130 | break; |
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131 | |
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132 | case 2: |
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133 | expon2i[i] = exp(rat * xi * lz); |
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134 | expon2v[i] = exp(rat * xv * lz); |
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135 | break; |
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136 | } |
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137 | } |
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138 | } /* exmake */ |
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139 | |
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140 | double evaluate(p) |
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141 | node *p; |
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142 | { |
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143 | double sum, sum2, sumc, y, lz, y1, z1zz, z1yy, prod12, prod1, prod2, prod3, |
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144 | sumterm, lterm; |
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145 | static contribarr like,term,clai; |
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146 | short i, j, lai; |
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147 | boolean recorduser; |
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148 | node *q, *r; |
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149 | sitelike x1, x2; |
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150 | |
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151 | if (!like){ |
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152 | like = (double *)Malloc(categs * sizeof(double)); |
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153 | term = (double *)Malloc(categs * sizeof(double)); |
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154 | clai = (double *)Malloc(categs * sizeof(double)); |
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155 | } |
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156 | recorduser = (!auto_ && usertree); |
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157 | sum = 0.0; |
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158 | if (p != curtree.root) { |
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159 | r = p; |
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160 | q = p->back; |
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161 | y = fabs(r->tyme - q->tyme); |
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162 | } else { |
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163 | r = p->next->back; |
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164 | q = p->next->next->back; |
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165 | y = r->tyme + q->tyme - 2 * p->tyme; |
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166 | } |
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167 | lz = -y; |
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168 | exmake(lz, 1L); |
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169 | for (i = 0; i < endsite; i++) { |
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170 | for (j = 0; j < categs; j++) { |
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171 | y1 = 1.0 - expon1v[j]; |
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172 | z1zz = expon1i[j] * expon1v[j]; |
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173 | z1yy = (1.0 - expon1i[j]) * expon1v[j]; |
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174 | memcpy(x1, r->x[i][j], sizeof(sitelike)); |
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175 | prod1 = freqa * x1[0] + freqc * x1[(short)C - (short)A] + |
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176 | freqg * x1[(short)G - (short)A] + freqt * x1[(short)T - (short)A]; |
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177 | memcpy(x2, q->x[i][j], sizeof(sitelike)); |
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178 | prod2 = freqa * x2[0] + freqc * x2[(short)C - (short)A] + |
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179 | freqg * x2[(short)G - (short)A] + freqt * x2[(short)T - (short)A]; |
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180 | prod3 = (x1[0] * freqa + x1[(short)G - (short)A] * freqg) * |
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181 | (x2[0] * freqar + x2[(short)G - (short)A] * freqgr) + |
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182 | (x1[(short)C - (short)A] * freqc + x1[(short)T - (short)A] * freqt) * |
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183 | (x2[(short)C - (short)A] * freqcy + x2[(short)T - (short)A] * freqty); |
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184 | prod12 = freqa * x1[0] * x2[0] + |
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185 | freqc * x1[(short)C - (short)A] * x2[(short)C - (short)A] + |
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186 | freqg * x1[(short)G - (short)A] * x2[(short)G - (short)A] + |
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187 | freqt * x1[(short)T - (short)A] * x2[(short)T - (short)A]; |
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188 | term[j] = z1zz * prod12 + z1yy * prod3 + y1 * prod1 * prod2; |
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189 | } |
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190 | sumterm = 0.0; |
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191 | for (j = 0; j < categs; j++) |
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192 | sumterm += probcat[j] * term[j]; |
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193 | lterm = log(sumterm); |
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194 | for (j = 0; j < categs; j++) |
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195 | clai[j] = term[j] / sumterm; |
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196 | memcpy(contribution[i], clai, categs * sizeof(double )); |
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197 | if (recorduser) |
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198 | l0gf[which - 1][i] = lterm; |
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199 | sum += aliasweight[i] * lterm; |
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200 | } |
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201 | if (auto_) { |
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202 | for (j = 0; j < categs; j++) |
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203 | like[j] = 1.0; |
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204 | for (i = 0; i < sites; i++) { |
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205 | if ((ally[i] > 0) && (location[ally[i]-1] > 0)) { |
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206 | sumc = 0.0; |
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207 | for (k = 1; k <= categs; k++) |
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208 | sumc += probcat[k - 1] * like[k - 1]; |
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209 | sumc *= lambda; |
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210 | lai = location[ally[i] - 1]; |
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211 | memcpy(clai, contribution[lai - 1], categs * sizeof(double)); |
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212 | for (j = 0; j < categs; j++) |
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213 | like[j] = (lambda1 * like[j] + sumc) * clai[j]; |
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214 | } else { |
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215 | for (j = 0; j < categs; j++) |
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216 | like[j] = lambda1 * like[j] + lambda; |
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217 | } |
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218 | } |
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219 | sum2 = 0.0; |
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220 | for (i = 0; i < categs; i++) |
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221 | sum2 += probcat[i] * like[i]; |
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222 | sum += log(sum2); |
