| 1 | // =============================================================== // |
|---|
| 2 | // // |
|---|
| 3 | // File : PARS_main.cxx // |
|---|
| 4 | // Purpose : // |
|---|
| 5 | // // |
|---|
| 6 | // Institute of Microbiology (Technical University Munich) // |
|---|
| 7 | // http://www.arb-home.de/ // |
|---|
| 8 | // // |
|---|
| 9 | // =============================================================== // |
|---|
| 10 | |
|---|
| 11 | #include "pars_main.hxx" |
|---|
| 12 | #include "pars_klprops.hxx" |
|---|
| 13 | #include "ap_tree_nlen.hxx" |
|---|
| 14 | #include "ap_main.hxx" |
|---|
| 15 | |
|---|
| 16 | #include <aw_awars.hxx> |
|---|
| 17 | #include <aw_preset.hxx> |
|---|
| 18 | #include <aw_msg.hxx> |
|---|
| 19 | #include <aw_root.hxx> |
|---|
| 20 | #include <aw_question.hxx> |
|---|
| 21 | |
|---|
| 22 | #include <awt.hxx> |
|---|
| 23 | #include <awt_sel_boxes.hxx> |
|---|
| 24 | #include <awt_filter.hxx> |
|---|
| 25 | |
|---|
| 26 | #include <ColumnStat.hxx> |
|---|
| 27 | #include <nds.h> |
|---|
| 28 | #include <arb_progress.h> |
|---|
| 29 | #include <arb_misc.h> |
|---|
| 30 | |
|---|
| 31 | #include <gui_aliview.hxx> |
|---|
| 32 | #include <ad_cb.h> |
|---|
| 33 | |
|---|
| 34 | #include <TreeCallbacks.hxx> |
|---|
| 35 | |
|---|
| 36 | #include <list> |
|---|
| 37 | #include <macros.hxx> |
|---|
| 38 | |
|---|
| 39 | #if defined(DEBUG) |
|---|
| 40 | # define TESTMENU |
|---|
| 41 | #endif // DEBUG |
|---|
| 42 | |
|---|
| 43 | using namespace std; |
|---|
| 44 | |
|---|
| 45 | AW_HEADER_MAIN |
|---|
| 46 | |
|---|
| 47 | #define AWAR_COLUMNSTAT_BASE "tmp/pars/colstat" |
|---|
| 48 | #define AWAR_COLUMNSTAT_NAME AWAR_COLUMNSTAT_BASE "/name" |
|---|
| 49 | |
|---|
| 50 | #define AWT_TREE_PARS(ntw) DOWNCAST(AWT_graphic_parsimony*, (ntw)->gfx) |
|---|
| 51 | |
|---|
| 52 | static ArbParsimony *GLOBAL_PARS = NULL; |
|---|
| 53 | |
|---|
| 54 | inline AWT_graphic_parsimony *global_tree() { return GLOBAL_PARS->get_tree(); } |
|---|
| 55 | inline AP_pars_root *global_tree_root() { return global_tree()->get_tree_root(); } |
|---|
| 56 | |
|---|
| 57 | // waaah more globals :( |
|---|
| 58 | AP_main *ap_main; // @@@ move into ArbParsimony? or eliminate ArbParsimony |
|---|
| 59 | |
|---|
| 60 | void ArbParsimony::set_tree(AWT_graphic_parsimony *tree_) { |
|---|
| 61 | ap_assert(!tree); // only call once |
|---|
| 62 | tree = tree_; |
|---|
| 63 | ap_main->set_tree_root(tree); |
|---|
| 64 | } |
|---|
| 65 | |
|---|
| 66 | static void pars_saveNrefresh_changed_tree(AWT_canvas *ntw) { |
|---|
| 67 | ap_assert((AWT_TREE(ntw) == global_tree())); |
|---|
| 68 | |
|---|
| 69 | GB_ERROR error = global_tree()->save(ntw->gb_main, 0, 0, 0); |
|---|
| 70 | if (error) aw_message(error); |
|---|
| 71 | |
|---|
| 72 | ntw->zoom_reset_and_refresh(); |
|---|
| 73 | } |
|---|
| 74 | |
|---|
| 75 | __ATTR__NORETURN static void pars_exit(AW_window *aww) { |
|---|
| 76 | AW_root *aw_root = aww->get_root(); |
|---|
| 77 | shutdown_macro_recording(aw_root); |
|---|
| 78 | |
|---|
| 79 | ap_main->accept(); |
|---|
| 80 | |
|---|
| 81 | aw_root->unlink_awars_from_DB(ap_main->get_gb_main()); |
|---|
| 82 | #if defined(DEBUG) |
|---|
| 83 | AWT_browser_forget_db(ap_main->get_gb_main()); |
|---|
| 84 | #endif // DEBUG |
|---|
| 85 | delete ap_main; // closes DB |
|---|
| 86 | ap_main = NULL; |
|---|
| 87 | |
|---|
| 88 | exit(EXIT_SUCCESS); |
|---|
| 89 | } |
|---|
| 90 | |
|---|
| 91 | static void AP_user_push_cb(AW_window *aww, AWT_canvas *) { |
|---|
| 92 | ap_main->user_push(); |
|---|
| 93 | aww->get_root()->awar(AWAR_STACKPOINTER)->write_int(ap_main->get_user_push_counter()); |
|---|
| 94 | } |
|---|
| 95 | |
|---|
| 96 | static void AP_user_pop_cb(AW_window *aww, AWT_canvas *ntw) { |
|---|
| 97 | if (ap_main->get_user_push_counter()<=0) { |
|---|
| 98 | aw_message("No tree on stack."); |
|---|
| 99 | return; |
|---|
| 100 | } |
|---|
| 101 | ap_main->user_pop(); |
|---|
| 102 | rootNode()->compute_tree(); |
|---|
| 103 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 104 | aww->get_root()->awar(AWAR_STACKPOINTER)->write_int(ap_main->get_user_push_counter()); |
|---|
| 105 | |
|---|
| 106 | pars_saveNrefresh_changed_tree(ntw); |
|---|
| 107 | |
|---|
| 108 | if (ap_main->get_user_push_counter() <= 0) { // last tree was popped => push again |
|---|
| 109 | AP_user_push_cb(aww, ntw); |
|---|
| 110 | } |
|---|
| 111 | } |
|---|
| 112 | |
|---|
| 113 | class InsertData { |
|---|
| 114 | int abort_flag; |
|---|
| 115 | long currentspecies; |
|---|
| 116 | |
|---|
| 117 | arb_progress progress; |
|---|
| 118 | |
|---|
| 119 | public: |
|---|
| 120 | |
|---|
| 121 | bool quick_add_flag; |
|---|
| 122 | InsertData(bool quick, long spec_count, int add_progress_steps) |
|---|
| 123 | : abort_flag(false), |
|---|
| 124 | currentspecies(0), |
|---|
| 125 | progress(GBS_global_string("Inserting %li species", spec_count), spec_count+add_progress_steps), |
|---|
| 126 | quick_add_flag(quick) |
|---|
| 127 | { |
|---|
| 128 | } |
|---|
| 129 | |
|---|
| 130 | bool every_sixteenth() { return (currentspecies & 0xf) == 0; } |
|---|
| 131 | |
|---|
| 132 | bool aborted() const { return abort_flag; } |
|---|
| 133 | void set_aborted(bool aborted_) { abort_flag = aborted_; } |
|---|
| 134 | |
|---|
| 135 | void inc() { |
|---|
| 136 | ++currentspecies; |
|---|
| 137 | progress.inc(); |
|---|
| 138 | abort_flag = progress.aborted(); |
|---|
| 139 | } |
|---|
| 140 | |
|---|
| 141 | arb_progress& get_progress() { return progress; } |
|---|
| 142 | }; |
|---|
| 143 | |
|---|
| 144 | |
|---|
| 145 | static int sort_sequences_by_length(const char*, long leaf0_ptr, const char*, long leaf1_ptr) { |
|---|
| 146 | AP_tree *leaf0 = (AP_tree*)leaf0_ptr; |
|---|
| 147 | AP_tree *leaf1 = (AP_tree*)leaf1_ptr; |
|---|
| 148 | |
|---|
| 149 | AP_FLOAT len0 = leaf0->get_seq()->weighted_base_count(); |
|---|
| 150 | AP_FLOAT len1 = leaf1->get_seq()->weighted_base_count(); |
|---|
| 151 | |
|---|
| 152 | return len0<len1 ? 1 : (len0>len1 ? -1 : 0); // longest sequence first |
|---|
| 153 | } |
|---|
| 154 | |
|---|
| 155 | static long transform_gbd_to_leaf(const char *key, long val, void *) { |
|---|
| 156 | if (!val) return val; |
|---|
| 157 | |
|---|
| 158 | #if defined(WARN_TODO) |
|---|
| 159 | #warning use create_linked_leaf() when impl |
|---|
| 160 | #endif |
|---|
| 161 | |
|---|
| 162 | GBDATA *gb_node = (GBDATA *)val; |
|---|
| 163 | AP_pars_root *troot = ap_main->get_tree_root(); |
|---|
| 164 | AP_tree_nlen *leaf = DOWNCAST(AP_tree_nlen*, troot->makeNode()); |
|---|
| 165 | |
|---|
| 166 | leaf->forget_origin(); // new leaf is not part of tree yet |
|---|
| 167 | |
|---|
| 168 | leaf->gb_node = gb_node; |
|---|
| 169 | leaf->name = strdup(key); |
|---|
| 170 | leaf->is_leaf = true; |
|---|
| 171 | |
|---|
| 172 | leaf->set_seq(troot->get_seqTemplate()->dup()); |
|---|
| 173 | GB_ERROR error = leaf->get_seq()->bind_to_species(gb_node); |
|---|
| 174 | if (error) { |
|---|
| 175 | aw_message(error); |
|---|
| 176 | delete leaf; leaf = 0; |
|---|
| 177 | } |
|---|
| 178 | return (long)leaf; |
|---|
| 179 | } |
|---|
| 180 | |
|---|
| 181 | static AP_tree_nlen *insert_species_in_tree(const char *key, AP_tree_nlen *leaf, InsertData *isits) { |
|---|
| 182 | if (!leaf) return leaf; |
|---|
| 183 | if (isits->aborted()) return leaf; |
|---|
| 184 | |
|---|
| 185 | AP_tree_nlen *tree = rootNode(); |
|---|
| 186 | |
|---|
| 187 | if (leaf->get_seq()->weighted_base_count() < MIN_SEQUENCE_LENGTH) { |
|---|
| 188 | aw_message(GBS_global_string("Species %s has too short sequence (%f, minimum is %i)", |
|---|
| 189 | key, |
|---|
| 190 | leaf->get_seq()->weighted_base_count(), |
|---|
| 191 | MIN_SEQUENCE_LENGTH)); |
|---|
| 192 | delete leaf; |
|---|
| 193 | return 0; |
|---|
| 194 | } |
|---|
| 195 | |
|---|
| 196 | if (!tree) { // no tree yet |
|---|
| 197 | static AP_tree_nlen *last_inserted = NULL; // @@@ move 'last_inserted' into 'InsertData' |
|---|
| 198 | |
|---|
| 199 | if (!last_inserted) { // store 1st leaf |
|---|
| 200 | last_inserted = leaf; |
|---|
| 201 | } |
|---|
| 202 | else { // 2nd leaf -> create initial tree |
|---|
| 203 | AP_pars_root *troot = ap_main->get_tree_root(); |
|---|
| 204 | |
|---|
| 205 | leaf->initial_insert(last_inserted, troot); |
|---|
| 206 | last_inserted = NULL; |
|---|
| 207 | |
|---|
| 208 | ap_assert(troot->get_root_node() == leaf->get_father()); |
|---|
| 209 | ASSERT_VALID_TREE(troot->get_root_node()); |
|---|
| 210 | } |
|---|
| 211 | } |
|---|
| 212 | else { |
|---|
| 213 | ASSERT_VALID_TREE(tree); |
|---|
| 214 | |
|---|
| 215 | AP_tree_nlen **branchlist; |
|---|
| 216 | |
|---|
| 217 | { |
|---|
| 218 | AP_tree **blist; |
|---|
| 219 | long bsum = 0; |
|---|
| 220 | |
|---|
| 221 | tree->buildBranchList(blist, bsum, true, -1); // get all branches |
