1 | // genbank and Macke converting program |
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2 | |
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3 | #include "genbank.h" |
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4 | #include "macke.h" |
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5 | |
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6 | static int paren_string(char *line, char *pstring, int index) { |
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7 | int len = str0len(line); |
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8 | int paren_num = 0; |
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9 | int indk; |
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10 | |
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11 | for (indk = 0; index < len; index++) { |
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12 | if (paren_num >= 1) |
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13 | pstring[indk++] = line[index]; |
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14 | if (line[index] == '(') |
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15 | paren_num++; |
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16 | if (line[index] == ')') |
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17 | paren_num--; |
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18 | } |
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19 | if (indk == 0) |
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20 | return (-1); |
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21 | pstring[--indk] = '\0'; |
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22 | return (index); |
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23 | } |
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24 | |
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25 | static void get_atcc_string(const char *line, char *temp, int index) { |
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26 | // Get the rest of the line until reaching certain terminators, such as ';', ',', '.',... |
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27 | |
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28 | int len = str0len(line); |
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29 | int paren_num = 0; |
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30 | int indk; |
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31 | |
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32 | for (indk = 0; index < len; index++, indk++) { |
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33 | temp[indk] = line[index]; |
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34 | if (temp[indk] == '(') |
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35 | paren_num++; |
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36 | if (temp[indk] == ')') |
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37 | if (paren_num == 0) |
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38 | break; |
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39 | else |
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40 | paren_num--; |
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41 | else if (paren_num == 0 && (temp[indk] == ';' || temp[indk] == '.' || temp[indk] == ',' || temp[indk] == '/' || temp[indk] == '\n')) |
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42 | break; |
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43 | } |
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44 | temp[indk] = '\0'; |
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45 | } |
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46 | |
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47 | static char *get_atcc(const Macke& macke, char *source) { |
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48 | static int cc_num = 16; |
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49 | static const char *CC[16] = { |
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50 | "ATCC", "CCM", "CDC", "CIP", "CNCTC", |
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51 | "DSM", "EPA", "JCM", "NADC", "NCDO", "NCTC", "NRCC", |
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52 | "NRRL", "PCC", "USDA", "VPI" |
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53 | }; |
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54 | |
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55 | int indi, indj, index; |
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56 | int length; |
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57 | char buffer[LONGTEXT], temp[LONGTEXT], pstring[LONGTEXT]; |
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58 | char atcc[LONGTEXT]; |
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59 | |
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60 | atcc[0] = '\0'; |
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61 | for (indi = 0; indi < cc_num; indi++) { |
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62 | index = 0; |
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63 | while ((index = paren_string(source, pstring, index)) > 0) { |
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64 | if ((indj = find_pattern(pstring, CC[indi])) >= 0) { |
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65 | // skip the key word |
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66 | indj += str0len(CC[indi]); |
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67 | // skip blank spaces |
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68 | indj = Skip_white_space(pstring, indj); |
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69 | // get strain |
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70 | get_atcc_string(pstring, buffer, indj); |
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71 | sprintf(temp, "%s %s", CC[indi], buffer); |
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72 | length = str0len(atcc); |
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73 | if (length > 0) { |
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74 | atcc[length] = '\0'; |
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75 | strcat(atcc, ", "); |
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76 | } |
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77 | strcat(atcc, temp); |
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78 | } |
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79 | } |
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80 | } |
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81 | // append eoln to the atcc string |
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82 | length = str0len(atcc); |
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83 | if (macke.atcc) { |
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84 | macke.atcc[length] = '\0'; |
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85 | } |
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86 | strcat(atcc, "\n"); |
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87 | return (nulldup(atcc)); |
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88 | } |
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89 | |
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90 | static char *genbank_get_atcc(const GenBank& gbk, const Macke& macke) { |
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91 | // Get atcc from SOURCE line in Genbank data file. |
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92 | char *atcc = NULL; |
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93 | |
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94 | // get culture collection # |