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223 | } |
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224 | curtree.likelihood = sum; |
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225 | if (!recorduser) |
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226 | return sum; |
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227 | l0gl[which - 1] = sum; |
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228 | if (which == 1) { |
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229 | maxwhich = 1; |
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230 | maxlogl = sum; |
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231 | return sum; |
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232 | } |
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233 | if (sum > maxlogl) { |
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234 | maxwhich = which; |
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235 | maxlogl = sum; |
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236 | } |
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237 | return sum; |
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238 | } /* evaluate */ |
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239 | |
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240 | void nuview(p) |
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241 | node *p; |
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242 | { |
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243 | short i, j; |
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244 | double lw, ww1, ww2, zz1, zz2, vv1, vv2, yy1, yy2, sum1, sum2, sumr1, sumr2, |
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245 | sumy1, sumy2; |
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246 | node *q, *r; |
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247 | sitelike xx1, xx2, xx3; |
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248 | |
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249 | q = p->next->back; |
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250 | r = p->next->next->back; |
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251 | if (q != NULL) |
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252 | lw = -fabs(p->tyme - q->tyme); |
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253 | else |
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254 | lw = 0.0; |
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255 | exmake(lw, 1L); |
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256 | if (r != NULL) |
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257 | lw = -fabs(p->tyme - r->tyme); |
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258 | else |
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259 | lw = 0.0; |
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260 | exmake(lw, 2L); |
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261 | for (i = 0; i < endsite; i++) { |
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262 | for (j = 0; j < categs; j++) { |
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263 | ww1 = expon1i[j]; |
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264 | zz1 = expon1v[j]; |
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265 | vv1 = 1.0 - ww1; |
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266 | yy1 = 1.0 - zz1; |
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267 | ww2 = expon2i[j]; |
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268 | zz2 = expon2v[j]; |
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269 | vv2 = 1.0 - ww2; |
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270 | yy2 = 1.0 - zz2; |
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271 | if (q != NULL) |
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272 | memcpy(xx1, q->x[i][j], sizeof(sitelike)); |
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273 | if (r != NULL) |
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274 | memcpy(xx2, r->x[i][j], sizeof(sitelike)); |
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275 | if (q == NULL) { |
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276 | xx1[0] = 1.0; |
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277 | xx1[(short)C - (short)A] = 1.0; |
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278 | xx1[(short)G - (short)A] = 1.0; |
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279 | xx1[(short)T - (short)A] = 1.0; |
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280 | } |
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281 | if (r == NULL) { |
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282 | xx2[0] = 1.0; |
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283 | xx2[(short)C - (short)A] = 1.0; |
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284 | xx2[(short)G - (short)A] = 1.0; |
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285 | xx2[(short)T - (short)A] = 1.0; |
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286 | } |
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287 | sum1 = yy1 * (freqa * xx1[0] + freqc * xx1[(short)C - (short)A] + |
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288 | freqg * xx1[(short)G - (short)A] + freqt * xx1[(short)T - (short)A]); |
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289 | sum2 = yy2 * (freqa * xx2[0] + freqc * xx2[(short)C - (short)A] + |
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290 | freqg * xx2[(short)G - (short)A] + freqt * xx2[(short)T - (short)A]); |
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291 | sumr1 = vv1 * (freqar * xx1[0] + freqgr * xx1[(short)G - (short)A]); |
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292 | sumr2 = vv2 * (freqar * xx2[0] + freqgr * xx2[(short)G - (short)A]); |
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293 | sumy1 = vv1 * (freqcy * xx1[(short)C - (short)A] + |
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294 | freqty * xx1[(short)T - (short)A]); |
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295 | sumy2 = vv2 * (freqcy * xx2[(short)C - (short)A] + |
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296 | freqty * xx2[(short)T - (short)A]); |
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297 | xx3[0] = (sum1 + zz1 * (ww1 * xx1[0] + sumr1)) * |
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298 | (sum2 + zz2 * (ww2 * xx2[0] + sumr2)); |
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299 | xx3[(short)C - (short)A] = |
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300 | (sum1 + zz1 * (ww1 * xx1[(short)C - (short)A] + sumy1)) * |
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301 | (sum2 + zz2 * (ww2 * xx2[(short)C - (short)A] + sumy2)); |
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302 | xx3[(short)G - (short)A] = |
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303 | (sum1 + zz1 * (ww1 * xx1[(short)G - (short)A] + sumr1)) * |
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304 | (sum2 + zz2 * (ww2 * xx2[(short)G - (short)A] + sumr2)); |
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305 | xx3[(short)T - (short)A] = |
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306 | (sum1 + zz1 * (ww1 * xx1[(short)T - (short)A] + sumy1)) * |
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307 | (sum2 + zz2 * (ww2 * xx2[(short)T - (short)A] + sumy2)); |
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308 | memcpy(p->x[i][j], xx3, sizeof(sitelike)); |
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309 | } |
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310 | } |
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311 | } /* nuview */ |
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312 | |
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313 | void getthree(p) |
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314 | node *p; |
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315 | { |
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316 | /* compute likelihood, slope, curvature at a new triple of points */ |
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317 | double tt, td; |