|---|
| 222 | branchlist = (AP_tree_nlen**)blist; |
|---|
| 223 | } |
|---|
| 224 | |
|---|
| 225 | AP_tree_nlen *bestposl = tree->get_leftson(); |
|---|
| 226 | AP_tree_nlen *bestposr = tree->get_rightson(); |
|---|
| 227 | |
|---|
| 228 | ap_assert(tree == rootNode()); |
|---|
| 229 | leaf->insert(bestposl); |
|---|
| 230 | tree = NULL; // tree may have changed |
|---|
| 231 | |
|---|
| 232 | { |
|---|
| 233 | AP_FLOAT curr_parsimony = rootNode()->costs(); |
|---|
| 234 | AP_FLOAT best_parsimony = curr_parsimony; |
|---|
| 235 | |
|---|
| 236 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 237 | |
|---|
| 238 | for (long counter = 0; !isits->aborted() && branchlist[counter]; counter += 2) { |
|---|
| 239 | AP_tree_nlen *bl = branchlist[counter]; |
|---|
| 240 | AP_tree_nlen *blf = branchlist[counter+1]; |
|---|
| 241 | |
|---|
| 242 | if (blf->father == bl) { |
|---|
| 243 | bl = branchlist[counter+1]; |
|---|
| 244 | blf = branchlist[counter]; |
|---|
| 245 | } |
|---|
| 246 | |
|---|
| 247 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 248 | if (bl->father) { |
|---|
| 249 | bl->set_root(); |
|---|
| 250 | } |
|---|
| 251 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 252 | |
|---|
| 253 | leaf->moveNextTo(bl, 0.5); |
|---|
| 254 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 255 | |
|---|
| 256 | curr_parsimony = rootNode()->costs(); |
|---|
| 257 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 258 | |
|---|
| 259 | if (curr_parsimony < best_parsimony) { |
|---|
| 260 | best_parsimony = curr_parsimony; |
|---|
| 261 | bestposl = bl; |
|---|
| 262 | bestposr = blf; |
|---|
| 263 | } |
|---|
| 264 | |
|---|
| 265 | } |
|---|
| 266 | } |
|---|
| 267 | delete [] branchlist; branchlist = 0; |
|---|
| 268 | if (bestposl->father != bestposr) { |
|---|
| 269 | bestposl = bestposr; |
|---|
| 270 | } |
|---|
| 271 | |
|---|
| 272 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 273 | |
|---|
| 274 | leaf->moveNextTo(bestposl, 0.5); |
|---|
| 275 | |
|---|
| 276 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 277 | |
|---|
| 278 | if (!isits->quick_add_flag) { |
|---|
| 279 | int deep = 5; |
|---|
| 280 | if (isits->every_sixteenth()) deep = -1; |
|---|
| 281 | |
|---|
| 282 | arb_progress progress("optimization"); |
|---|
| 283 | bestposl->get_father()->nn_interchange_rek(deep, AP_BL_NNI_ONLY, true); |
|---|
| 284 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 285 | } |
|---|
| 286 | AP_tree_nlen *brother = leaf->get_brother(); |
|---|
| 287 | if (brother->is_leaf && leaf->father->father) { |
|---|
| 288 | bool brother_is_short = 2 * brother->get_seq()->weighted_base_count() < leaf->get_seq()->weighted_base_count(); |
|---|
| 289 | |
|---|
| 290 | if (brother_is_short) { |
|---|
| 291 | brother->remove(); |
|---|
| 292 | leaf->remove(); |
|---|
| 293 | |
|---|
| 294 | for (int firstUse = 1; firstUse >= 0; --firstUse) { |
|---|
| 295 | AP_tree_nlen *to_insert = firstUse ? leaf : brother; |
|---|
| 296 | const char *format = firstUse ? "2:%s" : "shortseq:%s"; |
|---|
| 297 | |
|---|
| 298 | char *label = GBS_global_string_copy(format, to_insert->name); |
|---|
| 299 | insert_species_in_tree(label, to_insert, isits); |
|---|
| 300 | free(label); |
|---|
| 301 | } |
|---|
| 302 | } |
|---|
| 303 | } |
|---|
| 304 | |
|---|
| 305 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 306 | } |
|---|
| 307 | |
|---|
| 308 | return leaf; |
|---|
| 309 | } |
|---|
| 310 | |
|---|
| 311 | static long hash_insert_species_in_tree(const char *key, long leaf, void *cd_isits) { |
|---|
| 312 | InsertData *isits = (InsertData*)cd_isits; |
|---|
| 313 | long result = (long)insert_species_in_tree(key, (AP_tree_nlen*)leaf, isits); |
|---|
| 314 | isits->inc(); |
|---|
| 315 | return result; |
|---|
| 316 | } |
|---|
| 317 | |
|---|
| 318 | static long count_hash_elements(const char *, long val, void *cd_count) { |
|---|
| 319 | if (val) { |
|---|
| 320 | long *count = (long*)cd_count; |
|---|
| 321 | (*count)++; |
|---|
| 322 | } |
|---|
| 323 | return val; |
|---|
| 324 | } |
|---|
| 325 | |
|---|
| 326 | enum AddWhat { |
|---|
| 327 | NT_ADD_MARKED, |
|---|
| 328 | NT_ADD_SELECTED, |
|---|
| 329 | }; |
|---|
| 330 | |
|---|
| 331 | static void nt_add(AWT_graphic_parsimony *agt, AddWhat what, bool quick) { |
|---|
| 332 | GB_ERROR error = 0; |
|---|
| 333 | |
|---|
| 334 | AP_tree *oldrootleft = NULL; |
|---|
| 335 | AP_tree *oldrootright = NULL; |
|---|
| 336 | { |
|---|
| 337 | AP_tree_nlen *root = rootNode(); |
|---|
| 338 | if (root) { |
|---|
| 339 | root->reset_subtree_layout(); |
|---|
| 340 | oldrootleft = root->get_leftson(); |
|---|
| 341 | oldrootright = root->get_rightson(); |
|---|
| 342 | } |
|---|
| 343 | } |
|---|
| 344 | |
|---|
| 345 | GB_HASH *hash = 0; |
|---|
| 346 | GBDATA *gb_main = agt->gb_main; |
|---|
| 347 | { |
|---|
| 348 | GB_transaction ta(gb_main); |
|---|
| 349 | switch (what) { |
|---|
| 350 | case NT_ADD_SELECTED: { |
|---|
| 351 | char *name = GBT_readOrCreate_string(gb_main, AWAR_SPECIES_NAME, ""); |
|---|
| 352 | if (name && strlen(name)) { |
|---|
| 353 | GBDATA *gb_species = GBT_find_species(gb_main, name); |
|---|
| 354 | if (gb_species) { |
|---|
| 355 | hash = GBS_create_hash(1, GB_MIND_CASE); |
|---|
| 356 | GBS_write_hash(hash, name, (long)gb_species); |
|---|
| 357 | } |
|---|
| 358 | else error = GBS_global_string("Selected Species (%s) not found", name); |
|---|
| 359 | } |
|---|
| 360 | else error = "Please select a species"; |
|---|
| 361 | free(name); |
|---|
| 362 | break; |
|---|
| 363 | } |
|---|
| 364 | case NT_ADD_MARKED: { |
|---|
| 365 | hash = GBT_create_marked_species_hash(gb_main); |
|---|
| 366 | break; |
|---|
| 367 | } |
|---|
| 368 | } |
|---|
| 369 | } |
|---|
| 370 | |
|---|
| 371 | if (!error) { |
|---|
| 372 | ap_assert(hash); |
|---|
| 373 | |
|---|
| 374 | NT_remove_species_in_tree_from_hash(rootNode(), hash); |
|---|
| 375 | |
|---|
| 376 | long max_species = 0; |
|---|
| 377 | GBS_hash_do_loop(hash, count_hash_elements, &max_species); |
|---|
| 378 | |
|---|
| 379 | int implicitSteps = quick ? 1 : 2; // 1 step for calc_branchlengths, 1 step for NNI |
|---|
| 380 | InsertData isits(quick, max_species, implicitSteps); |
|---|
| 381 | |
|---|
| 382 | GB_begin_transaction(gb_main); |
|---|
| 383 | GBS_hash_do_loop(hash, transform_gbd_to_leaf, NULL); |
|---|
| 384 | GB_commit_transaction(gb_main); |
|---|
| 385 | |
|---|
| 386 | { |
|---|
| 387 | int skipped = max_species - GBS_hash_count_elems(hash); |
|---|
| 388 | if (skipped) { |
|---|
| 389 | aw_message(GBS_global_string("Skipped %i species (no data?)", skipped)); |
|---|
| 390 | isits.get_progress().inc_by(skipped); |
|---|
| 391 | } |
|---|
| 392 | } |
|---|
| 393 | |
|---|
| 394 | GBS_hash_do_sorted_loop(hash, hash_insert_species_in_tree, sort_sequences_by_length, &isits); |
|---|
| 395 | |
|---|
| 396 | if (!quick) { |
|---|
| 397 | rootEdge()->nni_rek(-1, false, AP_BL_NNI_ONLY, NULL); |
|---|
| 398 | ++isits.get_progress(); |
|---|
| 399 | } |
|---|
| 400 | |
|---|
| 401 | if (rootNode()) { |
|---|
| 402 | rootEdge()->calc_branchlengths(); |
|---|
| 403 | ++isits.get_progress(); |
|---|
| 404 | |
|---|
| 405 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 406 | rootNode()->compute_tree(); |
|---|
| 407 | |
|---|
| 408 | if (oldrootleft) { |
|---|
| 409 | if (oldrootleft->father == oldrootright) oldrootleft->set_root(); |
|---|
| 410 | else oldrootright->set_root(); |
|---|
| 411 | } |
|---|
| 412 | else { |
|---|
| 413 | ARB_edge innermost = rootNode()->get_tree_root()->find_innermost_edge(); |
|---|
| 414 | innermost.set_root(); |
|---|
| 415 | } |
|---|
| 416 | } |
|---|
| 417 | else { |
|---|
| 418 | error = "Tree lost (no leafs left)"; |
|---|
| 419 | isits.get_progress().done(); |
|---|
| 420 | } |
|---|
| 421 | } |
|---|
| 422 | |
|---|
| 423 | if (hash) GBS_free_hash(hash); |
|---|
| 424 | if (error) aw_message(error); |
|---|
| 425 | |
|---|
| 426 | // @@@ quick-add w/o NNI should sort according to original tree |
|---|
| 427 | agt->reorder_tree(BIG_BRANCHES_TO_TOP); |
|---|
| 428 | } |
|---|
| 429 | |
|---|
| 430 | // ------------------------------------------ |
|---|
| 431 | // Adding partial sequences to tree |
|---|
| 432 | |
|---|
| 433 | class PartialSequence { |
|---|
| 434 | GBDATA *gb_species; |
|---|
| 435 | mutable AP_tree_nlen *self; // self converted to leaf (ready for insertion) |
|---|
| 436 | const AP_tree_nlen *best_full_match; // full sequence position which matched best |
|---|
| 437 | long overlap; // size of overlapping region |
|---|
| 438 | long penalty; // weighted mismatches |
|---|
| 439 | bool released; |
|---|
| 440 | bool multi_match; |
|---|
| 441 | string multi_list; // list of equal-rated insertion-points (not containing self) |
