1 | #include <stdio.h> |
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2 | #include <stdlib.h> |
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3 | #include <string.h> |
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4 | #include <ctype.h> |
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5 | |
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6 | #include <arbdb.h> |
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7 | #include <arbdbt.h> |
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8 | #include <aw_root.hxx> |
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9 | #include <aw_device.hxx> |
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10 | #include <aw_awars.hxx> |
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11 | #include <aw_window.hxx> |
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12 | #include <awt.hxx> |
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13 | #include <awt_pro_a_nucs.hxx> |
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14 | #include <awt_codon_table.hxx> |
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15 | |
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16 | extern GBDATA *gb_main; |
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17 | |
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18 | int awt_pro_a_nucs_convert(char *data, long size, int pos) |
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19 | { |
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20 | char *p,c; |
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21 | int C; |
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22 | char *dest; |
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23 | char buffer[4]; |
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24 | long i; |
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25 | int stops = 0; |
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26 | for (p = data; *p ; p++) { |
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27 | c = *p; |
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28 | if ((c>='a') &&(c<='z') ) c=c+'A'-'a'; |
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29 | if (c=='U') c= 'T'; |
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30 | *p = c; |
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31 | } |
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32 | buffer[3] = 0; |
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33 | dest = data; |
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34 | for (p = data+pos,i=pos;i+2<size ;p+=3,i+=3){ |
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35 | buffer[0] = p[0]; |
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36 | buffer[1] = p[1]; |
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37 | buffer[2] = p[2]; |
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38 | int spro = (int)GBS_read_hash(awt_pro_a_nucs->t2i_hash,buffer); |
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39 | if (!spro) { |
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40 | C = 'X'; |
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41 | }else{ |
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42 | if (spro == '*') stops++; |
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43 | C = spro; |
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44 | if (spro == 's') C = 'S'; |
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45 | } |
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46 | *(dest++) = (char)C; |
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47 | } |
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48 | *(dest++) = 0; |
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49 | return stops; |
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50 | } |
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51 | |
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52 | GB_ERROR arb_r2a(GBDATA *gbmain, int startpos, char *ali_source, char *ali_dest) |
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53 | { |
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54 | GBDATA *gb_source; |
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55 | GBDATA *gb_dest; |
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56 | GBDATA *gb_species; |
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57 | GBDATA *gb_source_data; |
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58 | GBDATA *gb_dest_data; |
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59 | GB_ERROR error = 0; |
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60 | char *data; |
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61 | int count = 0; |
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62 | int stops = 0; |
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63 | |
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64 | gb_source = GBT_get_alignment(gbmain,ali_source); |
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65 | if (!gb_source) return "Please select a valid source alignment"; |
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66 | gb_dest = GBT_get_alignment(gbmain,ali_dest); |
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67 | if (!gb_dest) { |
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68 | char *msg = strdup(GBS_global_string( |
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69 | "You have not selected a destination alingment\n" |
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70 | "May I create one ('%s_pro') for you",ali_source)); |
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71 | if (aw_message(msg,"CREATE,CANCEL")){ |
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72 | delete msg; |
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73 | return "Cancelled"; |
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74 | } |
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75 | long slen = GBT_get_alignment_len(gbmain,ali_source); |
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76 | delete msg; |
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77 | ali_dest = strdup(GBS_global_string("%s_pro",ali_source)); |