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318 | node *q, *r, *sdown; |
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319 | |
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320 | sdown = curtree.nodep[p->number - 1]; |
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321 | q = sdown->next->back; |
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322 | r = sdown->next->next->back; |
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323 | sdown = sdown->back; |
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324 | td = fabs(tdelta); |
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325 | if (td < epsilon) |
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326 | td = epsilon; |
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327 | tt = p->tyme; |
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328 | if (q->tyme - tt < td) |
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329 | td = (q->tyme - tt) / 2.0; |
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330 | if (r->tyme - tt < td) |
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331 | td = (r->tyme - tt) / 2.0; |
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332 | if (sdown != NULL) { |
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333 | if (tt - sdown->tyme < td) |
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334 | td = (tt - sdown->tyme) / 2.0; |
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335 | } |
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336 | if (-tt > epsilon && td < epsilon) |
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337 | td = epsilon; |
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338 | if (tt == -td) |
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339 | td += epsilon; |
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340 | p->tyme = tt + td; |
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341 | x[0] = tt + td; |
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342 | nuview(p); |
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343 | lnl[0] = evaluate(p); |
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344 | p->tyme = tt - td; |
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345 | x[2] = tt - td; |
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346 | nuview(p); |
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347 | lnl[2] = evaluate(p); |
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348 | p->tyme = tt; |
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349 | x[1] = tt; |
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350 | nuview(p); |
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351 | lnl[1] = evaluate(p); |
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352 | } /* getthree */ |
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353 | |
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354 | |
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355 | void makenewv(p) |
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356 | node *p; |
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357 | { |
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358 | /* improve a node time */ |
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359 | short it, imin, imax, i; |
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360 | double tt, tfactor, tlow, thigh, oldlike, ymin, ymax, s32, s21, yold; |
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361 | boolean done, already; |
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362 | node *q, *r, *s, *sdown; |
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363 | |
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364 | s = curtree.nodep[p->number - 1]; |
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365 | q = s->next->back; |
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366 | r = s->next->next->back; |
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367 | sdown = s->back; |
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368 | if (s == curtree.root) |
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369 | tlow = -10.0; |
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370 | else |
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371 | tlow = sdown->tyme; |
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372 | thigh = q->tyme; |
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373 | if (r->tyme < thigh) |
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374 | thigh = r->tyme; |
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375 | done = (thigh - tlow < epsilon || thigh - s->tyme < epsilon |
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376 | || s->tyme - tlow < epsilon); |
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377 | it = 1; |
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378 | tdelta = (thigh - tlow) / 10.0; |
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379 | getthree(s); |
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380 | tfactor = 1.0; |
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381 | while (it < iterations && !done) { |
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382 | tt = s->tyme; |
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383 | ymax = lnl[0]; |
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384 | imax = 1; |
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385 | for (i = 2; i <= 3; i++) { |
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386 | if (lnl[i - 1] > ymax) { |
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387 | ymax = lnl[i - 1]; |
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388 | imax = i; |
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389 | } |
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390 | } |
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391 | if (imax != 2) { |
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392 | ymax = x[1]; |
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393 | x[1] = x[imax - 1]; |
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394 | x[imax - 1] = ymax; |
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395 | ymax = lnl[1]; |
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396 | lnl[1] = lnl[imax - 1]; |
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397 | lnl[imax - 1] = ymax; |
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398 | } |
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399 | tt = x[1]; |
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400 | oldlike = lnl[1]; |
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401 | yold = tt; |
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402 | s32 = (lnl[2] - lnl[1]) / (x[2] - x[1]); |
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403 | s21 = (lnl[1] - lnl[0]) / (x[1] - x[0]); |
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404 | if (fabs(x[2] - x[0]) > epsilon) |
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405 | curv = (s32 - s21) / ((x[2] - x[0]) / 2); |
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406 | else |
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407 | curv = 0.0; |
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408 | slope = (s32 + s21) / 2 - curv * (x[2] - 2 * x[1] + x[0]) / 4; |
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409 | if (curv >= 0.0) { |
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410 | if (slope < 0) |
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411 | tdelta = -fabs(tdelta); |
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412 | else |
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413 | tdelta = fabs(tdelta); |
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414 | } else |
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415 | tdelta = -(tfactor * slope / curv); |
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416 | if (tt + tdelta <= tlow + epsilon) |
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417 | tdelta = (tlow - tt) / 2; |
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418 | if (tt + tdelta >= thigh - epsilon) |