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95 | if (has_content(gbk.source)) { |
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96 | atcc = get_atcc(macke, gbk.source); |
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97 | } |
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98 | if (!has_content(atcc) && has_content(macke.strain)) { |
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99 | // add () to macke strain to be processed correctly |
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100 | char temp[LONGTEXT]; |
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101 | sprintf(temp, "(%s)", macke.strain); |
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102 | atcc = get_atcc(macke, temp); |
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103 | } |
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104 | return atcc; |
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105 | } |
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106 | |
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107 | void Macke::add_35end_remark(char end35, char yn) { |
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108 | if (yn == ' ') return; |
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109 | |
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110 | char *content = strf("%c' end complete: %s\n", end35, yn == 'y' ? "Yes" : "No"); |
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111 | add_remark(content); |
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112 | free(content); |
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113 | } |
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114 | |
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115 | void Macke::add_remarks_from(const GenbankRef& ref) { |
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116 | add_remark_if_content("ref:", ref.ref); |
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117 | add_remark_if_content("auth:", ref.author); |
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118 | add_remark_if_content("jour:", ref.journal); |
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119 | add_remark_if_content("title:", ref.title); |
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120 | add_remark_if_content("standard:", ref.standard); |
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121 | } |
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122 | |
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123 | void Macke::add_remarks_from(const OrgInfo& orginf) { |
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124 | add_remark_if_content("Source of strain:", orginf.source); // copy source of strain |
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125 | add_remark_if_content("Former name:", orginf.formname); // copy former name |
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126 | add_remark_if_content("Alternate name:", orginf.nickname); // copy alternate name |
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127 | add_remark_if_content("Common name:", orginf.commname); // copy common name |
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128 | add_remark_if_content("Host organism:", orginf.hostorg); // copy host organism |
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129 | } |
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130 | |
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131 | void Macke::add_remarks_from(const RDP_comments& comments) { |
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132 | add_remarks_from(comments.orginf); |
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133 | add_remarks_from(comments.seqinf); |
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134 | |
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135 | // other comments, not RDP DataBase specially defined |
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136 | int len = str0len(comments.others); |
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137 | if (len > 0) { |
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138 | for (int indi = 0, indj = 0; indi < len; indi++) { |
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139 | char temp[LONGTEXT]; |
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140 | temp[indj++] = comments.others[indi]; |
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141 | if (comments.others[indi] == '\n' || comments.others[indi] == '\0') { |
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142 | temp[indj] = '\0'; |
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143 | add_remark(temp); |
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144 | indj = 0; |
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145 | } |
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146 | } |
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147 | } |
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148 | } |
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149 | |
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150 | void Macke::add_remarks_from(const SeqInfo& seqinf) { |
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151 | add_remark_if_content("RDP ID:", seqinf.RDPid); // copy RDP ID |
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152 | add_remark_if_content("Sequencing methods:", seqinf.methods); // copy methods |
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153 | |
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154 | add_35end_remark('3', seqinf.comp3); |
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155 | add_35end_remark('5', seqinf.comp5); |
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156 | } |
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157 | |
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158 | void Macke::add_remarks_from(const GenBank& gbk) { |
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159 | // Create Macke remarks. |
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160 | |
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161 | // REFERENCE the first reference |
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162 | if (gbk.has_refs()) |
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163 | add_remark_if_content("ref:", gbk.get_ref(0).ref); |
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164 | |
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165 | // The rest of the REFERENCES |
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166 | for (int indi = 1; indi < gbk.get_refcount(); indi++) { |
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167 | add_remarks_from(gbk.get_ref(indi)); |
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168 | } |
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169 | |
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170 | add_remark_if_content("KEYWORDS:", gbk.keywords); // copy keywords as remark |
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171 | add_remark_if_content("GenBank ACCESSION:", gbk.accession); // copy accession as remark when genbank entry also exists. |
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172 | add_remarks_from(gbk.comments); |
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173 | } |
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174 | |
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175 | static void correct_subspecies(char *subspecies) { |
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176 | // Remove the strain information in subspecies which is sometime mistakenly written into it. |
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177 | int indj; |
