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2 | |
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3 | #ifndef _ALI_PREALIGNER_INC_ |
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4 | #define _ALI_PREALIGNER_INC_ |
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5 | |
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6 | #include "ali_profile.hxx" |
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7 | #include "ali_pathmap.hxx" |
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8 | #include "ali_tstack.hxx" |
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9 | #include "ali_solution.hxx" |
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10 | |
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11 | #define ALI_PREALIGNER_INS 1 |
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12 | #define ALI_PREALIGNER_SUB 2 |
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13 | #define ALI_PREALIGNER_DEL 3 |
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14 | #define ALI_PREALIGNER_MULTI_FLAG 4 |
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15 | |
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16 | |
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17 | |
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18 | struct ALI_PREALIGNER_CONTEXT { |
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19 | long max_number_of_maps; |
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20 | long max_number_of_maps_aligner; |
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21 | int intervall_border; |
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22 | int intervall_center; |
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23 | float max_cost_of_sub_percent; |
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24 | float max_cost_of_helix; |
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25 | unsigned long error_count; |
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26 | }; |
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27 | |
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28 | /* |
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29 | * Structure for a cell in the (simple) distance matrix |
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30 | */ |
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31 | struct ali_prealigner_cell { |
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32 | float d; |
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33 | |
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34 | ali_prealigner_cell(void) { |
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35 | d = 0.0; |
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36 | } |
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37 | }; |
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38 | |
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39 | /* |
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40 | * Structure for a column in the (simple) distance matrix |
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41 | */ |
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42 | struct ali_prealigner_column { |
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43 | unsigned long column_length; |
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44 | //ali_prealigner_cell (*cells)[]; |
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45 | ali_prealigner_cell **cells; |
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46 | |
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47 | ali_prealigner_column(unsigned long length) { |
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48 | column_length = length; |
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49 | //cells = (ali_prealigner_cell (*) [0]) calloc((unsigned int) column_length, sizeof(ali_prealigner_cell)); |
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50 | //cells = (ali_prealigner_cell (*) [1]) calloc((unsigned int) column_length, sizeof(ali_prealigner_cell)); |
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51 | cells = (ali_prealigner_cell **) calloc((unsigned int) column_length, sizeof(ali_prealigner_cell)); |
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52 | if (cells == 0) |
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53 | ali_fatal_error("Out of memory"); |
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54 | } |
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55 | ~ali_prealigner_column(void) { |
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56 | if (cells) |
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57 | free((char *) cells); |
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58 | } |
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59 | }; |
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60 | |
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61 | /* |
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62 | * Structure for the intersection of maps |
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63 | */ |
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64 | struct ali_prealigner_mask { |
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65 | ALI_MAP *map; |
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66 | float cost_of_binding; |
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67 | |
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68 | unsigned long calls, joins, last_new, last_joins; |
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69 | |
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70 | ali_prealigner_mask(void) { |
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71 | last_new = last_joins = 0; |
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72 | map = 0; |
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73 | calls = joins = 0; |
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74 | } |
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75 | |
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76 | void insert(ALI_MAP *in_map, float costs); |
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77 | void delete_expensive(ALI_PREALIGNER_CONTEXT *context,ALI_PROFILE *profile); |
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78 | void clear(void) { |
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79 | last_new = last_joins = 0; |
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80 | delete map; |
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81 | calls = joins = 0; |
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82 | } |
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83 | }; |
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84 | |
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85 | /* |
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86 | * Structure for a approximation of a map |
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87 | */ |
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88 | struct ali_prealigner_approx_element { |
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89 | ALI_MAP *map; |
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90 | char *ins_marker; |
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91 | |
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92 | ali_prealigner_approx_element(ALI_MAP *m = 0, char *im = 0) { |
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93 | map = m; |
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94 | ins_marker = im; |
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95 | } |
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96 | ~ali_prealigner_approx_element(void) { |
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97 | /* |
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98 | if (map) |
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99 | delete map; |
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100 | if (ins_marker) |
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101 | free((char *) ins_marker); |
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102 | */ |
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103 | } |
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104 | void print(void) { |
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105 | printf("map = %p, ins_marker = %p\n",map,ins_marker); |
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106 | map->print(); |
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107 | printf("<%20s>\n",ins_marker); |