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419 | tdelta = (thigh - tt) / 2; |
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420 | tt += tdelta; |
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421 | done = (fabs(yold - tt) < epsilon || fabs(tdelta) < epsilon); |
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422 | s->tyme = tt; |
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423 | nuview(s); |
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424 | lnlike = evaluate(s); |
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425 | ymin = lnl[0]; |
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426 | imin = 1; |
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427 | for (i = 2; i <= 3; i++) { |
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428 | if (lnl[i - 1] < ymin) { |
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429 | ymin = lnl[i - 1]; |
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430 | imin = i; |
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431 | } |
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432 | } |
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433 | already = (tt == x[0]) || (tt == x[1]) || (tt == x[2]); |
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434 | if (!already && ymin < lnlike) { |
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435 | x[imin - 1] = tt; |
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436 | lnl[imin - 1] = lnlike; |
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437 | } |
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438 | if (already || lnlike < oldlike) { |
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439 | tt = x[1]; |
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440 | tfactor /= 2; |
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441 | tdelta /= 2; |
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442 | curtree.likelihood = oldlike; |
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443 | lnlike = oldlike; |
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444 | } else |
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445 | tfactor = 1.0; |
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446 | p->tyme = tt; |
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447 | p->next->tyme = tt; |
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448 | p->next->next->tyme = tt; |
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449 | nuview(p); |
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450 | nuview(p->next); |
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451 | nuview(p->next->next); |
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452 | it++; |
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453 | } |
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454 | smoothed = smoothed && done; |
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455 | } /* makenewv */ |
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456 | |
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457 | void update(p) |
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458 | node *p; |
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459 | { |
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460 | /* improve time and recompute views at a node */ |
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461 | if (p == NULL) |
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462 | return; |
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463 | if (p->back != NULL) { |
---|
464 | if (!p->back->tip) |
---|
465 | nuview(p->back); |
---|
466 | } |
---|
467 | if (p->next->back != NULL) { |
---|
468 | if (!p->next->back->tip) |
---|
469 | nuview(p->next->back); |
---|
470 | } |
---|
471 | if (p->next->next->back != NULL) { |
---|
472 | if (!p->next->next->back->tip) |
---|
473 | nuview(p->next->next->back); |
---|
474 | } |
---|
475 | if (!lengths) { |
---|
476 | makenewv(p); |
---|
477 | return; |
---|
478 | } |
---|
479 | nuview(p); |
---|
480 | nuview(p->next); |
---|
481 | nuview(p->next->next); |
---|
482 | } /* update */ |
---|
483 | |
---|
484 | void smooth(p) |
---|
485 | node *p; |
---|
486 | { |
---|
487 | if (p == NULL) |
---|
488 | return; |
---|
489 | if (p->tip) |
---|
490 | return; |
---|
491 | update(p); |
---|
492 | smooth(p->next->back); |
---|
493 | update(p); |
---|
494 | smooth(p->next->next->back); |
---|
495 | update(p); |
---|
496 | } /* smooth */ |
---|
497 | |
---|
498 | void add(below, newtip, newfork) |
---|
499 | node *below, *newtip, *newfork; |
---|
500 | { |
---|
501 | /* inserts the nodes newfork and its descendant, newtip, in the tree. */ |
---|
502 | short i; |
---|
503 | boolean done; |
---|
504 | node *p; |
---|
505 | |
---|
506 | below = curtree.nodep[below->number - 1]; |
---|
507 | if (below->back != NULL) |
---|
508 | below->back->back = newfork; |
---|
509 | newfork->back = below->back; |
---|
510 | below->back = newfork->next->next; |
---|
511 | newfork->next->next->back = below; |
---|
512 | newfork->next->back = newtip; |
---|
513 | newtip->back = newfork->next; |
---|
514 | if (newtip->tyme < below->tyme) |
---|
515 | p = newtip; |
---|
516 | else p = below; |
---|
517 | newfork->tyme = p->tyme; |
---|
518 | if (curtree.root == below) |
---|
519 | curtree.root = newfork; |
---|
520 | if (newfork->back != NULL) { |
---|
521 | if (p->tyme > newfork->back->tyme) |
---|
522 | newfork->tyme = (p->tyme + newfork->back->tyme) / 2.0; |
---|
523 | else newfork->tyme = p->tyme - epsilon; |
---|
524 | newfork->next->tyme = newfork->tyme; |
---|
525 | newfork->next->next->tyme = newfork->tyme; |
---|
526 | do { |
---|
527 | p = curtree.nodep[p->back->number - 1]; |
---|
528 | done = (p == curtree.root); |
---|
529 | if (!done) |
---|
530 | done = (curtree.nodep[p->back->number - 1]->tyme < p->tyme - epsilon); |
---|
531 | if (!done) { |
---|
532 | curtree.nodep[p->back->number - 1]->tyme = p->tyme - epsilon; |
---|
533 | curtree.nodep[p->back->number - 1]->next->tyme = p->tyme - epsilon; |
---|
534 | curtree.nodep[p->back->number - 1]->next->next->tyme = p->tyme - epsilon; |
---|
535 | } |
---|
536 | } while (!done); |
---|
537 | } else { |
---|
538 | newfork->tyme = newfork->tyme - 0.1; |
---|
539 | newfork->next->tyme = newfork->tyme; |
---|
540 | newfork->next->next->tyme = newfork->tyme; |
---|
541 | } |
---|
542 | nuview(newfork); |
---|
543 | nuview(newfork->next); |
---|
544 | nuview(newfork->next->next); |
---|
545 | smoothed = false; |
---|
546 | i = 1; |
---|
547 | while (i < smoothings && !smoothed) { |
---|
548 | smoothed = true; |
---|
549 | smooth(newfork); |
---|
550 | smooth(newfork->back); |
---|
551 | i++; |
---|
552 | } |
---|
553 | } /* add */ |
---|
554 | |
---|
555 | void re_move(item, fork) |
---|
556 | node **item, **fork; |
---|
557 | { |
---|
558 | /* removes nodes item and its ancestor, fork, from the tree. |
---|
559 | the new descendant of fork's ancestor is made to be |
---|
560 | fork's second descendant (other than item). Also |
---|
561 | returns pointers to the deleted nodes, item and fork */ |
---|
562 | node *p, *q; |
---|
563 | |
---|
564 | if ((*item)->back == NULL) { |
---|
565 | *fork = NULL; |
---|
566 | return; |
---|
567 | } |
---|
568 | *fork = curtree.nodep[(*item)->back->number - 1]; |
---|
569 | if (curtree.root == *fork) { |
---|
570 | if (*item == (*fork)->next->back) |
---|
571 | curtree.root = (*fork)->next->next->back; |
---|
572 | else |
---|
573 | curtree.root = (*fork)->next->back; |
---|
574 | } |
---|
575 | p = (*item)->back->next->back; |
---|
576 | q = (*item)->back->next->next->back; |
---|
577 | if (p != NULL) |
---|
578 | p->back = q; |
---|
579 | if (q != NULL) |
---|
580 | q->back = p; |
---|
581 | (*fork)->back = NULL; |
---|
582 | p = (*fork)->next; |
---|
583 | while (p != *fork) { |
---|
584 | p->back = NULL; |
---|
585 | p = p->next; |
---|
586 | } |
---|
587 | (*item)->back = NULL; |
---|
588 | } /* remove */ |
---|
589 | |
---|
590 | void copynode(c, d) |
---|
591 | node *c, *d; |
---|
592 | { |
---|
593 | short i, j; |
---|
594 | |
---|
595 | for (i=0;i<endsite;i++) |
---|
596 | for (j = 0; j < categs; j++) |
---|
597 | memcpy(d->x[i][j],c->x[i][j], sizeof(sitelike)); |
---|