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178 | |
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179 | if ((indj = find_pattern(subspecies, "str\n")) >= 0 || (indj = find_strain(subspecies, 0)) >= 0) { |
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180 | ca_assert(subspecies[indj-1] == ' '); // assume to overwrite a space |
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181 | subspecies[indj - 1] = '\n'; |
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182 | subspecies[indj] = '\0'; |
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183 | } |
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184 | } |
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185 | |
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186 | static void check_consistency(const char *what, char* const& var, const char *New) { |
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187 | if (has_content(var)) { |
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188 | if (!str_equal(var, New)) { |
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189 | warningf(20, "Inconsistent %s definitions detected:\n" |
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190 | " %s" |
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191 | "and %s", what, var, New); |
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192 | } |
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193 | } |
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194 | else { |
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195 | strcpy(var, New); |
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196 | } |
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197 | } |
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198 | |
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199 | static void get_string(char *temp, const char *line, int index) { |
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200 | // Get the rest of the line until reaching certain terminators, |
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201 | // such as ';', ',', '.',... |
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202 | // Always append "\n" at the end of the result. |
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203 | |
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204 | index = Skip_white_space(line, index); |
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205 | |
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206 | int len = str0len(line); |
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207 | int paren_num = 0; |
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208 | int indk; |
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209 | |
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210 | for (indk = 0; index < len; index++, indk++) { |
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211 | temp[indk] = line[index]; |
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212 | if (temp[indk] == '(') |
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213 | paren_num++; |
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214 | if (temp[indk] == ')') |
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215 | if (paren_num == 0) |
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216 | break; |
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217 | else |
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218 | paren_num--; |
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219 | else if (temp[indk] == '\n' || (paren_num == 0 && temp[indk] == ';')) |
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220 | break; |
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221 | } |
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222 | if (indk > 1 && is_end_mark(temp[indk - 1])) |
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223 | indk--; |
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224 | temp[indk++] = '\n'; |
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225 | temp[indk] = '\0'; |
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226 | } |
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227 | |
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228 | static void copy_subspecies_and_check_consistency(char* const& subspecies, const char *from, int indj) { |
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229 | char temp[LONGTEXT]; |
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230 | get_string(temp, from, indj); |
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231 | correct_subspecies(temp); |
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232 | check_consistency("subspecies", subspecies, temp); |
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233 | } |
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234 | static void copy_strain_and_check_consistency(char* const& strain, const char *from, int indj) { |
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235 | char temp[LONGTEXT]; |
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236 | get_string(temp, from, indj); |
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237 | check_consistency("strain", strain, temp); |
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238 | } |
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239 | |
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240 | static void check_strain_from(char* const& strain, const char *from) { |
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241 | if (has_content(from)) { |
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242 | int indj = skip_strain(from, ' '); |
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243 | if (indj >= 0) copy_strain_and_check_consistency(strain, from, indj); |
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244 | } |
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245 | } |
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246 | |
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247 | static char *genbank_get_strain(const GenBank& gbk) { |
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248 | // Get strain from DEFINITION, COMMENT or SOURCE line in Genbank data file. |
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249 | char strain[LONGTEXT]; |
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250 | |
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251 | strain[0] = '\0'; |
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252 | |
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253 | if (has_content(gbk.comments.others)) { |
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254 | int indj = find_pattern(gbk.comments.others, "*source:"); |
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255 | if (indj >= 0) { |
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256 | int indk = skip_pattern(gbk.comments.others + indj, "strain="); |
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257 | if (indk >= 0) copy_strain_and_check_consistency(strain, gbk.comments.others, indj+indk); |
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258 | } |
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259 | } |
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260 | |
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261 | check_strain_from(strain, gbk.definition); |
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262 | check_strain_from(strain, gbk.source); |
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263 | |
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264 | return nulldup(strain); |
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265 | } |