|---|
| 442 | |
|---|
| 443 | AP_tree_nlen *get_self() const { |
|---|
| 444 | if (!self) { |
|---|
| 445 | ap_assert(!released); // request not possible, because leaf has already been released! |
|---|
| 446 | |
|---|
| 447 | self = (AP_tree_nlen*)transform_gbd_to_leaf(GBT_read_name(gb_species), (long)gb_species, NULL); |
|---|
| 448 | ap_assert(self); |
|---|
| 449 | } |
|---|
| 450 | return self; |
|---|
| 451 | } |
|---|
| 452 | |
|---|
| 453 | public: |
|---|
| 454 | PartialSequence(GBDATA *gb_species_) |
|---|
| 455 | : gb_species(gb_species_), self(0), best_full_match(0) |
|---|
| 456 | , overlap(0), penalty(LONG_MAX), released(false), multi_match(false) |
|---|
| 457 | { |
|---|
| 458 | } |
|---|
| 459 | PartialSequence(const PartialSequence& other) |
|---|
| 460 | : gb_species(other.gb_species), |
|---|
| 461 | self(other.self), |
|---|
| 462 | best_full_match(other.best_full_match), |
|---|
| 463 | overlap(other.overlap), |
|---|
| 464 | penalty(other.penalty), |
|---|
| 465 | released(other.released), |
|---|
| 466 | multi_match(other.multi_match), |
|---|
| 467 | multi_list(other.multi_list) |
|---|
| 468 | { |
|---|
| 469 | ap_assert(self == 0); // copying self not implemented |
|---|
| 470 | } |
|---|
| 471 | DECLARE_ASSIGNMENT_OPERATOR(PartialSequence); |
|---|
| 472 | ~PartialSequence() { ap_assert(self == 0); } |
|---|
| 473 | |
|---|
| 474 | GBDATA *get_species() const { return gb_species; } |
|---|
| 475 | const AP_tree_nlen *get_best_match() const { return best_full_match; } |
|---|
| 476 | AP_FLOAT get_branchlength() const { return AP_FLOAT(penalty)/overlap; } |
|---|
| 477 | void test_match(const AP_tree_nlen *leaf_full); |
|---|
| 478 | bool is_multi_match() const { return multi_match; } |
|---|
| 479 | |
|---|
| 480 | const char *get_name() const { |
|---|
| 481 | const char *name = get_self()->name; |
|---|
| 482 | ap_assert(name); |
|---|
| 483 | return name; |
|---|
| 484 | } |
|---|
| 485 | |
|---|
| 486 | string get_multilist() const { |
|---|
| 487 | ap_assert(is_multi_match()); |
|---|
| 488 | return string(best_full_match->name)+multi_list; |
|---|
| 489 | } |
|---|
| 490 | |
|---|
| 491 | AP_tree_nlen *release() { |
|---|
| 492 | AP_tree_nlen *s = self; |
|---|
| 493 | self = 0; |
|---|
| 494 | released = true; |
|---|
| 495 | return s; |
|---|
| 496 | } |
|---|
| 497 | |
|---|
| 498 | void dump(const char *whichMatch) const { |
|---|
| 499 | ap_assert(best_full_match); |
|---|
| 500 | printf("%s match for '%s' is '%s' (overlap=%li penalty=%li)\n", |
|---|
| 501 | whichMatch, get_name(), best_full_match->name, |
|---|
| 502 | overlap, penalty); |
|---|
| 503 | } |
|---|
| 504 | |
|---|
| 505 | }; |
|---|
| 506 | |
|---|
| 507 | void PartialSequence::test_match(const AP_tree_nlen *leaf_full) { |
|---|
| 508 | long curr_overlap; |
|---|
| 509 | long curr_penalty; |
|---|
| 510 | |
|---|
| 511 | leaf_full->get_seq()->partial_match(get_self()->get_seq(), &curr_overlap, &curr_penalty); |
|---|
| 512 | |
|---|
| 513 | bool better = false; |
|---|
| 514 | |
|---|
| 515 | if (curr_overlap > overlap) { |
|---|
| 516 | better = true; |
|---|
| 517 | } |
|---|
| 518 | else if (curr_overlap == overlap) { |
|---|
| 519 | if (curr_penalty<penalty) { |
|---|
| 520 | better = true; |
|---|
| 521 | } |
|---|
| 522 | else if (curr_penalty == penalty) { |
|---|
| 523 | // found two equal-rated insertion points -> store data for warning |
|---|
| 524 | #if defined(DEBUG) |
|---|
| 525 | if (!multi_match) dump("better"); |
|---|
| 526 | printf("Another equal match is against '%s' (overlap=%li penalty=%li)\n", leaf_full->name, curr_overlap, curr_penalty); |
|---|
| 527 | #endif // DEBUG |
|---|
| 528 | |
|---|
| 529 | multi_match = true; |
|---|
| 530 | multi_list.append(1, '/'); |
|---|
| 531 | multi_list.append(leaf_full->name); |
|---|
| 532 | } |
|---|
| 533 | } |
|---|
| 534 | |
|---|
| 535 | if (better) { |
|---|
| 536 | overlap = curr_overlap; |
|---|
| 537 | penalty = curr_penalty; |
|---|
| 538 | best_full_match = leaf_full; |
|---|
| 539 | multi_match = false; |
|---|
| 540 | multi_list = ""; |
|---|
| 541 | |
|---|
| 542 | #if defined(DEBUG) |
|---|
| 543 | dump("better"); |
|---|
| 544 | #endif |
|---|
| 545 | } |
|---|
| 546 | #if defined(DEBUG) |
|---|
| 547 | else if (!multi_match) { |
|---|
| 548 | printf("Worse match against '%s' (overlap=%li penalty=%li)\n", leaf_full->name, curr_overlap, curr_penalty); |
|---|
| 549 | } |
|---|
| 550 | #endif |
|---|
| 551 | } |
|---|
| 552 | |
|---|
| 553 | static GB_ERROR nt_best_partial_match_rek(list<PartialSequence>& partial, const AP_tree_nlen *tree) { |
|---|
| 554 | GB_ERROR error = 0; |
|---|
| 555 | |
|---|
| 556 | if (tree) { |
|---|
| 557 | if (tree->is_leaf && tree->name) { |
|---|
| 558 | if (tree->gb_node) { |
|---|
| 559 | int is_partial = GBT_is_partial(tree->gb_node, 0, true); // marks undef as 'full sequence' |
|---|
| 560 | if (is_partial == 0) { // do not consider other partial sequences |
|---|
| 561 | list<PartialSequence>::iterator i = partial.begin(); |
|---|
| 562 | list<PartialSequence>::iterator e = partial.end(); |
|---|
| 563 | for (; i != e; ++i) { |
|---|
| 564 | i->test_match(tree); |
|---|
| 565 | } |
|---|
| 566 | } |
|---|
| 567 | else if (is_partial == -1) { |
|---|
| 568 | error = GB_await_error(); |
|---|
| 569 | } |
|---|
| 570 | } |
|---|
| 571 | } |
|---|
| 572 | else { |
|---|
| 573 | error = nt_best_partial_match_rek(partial, tree->get_leftson()); |
|---|
| 574 | if (!error) error = nt_best_partial_match_rek(partial, tree->get_rightson()); |
|---|
| 575 | } |
|---|
| 576 | } |
|---|
| 577 | return error; |
|---|
| 578 | } |
|---|
| 579 | |
|---|
| 580 | static void count_partial_and_full(const AP_tree_nlen *at, int *partial, int *full, int *zombies, int default_value, bool define_if_undef) { |
|---|
| 581 | if (at->is_leaf) { |
|---|
| 582 | if (at->gb_node) { |
|---|
| 583 | int is_partial = GBT_is_partial(at->gb_node, default_value, define_if_undef); |
|---|
| 584 | if (is_partial) ++(*partial); |
|---|
| 585 | else ++(*full); |
|---|
| 586 | } |
|---|
| 587 | else { |
|---|
| 588 | ++(*zombies); |
|---|
| 589 | } |
|---|
| 590 | } |
|---|
| 591 | else { |
|---|
| 592 | count_partial_and_full(at->get_leftson(), partial, full, zombies, default_value, define_if_undef); |
|---|
| 593 | count_partial_and_full(at->get_rightson(), partial, full, zombies, default_value, define_if_undef); |
|---|
| 594 | } |
|---|
| 595 | } |
|---|
| 596 | |
|---|
| 597 | static const AP_tree_nlen *find_least_deep_leaf(const AP_tree_nlen *at, int depth, int *min_depth) { |
|---|
| 598 | if (depth >= *min_depth) { |
|---|
| 599 | return 0; // already found better or equal |
|---|
| 600 | } |
|---|
| 601 | |
|---|
| 602 | if (at->is_leaf) { |
|---|
| 603 | if (at->gb_node) { |
|---|
| 604 | *min_depth = depth; |
|---|
| 605 | return at; |
|---|
| 606 | } |
|---|
| 607 | return 0; |
|---|
| 608 | } |
|---|
| 609 | |
|---|
| 610 | const AP_tree_nlen *left = find_least_deep_leaf(at->get_leftson(), depth+1, min_depth); |
|---|
| 611 | const AP_tree_nlen *right = find_least_deep_leaf(at->get_rightson(), depth+1, min_depth); |
|---|
| 612 | |
|---|
| 613 | return right ? right : left; |
|---|
| 614 | } |
|---|
| 615 | inline AP_tree_nlen *find_least_deep_leaf(AP_tree_nlen *at, int depth, int *min_depth) { |
|---|
| 616 | return const_cast<AP_tree_nlen*>(find_least_deep_leaf(const_cast<const AP_tree_nlen*>(at), depth, min_depth)); |
|---|
| 617 | } |
|---|
| 618 | |
|---|
| 619 | static long push_partial(const char *, long val, void *cd_partial) { |
|---|
| 620 | list<PartialSequence> *partial = reinterpret_cast<list<PartialSequence> *>(cd_partial); |
|---|
| 621 | partial->push_back(PartialSequence((GBDATA*)val)); |
|---|
| 622 | return val; |
|---|
| 623 | } |
|---|
| 624 | |
|---|
| 625 | // ------------------------------- |
|---|
| 626 | // Add Partial sequences |
|---|
| 627 | |
|---|
| 628 | static void nt_add_partial(AWT_graphic_parsimony *agt) { |
|---|
| 629 | GB_ERROR error = NULL; |
|---|
| 630 | GBDATA *gb_main = agt->gb_main; |
|---|
| 631 | |
|---|
| 632 | GB_begin_transaction(gb_main); |
|---|
| 633 | |
|---|
| 634 | int full_marked_sequences = 0; |
|---|
| 635 | |
|---|
| 636 | arb_progress part_add_progress("Adding partial sequences"); |
|---|
| 637 | |
|---|
| 638 | { |
|---|
| 639 | list<PartialSequence> partial; |
|---|
| 640 | { |
|---|
| 641 | GB_HASH *partial_hash = GBS_create_hash(GBT_get_species_count(gb_main), GB_MIND_CASE); |
|---|
| 642 | |
|---|
| 643 | int marked_found = 0; |
|---|
| 644 | int partial_marked_sequences = 0; |
|---|
| 645 | int no_data = 0; // no data in alignment |
|---|
| 646 | |
|---|
| 647 | for (GBDATA *gb_marked = GBT_first_marked_species(gb_main); |
|---|