598 | d->tyme = c->tyme; |
---|
599 | d->v = c->v; |
---|
600 | d->xcoord = c->xcoord; |
---|
601 | d->ycoord = c->ycoord; |
---|
602 | d->ymin = c->ymin; |
---|
603 | d->ymax = c->ymax; |
---|
604 | d->haslength = c->haslength; |
---|
605 | d->initialized = c->initialized; |
---|
606 | } /* copynode */ |
---|
607 | |
---|
608 | void copy_(a, b) |
---|
609 | tree *a, *b; |
---|
610 | { |
---|
611 | short i, j=0; |
---|
612 | node *p, *q; |
---|
613 | |
---|
614 | for (i = 0; i < spp; i++) { |
---|
615 | copynode(a->nodep[i], b->nodep[i]); |
---|
616 | if (a->nodep[i]->back) { |
---|
617 | if (a->nodep[i]->back == a->nodep[a->nodep[i]->back->number - 1]) |
---|
618 | b->nodep[i]->back = b->nodep[a->nodep[i]->back->number - 1]; |
---|
619 | else if (a->nodep[i]->back == a->nodep[a->nodep[i]->back->number - 1]->next) |
---|
620 | b->nodep[i]->back = b->nodep[a->nodep[i]->back->number - 1]->next; |
---|
621 | else |
---|
622 | b->nodep[i]->back = b->nodep[a->nodep[i]->back->number - 1]->next->next; |
---|
623 | } |
---|
624 | else b->nodep[i]->back = NULL; |
---|
625 | } |
---|
626 | for (i = spp; i < nonodes; i++) { |
---|
627 | p = a->nodep[i]; |
---|
628 | q = b->nodep[i]; |
---|
629 | for (j = 1; j <= 3; j++) { |
---|
630 | copynode(p, q); |
---|
631 | if (p->back) { |
---|
632 | if (p->back == a->nodep[p->back->number - 1]) |
---|
633 | q->back = b->nodep[p->back->number - 1]; |
---|
634 | else if (p->back == a->nodep[p->back->number - 1]->next) |
---|
635 | q->back = b->nodep[p->back->number - 1]->next; |
---|
636 | else |
---|
637 | q->back = b->nodep[p->back->number - 1]->next->next; |
---|
638 | } |
---|
639 | else |
---|
640 | q->back = NULL; |
---|
641 | p = p->next; |
---|
642 | q = q->next; |
---|
643 | } |
---|
644 | } |
---|
645 | b->likelihood = a->likelihood; |
---|
646 | b->root = a->root; |
---|
647 | } /* copy */ |
---|
648 | |
---|
649 | void tryadd(p, item,nufork) |
---|
650 | node *p,**item,**nufork; |
---|
651 | |
---|
652 | { |
---|
653 | /* temporarily adds one fork and one tip to the tree. |
---|
654 | if the location where they are added yields greater |
---|
655 | likelihood than other locations tested up to that |
---|
656 | time, then keeps that location as there */ |
---|
657 | add(p, *item, *nufork); |
---|
658 | like = evaluate(p); |
---|
659 | if (lastrearr) { |
---|
660 | if (like >= bestree.likelihood) |
---|
661 | copy_(&curtree, &bestree); |
---|
662 | } |
---|
663 | if (like > bestyet) { |
---|
664 | bestyet = like; |
---|
665 | there = p; |
---|
666 | } |
---|
667 | re_move(item,nufork); |
---|
668 | } /* tryadd */ |
---|
669 | |
---|
670 | void addpreorder(p, item_, nufork_) |
---|
671 | node *p, *item_, *nufork_; |
---|
672 | { |
---|
673 | /* traverses a binary tree, calling PROCEDURE tryadd |
---|
674 | at a node before calling tryadd at its descendants */ |
---|
675 | node *item, *nufork; |
---|
676 | |
---|
677 | item = item_; |
---|
678 | nufork = nufork_; |
---|
679 | if (p == NULL) |
---|
680 | return; |
---|
681 | tryadd(p, &item,&nufork); |
---|
682 | if (!p->tip) { |
---|
683 | addpreorder(p->next->back, item, nufork); |
---|
684 | addpreorder(p->next->next->back,item,nufork); |
---|
685 | } |
---|
686 | } /* addpreorder */ |
---|
687 | |
---|
688 | |
---|
689 | void tryrearr(p, success) |
---|
690 | node *p; |
---|
691 | boolean *success; |
---|
692 | { |
---|
693 | /* evaluates one rearrangement of the tree. |
---|
694 | if the new tree has greater likelihood than the old |
---|
695 | one sets success = TRUE and keeps the new tree. |
---|
696 | otherwise, restores the old tree */ |
---|
697 | node *frombelow, *whereto, *forknode; |
---|
698 | double oldlike; |
---|
699 | |
---|
700 | if (p == curtree.root) |
---|
701 | return; |
---|
702 | forknode = curtree.nodep[p->back->number - 1]; |
---|
703 | if (forknode == curtree.root) |
---|
704 | return; |
---|
705 | oldlike = bestyet; |
---|
706 | if (forknode->next->back == p) |
---|
707 | frombelow = forknode->next->next->back; |
---|
708 | else |
---|
709 | frombelow = forknode->next->back; |
---|
710 | whereto = curtree.nodep[forknode->back->number - 1]; |
---|
711 | re_move(&p, &forknode); |
---|
712 | nuview(whereto); |
---|
713 | add(whereto, p, forknode); |
---|
714 | like = evaluate(p); |
---|
715 | if (like <= oldlike) { |
---|
716 | re_move(&p, &forknode); |
---|
717 | add(frombelow, p, forknode); |
---|
718 | } else { |
---|
719 | (*success) = true; |
---|
720 | bestyet = like; |
---|
721 | } |
---|
722 | } /* tryrearr */ |
---|
723 | |
---|
724 | void repreorder(p, success) |
---|
725 | node *p; |
---|
726 | boolean *success; |
---|
727 | { |
---|
728 | /* traverses a binary tree, calling PROCEDURE tryrearr |
---|
729 | at a node before calling tryrearr at its descendants */ |
---|
730 | if (p == NULL) |
---|
731 | return; |
---|
732 | tryrearr(p, success); |
---|
733 | if (p->tip) |
---|
734 | return; |
---|
735 | if (!(*success)) |
---|
736 | repreorder(p->next->back, success); |
---|
737 | if (!(*success)) |
---|
738 | repreorder(p->next->next->back,success); |
---|
739 | } /* repreorder */ |
---|
740 | |
---|
741 | Local Void rearrange(r) |
---|
742 | node **r; |
---|
743 | { |
---|
744 | /* traverses the tree (preorder), finding any local |
---|
745 | rearrangement which decreases the number of steps. |
---|
746 | if traversal succeeds in increasing the tree's |
---|
747 | likelihood, PROCEDURE rearrange runs traversal again */ |
---|
748 | boolean success; |
---|
749 | success = true; |
---|
750 | while (success) { |
---|
751 | success = false; |
---|
752 | repreorder(*r, &success); |
---|
753 | } |
---|
754 | } /* rearrange */ |
---|
755 | |
---|
756 | void getch(c) |
---|
757 | Char *c; |
---|
758 | { |
---|
759 | /* get next nonblank character */ |
---|
760 | do { |
---|
761 | if (eoln(infile)) { |
---|
762 | fscanf(infile, "%*[^\n]"); |
---|
763 | getc(infile); |
---|
764 | } |
---|
765 | *c = getc(infile); |
---|
766 | if (*c == '\n') |
---|
767 | *c = ' '; |
---|
768 | } while (*c == ' '); |
---|
769 | } /* getch */ |
---|
770 | |
---|
771 | void findch(c,rparens) |
---|
772 | Char c; |
---|
773 | short *rparens; |
---|
774 | { |
---|
775 | /* scan forward until find character c */ |
---|
776 | boolean done; |
---|
777 | |
---|
778 | done = false; |
---|
779 | while (!(done)) { |
---|
780 | if (c == ',') { |
---|
781 | if (ch == '(' || ch == ')' || ch == ';') { |
---|
782 | printf("\nERROR IN USER TREE: UNMATCHED PARENTHESIS OR MISSING COMMA\n"); |
---|
783 | exit(-1); |
---|
784 | } else if (ch == ',') |
---|
785 | done = true; |
---|
786 | } else if (c == ')') { |
---|
787 | if (ch == '(' || ch == ',' || ch == ';') { |
---|
788 | printf("\nERROR IN USER TREE: UNMATCHED PARENTHESIS OR NOT BIFURCATED NODE\n"); |
---|
789 | exit(-1); |
---|
790 | } else { |
---|
791 | if (ch == ')') { |
---|
792 | done = true; |
---|
793 | (*rparens)++; |
---|
794 | } |
---|
795 | } |
---|
796 | } else if (c == ';') { |
---|
797 | if (ch != ';') { |
---|
798 | printf("\nERROR IN USER TREE: UNMATCHED PARENTHESIS OR MISSING SEMICOLON\n"); |
---|
799 | exit(-1); |
---|
800 | } else |
---|
801 | done = true; |
---|
802 | } |
---|
803 | if ((done && ch == ')') || !(done)) |
---|
804 | getch(&ch); |
---|
805 | } |
---|
806 | } /* findch */ |
---|
807 | |
---|
808 | |
---|
809 | void processlength(p) |
---|
810 | node *p; |
---|
811 | { |
---|
812 | short digit, ordzero; |
---|
813 | double valyew, divisor; |
---|
814 | boolean pointread; |
---|
815 | |
---|
816 | ordzero = '0'; |
---|
817 | pointread = false; |
---|
818 | valyew = 0.0; |
---|
819 | divisor = 1.0; |
---|
820 | getch(&ch); |
---|
821 | digit = ch - ordzero; |
---|
822 | while (((unsigned short)digit <= 9) || ch == point){ |
---|
823 | if (ch == point) |
---|
824 | pointread = true; |
---|
825 | else { |
---|
826 | valyew = valyew * 10.0 + digit; |
---|
827 | if (pointread) |
---|
828 | divisor *= 10.0; |
---|
829 | } |
---|
830 | getch(&ch); |
---|
831 | digit = ch - ordzero; |
---|
832 | } |
---|
833 | p->v = valyew / divisor / fracchange; |
---|
834 | } /* processlength */ |
---|
835 | |
---|
836 | void addelement(p, nextnode,lparens,rparens,names) |
---|
837 | node **p; |
---|
838 | short *nextnode,*lparens,*rparens; |
---|