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266 | |
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267 | static char *genbank_get_subspecies(const GenBank& gbk) { |
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268 | // Get subspecies information from SOURCE, DEFINITION, or COMMENT line of Genbank data file. |
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269 | int indj; |
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270 | char subspecies[LONGTEXT]; |
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271 | |
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272 | subspecies[0] = '\0'; |
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273 | |
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274 | if (has_content(gbk.definition)) { |
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275 | if ((indj = skip_pattern(gbk.definition, "subsp. ")) >= 0) { |
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276 | copy_subspecies_and_check_consistency(subspecies, gbk.definition, indj); |
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277 | } |
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278 | } |
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279 | if (has_content(gbk.comments.others)) { |
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280 | if ((indj = find_pattern(gbk.comments.others, "*source:")) >= 0) { |
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281 | int indk = skip_subspecies(gbk.comments.others + indj, '='); |
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282 | if (indk >= 0) { |
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283 | copy_subspecies_and_check_consistency(subspecies, gbk.comments.others, indj+indk); |
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284 | } |
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285 | } |
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286 | } |
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287 | |
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288 | if (has_content(gbk.source)) { |
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289 | if ((indj = skip_subspecies(gbk.source, ' ')) >= 0) { |
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290 | copy_subspecies_and_check_consistency(subspecies, gbk.source, indj); |
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291 | } |
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292 | } |
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293 | |
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294 | return nulldup(subspecies); |
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295 | } |
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296 | |
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297 | static void mtog_decode_ref_and_remarks(const Macke& macke, GenBank& gbk) { |
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298 | // Decode remarks of Macke to GenBank format. |
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299 | ca_assert(gbk.get_refcount() == 0); |
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300 | |
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301 | if (has_content(macke.author)) freedup(gbk.get_new_ref().author, macke.author); |
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302 | if (has_content(macke.journal)) freedup(gbk.get_latest_ref().journal, macke.journal); |
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303 | if (has_content(macke.title)) freedup(gbk.get_latest_ref().title, macke.title); |
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304 | |
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305 | bool first_ref = true; |
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306 | |
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307 | RDP_comments& comments = gbk.comments; |
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308 | OrgInfo& orginf = comments.orginf; |
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309 | SeqInfo& seqinf = comments.seqinf; |
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310 | |
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311 | for (int ridx = 0; ridx < macke.get_rem_count(); ridx++) { |
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312 | char key[TOKENSIZE]; |
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313 | int offset = macke_key_word(macke.get_rem(ridx), 0, key); |
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314 | |
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315 | if (str_equal(key, "ref")) { |
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316 | GenbankRef& ref = first_ref ? gbk.get_latest_ref() : gbk.get_new_ref(); |
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317 | freeset(ref.ref, macke.copy_multi_rem(ridx, offset)); |
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318 | first_ref = false; |
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319 | } |
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320 | else if (str_equal(key, "auth")) { |
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321 | freeset(gbk.get_latest_ref().author, macke.copy_multi_rem(ridx, offset)); |
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322 | } |
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323 | else if (str_equal(key, "title")) { |
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324 | freeset(gbk.get_latest_ref().title, macke.copy_multi_rem(ridx, offset)); |
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325 | } |
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326 | else if (str_equal(key, "jour")) { |
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327 | freeset(gbk.get_latest_ref().journal, macke.copy_multi_rem(ridx, offset)); |
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328 | } |
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329 | else if (str_equal(key, "standard")) { |
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330 | freeset(gbk.get_latest_ref().standard, macke.copy_multi_rem(ridx, offset)); |
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331 | } |
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332 | else if (str_equal(key, "KEYWORDS")) { |
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333 | freeset(gbk.keywords, macke.copy_multi_rem(ridx, offset)); |
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334 | terminate_with(gbk.keywords, '.'); |
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335 | } |
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336 | else if (str_equal(key, "GenBank ACCESSION")) { |
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337 | freeset(gbk.accession, macke.copy_multi_rem(ridx, offset)); |
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338 | } |
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339 | else if (str_equal(key, "Source of strain")) { |
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340 | freeset(orginf.source, macke.copy_multi_rem(ridx, offset)); |
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341 | } |
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342 | else if (str_equal(key, "Former name")) { |
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343 | freeset(orginf.formname, macke.copy_multi_rem(ridx, offset)); |
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344 | } |
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345 | else if (str_equal(key, "Alternate name")) { |
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346 | freeset(orginf.nickname, macke.copy_multi_rem(ridx, offset)); |