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78 | gb_dest = GBT_create_alignment(gbmain,ali_dest,slen/3+1,0,1,"ami"); |
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79 | { |
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80 | char *fname = strdup(GBS_global_string("%s/data",ali_dest)); |
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81 | awt_add_new_changekey( gbmain,fname,GB_STRING); |
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82 | delete fname; |
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83 | } |
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84 | |
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85 | if (!gb_dest){ |
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86 | aw_closestatus(); |
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87 | return GB_get_error(); |
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88 | } |
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89 | } |
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90 | |
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91 | aw_openstatus("Translating"); |
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92 | int spec_count = GBT_count_species(gbmain); |
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93 | int spec_i = 0; |
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94 | |
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95 | for ( gb_species = GBT_first_marked_species(gbmain); |
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96 | gb_species; |
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97 | gb_species = GBT_next_marked_species(gb_species) ){ |
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98 | if (aw_status(double(spec_i++)/double(spec_count))){ |
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99 | error = "Aborted"; |
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100 | break; |
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101 | } |
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102 | gb_source = GB_find(gb_species,ali_source,0,down_level); |
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103 | if (!gb_source) continue; |
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104 | gb_source_data = GB_find(gb_source,"data",0,down_level); |
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105 | if (!gb_source_data) continue; |
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106 | data = GB_read_string(gb_source_data); |
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107 | if (!data) { |
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108 | GB_print_error(); |
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109 | continue; |
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110 | } |
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111 | stops += awt_pro_a_nucs_convert( |
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112 | data, |
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113 | GB_read_string_count(gb_source_data), |
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114 | startpos); |
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115 | count ++; |
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116 | gb_dest_data = GBT_add_data(gb_species,ali_dest,"data", GB_STRING); |
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117 | if (!gb_dest_data) return GB_get_error(); |
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118 | error = GB_write_string(gb_dest_data,data); |
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119 | free(data); |
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120 | if (error) break; |
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121 | } |
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122 | aw_closestatus(); |
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123 | if (!error){ |
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124 | char msg[256]; |
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125 | sprintf(msg, |
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126 | "%i taxa converted\n" |
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127 | " %f stops per sequence found",count,(double)stops/(double)count); |
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128 | aw_message(msg); |
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129 | } |
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130 | return error; |
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131 | } |
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132 | |
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133 | void transpro_event(AW_window *aww){ |
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134 | AW_root *aw_root = aww->get_root(); |
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135 | GB_ERROR error; |
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136 | GB_begin_transaction(gb_main); |
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137 | |
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138 | #if defined(DEBUG) && 0 |
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139 | test_AWT_get_codons(); |
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140 | #endif |
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141 | awt_pro_a_nucs_convert_init(gb_main); |
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142 | char *ali_source = aw_root->awar("transpro/source")->read_string(); |
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143 | char *ali_dest = aw_root->awar("transpro/dest")->read_string(); |
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144 | int startpos = (int)aw_root->awar("transpro/pos")->read_int(); |
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145 | |
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146 | error = arb_r2a(gb_main, startpos,ali_source,ali_dest); |
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147 | if (error) { |
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148 | GB_abort_transaction(gb_main); |
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149 | aw_message(error); |
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150 | }else{ |
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151 | GBT_check_data(gb_main,0); |