839 | boolean *names; |
---|
840 | { |
---|
841 | /* recursive procedure adds nodes to user-defined tree */ |
---|
842 | node *q; |
---|
843 | short i, n; |
---|
844 | boolean found; |
---|
845 | Char str[nmlngth]; |
---|
846 | |
---|
847 | getch(&ch); |
---|
848 | if (ch == '(') { |
---|
849 | if ((*lparens) >= spp - 1) { |
---|
850 | printf("\nERROR IN USER TREE: TOO MANY LEFT PARENTHESES\n"); |
---|
851 | exit(-1); |
---|
852 | } else { |
---|
853 | (*lparens)++; |
---|
854 | (*nextnode)++; |
---|
855 | q = curtree.nodep[(*nextnode) - 1]; |
---|
856 | addelement(&q->next->back, nextnode,lparens,rparens,names); |
---|
857 | q->next->back->back = q->next; |
---|
858 | findch(',',rparens); |
---|
859 | addelement(&q->next->next->back, nextnode,lparens,rparens,names); |
---|
860 | q->next->next->back->back = q->next->next; |
---|
861 | findch(')',rparens); |
---|
862 | *p = q; |
---|
863 | } |
---|
864 | } else { |
---|
865 | for (i = 0; i < nmlngth; i++) |
---|
866 | str[i] = ' '; |
---|
867 | n = 1; |
---|
868 | do { |
---|
869 | if (ch == '_') |
---|
870 | ch = ' '; |
---|
871 | str[n - 1] = ch; |
---|
872 | if (eoln(infile)) { |
---|
873 | fscanf(infile, "%*[^\n]"); |
---|
874 | getc(infile); |
---|
875 | } |
---|
876 | ch = getc(infile); |
---|
877 | if (ch == '\n') |
---|
878 | ch = ' '; |
---|
879 | n++; |
---|
880 | } while (ch != ':' && ch != ',' && ch != ')' && n <= nmlngth); |
---|
881 | if (ch == ')') |
---|
882 | (*rparens)++; |
---|
883 | n = 1; |
---|
884 | do { |
---|
885 | found = true; |
---|
886 | for (i = 0; i < nmlngth; i++) |
---|
887 | found = (found && str[i] == naym[n - 1][i]); |
---|
888 | if (found) { |
---|
889 | if (names[n - 1] == false) { |
---|
890 | *p = curtree.nodep[n - 1]; |
---|
891 | names[n - 1] = true; |
---|
892 | } else { |
---|
893 | printf("\nERROR IN USER TREE: DUPLICATE NAME FOUND -- "); |
---|
894 | for (i = 0; i < nmlngth; i++) |
---|
895 | putchar(naym[n - 1][i]); |
---|
896 | putchar('\n'); |
---|
897 | exit(-1); |
---|
898 | } |
---|
899 | } else |
---|
900 | n++; |
---|
901 | } while (!(n > spp || found)); |
---|
902 | if (n > spp) { |
---|
903 | printf("Cannot find species: "); |
---|
904 | for (i = 0; i < nmlngth; i++) |
---|
905 | putchar(str[i]); |
---|
906 | putchar('\n'); |
---|
907 | exit(-1); |
---|
908 | } |
---|
909 | } |
---|
910 | if (!lengths) |
---|
911 | return; |
---|
912 | if (ch == ':' || ch == ';') { |
---|
913 | if ((*rparens) < spp && ch == ':') |
---|
914 | processlength(*p); |
---|
915 | return; |
---|
916 | } |
---|
917 | printf("ERROR IN USER TREE: UNMATCHED PARENTHESES\n"); |
---|
918 | printf(" OR BRANCH LENGTHS OPTION CHOSEN IN MENU\n"); |
---|
919 | printf(" WITH NO INPUT BRANCH LENGTHS\n"); |
---|
920 | exit(-1); |
---|
921 | } /* addelement */ |
---|
922 | |
---|
923 | void tymetrav(p, x) |
---|
924 | node *p; |
---|
925 | double *x; |
---|
926 | { |
---|
927 | /* set up times of nodes */ |
---|
928 | if (!p->tip) { |
---|
929 | tymetrav(p->next->back, x); |
---|
930 | tymetrav(p->next->next->back,x); |
---|
931 | } else |
---|
932 | (*x) = 0.0; |
---|
933 | p->tyme = (*x); |
---|
934 | (*x) -= p->v; |
---|
935 | } /* tymetrav */ |
---|
936 | |
---|
937 | void treeread() |
---|
938 | { |
---|
939 | /* read in user-defined tree and set it up */ |
---|
940 | short nextnode, lparens, rparens; |
---|
941 | boolean *names; |
---|
942 | double x; |
---|
943 | short i; |
---|
944 | |
---|
945 | nextnode = spp; |
---|
946 | names = (boolean *)Malloc(spp*sizeof(boolean)); |
---|
947 | for (i = 0; i < spp; i++) |
---|
948 | names[i] = false; |
---|
949 | lparens = 0; |
---|
950 | rparens = 0; |
---|
951 | addelement(&curtree.root, &nextnode,&lparens,&rparens,names); |
---|
952 | curtree.root->back = NULL; |
---|
953 | findch(';',&rparens); |
---|
954 | if (progress) |
---|
955 | printf("\n\n"); |
---|
956 | if (lengths) |
---|
957 | tymetrav(curtree.root, &x); |
---|
958 | fscanf(infile, "%*[^\n]"); |
---|
959 | getc(infile); |
---|
960 | free(names); |
---|
961 | } /* treeread */ |
---|
962 | |
---|
963 | void coordinates(p, tipy) |
---|
964 | node *p; |
---|
965 | short *tipy; |
---|
966 | { |
---|
967 | /* establishes coordinates of nodes */ |
---|
968 | node *q, *first, *last; |
---|
969 | |
---|
970 | if (p->tip) { |
---|
971 | p->xcoord = 0; |
---|
972 | p->ycoord = (*tipy); |
---|
973 | p->ymin = (*tipy); |
---|
974 | p->ymax = (*tipy); |
---|
975 | (*tipy) += down; |
---|
976 | return; |
---|
977 | } |
---|
978 | q = p->next; |
---|
979 | do { |
---|
980 | coordinates(q->back, tipy); |
---|
981 | q = q->next; |
---|
982 | } while (p != q); |
---|
983 | first = p->next->back; |
---|
984 | q = p->next; |
---|
985 | while (q->next != p) |
---|
986 | q = q->next; |
---|
987 | last = q->back; |
---|
988 | p->xcoord = (short)(0.5 - over * p->tyme); |
---|
989 | p->ycoord = (first->ycoord + last->ycoord) / 2; |
---|
990 | p->ymin = first->ymin; |
---|
991 | p->ymax = last->ymax; |
---|
992 | } /* coordinates */ |
---|
993 | |
---|
994 | void drawline(i, scale) |
---|
995 | short i; |
---|
996 | double scale; |
---|
997 | { |
---|
998 | /* draws one row of the tree diagram by moving up tree */ |
---|
999 | node *p, *q, *r, *first, *last; |
---|
1000 | short n, j; |
---|
1001 | boolean extra, done; |
---|
1002 | |
---|
1003 | p = curtree.root; |
---|
1004 | q = curtree.root; |
---|
1005 | extra = false; |
---|
1006 | if (p->ycoord == i) { |
---|
1007 | if (p->number - spp >= 10) |
---|
1008 | fprintf(outfile, "-%2hd", p->number - spp); |
---|
1009 | else |
---|
1010 | fprintf(outfile, "--%hd", p->number - spp); |
---|
1011 | extra = true; |
---|
1012 | } else |
---|
1013 | fprintf(outfile, " "); |
---|
1014 | do { |
---|
1015 | if (!p->tip) { |
---|
1016 | r = p->next; |
---|
1017 | done = false; |
---|
1018 | do { |
---|
1019 | if (i >= r->back->ymin && i <= r->back->ymax) { |
---|
1020 | q = r->back; |
---|
1021 | done = true; |
---|
1022 | } |
---|
1023 | r = r->next; |
---|
1024 | } while (!(done || r == p)); |
---|
1025 | first = p->next->back; |
---|
1026 | r = p->next; |
---|
1027 | while (r->next != p) |
---|
1028 | r = r->next; |
---|
1029 | last = r->back; |
---|
1030 | } |
---|
1031 | done = (p == q); |
---|
1032 | n = (short)(scale * (p->xcoord - q->xcoord) + 0.5); |
---|
1033 | if (n < 3 && !q->tip) |
---|
1034 | n = 3; |
---|
1035 | if (extra) { |
---|
1036 | n--; |
---|
1037 | extra = false; |
---|
1038 | } |
---|
1039 | if (q->ycoord == i && !done) { |
---|
1040 | if (p->ycoord != q->ycoord) |
---|
1041 | putc('+', outfile); |
---|
1042 | else |
---|
1043 | putc('-', outfile); |
---|
1044 | if (!q->tip) { |
---|
1045 | for (j = 1; j <= n - 2; j++) |
---|
1046 | putc('-', outfile); |
---|
1047 | if (q->number - spp >= 10) |
---|
1048 | fprintf(outfile, "%2hd", q->number - spp); |
---|
1049 | else |
---|
1050 | fprintf(outfile, "-%hd", q->number - spp); |
---|
1051 | extra = true; |
---|
1052 | } else { |
---|
1053 | for (j = 1; j < n; j++) |
---|
1054 | putc('-', outfile); |
---|
1055 | } |
---|
1056 | } else if (!p->tip) { |
---|
1057 | if (last->ycoord > i && first->ycoord < i && i != p->ycoord) { |
---|
1058 | putc('!', outfile); |
---|
1059 | for (j = 1; j < n; j++) |
---|
1060 | putc(' ', outfile); |
---|
1061 | } else { |
---|
1062 | for (j = 1; j <= n; j++) |
---|
1063 | putc(' ', outfile); |
---|
1064 | } |
---|
1065 | } else { |
---|
1066 | for (j = 1; j <= n; j++) |
---|
1067 | putc(' ', outfile); |
---|
1068 | } |
---|
1069 | if (p != q) |
---|
1070 | p = q; |
---|
1071 | } while (!done); |
---|
1072 | if (p->ycoord == i && p->tip) { |
---|
1073 | for (j = 0; j < nmlngth; j++) |
---|
1074 | putc(naym[p->number - 1][j], outfile); |
---|
1075 | } |
---|
1076 | putc('\n', outfile); |
---|
1077 | } /* drawline */ |
---|
1078 | |
---|
1079 | void printree() |
---|
1080 | { |
---|
1081 | /* prints out diagram of the tree */ |
---|
1082 | /* Local variables for printree: */ |
---|
1083 | short tipy; |
---|
1084 | double scale; |
---|
1085 | short i; |
---|
1086 | node *p; |
---|
1087 | |
---|
1088 | if (!treeprint) |
---|
1089 | return; |
---|
1090 | putc('\n', outfile); |
---|
1091 | tipy = 1; |
---|
1092 | coordinates(curtree.root, &tipy); |
---|
1093 | p = curtree.root; |
---|