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347 | } |
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348 | else if (str_equal(key, "Common name")) { |
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349 | freeset(orginf.commname, macke.copy_multi_rem(ridx, offset)); |
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350 | } |
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351 | else if (str_equal(key, "Host organism")) { |
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352 | freeset(orginf.hostorg, macke.copy_multi_rem(ridx, offset)); |
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353 | } |
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354 | else if (str_equal(key, "RDP ID")) { |
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355 | freeset(seqinf.RDPid, macke.copy_multi_rem(ridx, offset)); |
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356 | } |
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357 | else if (str_equal(key, "Sequencing methods")) { |
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358 | freeset(seqinf.methods, macke.copy_multi_rem(ridx, offset)); |
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359 | } |
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360 | else if (str_equal(key, "3' end complete")) { |
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361 | scan_token_or_die(key, macke.get_rem(ridx) + offset); |
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362 | seqinf.comp3 = str_equal(key, "Yes") ? 'y' : 'n'; |
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363 | } |
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364 | else if (str_equal(key, "5' end complete")) { |
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365 | scan_token_or_die(key, macke.get_rem(ridx) + offset); |
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366 | seqinf.comp5 = str_equal(key, "Yes") ? 'y' : 'n'; |
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367 | } |
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368 | else { // other (non-interpreted) comments |
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369 | Append(comments.others, macke.get_rem(ridx)); |
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370 | } |
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371 | } |
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372 | } |
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373 | |
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374 | static void mtog_genbank_def_and_source(const Macke& macke, GenBank& gbk) { |
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375 | // Define GenBank DEFINITION and SOURCE lines the way RDP group likes. |
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376 | copy_content(gbk.definition, macke.name); |
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377 | if (has_content(macke.subspecies)) { |
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378 | if (!has_content(gbk.definition)) { |
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379 | warning(22, "Genus and Species not defined"); |
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380 | skip_eolnl_and_append(gbk.definition, "subsp. "); |
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381 | } |
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382 | else |
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383 | skip_eolnl_and_append(gbk.definition, " subsp. "); |
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384 | |
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385 | Append(gbk.definition, macke.subspecies); |
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386 | } |
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387 | |
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388 | if (has_content(macke.strain)) { |
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389 | if (!has_content(gbk.definition)) { |
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390 | warning(23, "Genus and Species and Subspecies not defined"); |
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391 | skip_eolnl_and_append(gbk.definition, "str. "); |
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392 | } |
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393 | else |
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394 | skip_eolnl_and_append(gbk.definition, " str. "); |
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395 | |
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396 | Append(gbk.definition, macke.strain); |
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397 | } |
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398 | |
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399 | // create SOURCE line, temp. |
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400 | if (copy_content(gbk.source, gbk.definition)) terminate_with(gbk.source, '.'); |
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401 | |
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402 | // append keyword to definition, if there is keyword. |
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403 | if (has_content(gbk.keywords)) { |
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404 | if (has_content(gbk.definition)) |
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405 | skip_eolnl_and_append(gbk.definition, "; \n"); |
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406 | |
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407 | // Here keywords must be ended by a '.' already |
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408 | skip_eolnl_and_append(gbk.definition, gbk.keywords); |
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409 | } |
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410 | else |
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411 | skip_eolnl_and_append(gbk.definition, ".\n"); |
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412 | } |
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413 | |
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414 | int mtog(const Macke& macke, GenBank& gbk, const Seq& seq) { // __ATTR__USERESULT |
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415 | // Convert Macke format to Genbank format. |
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416 | int indi; |
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417 | char temp[LONGTEXT]; |
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418 | |
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419 | strcpy(temp, macke.seqabbr); |
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420 | |
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421 | for (indi = str0len(temp); indi < 13; temp[indi++] = ' ') {} |
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422 | |
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423 | if (has_content(macke.date)) |
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424 | sprintf((temp + 10), "%7d bp RNA RNA %s\n", seq.get_len(), genbank_date(macke.date)); |
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425 | else |
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426 | sprintf((temp + 10), "%7d bp RNA RNA %s\n", seq.get_len(), genbank_date(today_date())); |
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427 | |
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428 | freedup(gbk.locus, temp); |
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429 | |
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430 | // GenBank ORGANISM |
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431 | if (copy_content(gbk.organism, macke.name)) terminate_with(gbk.organism, '.'); |