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152 | GB_commit_transaction(gb_main); |
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153 | } |
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154 | |
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155 | delete ali_source; |
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156 | delete ali_dest; |
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157 | } |
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158 | |
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159 | void nt_trans_cursorpos_changed(AW_root *awr) { |
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160 | int pos = awr->awar(AWAR_CURSOR_POSITION)->read_int()-1; |
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161 | pos = pos %3; |
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162 | awr->awar("transpro/pos")->write_int(pos); |
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163 | } |
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164 | |
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165 | AW_window *create_dna_2_pro_window(AW_root *root) { |
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166 | AWUSE(root); |
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167 | GB_transaction dummy(gb_main); |
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168 | |
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169 | AW_window_simple *aws = new AW_window_simple; |
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170 | aws->init( root, "TRANSLATE_DNA_TO_PRO", "TRANSLATE DNA TO PRO", 10, 10 ); |
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171 | |
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172 | aws->load_xfig("transpro.fig"); |
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173 | |
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174 | aws->callback( (AW_CB0)AW_POPDOWN); |
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175 | aws->at("close"); |
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176 | aws->create_button("CLOSE","CLOSE","C"); |
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177 | |
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178 | aws->callback( AW_POPUP_HELP,(AW_CL)"translate_dna_2_pro.hlp"); |
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179 | aws->at("help"); |
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180 | aws->create_button("HELP","HELP","H"); |
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181 | |
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182 | aws->at("source"); |
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183 | awt_create_selection_list_on_ad(gb_main,(AW_window *)aws, |
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184 | "transpro/source","dna=:rna="); |
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185 | |
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186 | aws->at("dest"); |
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187 | awt_create_selection_list_on_ad(gb_main,(AW_window *)aws, |
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188 | "transpro/dest","pro=:ami="); |
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189 | |
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190 | root->awar_int(AP_PRO_TYPE_AWAR, 0, gb_main); |
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191 | aws->at("table"); |
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192 | aws->create_option_menu(AP_PRO_TYPE_AWAR); |
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193 | for (int code_nr=0; code_nr<AWT_CODON_CODES; code_nr++) { |
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194 | aws->insert_option(AWT_get_codon_code_name(code_nr), "", code_nr); |
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195 | } |
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196 | aws->update_option_menu(); |
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197 | |
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198 | // { |
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199 | // aws->insert_option("Universal","U",AP_UNIVERSAL); |
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200 | // aws->insert_option("Mito","M",AP_MITO); |
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201 | // aws->insert_option("Vert-Mito","V",AP_VERTMITO); |
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202 | // aws->insert_option("Fly-Mito","F",AP_FLYMITO); |
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203 | // aws->insert_option("Yeast-Mito","Y",AP_YEASTMITO); |
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204 | // aws->update_option_menu(); |
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205 | // } |
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206 | |
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207 | aws->at("pos"); |
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208 | aws->create_option_menu("transpro/pos",0,""); |
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209 | aws->insert_option( "1", "1", 0 ); |
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210 | aws->insert_option( "2", "2", 1 ); |
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211 | aws->insert_option( "3", "3", 2 ); |
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212 | aws->update_option_menu(); |
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213 | |
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214 | aws->get_root()->awar_int(AWAR_CURSOR_POSITION)->add_callback(nt_trans_cursorpos_changed); |
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215 | |
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216 | aws->at("translate"); |
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217 | aws->callback(transpro_event); |
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218 | aws->highlight(); |
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219 | aws->create_button("TRANSLATE","TRANSLATE","T"); |
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220 | |
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221 | return (AW_window *)aws; |
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222 | } |
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223 | |