1094 | while (!p->tip) |
---|
1095 | p = p->next->back; |
---|
1096 | scale = 1.0 / (short)(p->tyme - curtree.root->tyme + 1.000); |
---|
1097 | putc('\n', outfile); |
---|
1098 | for (i = 1; i <= tipy - down; i++) |
---|
1099 | drawline(i, scale); |
---|
1100 | putc('\n', outfile); |
---|
1101 | } /* printree */ |
---|
1102 | |
---|
1103 | #undef down |
---|
1104 | #undef over |
---|
1105 | |
---|
1106 | void describe(p) |
---|
1107 | node *p; |
---|
1108 | { |
---|
1109 | short i; |
---|
1110 | double v; |
---|
1111 | |
---|
1112 | if (p == curtree.root) |
---|
1113 | fprintf(outfile, " root "); |
---|
1114 | else |
---|
1115 | fprintf(outfile, "%4hd ", p->back->number - spp); |
---|
1116 | if (p->tip) { |
---|
1117 | for (i = 0; i < nmlngth; i++) |
---|
1118 | putc(naym[p->number - 1][i], outfile); |
---|
1119 | } else |
---|
1120 | fprintf(outfile, "%4hd ", p->number - spp); |
---|
1121 | if (p != curtree.root) { |
---|
1122 | fprintf(outfile, "%10.5f", fracchange * (p->tyme - curtree.root->tyme)); |
---|
1123 | v = fracchange * (p->tyme - curtree.nodep[p->back->number - 1]->tyme); |
---|
1124 | fprintf(outfile, "%12.5f", v); |
---|
1125 | } |
---|
1126 | putc('\n', outfile); |
---|
1127 | if (!p->tip) { |
---|
1128 | describe(p->next->back); |
---|
1129 | describe(p->next->next->back); |
---|
1130 | } |
---|
1131 | } /* describe */ |
---|
1132 | |
---|
1133 | void summarize() |
---|
1134 | { |
---|
1135 | short i, j, mx; |
---|
1136 | double mode, sum; |
---|
1137 | double *like,*nulike; |
---|
1138 | short **mp; |
---|
1139 | |
---|
1140 | like = (double *)Malloc(categs * sizeof(double)); |
---|
1141 | nulike = (double *)Malloc(categs * sizeof(double)); |
---|
1142 | mp = (short **)Malloc(sites * sizeof(short *)); |
---|
1143 | for (i=0; i<=sites-1; i++) |
---|
1144 | mp[i] = (short *)Malloc(sizeof(short)*categs); |
---|
1145 | fprintf(outfile, "\nLn Likelihood = %11.5f\n\n", curtree.likelihood); |
---|
1146 | fprintf(outfile, " Ancestor Node Node Time Length\n"); |
---|
1147 | fprintf(outfile, " -------- ---- ---- ---- ------\n"); |
---|
1148 | describe(curtree.root); |
---|
1149 | putc('\n', outfile); |
---|
1150 | if (ctgry && categs > 1) { |
---|
1151 | for (i = 0; i < categs; i++) |
---|
1152 | like[i] = 1.0; |
---|
1153 | for (i = sites - 1; i >= 0; i--) { |
---|
1154 | sum = 0.0; |
---|
1155 | for (j = 0; j < categs; j++) { |
---|
1156 | nulike[j] = (lambda1 + lambda * probcat[j]) * like[j]; |
---|
1157 | mp[i][j] = j + 1; |
---|
1158 | for (k = 1; k <= categs; k++) { |
---|
1159 | if (k != j + 1) { |
---|
1160 | if (lambda * probcat[k - 1] * like[k - 1] > nulike[j]) { |
---|
1161 | nulike[j] = lambda * probcat[k - 1] * like[k - 1]; |
---|
1162 | mp[i][j] = k; |
---|
1163 | } |
---|
1164 | } |
---|
1165 | } |
---|
1166 | if ((ally[i] > 0) && (location[ally[i]-1] > 0)) |
---|
1167 | nulike[j] *= contribution[location[ally[i] - 1] - 1][j]; |
---|
1168 | sum += nulike[j]; |
---|
1169 | } |
---|
1170 | for (j = 0; j < categs; j++) |
---|
1171 | nulike[j] /= sum; |
---|
1172 | memcpy(like, nulike, categs * sizeof(double)); |
---|
1173 | } |
---|
1174 | mode = 0.0; |
---|
1175 | mx = 1; |
---|
1176 | for (i = 1; i <= categs; i++) { |
---|
1177 | if (probcat[i - 1] * like[i - 1] > mode) { |
---|
1178 | mx = i; |
---|
1179 | mode = probcat[i - 1] * like[i - 1]; |
---|
1180 | } |
---|
1181 | } |
---|
1182 | fprintf(outfile, |
---|
1183 | "\nCombination of categories that contributes the most to the likelihood:\n"); |
---|
1184 | for (i = 1; i <= nmlngth + 3; i++) |
---|
1185 | putc(' ', outfile); |
---|
1186 | for (i = 1; i <= sites; i++) { |
---|
1187 | fprintf(outfile, "%hd", mx); |
---|
1188 | if (i % 10 == 0) |
---|
1189 | putc(' ', outfile); |
---|
1190 | if (i % 60 == 0 && i != sites) { |
---|
1191 | putc('\n', outfile); |
---|
1192 | for (j = 1; j <= nmlngth + 3; j++) |
---|
1193 | putc(' ', outfile); |
---|
1194 | } |
---|
1195 | mx = mp[i - 1][mx - 1]; |
---|
1196 | } |
---|
1197 | } |
---|
1198 | putc('\n', outfile); |
---|
1199 | free(like); |
---|
1200 | free(nulike); |
---|
1201 | for (i=0;i<sites;++i) |
---|
1202 | free(mp[i]); |
---|
1203 | free(mp); |
---|
1204 | } /* summarize */ |
---|
1205 | |
---|
1206 | void treeout(p) |
---|
1207 | node *p; |
---|
1208 | { |
---|
1209 | /* write out file with representation of final tree */ |
---|
1210 | short i, n, w; |
---|
1211 | Char c; |
---|
1212 | double x; |
---|
1213 | |
---|
1214 | if (p->tip) { |
---|
1215 | n = 0; |
---|
1216 | for (i = 1; i <= nmlngth; i++) { |
---|
1217 | if (naym[p->number - 1][i - 1] != ' ') |
---|
1218 | n = i; |
---|
1219 | } |
---|
1220 | for (i = 0; i < n; i++) { |
---|
1221 | c = naym[p->number - 1][i]; |
---|
1222 | if (c == ' ') |
---|
1223 | c = '_'; |
---|
1224 | putc(c, treefile); |
---|
1225 | } |
---|
1226 | col += n; |
---|
1227 | } else { |
---|
1228 | putc('(', treefile); |
---|
1229 | col++; |
---|
1230 | treeout(p->next->back); |
---|
1231 | putc(',', treefile); |
---|
1232 | col++; |
---|
1233 | if (col > 55) { |
---|
1234 | putc('\n', treefile); |
---|
1235 | col = 0; |
---|
1236 | } |
---|
1237 | treeout(p->next->next->back); |
---|
1238 | putc(')', treefile); |
---|
1239 | col++; |
---|
1240 | } |
---|
1241 | if (p == curtree.root) { |
---|
1242 | fprintf(treefile, ";\n"); |
---|
1243 | return; |
---|
1244 | } |
---|
1245 | x = fracchange * (p->tyme - curtree.nodep[p->back->number - 1]->tyme); |
---|
1246 | if (x > 0.0) |
---|
1247 | w = (short)(0.4342944822 * log(x)); |
---|
1248 | else if (x == 0.0) |
---|
1249 | w = 0; |
---|
1250 | else |
---|
1251 | w = (short)(0.4342944822 * log(-x)) + 1; |
---|
1252 | if (w < 0) |
---|
1253 | w = 0; |
---|
1254 | fprintf(treefile, ":%*.5f", (int)(w + 7), x); |
---|
1255 | col += w + 8; |
---|
1256 | } /* treeout */ |
---|
1257 | |
---|
1258 | |
---|
1259 | void nodeinit(p) |
---|
1260 | node *p; |
---|
1261 | { |
---|
1262 | /* set up times at one node */ |
---|
1263 | node *q, *r; |
---|
1264 | double lowertyme; |
---|
1265 | |
---|
1266 | q = p->next->back; |
---|
1267 | r = p->next->next->back; |
---|
1268 | lowertyme = q->tyme; |
---|
1269 | if (r->tyme < q->tyme) |
---|
1270 | lowertyme = r->tyme; |
---|
1271 | p->tyme = lowertyme - 0.1; |
---|
1272 | p->next->tyme = p->tyme; |
---|
1273 | p->next->next->tyme = p->tyme; |
---|
1274 | q->v = q->tyme - p->tyme; |
---|
1275 | p->next->v = q->v; |
---|
1276 | r->v = r->tyme - p->tyme; |
---|
1277 | p->next->next->v = r->v; |
---|
1278 | } /* nodeinit */ |
---|
1279 | |
---|
1280 | void initrav(p) |
---|
1281 | node *p; |
---|
1282 | { |
---|
1283 | /* traverse to set up times throughout tree */ |
---|
1284 | if (p->tip) |
---|
1285 | return; |
---|
1286 | initrav(p->next->back); |
---|
1287 | initrav(p->next->next->back); |
---|
1288 | nodeinit(p); |
---|
1289 | } /* initrav */ |
---|
1290 | |
---|
1291 | |
---|
1292 | void travinit(p) |
---|
1293 | node *p; |
---|
1294 | { |
---|
1295 | /* traverse to set up initial values */ |
---|
1296 | if (p == NULL) |
---|
1297 | return; |
---|
1298 | if (p->tip) |
---|
1299 | return; |
---|
1300 | if (p->initialized) |
---|
1301 | return; |
---|
1302 | travinit(p->next->back); |
---|
1303 | travinit(p->next->next->back); |
---|
1304 | nuview(p); |
---|
1305 | p->initialized = true; |
---|
1306 | } /* travinit */ |
---|
1307 | |
---|
1308 | void travsp(p) |
---|
1309 | node *p; |
---|
1310 | { |
---|
1311 | /* traverse to find tips */ |
---|
1312 | if (p == curtree.root) |
---|
1313 | travinit(p); |
---|
1314 | if (p->tip) |
---|
1315 | travinit(p->back); |
---|
1316 | else { |
---|
1317 | travsp(p->next->back); |
---|
1318 | travsp(p->next->next->back); |
---|
1319 | } |
---|
1320 | } /* travsp */ |
---|
1321 | |
---|
1322 | void treevaluate() |
---|
1323 | { |
---|
1324 | /* evaluate likelihood of tree, after iterating branch lengths */ |
---|
1325 | short i; |
---|
1326 | double dummy; |
---|
1327 | |
---|
1328 | for (i = 0; i < spp; i++) |
---|
1329 | curtree.nodep[i]->initialized = false; |
---|
1330 | for (i = spp; i < nonodes; i++) { |
---|
1331 | curtree.nodep[i]->initialized = false; |
---|
1332 | curtree.nodep[i]->next->initialized = false; |
---|
1333 | curtree.nodep[i]->next->next->initialized = false; |
---|
1334 | } |
---|