| 648 | !error && gb_marked; |
|---|
| 649 | gb_marked = GBT_next_marked_species(gb_marked)) |
|---|
| 650 | { |
|---|
| 651 | ++marked_found; |
|---|
| 652 | |
|---|
| 653 | if (GBT_find_sequence(gb_marked, ap_main->get_aliname())) { // species has sequence in alignment |
|---|
| 654 | const char *name = GBT_read_name(gb_marked); |
|---|
| 655 | |
|---|
| 656 | switch (GBT_is_partial(gb_marked, 1, true)) { // marks undef as 'partial sequence' |
|---|
| 657 | case 0: { // full sequences |
|---|
| 658 | GBT_message(gb_main, GBS_global_string("'%s' is a full sequence (cannot add partial)", name)); |
|---|
| 659 | ++full_marked_sequences; |
|---|
| 660 | break; |
|---|
| 661 | } |
|---|
| 662 | case 1: // partial sequences |
|---|
| 663 | ++partial_marked_sequences; |
|---|
| 664 | GBS_write_hash(partial_hash, name, (long)gb_marked); |
|---|
| 665 | break; |
|---|
| 666 | case -1: // error |
|---|
| 667 | error = GB_await_error(); |
|---|
| 668 | break; |
|---|
| 669 | default: |
|---|
| 670 | ap_assert(0); |
|---|
| 671 | break; |
|---|
| 672 | } |
|---|
| 673 | } |
|---|
| 674 | else { |
|---|
| 675 | no_data++; |
|---|
| 676 | } |
|---|
| 677 | } |
|---|
| 678 | |
|---|
| 679 | if (!error && !marked_found) error = "There are no marked species"; |
|---|
| 680 | |
|---|
| 681 | if (!error) { |
|---|
| 682 | NT_remove_species_in_tree_from_hash(rootNode(), partial_hash); // skip all species which are in tree |
|---|
| 683 | GBS_hash_do_loop(partial_hash, push_partial, &partial); // build partial list from hash |
|---|
| 684 | |
|---|
| 685 | int partials_already_in_tree = partial_marked_sequences - partial.size(); |
|---|
| 686 | |
|---|
| 687 | if (no_data>0) GBT_message(gb_main, GBS_global_string("%i marked species have no data in '%s'", no_data, ap_main->get_aliname())); |
|---|
| 688 | if (full_marked_sequences>0) GBT_message(gb_main, GBS_global_string("%i marked species are declared full sequences", full_marked_sequences)); |
|---|
| 689 | if (partials_already_in_tree>0) GBT_message(gb_main, GBS_global_string("%i marked species are already in tree", partials_already_in_tree)); |
|---|
| 690 | |
|---|
| 691 | if (partial.empty()) error = "No species left to add"; |
|---|
| 692 | } |
|---|
| 693 | |
|---|
| 694 | GBS_free_hash(partial_hash); |
|---|
| 695 | } |
|---|
| 696 | |
|---|
| 697 | if (!error) error = GBT_add_new_changekey(gb_main, "ARB_partial", GB_INT); |
|---|
| 698 | |
|---|
| 699 | if (!error) { |
|---|
| 700 | rootNode()->reset_subtree_layout(); |
|---|
| 701 | |
|---|
| 702 | // find best matching full sequence for each partial sequence |
|---|
| 703 | error = nt_best_partial_match_rek(partial, rootNode()); |
|---|
| 704 | |
|---|
| 705 | list<PartialSequence>::iterator i = partial.begin(); |
|---|
| 706 | list<PartialSequence>::iterator e = partial.end(); |
|---|
| 707 | |
|---|
| 708 | arb_progress part_insert_progress(partial.size()); |
|---|
| 709 | |
|---|
| 710 | #if defined(DEBUG) |
|---|
| 711 | // show results : |
|---|
| 712 | for (; i != e; ++i) i->dump("best"); |
|---|
| 713 | i = partial.begin(); |
|---|
| 714 | #endif // DEBUG |
|---|
| 715 | |
|---|
| 716 | for (; i != e && !error; ++i) { |
|---|
| 717 | const char *name = i->get_name(); |
|---|
| 718 | |
|---|
| 719 | if (i->is_multi_match()) { |
|---|
| 720 | GBT_message(gb_main, GBS_global_string("Insertion of '%s' is ambiguous.\n" |
|---|
| 721 | "(took first of equal scored insertion points: %s)", |
|---|
| 722 | name, i->get_multilist().c_str())); |
|---|
| 723 | } |
|---|
| 724 | |
|---|
| 725 | AP_tree_nlen *part_leaf = i->release(); |
|---|
| 726 | AP_tree_nlen *full_seq = const_cast<AP_tree_nlen*>(i->get_best_match()); |
|---|
| 727 | AP_tree_nlen *brother = full_seq->get_brother(); |
|---|
| 728 | int is_partial = 0; |
|---|
| 729 | AP_tree_nlen *target = 0; |
|---|
| 730 | |
|---|
| 731 | if (brother->is_leaf) { |
|---|
| 732 | if (brother->gb_node) { |
|---|
| 733 | is_partial = GBT_is_partial(brother->gb_node, 0, true); |
|---|
| 734 | |
|---|
| 735 | if (is_partial) { // brother is partial sequence |
|---|
| 736 | target = brother; // insert as brother of brother |
|---|
| 737 | } |
|---|
| 738 | else { |
|---|
| 739 | target = full_seq; // insert as brother of full_seq |
|---|
| 740 | } |
|---|
| 741 | } |
|---|
| 742 | else { |
|---|
| 743 | error = "There are zombies in your tree - please remove them"; |
|---|
| 744 | } |
|---|
| 745 | } |
|---|
| 746 | else { |
|---|
| 747 | int partial_count = 0; |
|---|
| 748 | int full_count = 0; |
|---|
| 749 | int zombie_count = 0; |
|---|
| 750 | |
|---|
| 751 | count_partial_and_full(brother, &partial_count, &full_count, &zombie_count, 0, true); |
|---|
| 752 | |
|---|
| 753 | if (zombie_count) { |
|---|
| 754 | error = "There are zombies in your tree - please remove them"; |
|---|
| 755 | } |
|---|
| 756 | else if (full_count) { |
|---|
| 757 | // brother is a subtree containing full sequences |
|---|
| 758 | // -> add new brother to full_seq found above |
|---|
| 759 | target = full_seq; |
|---|
| 760 | } |
|---|
| 761 | else { // brother subtree only contains partial sequences |
|---|
| 762 | // find one of the least-deep leafs |
|---|
| 763 | int depth = INT_MAX; |
|---|
| 764 | target = find_least_deep_leaf(brother, 0, &depth); |
|---|
| 765 | is_partial = 1; |
|---|
| 766 | } |
|---|
| 767 | } |
|---|
| 768 | |
|---|
| 769 | |
|---|
| 770 | if (!error) { |
|---|
| 771 | #if defined(DEBUG) |
|---|
| 772 | printf("inserting '%s'\n", name); |
|---|
| 773 | #endif // DEBUG |
|---|
| 774 | part_leaf->insert(target); |
|---|
| 775 | |
|---|
| 776 | // we need to create the sequence of the father node! |
|---|
| 777 | AP_tree_nlen *father = part_leaf->get_father(); |
|---|
| 778 | father->costs(); |
|---|
| 779 | |
|---|
| 780 | // ensure full-sequence is always on top |
|---|
| 781 | if (father->rightson == target) { |
|---|
| 782 | father->swap_sons(); |
|---|
| 783 | } |
|---|
| 784 | |
|---|
| 785 | if (!error) { // now correct the branch lengths modified by insert() |
|---|
| 786 | // calc the original branchlen (of target leaf branch) |
|---|
| 787 | GBT_LEN orglen = father->get_branchlength()+target->get_branchlength(); |
|---|
| 788 | |
|---|
| 789 | if (is_partial) { // we have a subtree of partial sequences |
|---|
| 790 | target->set_branchlength(orglen); // restore original branchlength |
|---|
| 791 | father->set_branchlength(0); // all father branches are zero length |
|---|
| 792 | } |
|---|
| 793 | else { // we have a subtree of one full+one partial sequence |
|---|
| 794 | ap_assert(full_seq->get_father() == father); |
|---|
| 795 | |
|---|
| 796 | father->set_branchlength(orglen); // father branch represents original length (w/o partial seq) |
|---|
| 797 | full_seq->set_branchlength(0); // full seq has no sub-branch length |
|---|
| 798 | } |
|---|
| 799 | part_leaf->set_branchlength(i->get_branchlength()); |
|---|
| 800 | printf("Adding with branchlength=%f\n", i->get_branchlength()); |
|---|
| 801 | } |
|---|
| 802 | } |
|---|
| 803 | else { |
|---|
| 804 | delete part_leaf; |
|---|
| 805 | } |
|---|
| 806 | |
|---|
| 807 | part_insert_progress.inc_and_check_user_abort(error); |
|---|
| 808 | } |
|---|
| 809 | } |
|---|
| 810 | } |
|---|
| 811 | |
|---|
| 812 | if (full_marked_sequences) { |
|---|
| 813 | GBT_message(gb_main, GBS_global_string("%i marked full sequences were not added", full_marked_sequences)); |
|---|
| 814 | } |
|---|
| 815 | |
|---|
| 816 | if (error) { |
|---|
| 817 | GBT_message(gb_main, error); |
|---|
| 818 | GB_abort_transaction(gb_main); |
|---|
| 819 | } |
|---|
| 820 | else { |
|---|
| 821 | GB_commit_transaction(gb_main); |
|---|
| 822 | } |
|---|
| 823 | } |
|---|
| 824 | |
|---|
| 825 | static void NT_add_partial_and_update(UNFIXED, AWT_canvas *ntw) { |
|---|
| 826 | nt_add_partial(AWT_TREE_PARS(ntw)); |
|---|
| 827 | pars_saveNrefresh_changed_tree(ntw); |
|---|
| 828 | } |
|---|
| 829 | |
|---|
| 830 | // ------------------------------- |
|---|
| 831 | // add marked / selected |
|---|
| 832 | |
|---|
| 833 | static void nt_add_and_update(AWT_canvas *ntw, AddWhat what, bool quick) { |
|---|
| 834 | nt_add(AWT_TREE_PARS(ntw), what, quick); |
|---|
| 835 | pars_saveNrefresh_changed_tree(ntw); |
|---|
| 836 | } |
|---|
| 837 | |
|---|
| 838 | static void NT_add_and_NNI(UNFIXED, AWT_canvas *ntw, AddWhat what) { nt_add_and_update(ntw, what, false); } |
|---|
| 839 | static void NT_add_quick (UNFIXED, AWT_canvas *ntw, AddWhat what) { nt_add_and_update(ntw, what, true); } |
|---|
| 840 | |
|---|
| 841 | // ------------------------------------------ |
|---|
| 842 | // remove and add marked / selected |
|---|
| 843 | |
|---|
| 844 | static void nt_reAdd(AWT_graphic_parsimony *agt, AddWhat what, bool quick) { |
|---|
| 845 | if (agt->get_root_node()) { |
|---|