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224 | // Realign a dna alignment with a given protein source |
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225 | |
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226 | #if 1 |
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227 | |
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228 | static int synchronizeCodons(const char *proteins, const char *dna, int minCatchUp, int maxCatchUp, int *foundCatchUp, |
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229 | const AWT_allowedCode& initially_allowed_code, AWT_allowedCode& allowed_code_left) { |
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230 | |
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231 | for (int catchUp=minCatchUp; catchUp<=maxCatchUp; catchUp++) { |
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232 | const char *dna_start = dna+catchUp; |
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233 | AWT_allowedCode allowed_code; |
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234 | allowed_code = initially_allowed_code; |
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235 | |
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236 | for (int p=0; ; p++) { |
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237 | char prot = proteins[p]; |
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238 | |
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239 | if (!prot) { // all proteins were synchronized |
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240 | *foundCatchUp = catchUp; |
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241 | return 1; |
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242 | } |
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243 | |
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244 | if (!AWT_is_codon(prot, dna_start, allowed_code, allowed_code_left)) break; |
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245 | |
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246 | allowed_code = allowed_code_left; // if synchronized: use left codes as allowed codes! |
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247 | dna_start += 3; |
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248 | } |
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249 | } |
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250 | |
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251 | return 0; |
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252 | } |
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253 | |
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254 | #define SYNC_LENGTH 4 |
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255 | // every X in amino-alignment, it represents 1 to 3 bases in DNA-Alignment |
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256 | // SYNC_LENGTH is the # of codons which will be syncronized (ahead!) |
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257 | // before deciding "X was realigned correctly" |
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258 | |
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259 | GB_ERROR arb_transdna(GBDATA *gbmain, char *ali_source, char *ali_dest) |
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260 | { |
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261 | // GBDATA *gb_source; |
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262 | // GBDATA *gb_dest; |
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263 | // GBDATA *gb_species; |
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264 | // GBDATA *gb_source_data; |
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265 | // GBDATA *gb_dest_data; |
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266 | // GB_ERROR error; |
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267 | // char *source; |
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268 | // char *dest; |
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269 | // char *buffer; |
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270 | |
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271 | AWT_initialize_codon_tables(); |
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272 | #if defined(DEBUG) && 0 |
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273 | AWT_dump_codons(); |
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274 | #endif |
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275 | |
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276 | GBDATA *gb_source = GBT_get_alignment(gbmain,ali_source); if (!gb_source) return "Please select a valid source alignment"; |
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277 | GBDATA *gb_dest = GBT_get_alignment(gbmain,ali_dest); if (!gb_dest) return "Please select a valid destination alignment"; |
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278 | |
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279 | long ali_len = GBT_get_alignment_len(gbmain,ali_dest); |
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280 | GB_ERROR error = 0; |
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281 | |
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282 | aw_openstatus("Re-aligner"); |
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283 | int no_of_marked_species = GBT_count_marked_species(gbmain); |
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284 | int no_of_realigned_species = 0; |
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285 | int ignore_fail_pos = 0; |
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286 | |
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287 | for (GBDATA *gb_species = GBT_first_marked_species(gbmain); |
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288 | !error && gb_species; |
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289 | gb_species = GBT_next_marked_species(gb_species) ) { |
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290 | |
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291 | { |
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292 | char stat[200]; |
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293 | |