1335 | if (!lengths) |
---|
1336 | initrav(curtree.root); |
---|
1337 | travsp(curtree.root); |
---|
1338 | for (i = 1; i <= smoothings * 4; i++) |
---|
1339 | smooth(curtree.root); |
---|
1340 | dummy = evaluate(curtree.root); |
---|
1341 | } /* treevaluate */ |
---|
1342 | |
---|
1343 | |
---|
1344 | void maketree() |
---|
1345 | { |
---|
1346 | /* constructs a binary tree from the pointers in curtree.nodep, |
---|
1347 | adds each node at location which yields highest likelihood |
---|
1348 | then rearranges the tree for greatest likelihood */ |
---|
1349 | |
---|
1350 | short i, j, numtrees, num; |
---|
1351 | double bestlike, gotlike, sum, sum2, sd; |
---|
1352 | node *item, *nufork, *dummy, *p1, *p2, *p3; |
---|
1353 | double TEMP; |
---|
1354 | |
---|
1355 | if (!usertree) { |
---|
1356 | for (i = 1; i <= spp; i++) |
---|
1357 | enterorder[i - 1] = i; |
---|
1358 | if (jumble) { |
---|
1359 | for (i = 0; i < spp; i++) { |
---|
1360 | j = (short)(randum(seed) * spp) + 1; |
---|
1361 | k = enterorder[j - 1]; |
---|
1362 | enterorder[j - 1] = enterorder[i]; |
---|
1363 | enterorder[i] = k; |
---|
1364 | } |
---|
1365 | } |
---|
1366 | curtree.root = curtree.nodep[spp]; |
---|
1367 | if (progress) { |
---|
1368 | printf("\nAdding species:\n"); |
---|
1369 | printf(" "); |
---|
1370 | } |
---|
1371 | add(curtree.nodep[enterorder[0] - 1], curtree.nodep[enterorder[1] - 1], |
---|
1372 | curtree.nodep[spp]); |
---|
1373 | if (progress) { |
---|
1374 | for (i = 0; i < nmlngth; i++) |
---|
1375 | putchar(naym[enterorder[0] - 1][i]); |
---|
1376 | printf("\n "); |
---|
1377 | for (i = 0; i < nmlngth; i++) |
---|
1378 | putchar(naym[enterorder[1] - 1][i]); |
---|
1379 | putchar('\n'); |
---|
1380 | } |
---|
1381 | lastrearr = false; |
---|
1382 | for (i = 3; i <= spp; i++) { |
---|
1383 | bestree.likelihood = -999999.0; |
---|
1384 | bestyet = -999999.0; |
---|
1385 | there = curtree.root; |
---|
1386 | item = curtree.nodep[enterorder[i - 1] - 1]; |
---|
1387 | nufork = curtree.nodep[spp + i - 2]; |
---|
1388 | addpreorder(curtree.root, item, nufork); |
---|
1389 | add(there, item, nufork); |
---|
1390 | like = bestyet; |
---|
1391 | rearrange(&curtree.root); |
---|
1392 | if (curtree.likelihood > bestree.likelihood) |
---|
1393 | copy_(&curtree, &bestree); |
---|
1394 | if (progress) { |
---|
1395 | printf(" "); |
---|
1396 | for (j = 0; j < nmlngth; j++) |
---|
1397 | putchar(naym[enterorder[i - 1] - 1][j]); |
---|
1398 | putchar('\n'); |
---|
1399 | } |
---|
1400 | lastrearr = (i == spp); |
---|
1401 | if (lastrearr && globle) { |
---|
1402 | if (progress) { |
---|
1403 | printf("Doing global rearrangements\n"); |
---|
1404 | printf(" !"); |
---|
1405 | for (j = 1; j <= nonodes; j++) |
---|
1406 | putchar('-'); |
---|
1407 | printf("!\n"); |
---|
1408 | } |
---|
1409 | bestlike = bestyet; |
---|
1410 | do { |
---|
1411 | if (progress) |
---|
1412 | printf(" "); |
---|
1413 | gotlike = bestlike; |
---|
1414 | for (j = 0; j < nonodes; j++) { |
---|
1415 | bestyet = -999999.00; |
---|
1416 | item = curtree.nodep[j]; |
---|
1417 | if (item != curtree.root) { |
---|
1418 | nufork = curtree.nodep[curtree.nodep[j]->back->number - 1]; |
---|
1419 | re_move(&item, &nufork); |
---|
1420 | there = curtree.root; |
---|
1421 | addpreorder(curtree.root, item, nufork); |
---|
1422 | add(there, item, nufork); |
---|
1423 | } |
---|
1424 | if (progress) |
---|
1425 | putchar('.'); |
---|
1426 | } |
---|
1427 | if (progress) |
---|
1428 | putchar('\n'); |
---|
1429 | } while (bestlike < gotlike); |
---|
1430 | } |
---|
1431 | } |
---|
1432 | if (njumble > 1 && lastrearr) { |
---|
1433 | for (i = 0; i < spp; i++) |
---|
1434 | re_move(&curtree.nodep[i], &dummy); |
---|
1435 | if (jumb == 1 || bestree2.likelihood < bestree.likelihood) |
---|
1436 | copy_(&bestree, &bestree2); |
---|
1437 | } |
---|
1438 | if (jumb == njumble) { |
---|
1439 | if (njumble > 1) copy_(&bestree2, &curtree); |
---|
1440 | else copy_(&bestree, &curtree); |
---|
1441 | fprintf(outfile, "\n\n"); |
---|
1442 | curtree.likelihood = evaluate(curtree.root); |
---|
1443 | printree(); |
---|
1444 | summarize(); |
---|
1445 | if (trout) { |
---|
1446 | col = 0; |
---|
1447 | treeout(curtree.root); |
---|
1448 | } |
---|
1449 | } |
---|
1450 | } else { |
---|
1451 | fscanf(infile, "%hd%*[^\n]", &numtrees); |
---|
1452 | l0gl = (double *)Malloc(numtrees * sizeof(double)); |
---|
1453 | l0gf = (double **)Malloc(numtrees * sizeof(double *)); |
---|
1454 | for (i=0;i<numtrees;++i) |
---|
1455 | l0gf[i] = (double *)Malloc(endsite * sizeof(double)); |
---|
1456 | getc(infile); |
---|
1457 | if (treeprint) { |
---|
1458 | fprintf(outfile, "User-defined tree"); |
---|
1459 | if (numtrees > 1) |
---|
1460 | putc('s', outfile); |
---|
1461 | fprintf(outfile, ":\n\n"); |
---|
1462 | } |
---|
1463 | fprintf(outfile, "\n\n"); |
---|
1464 | which = 1; |
---|
1465 | while (which <= numtrees) { |
---|
1466 | setuptree(&curtree); |
---|
1467 | treeread(); |
---|
1468 | treevaluate(); |
---|
1469 | printree(); |
---|
1470 | summarize(); |
---|
1471 | if (trout) { |
---|
1472 | col = 0; |
---|
1473 | treeout(curtree.root); |
---|
1474 | } |
---|
1475 | which++; |
---|
1476 | } |
---|
1477 | putc('\n', outfile); |
---|
1478 | if (!auto_ && numtrees > 1 && weightsum > 1 ) { |
---|
1479 | fprintf(outfile, "Tree Ln L Diff Ln L Its S.D."); |
---|
1480 | fprintf(outfile, " Significantly worse?\n\n"); |
---|
1481 | num = numtrees; |
---|
1482 | for (which = 1; which <= num; which++) { |
---|
1483 | fprintf(outfile, "%3hd%12.5f", which, l0gl[which - 1]); |
---|
1484 | if (maxwhich == which) |
---|
1485 | fprintf(outfile, " <------ best\n"); |
---|
1486 | else { |
---|
1487 | sum = 0.0; |
---|
1488 | sum2 = 0.0; |
---|
1489 | for (j = 0; j < endsite; j++) { |
---|
1490 | sum += aliasweight[j] * |
---|
1491 | (l0gf[maxwhich - 1][j] - l0gf[which - 1][j]); |
---|
1492 | TEMP = l0gf[maxwhich - 1][j] - l0gf[which - 1][j]; |
---|
1493 | sum2 += aliasweight[j] * (TEMP * TEMP); |
---|
1494 | } |
---|
1495 | sd = sqrt(weightsum / (weightsum - 1.0) * (sum2 - sum * sum / weightsum)); |
---|
1496 | fprintf(outfile, "%12.5f%12.4f", |
---|
1497 | l0gl[which - 1] - maxlogl, sd); |
---|
1498 | if (sum > 1.95996 * sd) |
---|
1499 | fprintf(outfile, " Yes\n"); |
---|
1500 | else |
---|
1501 | fprintf(outfile, " No\n"); |
---|
1502 | } |
---|
1503 | } |
---|
1504 | fprintf(outfile, "\n\n"); |
---|
1505 | } |
---|
1506 | free(l0gl); |
---|
1507 | for (i=0;i<numtrees;++i) |
---|
1508 | free(l0gf[i]); |
---|
1509 | free(l0gf); |
---|
1510 | } |
---|
1511 | if (jumb == njumble) { |
---|
1512 | if (progress) { |
---|
1513 | printf("\nOutput written to output file\n\n"); |
---|
1514 | if (trout) |
---|
1515 | printf("Tree(s) also written onto file\n\n"); |
---|
1516 | } |
---|
1517 | for (i=0; i<spp;i++){ |
---|
1518 | for (j=0;j<endsite;++j){ |
---|
1519 | free(curtree.nodep[i]->x[j]); |
---|
1520 | if (!usertree) { |
---|
1521 | free(bestree.nodep[i]->x[j]); |
---|
1522 | if (njumble > 1) |
---|
1523 | free(bestree2.nodep[i]->x[j]); |
---|
1524 | } |
---|
1525 | } |
---|
1526 | free(curtree.nodep[i]->x); |
---|
1527 | if (!usertree) { |
---|
1528 | free(bestree.nodep[i]->x); |
---|
1529 | if (njumble > 1) |
---|
1530 | free(bestree2.nodep[i]->x); |
---|
1531 | } |
---|
1532 | } |
---|
1533 | for (i=spp; i < nonodes ; i++){ |
---|
1534 | p1 = curtree.nodep[i]; |
---|
1535 | if (!usertree) { |
---|
1536 | p2 = bestree.nodep[i]; |
---|
1537 | if (njumble > 1) |
---|
1538 | p3 = bestree2.nodep[i]; |
---|
1539 | } |
---|
1540 | for (k=0;k<3;++k) { |
---|
1541 | for (j=0;j<endsite;++j){ |
---|
1542 | free(p1->x[j]); |
---|
1543 | if (!usertree) { |
---|
1544 | free(p2->x[j]); |
---|
1545 | if (njumble > 1) |
---|
1546 | free(p3->x[j]); |
---|
1547 | } |
---|
1548 | } |
---|
1549 | free(p1->x); |
---|
1550 | if (!usertree) { |
---|
1551 | free(p2->x); |
---|
1552 | if (njumble > 1) |
---|
1553 | free(p3->x); |
---|
1554 | } |
---|
1555 | p1=p1->next; |
---|
1556 | if (!usertree) { |
---|
1557 | p2=p2->next; |
---|
1558 | if (njumble > 1) |
---|
1559 | p3=p3->next; |
---|
1560 | } |
---|
1561 | } |
---|
1562 | } |
---|
1563 | } |
---|
1564 | } /* maketree */ |
---|
1565 | |
---|
1566 | |
---|