| 846 | ap_assert(what == NT_ADD_MARKED); // code below will misbehave for NT_ADD_SELECTED |
|---|
| 847 | agt->get_tree_root()->remove_leafs(AWT_RemoveType(AWT_REMOVE_BUT_DONT_FREE|AWT_REMOVE_MARKED)); |
|---|
| 848 | nt_add(agt, what, quick); |
|---|
| 849 | } |
|---|
| 850 | } |
|---|
| 851 | |
|---|
| 852 | static void nt_reAdd_and_update(AWT_canvas *ntw, AddWhat what, bool quick) { |
|---|
| 853 | nt_reAdd(AWT_TREE_PARS(ntw), what, quick); |
|---|
| 854 | pars_saveNrefresh_changed_tree(ntw); |
|---|
| 855 | } |
|---|
| 856 | |
|---|
| 857 | static void NT_reAdd_and_NNI(UNFIXED, AWT_canvas *ntw, AddWhat what) { nt_reAdd_and_update(ntw, what, false); } |
|---|
| 858 | static void NT_reAdd_quick (UNFIXED, AWT_canvas *ntw, AddWhat what) { nt_reAdd_and_update(ntw, what, true); } |
|---|
| 859 | |
|---|
| 860 | // -------------------------------------------------------------------------------- |
|---|
| 861 | |
|---|
| 862 | static void calc_branchlengths(AWT_graphic_parsimony *agt) { |
|---|
| 863 | arb_progress progress("Calculating Branch Lengths"); |
|---|
| 864 | rootEdge()->calc_branchlengths(); |
|---|
| 865 | agt->reorder_tree(BIG_BRANCHES_TO_TOP); |
|---|
| 866 | } |
|---|
| 867 | |
|---|
| 868 | static void NT_calc_branch_lengths(AW_window *, AWT_canvas *ntw) { |
|---|
| 869 | calc_branchlengths(AWT_TREE_PARS(ntw)); |
|---|
| 870 | pars_saveNrefresh_changed_tree(ntw); |
|---|
| 871 | } |
|---|
| 872 | |
|---|
| 873 | static void NT_bootstrap(AW_window *, AWT_canvas *ntw, bool limit_only) { |
|---|
| 874 | arb_progress progress("Calculating Bootstrap Limit"); |
|---|
| 875 | AP_BL_MODE mode = AP_BL_MODE((limit_only ? AP_BL_BOOTSTRAP_LIMIT : AP_BL_BOOTSTRAP_ESTIMATE)|AP_BL_BL_ONLY); |
|---|
| 876 | rootEdge()->nni_rek(-1, false, mode, NULL); |
|---|
| 877 | AWT_TREE(ntw)->reorder_tree(BIG_BRANCHES_TO_TOP); |
|---|
| 878 | AWT_TREE(ntw)->displayed_root = AWT_TREE(ntw)->get_root_node(); |
|---|
| 879 | pars_saveNrefresh_changed_tree(ntw); |
|---|
| 880 | } |
|---|
| 881 | |
|---|
| 882 | static void optimizeTree(AWT_graphic_parsimony *agt) { |
|---|
| 883 | arb_progress progress("Optimizing Tree"); |
|---|
| 884 | agt->get_parsimony().optimize_tree(rootNode(), progress); |
|---|
| 885 | ASSERT_VALID_TREE(rootNode()); |
|---|
| 886 | rootEdge()->calc_branchlengths(); |
|---|
| 887 | agt->reorder_tree(BIG_BRANCHES_TO_TOP); |
|---|
| 888 | rootNode()->compute_tree(); |
|---|
| 889 | } |
|---|
| 890 | static void NT_optimize(AW_window *, AWT_canvas *ntw) { |
|---|
| 891 | optimizeTree(AWT_TREE_PARS(ntw)); |
|---|
| 892 | pars_saveNrefresh_changed_tree(ntw); |
|---|
| 893 | } |
|---|
| 894 | |
|---|
| 895 | static void recursiveNNI(AWT_graphic_parsimony *agt) { |
|---|
| 896 | arb_progress progress("Recursive NNI"); |
|---|
| 897 | AP_FLOAT orgPars = rootNode()->costs(); |
|---|
| 898 | AP_FLOAT prevPars = orgPars; |
|---|
| 899 | progress.subtitle(GBS_global_string("Old parsimony: %.1f", orgPars)); |
|---|
| 900 | while (!progress.aborted()) { |
|---|
| 901 | AP_FLOAT currPars = rootEdge()->nni_rek(-1, true, AP_BL_NNI_ONLY, NULL); |
|---|
| 902 | if (currPars == prevPars) break; // no improvement -> abort |
|---|
| 903 | progress.subtitle(GBS_global_string("New parsimony: %.1f (gain: %.1f)", currPars, orgPars-currPars)); |
|---|
| 904 | prevPars = currPars; |
|---|
| 905 | } |
|---|
| 906 | rootEdge()->calc_branchlengths(); |
|---|
| 907 | agt->reorder_tree(BIG_BRANCHES_TO_TOP); |
|---|
| 908 | rootNode()->compute_tree(); |
|---|
| 909 | } |
|---|
| 910 | |
|---|
| 911 | static void NT_recursiveNNI(AW_window *, AWT_canvas *ntw) { |
|---|
| 912 | recursiveNNI(AWT_TREE_PARS(ntw)); |
|---|
| 913 | pars_saveNrefresh_changed_tree(ntw); |
|---|
| 914 | } |
|---|
| 915 | |
|---|
| 916 | static AW_window *PARS_create_tree_settings_window(AW_root *aw_root) { |
|---|
| 917 | static AW_window_simple *aws = 0; |
|---|
| 918 | if (!aws) { |
|---|
| 919 | aws = new AW_window_simple; |
|---|
| 920 | aws->init(aw_root, "SAVE_DB", "SAVE ARB DB"); |
|---|
| 921 | aws->load_xfig("awt/tree_settings.fig"); |
|---|
| 922 | |
|---|
| 923 | aws->at("close"); aws->callback((AW_CB0)AW_POPDOWN); |
|---|
| 924 | aws->create_button("CLOSE", "CLOSE", "C"); |
|---|
| 925 | |
|---|
| 926 | aws->at("help"); aws->callback(makeHelpCallback("nt_tree_settings.hlp")); |
|---|
| 927 | aws->create_button("HELP", "HELP", "H"); |
|---|
| 928 | |
|---|
| 929 | aws->at("button"); |
|---|
| 930 | aws->auto_space(10, 10); |
|---|
| 931 | aws->label_length(30); |
|---|
| 932 | |
|---|
| 933 | aws->label("Base Line Width"); |
|---|
| 934 | aws->create_input_field(AWAR_DTREE_BASELINEWIDTH, 4); |
|---|
| 935 | aws->at_newline(); |
|---|
| 936 | |
|---|
| 937 | aws->label("Relative vert. Dist"); |
|---|
| 938 | aws->create_input_field(AWAR_DTREE_VERICAL_DIST, 4); |
|---|
| 939 | aws->at_newline(); |
|---|
| 940 | |
|---|
| 941 | TREE_insert_jump_option_menu(aws, "On species change", AWAR_DTREE_AUTO_JUMP); |
|---|
| 942 | TREE_insert_jump_option_menu(aws, "On tree change", AWAR_DTREE_AUTO_JUMP_TREE); |
|---|
| 943 | } |
|---|
| 944 | return aws; |
|---|
| 945 | } |
|---|
| 946 | |
|---|
| 947 | // ----------------------- |
|---|
| 948 | // test functions |
|---|
| 949 | |
|---|
| 950 | #if defined(TESTMENU) |
|---|
| 951 | static void refreshTree(AWT_canvas *ntw) { |
|---|
| 952 | GB_transaction ta(ntw->gb_main); |
|---|
| 953 | |
|---|
| 954 | AWT_TREE(ntw)->check_update(ntw->gb_main); |
|---|
| 955 | GB_ERROR error = AWT_TREE(ntw)->save(ntw->gb_main, 0, 0, 0); |
|---|
| 956 | if (error) aw_message(error); |
|---|
| 957 | ntw->zoom_reset_and_refresh(); |
|---|
| 958 | } |
|---|
| 959 | #endif // TESTMENU |
|---|
| 960 | |
|---|
| 961 | static void setBranchlens(AP_tree_nlen *node, double newLen) |
|---|
| 962 | { |
|---|
| 963 | node->setBranchlen(newLen, newLen); |
|---|
| 964 | |
|---|
| 965 | if (!node->is_leaf) |
|---|
| 966 | { |
|---|
| 967 | setBranchlens(node->get_leftson(), newLen); |
|---|
| 968 | setBranchlens(node->get_rightson(), newLen); |
|---|
| 969 | } |
|---|
| 970 | } |
|---|
| 971 | #if defined(TESTMENU) |
|---|
| 972 | static void TESTMENU_setBranchlen(AW_window *, AWT_canvas *ntw) |
|---|
| 973 | { |
|---|
| 974 | AP_tree_nlen *root = rootNode(); |
|---|
| 975 | |
|---|
| 976 | setBranchlens(root, 1.0); |
|---|
| 977 | refreshTree(ntw); |
|---|
| 978 | } |
|---|
| 979 | |
|---|
| 980 | static void TESTMENU_treeStats(AW_window *) { |
|---|
| 981 | ARB_tree_info tinfo; |
|---|
| 982 | AP_tree_nlen *root = rootNode(); |
|---|
| 983 | |
|---|
| 984 | if (root) { |
|---|
| 985 | { |
|---|
| 986 | GB_transaction ta(root->get_tree_root()->get_gb_main()); |
|---|
| 987 | root->calcTreeInfo(tinfo); |
|---|
| 988 | } |
|---|
| 989 | |
|---|
| 990 | puts("Tree stats:"); |
|---|
| 991 | |
|---|
| 992 | printf("nodes =%6zu\n", tinfo.nodes()); |
|---|
| 993 | printf(" inner =%6zu\n", tinfo.innerNodes); |
|---|
| 994 | printf(" groups =%6zu\n", tinfo.groups); |
|---|
| 995 | printf(" leafs =%6zu\n", tinfo.leafs); |
|---|
| 996 | printf(" unlinked =%6zu (zombies?)\n", tinfo.unlinked); |
|---|
| 997 | printf(" linked =%6zu\n", tinfo.linked()); |
|---|
| 998 | printf(" marked =%6zu\n", tinfo.marked); |
|---|
| 999 | } |
|---|
| 1000 | else { |
|---|
| 1001 | puts("No tree"); |
|---|
| 1002 | } |
|---|
| 1003 | } |
|---|
| 1004 | |
|---|
| 1005 | static void TESTMENU_mixTree(AW_window *, AWT_canvas *ntw) |
|---|
| 1006 | { |
|---|
| 1007 | rootEdge()->mixTree(100); |
|---|
| 1008 | refreshTree(ntw); |
|---|
| 1009 | } |
|---|
| 1010 | |
|---|
| 1011 | static void TESTMENU_sortTreeByName(AW_window *, AWT_canvas *ntw) |
|---|
| 1012 | { |
|---|
| 1013 | AP_tree_nlen *root = rootNode(); |
|---|
| 1014 | |
|---|
| 1015 | root->sortByName(); |
|---|
| 1016 | refreshTree(ntw); |
|---|
| 1017 | } |
|---|
| 1018 | |
|---|
| 1019 | static void TESTMENU_buildAndDumpChain(AW_window *) |
|---|
| 1020 | { |
|---|
| 1021 | AP_tree_nlen *root = rootNode(); |
|---|
| 1022 | |
|---|
| 1023 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(2); |
|---|
| 1024 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(3); |
|---|
| 1025 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(4); |
|---|
| 1026 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(5); |
|---|
| 1027 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(6); |
|---|
| 1028 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(7); |
|---|
| 1029 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(8); |
|---|
| 1030 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(9); |
|---|
| 1031 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(10); |
|---|
| 1032 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(11); |
|---|
| 1033 | root->get_leftson()->edgeTo(root->get_rightson())->testChain(-1); |
|---|
| 1034 | } |