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294 | sprintf(stat, "Re-aligning #%i of %i ...", no_of_realigned_species+1, no_of_marked_species); |
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295 | aw_status(stat); |
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296 | } |
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297 | |
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298 | gb_source = GB_find(gb_species,ali_source,0,down_level); if (!gb_source) continue; |
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299 | GBDATA *gb_source_data = GB_find(gb_source,"data",0,down_level);if (!gb_source_data) continue; |
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300 | gb_dest = GB_find(gb_species,ali_dest,0,down_level); if (!gb_dest) continue; |
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301 | GBDATA *gb_dest_data = GB_find(gb_dest,"data",0,down_level); if (!gb_dest_data) continue; |
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302 | |
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303 | char *source = GB_read_string(gb_source_data); if (!source) { GB_print_error(); continue; } |
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304 | char *dest = GB_read_string(gb_dest_data); if (!dest) { GB_print_error(); continue; } |
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305 | |
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306 | long source_len = GB_read_string_count(gb_source_data); |
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307 | long dest_len = GB_read_string_count(gb_dest_data); |
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308 | |
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309 | // compress destination DNA (=remove align-characters): |
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310 | char *compressed_dest = (char*)malloc(dest_len+1); |
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311 | { |
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312 | char *f = dest; |
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313 | char *t = compressed_dest; |
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314 | |
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315 | while (1) { |
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316 | char c = *f++; |
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317 | if (!c) break; |
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318 | if (c!='.' && c!='-') *t++ = c; |
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319 | } |
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320 | *t = 0; |
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321 | } |
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322 | |
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323 | int failed = 0; |
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324 | const char *fail_reason = 0; |
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325 | |
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326 | char *buffer = (char*)malloc(ali_len+1); |
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327 | if (ali_len<source_len*3) { |
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328 | failed = 1; |
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329 | fail_reason = GBS_global_string("Alignment '%s' is too short (increase its length at ARB_NT/Sequence/Admin to %li)", ali_dest, source_len*3L); |
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330 | ignore_fail_pos = 1; |
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331 | } |
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332 | |
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333 | AWT_allowedCode allowed_code; |
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334 | |
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335 | char *d = compressed_dest; |
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336 | char *s = source; |
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337 | |
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338 | if (!failed) { |
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339 | char *p = buffer; |
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340 | int x_count = 0; |
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341 | const char *x_start = 0; |
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342 | |
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343 | for (;;) { |
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344 | char c = *s++; |
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345 | if (!c) { |
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346 | if (x_count) { |
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347 | int off = -(x_count*3); |
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348 | while (d[0]) { |
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349 | p[off++] = *d++; |
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350 | } |
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351 | } |
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352 | break; |
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353 | } |
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354 | |
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355 | if (c=='.' || c=='-') { |
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356 | p[0] = p[1] = p[2] = c; |
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357 | p += 3; |
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358 | } |
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359 | else if (toupper(c)=='X') { // one X represents 1 to 3 DNAs |
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360 | x_start = s-1; |
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361 | x_count = 1; |
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362 | int gap_count = 0; |
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363 | |
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364 | for (;;) { |
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365 | char c2 = toupper(s[0]); |
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366 | |
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367 | if (c2=='X') { |
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368 | x_count++; |