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108 | } |
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109 | }; |
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110 | |
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111 | /* |
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112 | * Structure for a list of approximated maps |
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113 | */ |
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114 | struct ali_prealigner_approximation { |
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115 | ALI_TLIST<ali_prealigner_approx_element *> *approx_list; |
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116 | float cost_of_binding; |
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117 | |
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118 | ali_prealigner_approximation(void) { |
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119 | cost_of_binding = 0.0; |
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120 | approx_list = new ALI_TLIST<ali_prealigner_approx_element *>; |
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121 | } |
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122 | ~ali_prealigner_approximation(void) { |
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123 | if (approx_list) { |
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124 | clear(); |
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125 | delete approx_list; |
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126 | } |
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127 | } |
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128 | |
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129 | /* |
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130 | * Insert a new approximation (dependence of the costs) |
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131 | */ |
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132 | void insert(ALI_MAP *in_map, char *in_insert_marker, float costs) { |
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133 | ali_prealigner_approx_element *approx_elem; |
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134 | |
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135 | if (approx_list == 0) |
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136 | approx_list = new ALI_TLIST<ali_prealigner_approx_element *>; |
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137 | |
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138 | if (costs < cost_of_binding || approx_list->is_empty()) { |
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139 | cost_of_binding = costs; |
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140 | clear(); |
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141 | } |
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142 | |
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143 | if (costs == cost_of_binding) { |
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144 | if (approx_list->cardinality() < 20) { |
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145 | approx_elem = new ali_prealigner_approx_element(in_map, |
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146 | in_insert_marker); |
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147 | |
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148 | approx_list->append_end(approx_elem); |
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149 | } |
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150 | else { |
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151 | delete in_map; |
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152 | delete in_insert_marker; |
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153 | } |
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154 | } |
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155 | else { |
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156 | delete in_map; |
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157 | delete in_insert_marker; |
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158 | } |
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159 | } |
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160 | ALI_TLIST<ali_prealigner_approx_element *> *list(void) { |
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161 | ALI_TLIST<ali_prealigner_approx_element *> *ret_list; |
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162 | ret_list = approx_list; |
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163 | approx_list = 0; |
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164 | return ret_list; |
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165 | } |
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166 | void clear(void) { |
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167 | if (approx_list) { |
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168 | if (!approx_list->is_empty()) { |
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169 | delete approx_list->first(); |
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170 | while (approx_list->is_next()) |
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171 | delete approx_list->next(); |
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172 | approx_list->make_empty(); |
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173 | } |
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174 | } |
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175 | } |
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176 | void print(void) { |
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177 | ali_prealigner_approx_element *approx_elem; |
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178 | printf("\nList of Approximations\n"); |
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179 | printf("cost_of_binding = %f\n",cost_of_binding); |
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180 | if (approx_list) { |
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181 | if (!approx_list->is_empty()) { |
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182 | approx_elem = approx_list->first(); |
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183 | approx_elem->print(); |
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184 | while (approx_list->is_next()) { |
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185 | approx_elem = approx_list->next(); |
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186 | approx_elem->print(); |
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187 | } |
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188 | } |
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189 | else { |
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190 | printf("List is empty\n"); |
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191 | } |
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192 | } |
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193 | else { |
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194 | printf("List not existent\n"); |
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195 | } |
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196 | } |
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197 | }; |
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198 | |
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199 | |
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200 | |
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201 | /* |
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202 | * Class of the prealigner |
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203 | */ |
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204 | class ALI_PREALIGNER { |
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205 | ALI_PROFILE *profile; |
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206 | ALI_PATHMAP *path_map; |
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207 | ALI_SUB_SOLUTION *sub_solution; |
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208 | |
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209 | ali_prealigner_mask result_mask; |
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210 | unsigned long result_mask_counter; |
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211 | unsigned long start_x, end_x, start_y, end_y; |
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212 | ali_prealigner_approximation result_approx; |