|---|
| 1035 | |
|---|
| 1036 | static void init_TEST_menu(AW_window_menu_modes *awm, AWT_canvas *ntw) |
|---|
| 1037 | { |
|---|
| 1038 | awm->create_menu("Test[debug]", "g", AWM_ALL); |
|---|
| 1039 | |
|---|
| 1040 | awm->insert_menu_topic("mixtree", "Mix tree", "M", "", AWM_ALL, makeWindowCallback(TESTMENU_mixTree, ntw)); |
|---|
| 1041 | awm->insert_menu_topic("treestat", "Tree statistics", "s", "", AWM_ALL, TESTMENU_treeStats); |
|---|
| 1042 | awm->insert_menu_topic("setlens", "Set branchlens", "b", "", AWM_ALL, makeWindowCallback(TESTMENU_setBranchlen, ntw)); |
|---|
| 1043 | awm->insert_menu_topic("sorttreebyname", "Sort tree by name", "o", "", AWM_ALL, makeWindowCallback(TESTMENU_sortTreeByName, ntw)); |
|---|
| 1044 | awm->insert_menu_topic("buildndumpchain", "Build & dump chain", "c", "", AWM_ALL, TESTMENU_buildAndDumpChain); |
|---|
| 1045 | } |
|---|
| 1046 | #endif // TESTMENU |
|---|
| 1047 | |
|---|
| 1048 | static GB_ERROR pars_check_size(AW_root *awr, GB_ERROR& warning) { |
|---|
| 1049 | GB_ERROR error = NULL; |
|---|
| 1050 | warning = NULL; |
|---|
| 1051 | |
|---|
| 1052 | char *tree_name = awr->awar(AWAR_TREE)->read_string(); |
|---|
| 1053 | char *filter = awr->awar(AWAR_FILTER_FILTER)->read_string(); |
|---|
| 1054 | long ali_len = 0; |
|---|
| 1055 | |
|---|
| 1056 | if (strlen(filter)) { |
|---|
| 1057 | int i; |
|---|
| 1058 | for (i=0; filter[i]; i++) { |
|---|
| 1059 | if (filter[i] != '0') ali_len++; |
|---|
| 1060 | } |
|---|
| 1061 | } |
|---|
| 1062 | else { |
|---|
| 1063 | char *ali_name = awr->awar(AWAR_ALIGNMENT)->read_string(); |
|---|
| 1064 | ali_len = GBT_get_alignment_len(ap_main->get_gb_main(), ali_name); |
|---|
| 1065 | if (ali_len<=0) { |
|---|
| 1066 | error = "Please select a valid alignment"; |
|---|
| 1067 | GB_clear_error(); |
|---|
| 1068 | } |
|---|
| 1069 | free(ali_name); |
|---|
| 1070 | } |
|---|
| 1071 | |
|---|
| 1072 | if (!error) { |
|---|
| 1073 | long tree_size = GBT_size_of_tree(ap_main->get_gb_main(), tree_name); |
|---|
| 1074 | if (tree_size == -1) { |
|---|
| 1075 | error = "Please select an existing tree"; |
|---|
| 1076 | } |
|---|
| 1077 | else { |
|---|
| 1078 | unsigned long expected_memuse = (ali_len * tree_size * 4 / 1024); |
|---|
| 1079 | if (expected_memuse > GB_get_usable_memory()) { |
|---|
| 1080 | warning = GBS_global_string("Estimated memory usage (%s) exceeds physical memory (will swap)\n" |
|---|
| 1081 | "(did you specify a filter?)", |
|---|
| 1082 | GBS_readable_size(expected_memuse, "b")); |
|---|
| 1083 | } |
|---|
| 1084 | } |
|---|
| 1085 | } |
|---|
| 1086 | |
|---|
| 1087 | free(filter); |
|---|
| 1088 | free(tree_name); |
|---|
| 1089 | |
|---|
| 1090 | ap_assert(!GB_have_error()); |
|---|
| 1091 | return error; |
|---|
| 1092 | } |
|---|
| 1093 | |
|---|
| 1094 | static void pars_reset_optimal_parsimony(AW_window *aww, AWT_canvas *ntw) { |
|---|
| 1095 | AW_root *awr = aww->get_root(); |
|---|
| 1096 | awr->awar(AWAR_BEST_PARSIMONY)->write_int(awr->awar(AWAR_PARSIMONY)->read_int()); |
|---|
| 1097 | ntw->refresh(); |
|---|
| 1098 | } |
|---|
| 1099 | |
|---|
| 1100 | |
|---|
| 1101 | static void pars_start_cb(AW_window *aw_parent, WeightedFilter *wfilt, const PARS_commands *cmds) { |
|---|
| 1102 | AW_root *awr = aw_parent->get_root(); |
|---|
| 1103 | GBDATA *gb_main = ap_main->get_gb_main(); |
|---|
| 1104 | GB_begin_transaction(gb_main); |
|---|
| 1105 | { |
|---|
| 1106 | GB_ERROR warning; |
|---|
| 1107 | GB_ERROR error = pars_check_size(awr, warning); |
|---|
| 1108 | |
|---|
| 1109 | if (warning && !error) { |
|---|
| 1110 | char *question = GBS_global_string_copy("%s\nDo you want to continue?", warning); |
|---|
| 1111 | bool cont = aw_ask_sure("swap_warning", question); |
|---|
| 1112 | free(question); |
|---|
| 1113 | |
|---|
| 1114 | if (!cont) error = "User abort"; |
|---|
| 1115 | |
|---|
| 1116 | } |
|---|
| 1117 | |
|---|
| 1118 | if (error) { |
|---|
| 1119 | aw_message(error); |
|---|
| 1120 | GB_commit_transaction(gb_main); |
|---|
| 1121 | return; |
|---|
| 1122 | } |
|---|
| 1123 | } |
|---|
| 1124 | |
|---|
| 1125 | |
|---|
| 1126 | AW_window_menu_modes *awm = new AW_window_menu_modes; |
|---|
| 1127 | awm->init(awr, "ARB_PARSIMONY", "ARB_PARSIMONY", 400, 200); |
|---|
| 1128 | |
|---|
| 1129 | GLOBAL_PARS->generate_tree(wfilt); |
|---|
| 1130 | |
|---|
| 1131 | AWT_canvas *ntw; |
|---|
| 1132 | { |
|---|
| 1133 | AP_tree_display_type old_sort_type = global_tree()->tree_sort; |
|---|
| 1134 | global_tree()->set_tree_type(AP_LIST_SIMPLE, NULL); // avoid NDS warnings during startup |
|---|
| 1135 | ntw = new AWT_canvas(gb_main, awm, awm->get_window_id(), global_tree(), AWAR_TREE); |
|---|
| 1136 | global_tree()->set_tree_type(old_sort_type, ntw); |
|---|
| 1137 | } |
|---|
| 1138 | |
|---|
| 1139 | { |
|---|
| 1140 | GB_ERROR error = 0; |
|---|
| 1141 | arb_progress progress("loading tree"); |
|---|
| 1142 | NT_reload_tree_event(awr, ntw, 0); // load tree (but do not expose - first zombies need to be removed) |
|---|
| 1143 | if (!global_tree()->get_root_node()) { |
|---|
| 1144 | error = "Failed to load the selected tree"; |
|---|
| 1145 | } |
|---|
| 1146 | else { |
|---|
| 1147 | AP_tree_edge::initialize(rootNode()); // builds edges |
|---|
| 1148 | long removed = global_tree_root()->remove_leafs(AWT_REMOVE_ZOMBIES); |
|---|
| 1149 | |
|---|
| 1150 | PARS_tree_init(global_tree()); |
|---|
| 1151 | removed += global_tree_root()->remove_leafs(AWT_RemoveType(AWT_REMOVE_ZOMBIES | AWT_REMOVE_NO_SEQUENCE)); |
|---|
| 1152 | |
|---|
| 1153 | if (!global_tree()->get_root_node()) { |
|---|
| 1154 | const char *aliname = global_tree_root()->get_aliview()->get_aliname(); |
|---|
| 1155 | error = GBS_global_string("Less than 2 species contain data in '%s'\n" |
|---|
| 1156 | "Tree vanished", aliname); |
|---|
| 1157 | } |
|---|
| 1158 | else if (removed) { |
|---|
| 1159 | aw_message(GBS_global_string("Removed %li leafs (zombies or species w/o data in alignment)", removed)); |
|---|
| 1160 | } |
|---|
| 1161 | |
|---|
| 1162 | error = GB_end_transaction(ntw->gb_main, error); |
|---|
| 1163 | if (!error) { |
|---|
| 1164 | progress.subtitle("Calculating inner nodes"); |
|---|
| 1165 | GLOBAL_PARS->get_root_node()->costs(); |
|---|
| 1166 | } |
|---|
| 1167 | } |
|---|
| 1168 | if (error) aw_popup_exit(error); |
|---|
| 1169 | } |
|---|
| 1170 | |
|---|
| 1171 | awr->awar(AWAR_COLOR_GROUPS_USE)->add_callback(makeRootCallback(TREE_recompute_cb, ntw)); |
|---|
| 1172 | |
|---|
| 1173 | if (cmds->add_marked) NT_add_quick(NULL, ntw, NT_ADD_MARKED); |
|---|
| 1174 | if (cmds->add_selected) NT_add_quick(NULL, ntw, NT_ADD_SELECTED); |
|---|
| 1175 | if (cmds->calc_branch_lengths) NT_calc_branch_lengths(awm, ntw); |
|---|
| 1176 | if (cmds->calc_bootstrap) NT_bootstrap(awm, ntw, 0); |
|---|
| 1177 | if (cmds->quit) pars_exit(awm); |
|---|
| 1178 | |
|---|
| 1179 | GB_transaction ta(ntw->gb_main); |
|---|
| 1180 | |
|---|
| 1181 | GBDATA *gb_arb_presets = GB_search(ntw->gb_main, "arb_presets", GB_CREATE_CONTAINER); |
|---|
| 1182 | GB_add_callback(gb_arb_presets, GB_CB_CHANGED, makeDatabaseCallback(AWT_expose_cb, ntw)); |
|---|
| 1183 | |
|---|
| 1184 | #if defined(DEBUG) |
|---|
| 1185 | AWT_create_debug_menu(awm); |
|---|
| 1186 | #endif // DEBUG |
|---|
| 1187 | |
|---|
| 1188 | awm->create_menu("File", "F", AWM_ALL); |
|---|
| 1189 | { |
|---|
| 1190 | insert_macro_menu_entry(awm, false); |
|---|
| 1191 | awm->insert_menu_topic("print_tree", "Print Tree ...", "P", "tree2prt.hlp", AWM_ALL, makeWindowCallback(AWT_popup_print_window, ntw)); |
|---|
| 1192 | awm->insert_menu_topic("quit", "Quit", "Q", "quit.hlp", AWM_ALL, pars_exit); |
|---|
| 1193 | } |
|---|
| 1194 | |
|---|
| 1195 | awm->create_menu("Species", "S", AWM_ALL); |
|---|
| 1196 | { |
|---|
| 1197 | NT_insert_mark_submenus(awm, ntw, 0); |
|---|
| 1198 | |
|---|
| 1199 | } |
|---|
| 1200 | awm->create_menu("Tree", "T", AWM_ALL); |
|---|
| 1201 | { |
|---|
| 1202 | |
|---|
| 1203 | awm->insert_menu_topic("nds", "NDS (Node Display Setup) ...", "N", "props_nds.hlp", AWM_ALL, makeCreateWindowCallback(AWT_create_nds_window, ntw->gb_main)); |
|---|
| 1204 | |
|---|
| 1205 | awm->sep______________(); |
|---|
| 1206 | awm->insert_menu_topic("tree_2_xfig", "Export tree to XFIG ...", "E", "tree2file.hlp", AWM_ALL, makeWindowCallback(AWT_popup_tree_export_window, ntw)); |
|---|
| 1207 | awm->insert_menu_topic("tree_print", "Print tree ...", "P", "tree2prt.hlp", AWM_ALL, makeWindowCallback(AWT_popup_print_window, ntw)); |
|---|
| 1208 | awm->sep______________(); |
|---|
| 1209 | NT_insert_collapse_submenu(awm, ntw); |
|---|
| 1210 | awm->sep______________(); |
|---|
| 1211 | awm->insert_sub_menu("Remove Species from Tree", "R"); |
|---|
| 1212 | { |
|---|