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369 | } |
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370 | else { |
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371 | if (c2!='.' && c2!='-') break; |
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372 | gap_count++; |
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373 | } |
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374 | s++; |
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375 | } |
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376 | |
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377 | int setgap = (x_count+gap_count)*3; |
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378 | memset(p, '.', setgap); |
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379 | p += setgap; |
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380 | } |
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381 | else { |
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382 | AWT_allowedCode allowed_code_left; |
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383 | |
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384 | if (x_count) { // synchronize |
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385 | char protein[SYNC_LENGTH+1]; |
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386 | int count; |
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387 | { |
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388 | int off; |
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389 | |
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390 | protein[0] = toupper(c); |
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391 | for (count=1,off=0; count<SYNC_LENGTH; off++) { |
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392 | char c2 = s[off]; |
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393 | |
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394 | if (c2!='.' && c2!='-') { |
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395 | c2 = toupper(c2); |
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396 | if (c2=='X') break; // can't sync X |
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397 | protein[count++] = c2; |
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398 | } |
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399 | } |
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400 | } |
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401 | |
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402 | gb_assert(count>=1); |
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403 | protein[count] = 0; |
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404 | |
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405 | int catchUp; |
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406 | if (count<SYNC_LENGTH) { |
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407 | int sync_possibilities = 0; |
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408 | int *sync_possible_with_catchup = new int[x_count*3+1]; |
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409 | int maxCatchup = x_count*3; |
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410 | |
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411 | catchUp = x_count-1; |
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412 | for (;;) { |
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413 | if (!synchronizeCodons(protein, d, catchUp+1, maxCatchup, &catchUp, allowed_code, allowed_code_left)) { |
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414 | break; |
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415 | } |
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416 | sync_possible_with_catchup[sync_possibilities++] = catchUp; |
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417 | } |
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418 | |
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419 | if (sync_possibilities==0) { |
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420 | delete sync_possible_with_catchup; |
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421 | failed = 1; |
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422 | fail_reason = "Can't syncronize after 'X'"; |
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423 | break; |
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424 | } |
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425 | if (sync_possibilities>1) { |
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426 | delete sync_possible_with_catchup; |
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427 | failed = 1; |
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428 | fail_reason = "Not enough data behind 'X' (please contact ARB-Support)"; |
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429 | break; |
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430 | } |
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431 | |
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432 | gb_assert(sync_possibilities==1); |
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433 | catchUp = sync_possible_with_catchup[0]; |
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434 | delete sync_possible_with_catchup; |
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435 | } |
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436 | else if (!synchronizeCodons(protein, d, x_count, x_count*3, &catchUp, allowed_code, allowed_code_left)) { |
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437 | failed = 1; |
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438 | fail_reason = "Can't syncronize after 'X'"; |
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439 | break; |
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440 | } |
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441 | |
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442 | allowed_code = allowed_code_left; |
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443 | |
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444 | // copy 'catchUp' characters (they are the content of the found Xs): |
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445 | { |