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213 | |
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214 | float minimum2(float a, float b); |
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215 | float minimum3(float a, float b, float c); |
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216 | |
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217 | void calculate_first_column_first_cell(ali_prealigner_cell *akt_cell); |
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218 | void calculate_first_column_cell(ali_prealigner_cell *up_cell, |
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219 | ali_prealigner_cell *akt_cell, |
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220 | unsigned long pos_y); |
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221 | void calculate_first_column(ali_prealigner_column *akt_column); |
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222 | |
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223 | void calculate_first_cell(ali_prealigner_cell *left_cell, |
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224 | ali_prealigner_cell *akt_cell, |
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225 | unsigned long pos_x); |
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226 | void calculate_cell( |
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227 | ali_prealigner_cell *diag_cell, ali_prealigner_cell *left_cell, |
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228 | ali_prealigner_cell *up_cell, ali_prealigner_cell *akt_cell, |
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229 | unsigned long pos_x, unsigned long pos_y); |
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230 | void calculate_column(ali_prealigner_column *prev_col, |
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231 | ali_prealigner_column *akt_col, |
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232 | unsigned long pos_x); |
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233 | |
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234 | void calculate_last_column_first_cell(ali_prealigner_cell *left_cell, |
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235 | ali_prealigner_cell *akt_cell, |
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236 | unsigned long pos_x); |
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237 | void calculate_last_column_cell( |
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238 | ali_prealigner_cell *diag_cell, ali_prealigner_cell *left_cell, |
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239 | ali_prealigner_cell *up_cell, ali_prealigner_cell *akt_cell, |
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240 | unsigned long pos_x, unsigned long pos_y); |
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241 | void calculate_last_column(ali_prealigner_column *prev_col, |
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242 | ali_prealigner_column *akt_col, |
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243 | unsigned long pos_x); |
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244 | |
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245 | void calculate_matrix(void); |
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246 | |
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247 | int find_multiple_path(unsigned long start_x, unsigned long start_y, |
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248 | unsigned long *end_x, unsigned long *end_y); |
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249 | void generate_solution(ALI_MAP *map); |
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250 | void generate_result_mask(ALI_TSTACK<unsigned char> *stack); |
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251 | void mapper_pre(ALI_TSTACK<unsigned char> *stack, |
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252 | unsigned long pos_x, unsigned long pos_y); |
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253 | void mapper_post(ALI_TSTACK<unsigned char> *stack, |
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254 | unsigned long pos_x, unsigned long pos_y); |
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255 | void mapper_post_multi(ALI_TSTACK<unsigned char> *stack, |
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256 | unsigned long pos_x, unsigned long pos_y); |
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257 | void mapper_random(ALI_TSTACK<unsigned char> *stack, |
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258 | unsigned long pos_x, unsigned long pos_y); |
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259 | void mapper(ALI_TSTACK<unsigned char> *stack, |
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260 | unsigned long pos_x, unsigned long pos_y); |
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261 | void quick_mapper(ALI_TSTACK<unsigned char> *stack, |
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262 | unsigned long pos_x, unsigned long pos_y); |
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263 | void make_map(void); |
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264 | void make_quick_map(void); |
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265 | |
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266 | void generate_approximation(ALI_SUB_SOLUTION *work_sol); |
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267 | void mapper_approximation(unsigned long area_number, |
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268 | ALI_TARRAY<ALI_TLIST<ALI_MAP *> *> *map_lists, |
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269 | ALI_SUB_SOLUTION *work_sol); |
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270 | void make_approximation(ALI_PREALIGNER_CONTEXT *context); |
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271 | |
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272 | unsigned long number_of_solutions(void); |
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273 | |
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274 | public: |
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275 | |
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276 | ALI_PREALIGNER(ALI_PREALIGNER_CONTEXT *context, ALI_PROFILE *profile, |
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277 | unsigned long start_x, unsigned long end_x, |
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278 | unsigned long start_y, unsigned long end_y); |
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279 | ~ALI_PREALIGNER(void) { |
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280 | if (sub_solution) |
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281 | delete sub_solution; |
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282 | } |
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283 | |
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284 | ALI_SEQUENCE *sequence(void) { |
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285 | return result_mask.map->sequence(profile->sequence()); |
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286 | } |
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287 | ALI_SEQUENCE *sequence_without_inserts(void) { |
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288 | return result_mask.map->sequence_without_inserts(profile->sequence()); |
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289 | } |
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290 | ALI_SUB_SOLUTION *solution(void) { |
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291 | ALI_SUB_SOLUTION *ret_sol = sub_solution; |
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292 | sub_solution = 0; |
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293 | return ret_sol; |
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294 | } |
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295 | ALI_TLIST<ali_prealigner_approx_element *> *approximation(void) { |
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296 | return result_approx.list(); |
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297 | } |
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298 | }; |
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299 | |
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300 | |
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301 | #endif |
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302 | |
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