| 1213 | awm->insert_menu_topic("tree_remove_deleted", "Remove Zombies", "Z", "trm_del.hlp", AWM_ALL, makeWindowCallback(NT_remove_leafs, ntw, AWT_RemoveType(AWT_REMOVE_BUT_DONT_FREE|AWT_REMOVE_ZOMBIES))); |
|---|
| 1214 | awm->insert_menu_topic("tree_remove_marked", "Remove Marked", "M", "trm_mrkd.hlp", AWM_ALL, makeWindowCallback(NT_remove_leafs, ntw, AWT_RemoveType(AWT_REMOVE_BUT_DONT_FREE|AWT_REMOVE_MARKED))); |
|---|
| 1215 | awm->insert_menu_topic("tree_keep_marked", "Keep Marked", "K", "tkeep_mrkd.hlp", AWM_ALL, makeWindowCallback(NT_remove_leafs, ntw, AWT_RemoveType(AWT_REMOVE_BUT_DONT_FREE|AWT_KEEP_MARKED))); |
|---|
| 1216 | } |
|---|
| 1217 | awm->close_sub_menu(); |
|---|
| 1218 | awm->insert_sub_menu("Add Species to Tree", "A"); |
|---|
| 1219 | { |
|---|
| 1220 | awm->insert_menu_topic("add_marked", "Add Marked Species", "M", "pa_quick.hlp", AWM_ALL, makeWindowCallback(NT_add_quick, ntw, NT_ADD_MARKED)); |
|---|
| 1221 | awm->insert_menu_topic("add_marked_nni", "Add Marked Species + Local Optimization (NNI)", "N", "pa_add.hlp", AWM_ALL, makeWindowCallback(NT_add_and_NNI, ntw, NT_ADD_MARKED)); |
|---|
| 1222 | awm->insert_menu_topic("rm_add_marked", "Remove & Add Marked Species", "R", "pa_quick.hlp", AWM_ALL, makeWindowCallback(NT_reAdd_quick, ntw, NT_ADD_MARKED)); |
|---|
| 1223 | awm->insert_menu_topic("rm_add_marked_nni|", "Remove & Add Marked + Local Optimization (NNI)", "L", "pa_add.hlp", AWM_ALL, makeWindowCallback(NT_reAdd_and_NNI, ntw, NT_ADD_MARKED)); |
|---|
| 1224 | awm->sep______________(); |
|---|
| 1225 | awm->insert_menu_topic("add_marked_partial", "Add Marked Partial Species", "P", "pa_partial.hlp", AWM_ALL, makeWindowCallback(NT_add_partial_and_update, ntw)); |
|---|
| 1226 | awm->sep______________(); |
|---|
| 1227 | awm->insert_menu_topic("add_selected", "Add Selected Species", "S", "pa_quick.hlp", AWM_ALL, makeWindowCallback(NT_add_quick, ntw, NT_ADD_SELECTED)); |
|---|
| 1228 | awm->insert_menu_topic("add_selected_nni", "Add Selected Species + Local Optimization (NNI)", "O", "pa_add.hlp", AWM_ALL, makeWindowCallback(NT_add_and_NNI, ntw, NT_ADD_SELECTED)); |
|---|
| 1229 | } |
|---|
| 1230 | awm->close_sub_menu(); |
|---|
| 1231 | awm->sep______________(); |
|---|
| 1232 | awm->insert_sub_menu("Tree Optimization", "O"); |
|---|
| 1233 | { |
|---|
| 1234 | awm->insert_menu_topic("nni", "Local Optimization (NNI) of Marked Visible Nodes", "L", "", AWM_ALL, makeWindowCallback(NT_recursiveNNI, ntw)); |
|---|
| 1235 | awm->insert_menu_topic("kl_optimization", "Global Optimization of Marked Visible Nodes", "G", "pa_optimizer.hlp", AWM_ALL, makeWindowCallback(NT_optimize, ntw)); |
|---|
| 1236 | } |
|---|
| 1237 | awm->close_sub_menu(); |
|---|
| 1238 | awm->insert_menu_topic("reset", "Reset optimal parsimony", "s", "", AWM_ALL, makeWindowCallback(pars_reset_optimal_parsimony, ntw)); |
|---|
| 1239 | awm->sep______________(); |
|---|
| 1240 | awm->insert_menu_topic("beautify_tree", "Beautify Tree", "B", "resorttree.hlp", AWM_ALL, makeWindowCallback(NT_resort_tree_cb, ntw, BIG_BRANCHES_TO_TOP)); |
|---|
| 1241 | awm->insert_menu_topic("calc_branch_lengths", "Calculate Branch Lengths", "L", "pa_branchlengths.hlp", AWM_ALL, makeWindowCallback(NT_calc_branch_lengths, ntw)); |
|---|
| 1242 | awm->sep______________(); |
|---|
| 1243 | awm->insert_menu_topic("calc_upper_bootstrap_indep", "Calculate Upper Bootstrap Limit (dependent NNI)", "d", "pa_bootstrap.hlp", AWM_ALL, makeWindowCallback(NT_bootstrap, ntw, false)); |
|---|
| 1244 | awm->insert_menu_topic("calc_upper_bootstrap_dep", "Calculate Upper Bootstrap Limit (independent NNI)", "i", "pa_bootstrap.hlp", AWM_ALL, makeWindowCallback(NT_bootstrap, ntw, true)); |
|---|
| 1245 | awm->insert_menu_topic("tree_remove_remark", "Remove Bootstrap Values", "V", "trm_boot.hlp", AWM_ALL, makeWindowCallback(NT_remove_bootstrap, ntw)); |
|---|
| 1246 | } |
|---|
| 1247 | |
|---|
| 1248 | #if defined(TESTMENU) |
|---|
| 1249 | init_TEST_menu(awm, ntw); |
|---|
| 1250 | #endif // TESTMENU |
|---|
| 1251 | |
|---|
| 1252 | awm->create_menu("Reset", "R", AWM_ALL); |
|---|
| 1253 | { |
|---|
| 1254 | awm->insert_menu_topic("reset_logical_zoom", "Logical Zoom", "L", "rst_log_zoom.hlp", AWM_ALL, makeWindowCallback(NT_reset_lzoom_cb, ntw)); |
|---|
| 1255 | awm->insert_menu_topic("reset_physical_zoom", "Physical Zoom", "P", "rst_phys_zoom.hlp", AWM_ALL, makeWindowCallback(NT_reset_pzoom_cb, ntw)); |
|---|
| 1256 | } |
|---|
| 1257 | |
|---|
| 1258 | awm->create_menu("Properties", "P", AWM_ALL); |
|---|
| 1259 | { |
|---|
| 1260 | awm->insert_menu_topic("props_menu", "Menu: Colors and Fonts ...", "M", "props_frame.hlp", AWM_ALL, AW_preset_window); |
|---|
| 1261 | awm->insert_menu_topic("props_tree", "Tree: Colors and Fonts ...", "C", "pars_props_data.hlp", AWM_ALL, makeCreateWindowCallback(AW_create_gc_window, ntw->gc_manager)); |
|---|
| 1262 | awm->insert_menu_topic("props_tree2", "Tree: Settings ...", "T", "nt_tree_settings.hlp", AWM_ALL, PARS_create_tree_settings_window); |
|---|
| 1263 | awm->insert_menu_topic("props_kl", "KERN. LIN ...", "K", "kernlin.hlp", AWM_ALL, makeCreateWindowCallback(create_kernighan_window)); |
|---|
| 1264 | awm->sep______________(); |
|---|
| 1265 | AW_insert_common_property_menu_entries(awm); |
|---|
| 1266 | awm->sep______________(); |
|---|
| 1267 | awm->insert_menu_topic("save_props", "Save Defaults (pars.arb)", "D", "savedef.hlp", AWM_ALL, AW_save_properties); |
|---|
| 1268 | } |
|---|
| 1269 | awm->button_length(5); |
|---|
| 1270 | |
|---|
| 1271 | awm->insert_help_topic("ARB_PARSIMONY help", "P", "arb_pars.hlp", AWM_ALL, makeHelpCallback("arb_pars.hlp")); |
|---|
| 1272 | |
|---|
| 1273 | // ---------------------- |
|---|
| 1274 | // mode buttons |
|---|
| 1275 | // |
|---|
| 1276 | // keep them synchronized as far as possible with those in ARB_PARSIMONY |
|---|
| 1277 | // see ../NTREE/NT_extern.cxx@keepModesSynchronized |
|---|
| 1278 | |
|---|
| 1279 | awm->create_mode("mode_select.xpm", "mode_select.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_SELECT)); |
|---|
| 1280 | awm->create_mode("mode_mark.xpm", "mode_mark.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_MARK)); |
|---|
| 1281 | awm->create_mode("mode_group.xpm", "mode_group.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_GROUP)); |
|---|
| 1282 | awm->create_mode("mode_zoom.xpm", "mode_pzoom.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_ZOOM)); |
|---|
| 1283 | awm->create_mode("mode_lzoom.xpm", "mode_lzoom.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_LZOOM)); |
|---|
| 1284 | |
|---|
| 1285 | // reserve mode-locations (to put the modes below at the same position as in ARB_NT) |
|---|
| 1286 | awm->create_mode("mode_empty.xpm", "mode.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_EMPTY)); |
|---|
| 1287 | awm->create_mode("mode_empty.xpm", "mode.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_EMPTY)); |
|---|
| 1288 | |
|---|
| 1289 | // topology-modification-modes |
|---|
| 1290 | awm->create_mode("mode_setroot.xpm", "mode_setroot.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_SETROOT)); |
|---|
| 1291 | awm->create_mode("mode_swap.xpm", "mode_swap.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_SWAP)); |
|---|
| 1292 | awm->create_mode("mode_move.xpm", "mode_move.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_MOVE)); |
|---|
| 1293 | |
|---|
| 1294 | awm->create_mode("mode_nni.xpm", "mode_nni.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_NNI)); |
|---|
| 1295 | awm->create_mode("mode_kernlin.xpm", "mode_kernlin.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_KERNINGHAN)); |
|---|
| 1296 | awm->create_mode("mode_optimize.xpm", "mode_optimize.hlp", AWM_ALL, makeWindowCallback(nt_mode_event, ntw, AWT_MODE_OPTIMIZE)); |
|---|
| 1297 | |
|---|
| 1298 | awm->at(5, 2); |
|---|
| 1299 | awm->auto_space(0, -2); |
|---|
| 1300 | awm->shadow_width(1); |
|---|
| 1301 | |
|---|
| 1302 | |
|---|
| 1303 | int db_treex, db_treey; |
|---|
| 1304 | awm->get_at_position(&db_treex, &db_treey); |
|---|
| 1305 | awm->callback(makeHelpCallback("nt_tree_select.hlp")); |
|---|
| 1306 | awm->button_length(16); |
|---|
| 1307 | awm->help_text("nt_tree_select.hlp"); |
|---|
| 1308 | awm->create_button(0, AWAR_TREE); |
|---|
| 1309 | |
|---|
| 1310 | |
|---|
| 1311 | int db_stackx, db_stacky; |
|---|
| 1312 | awm->label_length(8); |
|---|
| 1313 | awm->label("Stored"); |
|---|
| 1314 | awm->get_at_position(&db_stackx, &db_stacky); |
|---|
| 1315 | awm->button_length(6); |
|---|
| 1316 | awm->callback(makeHelpCallback("ap_stack.hlp")); |
|---|
| 1317 | awm->help_text("ap_stack.hlp"); |
|---|
| 1318 | awm->create_button(0, AWAR_STACKPOINTER); |
|---|
| 1319 | |
|---|
| 1320 | int db_parsx, db_parsy; |
|---|
| 1321 | awm->label_length(14); |