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446 | const char *after = s-1; |
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447 | const char *i; |
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448 | int off = int(after-x_start); |
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449 | gb_assert(off>=x_count); |
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450 | off = -(off*3); |
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451 | int x_rest = x_count; |
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452 | |
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453 | for (i=x_start; i<after; i++) { |
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454 | switch (i[0]) { |
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455 | case 'x': |
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456 | case 'X': |
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457 | { |
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458 | int take_per_X = catchUp/x_rest; |
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459 | int o; |
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460 | for (o=0; o<3; o++) { |
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461 | if (o<take_per_X) { |
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462 | p[off++] = *d++; |
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463 | } |
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464 | else { |
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465 | p[off++] = '.'; |
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466 | } |
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467 | } |
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468 | x_rest--; |
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469 | break; |
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470 | } |
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471 | case '.': |
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472 | case '-': |
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473 | p[off++] = i[0]; |
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474 | p[off++] = i[0]; |
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475 | p[off++] = i[0]; |
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476 | break; |
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477 | default: |
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478 | gb_assert(0); |
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479 | break; |
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480 | } |
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481 | } |
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482 | } |
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483 | x_count = 0; |
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484 | } |
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485 | else { |
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486 | if (!AWT_is_codon(c, d, allowed_code, allowed_code_left)) { |
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487 | failed = 1; |
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488 | fail_reason = "Not a codon"; |
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489 | break; |
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490 | } |
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491 | |
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492 | allowed_code = allowed_code_left; |
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493 | } |
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494 | |
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495 | // copy one codon: |
---|
496 | p[0] = d[0]; |
---|
497 | p[1] = d[1]; |
---|
498 | p[2] = d[2]; |
---|
499 | |
---|
500 | p += 3; |
---|
501 | d += 3; |
---|
502 | } |
---|
503 | } |
---|
504 | |
---|
505 | if (!failed) { |
---|
506 | int len = p-buffer; |
---|
507 | int rest = ali_len-len; |
---|
508 | |
---|
509 | memset(p, '.', rest); |
---|
510 | p += rest; |
---|
511 | p[0] = 0; |
---|
512 | } |
---|
513 | } |
---|
514 | |
---|
515 | if (failed) { |
---|
516 | int source_fail_pos = (s-1)-source+1; |
---|
517 | int dest_fail_pos = 0; |
---|
518 | { |
---|
519 | int fail_d_base_count = d-compressed_dest; |
---|
520 | char *dp = dest; |
---|
521 | |
---|
522 | for (;;) { |
---|
523 | char c = *dp++; |
---|
524 | |
---|
525 | if (!c) { |
---|
526 | gb_assert(c); |
---|
527 | break; |
---|
528 | } |
---|
529 | if (c!='.' && c!='-') { |
---|
530 | if (!fail_d_base_count) { |
---|
531 | dest_fail_pos = (dp-1)-dest+1; |
---|
532 | break; |
---|
533 | } |
---|
534 | fail_d_base_count--; |
---|
535 | } |
---|
536 | } |
---|
537 | } |
---|
538 | |
---|
539 | { |
---|
540 | char *name = GBT_read_name(gb_species); |
---|
541 | if (!name) name = strdup("(unknown species)"); |
---|
542 | |
---|
543 | char *dup_fail_reason = strdup(fail_reason); // otherwise it may be destroyed by GBS_global_string |
---|
544 | aw_message(GBS_global_string("Automatic re-align failed for '%s'", name)); |
---|
545 | |
---|
546 | if (ignore_fail_pos) { |
---|
547 | aw_message(GBS_global_string("Reason: %s", dup_fail_reason)); |
---|
548 | } |
---|
549 | else { |
---|
550 | aw_message(GBS_global_string("Reason: %s at %s:%i / %s:%i", dup_fail_reason, ali_source, source_fail_pos, ali_dest, dest_fail_pos)); |
---|
551 | } |
---|
552 | |
---|
553 | free(dup_fail_reason); |
---|
554 | free(name); |
---|
555 | } |
---|
556 | } |
---|
557 | else { |
---|
558 | gb_assert(strlen(buffer)==(unsigned)ali_len); |
---|
559 | error = GB_write_string(gb_dest_data,buffer); |
---|
560 | } |
---|
561 | |
---|
562 | free(buffer); |
---|
563 | free(compressed_dest); |
---|
564 | free(dest); |
---|
565 | free(source); |
---|
566 | |
---|
567 | no_of_realigned_species++; |
---|
568 | GB_status(double(no_of_realigned_species)/double(no_of_marked_species)); |
---|
569 | } |
---|
570 | aw_closestatus(); |
---|
571 | if (error) return error; |
---|
572 | |
---|
573 | GBT_check_data(gbmain,ali_dest); |
---|
574 | |
---|
575 | return 0; |
---|
576 | } |
---|
577 | |
---|
578 | #undef SYNC_LENGTH |
---|
579 | |
---|
580 | |
---|
581 | #else |
---|
582 | // old version: |
---|
583 | GB_ERROR arb_transdna(GBDATA *gbmain, char *ali_source, char *ali_dest) |