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432 | |
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433 | RDP_comments& comments = gbk.comments; |
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434 | OrgInfo& orginf = comments.orginf; |
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435 | SeqInfo& seqinf = comments.seqinf; |
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436 | |
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437 | copy_content(seqinf.methods, macke.rna); |
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438 | |
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439 | if (!copy_content(seqinf.gbkentry, macke.acs)) |
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440 | copy_content(seqinf.gbkentry, macke.nbk); |
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441 | |
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442 | copy_content(orginf.cultcoll, macke.atcc); |
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443 | mtog_decode_ref_and_remarks(macke, gbk); |
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444 | |
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445 | // final conversion of cultcoll |
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446 | if (!has_content(orginf.cultcoll)) copy_content(orginf.cultcoll, macke.atcc); |
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447 | |
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448 | // define GenBank DEFINITION, after GenBank KEYWORD is defined. |
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449 | mtog_genbank_def_and_source(macke, gbk); |
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450 | |
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451 | return (1); |
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452 | } |
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453 | |
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454 | int gtom(const GenBank& gbk, Macke& macke) { // __ATTR__USERESULT |
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455 | // Convert from Genbank format to Macke format. |
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456 | |
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457 | // copy sequence abbr, assume every entry in gbk must end with \n\0 |
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458 | // no '\n' at the end of the string |
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459 | { |
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460 | char temp[LONGTEXT]; |
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461 | genbank_key_word(gbk.locus, 0, temp); |
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462 | freedup(macke.seqabbr, temp); |
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463 | } |
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464 | |
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465 | // copy name and definition |
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466 | if (!copy_content(macke.name, gbk.organism) && has_content(gbk.definition)) { |
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467 | char genus[TOKENSIZE]; |
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468 | char species[TOKENSIZE]; |
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469 | |
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470 | ASSERT_RESULT(int, 2, sscanf(gbk.definition, "%s %s", genus, species)); |
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471 | |
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472 | int last = str0len(species)-1; |
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473 | if (species[last] == ';') species[last] = '\0'; |
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474 | |
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475 | freeset(macke.name, strf("%s %s\n", genus, species)); |
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476 | } |
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477 | |
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478 | const OrgInfo& orginf = gbk.comments.orginf; |
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479 | const SeqInfo& seqinf = gbk.comments.seqinf; |
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480 | |
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481 | copy_content(macke.atcc, orginf.cultcoll); // copy cultcoll name and number |
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482 | copy_content(macke.rna, seqinf.methods); // copy rna(methods) |
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483 | |
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484 | freeset(macke.date, gbk.get_date()); Append(macke.date, "\n"); |
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485 | |
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486 | // copy genbank entry (gbkentry has higher priority than gbk.accession) |
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487 | if (!copy_content(macke.acs, seqinf.gbkentry)) { |
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488 | char buffer[TOKENSIZE]; |
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489 | if (has_content(gbk.accession) && !str_equal(gbk.accession, "No information\n")) { |
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490 | scan_token_or_die(buffer, gbk.accession); |
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491 | strcat(buffer, "\n"); |
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492 | } |
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493 | else { |
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494 | strcpy(buffer, "\n"); |
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495 | } |
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496 | freedup(macke.acs, buffer); |
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497 | } |
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498 | |
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499 | // copy the first reference from GenBank to Macke |
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500 | if (gbk.has_refs()) { |
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501 | copy_content(macke.author, gbk.get_ref(0).author); |
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502 | copy_content(macke.journal, gbk.get_ref(0).journal); |
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503 | copy_content(macke.title, gbk.get_ref(0).title); |
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504 | } |
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505 | // the rest of references are put into remarks, rem:..... |
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506 | macke.add_remarks_from(gbk); |
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507 | |
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508 | // adjust the strain, subspecies, and atcc information |
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509 | freeset(macke.strain, genbank_get_strain(gbk)); |
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510 | freeset(macke.subspecies, genbank_get_subspecies(gbk)); |
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511 | if (!has_content(macke.atcc)) { |
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512 | freeset(macke.atcc, genbank_get_atcc(gbk, macke)); |
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513 | } |
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514 | |
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515 | return (1); |
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516 | } |
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