---|
584 | { |
---|
585 | GBDATA *gb_source; |
---|
586 | GBDATA *gb_dest; |
---|
587 | GBDATA *gb_species; |
---|
588 | GBDATA *gb_source_data; |
---|
589 | GBDATA *gb_dest_data; |
---|
590 | GB_ERROR error; |
---|
591 | char *source; |
---|
592 | char *dest; |
---|
593 | char *buffer; |
---|
594 | |
---|
595 | gb_source = GBT_get_alignment(gbmain,ali_source); |
---|
596 | if (!gb_source) return "Please select a valid source alignment"; |
---|
597 | gb_dest = GBT_get_alignment(gbmain,ali_dest); |
---|
598 | if (!gb_dest) return "Please select a valid destination alignment"; |
---|
599 | long dest_len = GBT_get_alignment_len(gbmain,ali_dest); |
---|
600 | |
---|
601 | for (gb_species = GBT_first_marked_species(gbmain); |
---|
602 | gb_species; |
---|
603 | gb_species = GBT_next_marked_species(gb_species) ){ |
---|
604 | |
---|
605 | gb_source = GB_find(gb_species,ali_source,0,down_level); if (!gb_source) continue; |
---|
606 | gb_source_data = GB_find(gb_source,"data",0,down_level); if (!gb_source_data) continue; |
---|
607 | gb_dest = GB_find(gb_species,ali_dest,0,down_level); if (!gb_dest) continue; |
---|
608 | gb_dest_data = GB_find(gb_dest,"data",0,down_level); if (!gb_dest_data) continue; |
---|
609 | |
---|
610 | source = GB_read_string(gb_source_data); if (!source) { GB_print_error(); continue; } |
---|
611 | dest = GB_read_string(gb_dest_data); if (!dest) { GB_print_error(); continue; } |
---|
612 | |
---|
613 | buffer = (char *)calloc(sizeof(char), (size_t)(GB_read_string_count(gb_source_data)*3 + GB_read_string_count(gb_dest_data) + dest_len ) ); |
---|
614 | |
---|
615 | char *p = buffer; |
---|
616 | char *s = source; |
---|
617 | char *d = dest; |
---|
618 | |
---|
619 | char *lastDNA = 0; // pointer to buffer |
---|
620 | |
---|
621 | for (; *s; s++){ /* source is pro */ |
---|
622 | /* insert triple '.' for every '.' |
---|
623 | insert triple '-' for every - |
---|
624 | insert triple for rest */ |
---|
625 | switch (*s){ |
---|
626 | case '.': |
---|
627 | case '-': |
---|
628 | p[0] = p[1] = p[2] = s[0]; |
---|
629 | p += 3; |
---|
630 | break; |
---|
631 | |
---|
632 | default: |
---|
633 | while (*d && (*d=='.' || *d =='-')) d++; |
---|
634 | if(!*d) break; |
---|
635 | |
---|
636 | lastDNA = p; |
---|
637 | *(p++) = *(d++); /* copy dna to dna */ |
---|
638 | |
---|
639 | while (*d && (*d=='.' || *d =='-')) d++; |
---|
640 | if(!*d) break; |
---|
641 | |
---|
642 | lastDNA = p; |
---|
643 | *(p++) = *(d++); /* copy dna to dna */ |
---|
644 | |
---|
645 | while (*d && (*d=='.' || *d =='-')) d++; |
---|
646 | if(!*d) break; |
---|
647 | |
---|
648 | lastDNA = p; |
---|
649 | *(p++) = *(d++); /* copy dna to dna */ |
---|
650 | |
---|
651 | break; |
---|
652 | } |
---|
653 | } |
---|
654 | |
---|
655 | p = lastDNA+1; |
---|
656 | while (*d) { |
---|
657 | if (*d == '.' || *d == '-') { |
---|
658 | d++; |
---|
659 | }else{ |
---|
660 | *(p++) = *(d++); // append rest characters |
---|
661 | } |
---|
662 | } |
---|
663 | |
---|
664 | while ((p-buffer)<dest_len) *(p++) = '.'; // append . |
---|
665 | *p = 0; |
---|
666 | |
---|
667 | gb_assert(strlen(buffer)==dest_len); |
---|
668 | |
---|
669 | error = GB_write_string(gb_dest_data,buffer); |
---|
670 | |
---|
671 | free(source); |
---|
672 | free(dest); |
---|
673 | free(buffer); |
---|
674 | |
---|
675 | if (error) return error; |
---|
676 | } |
---|
677 | |
---|
678 | GBT_check_data(gbmain,ali_dest); |
---|
679 | |
---|
680 | return 0; |
---|
681 | } |
---|
682 | |
---|
683 | #endif |
---|
684 | |
---|
685 | |
---|
686 | void transdna_event(AW_window *aww) |
---|
687 | { |
---|
688 | AW_root *aw_root = aww->get_root(); |
---|
689 | GB_ERROR error; |
---|
690 | |
---|
691 | char *ali_source = aw_root->awar("transpro/dest")->read_string(); |
---|
692 | char *ali_dest = aw_root->awar("transpro/source")->read_string(); |
---|
693 | GB_begin_transaction(gb_main); |
---|
694 | error = arb_transdna(gb_main,ali_source,ali_dest); |
---|
695 | if (error) { |
---|
696 | GB_abort_transaction(gb_main); |
---|
697 | aw_message(error,"OK"); |
---|
698 | }else{ |
---|
699 | GBT_check_data(gb_main,ali_dest); |
---|
700 | GB_commit_transaction(gb_main); |
---|
701 | } |
---|
702 | delete ali_source; |
---|
703 | delete ali_dest; |
---|
704 | |
---|
705 | } |
---|
706 | |
---|
707 | AW_window *create_realign_dna_window(AW_root *root) |
---|
708 | { |
---|
709 | AWUSE(root); |
---|
710 | |
---|
711 | AW_window_simple *aws = new AW_window_simple; |
---|
712 | aws->init( root, "REALIGN_DNA", "REALIGN DNA", 10, 10 ); |
---|
713 | |
---|
714 | aws->load_xfig("transdna.fig"); |
---|
715 | |
---|
716 | aws->callback( (AW_CB0)AW_POPDOWN); |
---|
717 | aws->at("close"); |
---|
718 | aws->create_button("CLOSE","CLOSE","C"); |
---|
719 | |
---|
720 | aws->callback( AW_POPUP_HELP,(AW_CL)"realign_dna.hlp"); |
---|
721 | aws->at("help"); |
---|
722 | aws->create_button("HELP","HELP","H"); |
---|
723 | |
---|
724 | aws->at("source"); |
---|
725 | awt_create_selection_list_on_ad(gb_main,(AW_window *)aws, |
---|
726 | "transpro/source","dna=:rna="); |
---|
727 | aws->at("dest"); |
---|
728 | awt_create_selection_list_on_ad(gb_main,(AW_window *)aws, |
---|
729 | "transpro/dest","pro=:ami="); |
---|
730 | |
---|
731 | aws->at("realign"); |
---|
732 | aws->callback(transdna_event); |
---|
733 | aws->highlight(); |
---|
734 | aws->create_button("REALIGN","REALIGN","T"); |
---|
735 | |
---|
736 | return (AW_window *)aws; |
---|
737 | } |
---|
738 | |
---|
739 | |
---|
740 | void create_transpro_menus(AW_window *awmm) |
---|
741 | { |
---|
742 | awmm->insert_menu_topic("dna_2_pro", "Translate Nucleic to Amino Acid ...","T","translate_dna_2_pro.hlp", AWM_PRO, AW_POPUP, (AW_CL)create_dna_2_pro_window, 0 ); |
---|
743 | awmm->insert_menu_topic("realign_dna", "Realign Nucleic Acid according to Aligned Protein ...","r","realign_dna.hlp", AWM_PRO, AW_POPUP, (AW_CL)create_realign_dna_window, 0 ); |
---|
744 | } |
---|
745 | |
---|
746 | void create_transpro_variables(AW_root *root,AW_default db1) |
---|
747 | { |
---|
748 | root->awar_string( "transpro/source", "" , db1); |
---|
749 | root->awar_string( "transpro/dest", "" , db1); |
---|
750 | root->awar_int( "transpro/pos", 0 , db1); |
---|
751 | } |
---|