|---|
| 1322 | awm->label("Current Pars:"); |
|---|
| 1323 | awm->get_at_position(&db_parsx, &db_parsy); |
|---|
| 1324 | |
|---|
| 1325 | awm->button_length(10); |
|---|
| 1326 | awm->create_button(0, AWAR_PARSIMONY, 0, "+"); |
|---|
| 1327 | |
|---|
| 1328 | awm->button_length(0); |
|---|
| 1329 | |
|---|
| 1330 | awm->callback(makeWindowCallback(NT_jump_cb, ntw, AP_JUMP_BY_BUTTON)); |
|---|
| 1331 | awm->help_text("tr_jump.hlp"); |
|---|
| 1332 | awm->create_button("JUMP", "Jump", 0); |
|---|
| 1333 | |
|---|
| 1334 | awm->callback(makeHelpCallback("arb_pars.hlp")); |
|---|
| 1335 | awm->help_text("help.hlp"); |
|---|
| 1336 | awm->create_button("HELP", "HELP", "H"); |
|---|
| 1337 | |
|---|
| 1338 | awm->at_newline(); |
|---|
| 1339 | |
|---|
| 1340 | awm->button_length(8); |
|---|
| 1341 | awm->at_x(db_stackx); |
|---|
| 1342 | awm->callback(makeWindowCallback(AP_user_pop_cb, ntw)); |
|---|
| 1343 | awm->help_text("ap_stack.hlp"); |
|---|
| 1344 | awm->create_button("POP", "RESTORE", 0); |
|---|
| 1345 | |
|---|
| 1346 | awm->button_length(6); |
|---|
| 1347 | awm->callback(makeWindowCallback(AP_user_push_cb, ntw)); |
|---|
| 1348 | awm->help_text("ap_stack.hlp"); |
|---|
| 1349 | awm->create_button("PUSH", "STORE", 0); |
|---|
| 1350 | |
|---|
| 1351 | awm->at_x(db_parsx); |
|---|
| 1352 | awm->label_length(14); |
|---|
| 1353 | awm->label("Optimal Pars:"); |
|---|
| 1354 | |
|---|
| 1355 | awm->button_length(10); |
|---|
| 1356 | awm->create_button(0, AWAR_BEST_PARSIMONY, 0, "+"); |
|---|
| 1357 | |
|---|
| 1358 | awm->button_length(0); |
|---|
| 1359 | awm->auto_space(0, -2); |
|---|
| 1360 | |
|---|
| 1361 | awm->at_x(db_treex); |
|---|
| 1362 | awm->callback(makeWindowCallback(NT_set_tree_style, ntw, AP_TREE_RADIAL)); |
|---|
| 1363 | awm->help_text("tr_type_radial.hlp"); |
|---|
| 1364 | awm->create_button("RADIAL_TREE", "#radial.xpm", 0); |
|---|
| 1365 | |
|---|
| 1366 | awm->callback(makeWindowCallback(NT_set_tree_style, ntw, AP_TREE_NORMAL)); |
|---|
| 1367 | awm->help_text("tr_type_list.hlp"); |
|---|
| 1368 | awm->create_button("LIST_TREE", "#dendro.xpm", 0); |
|---|
| 1369 | |
|---|
| 1370 | awm->at_newline(); |
|---|
| 1371 | awm->at(db_treex, awm->get_at_yposition()); |
|---|
| 1372 | |
|---|
| 1373 | { |
|---|
| 1374 | SmartPtr<AW_at_storage> maxSize(AW_at_storage::make(awm, AW_AT_MAXSIZE)); |
|---|
| 1375 | |
|---|
| 1376 | awm->button_length(AWAR_FOOTER_MAX_LEN); |
|---|
| 1377 | awm->create_button(0, AWAR_FOOTER); |
|---|
| 1378 | awm->at_newline(); |
|---|
| 1379 | awm->restore_at_from(*maxSize); |
|---|
| 1380 | } |
|---|
| 1381 | |
|---|
| 1382 | awm->get_at_position(&db_treex, &db_treey); |
|---|
| 1383 | awm->set_info_area_height(db_treey); |
|---|
| 1384 | |
|---|
| 1385 | awm->set_bottom_area_height(0); |
|---|
| 1386 | |
|---|
| 1387 | aw_parent->hide(); // hide parent |
|---|
| 1388 | awm->show(); |
|---|
| 1389 | |
|---|
| 1390 | awr->awar(AWAR_SPECIES_NAME)->add_callback(makeRootCallback(TREE_auto_jump_cb, ntw, false)); |
|---|
| 1391 | |
|---|
| 1392 | AP_user_push_cb(aw_parent, ntw); // push initial tree |
|---|
| 1393 | } |
|---|
| 1394 | |
|---|
| 1395 | static AW_window *create_pars_init_window(AW_root *awr, const PARS_commands *cmds) { |
|---|
| 1396 | AW_window_simple *aws = new AW_window_simple; |
|---|
| 1397 | aws->init(awr, "PARS_PROPS", "SET PARSIMONY OPTIONS"); |
|---|
| 1398 | aws->load_xfig("pars/init.fig"); |
|---|
| 1399 | |
|---|
| 1400 | aws->button_length(10); |
|---|
| 1401 | aws->label_length(10); |
|---|
| 1402 | |
|---|
| 1403 | aws->callback(pars_exit); |
|---|
| 1404 | aws->at("close"); |
|---|
| 1405 | aws->create_button("ABORT", "ABORT", "A"); |
|---|
| 1406 | |
|---|
| 1407 | aws->callback(makeHelpCallback("arb_pars_init.hlp")); |
|---|
| 1408 | aws->at("help"); |
|---|
| 1409 | aws->create_button("HELP", "HELP", "H"); |
|---|
| 1410 | |
|---|
| 1411 | GBDATA *gb_main = ap_main->get_gb_main(); |
|---|
| 1412 | WeightedFilter *weighted_filter = // do NOT free (bound to callbacks) |
|---|
| 1413 | new WeightedFilter(gb_main, aws->get_root(), AWAR_FILTER_NAME, AWAR_COLUMNSTAT_NAME, aws->get_root()->awar_string(AWAR_ALIGNMENT)); |
|---|
| 1414 | |
|---|
| 1415 | aws->at("filter"); |
|---|
| 1416 | aws->callback(makeCreateWindowCallback(awt_create_select_filter_win, weighted_filter->get_adfiltercbstruct())); |
|---|
| 1417 | aws->create_button("SELECT_FILTER", AWAR_FILTER_NAME); |
|---|
| 1418 | |
|---|
| 1419 | aws->at("weights"); |
|---|
| 1420 | aws->callback(makeCreateWindowCallback(COLSTAT_create_selection_window, weighted_filter->get_column_stat())); |
|---|
| 1421 | aws->sens_mask(AWM_EXP); |
|---|
| 1422 | aws->create_button("SELECT_CSP", AWAR_COLUMNSTAT_NAME); |
|---|
| 1423 | aws->sens_mask(AWM_ALL); |
|---|
| 1424 | |
|---|
| 1425 | aws->at("alignment"); |
|---|
| 1426 | awt_create_ALI_selection_list(gb_main, aws, AWAR_ALIGNMENT, "*="); |
|---|
| 1427 | |
|---|
| 1428 | aws->at("tree"); |
|---|
| 1429 | awt_create_TREE_selection_list(gb_main, aws, AWAR_TREE, true); |
|---|
| 1430 | |
|---|
| 1431 | aws->callback(makeWindowCallback(pars_start_cb, weighted_filter, cmds)); |
|---|
| 1432 | aws->at("go"); |
|---|
| 1433 | aws->create_button("GO", "GO", "G"); |
|---|
| 1434 | |
|---|
| 1435 | return aws; |
|---|
| 1436 | } |
|---|
| 1437 | |
|---|
| 1438 | static void create_parsimony_variables(AW_root *aw_root, AW_default db) { |
|---|
| 1439 | // kernighan |
|---|
| 1440 | |
|---|
| 1441 | aw_root->awar_float("genetic/kh/nodes", 1.7, db); |
|---|
| 1442 | aw_root->awar_int("genetic/kh/maxdepth", 15, db); |
|---|
| 1443 | aw_root->awar_int("genetic/kh/incdepth", 5, db); |
|---|
| 1444 | |
|---|
| 1445 | aw_root->awar_int("genetic/kh/static/enable", 1, db); |
|---|
| 1446 | aw_root->awar_int("genetic/kh/static/depth0", 2, db); |
|---|
| 1447 | aw_root->awar_int("genetic/kh/static/depth1", 2, db); |
|---|
| 1448 | aw_root->awar_int("genetic/kh/static/depth2", 2, db); |
|---|
| 1449 | aw_root->awar_int("genetic/kh/static/depth3", 2, db); |
|---|
| 1450 | aw_root->awar_int("genetic/kh/static/depth4", 1, db); |
|---|
| 1451 | |
|---|
| 1452 | aw_root->awar_int("genetic/kh/dynamic/enable", 1, db); |
|---|
| 1453 | aw_root->awar_int("genetic/kh/dynamic/start", 100, db); |
|---|
| 1454 | aw_root->awar_int("genetic/kh/dynamic/maxx", 6, db); |
|---|
| 1455 | aw_root->awar_int("genetic/kh/dynamic/maxy", 150, db); |
|---|
| 1456 | |
|---|
| 1457 | aw_root->awar_int("genetic/kh/function_type", AP_QUADRAT_START, db); |
|---|
| 1458 | |
|---|
| 1459 | awt_create_dtree_awars(aw_root, db); |
|---|
| 1460 | } |
|---|
| 1461 | |
|---|
| 1462 | static void pars_create_all_awars(AW_root *awr, AW_default aw_def, GBDATA *gb_main) { |
|---|
| 1463 | awr->awar_string(AWAR_SPECIES_NAME, "", gb_main); |
|---|
| 1464 | awr->awar_string(AWAR_FOOTER, "", aw_def); |
|---|
| 1465 | awr->awar_string(AWAR_FILTER_NAME, "none", gb_main); |
|---|
| 1466 | |
|---|
| 1467 | { |
|---|
| 1468 | GB_transaction ta(gb_main); |
|---|
| 1469 | char *dali = GBT_get_default_alignment(gb_main); |
|---|
| 1470 | |
|---|
| 1471 | awr->awar_string(AWAR_ALIGNMENT, dali, gb_main)->write_string(dali); |
|---|
| 1472 | free(dali); |
|---|
| 1473 | } |
|---|
| 1474 | |
|---|
| 1475 | awt_set_awar_to_valid_filter_good_for_tree_methods(gb_main, awr, AWAR_FILTER_NAME); |
|---|
| 1476 | |
|---|
| 1477 | awr->awar_string(AWAR_FILTER_FILTER, "", gb_main); |
|---|
| 1478 | awr->awar_string(AWAR_FILTER_ALIGNMENT, "", aw_def); |
|---|
| 1479 | |
|---|
| 1480 | awr->awar(AWAR_FILTER_ALIGNMENT)->map(AWAR_ALIGNMENT); |
|---|
| 1481 | |
|---|
| 1482 | awr->awar_int(AWAR_PARS_TYPE, PARS_WAGNER, gb_main); |
|---|
| 1483 | |
|---|
| 1484 | { |
|---|
| 1485 | GB_transaction ta(gb_main); |
|---|
| 1486 | GBDATA *gb_tree_name = GB_search(gb_main, AWAR_TREE, GB_STRING); |
|---|
| 1487 | char *tree_name = GB_read_string(gb_tree_name); |
|---|
| 1488 | |
|---|
| 1489 | awr->awar_string(AWAR_TREE, "", aw_def)->write_string(tree_name); |
|---|
| 1490 | free(tree_name); |
|---|
| 1491 | } |
|---|
| 1492 | |
|---|
| 1493 | awr->awar_int(AWAR_PARSIMONY, 0, aw_def); |
|---|
| 1494 | awr->awar_int(AWAR_BEST_PARSIMONY, 0, aw_def); |
|---|
| 1495 | awr->awar_int(AWAR_STACKPOINTER, 0, aw_def); |
|---|
| 1496 | |
|---|
| 1497 | create_parsimony_variables(awr, gb_main); |
|---|
| 1498 | create_nds_vars(awr, aw_def, gb_main); |
|---|
| 1499 | |
|---|
| 1500 | #if defined(DEBUG) |
|---|
| 1501 | AWT_create_db_browser_awars(awr, aw_def); |
|---|
| 1502 | #endif // DEBUG |
|---|
| 1503 | |
|---|
| 1504 | GB_ERROR error = ARB_init_global_awars(awr, aw_def, gb_main); |
|---|
| 1505 | if (error) aw_message(error); |
|---|
| 1506 | } |
|---|
| 1507 | |
|---|
| 1508 | static AW_root *AD_map_viewer_aw_root = 0; |
|---|
| 1509 | |
|---|
| 1510 | void PARS_map_viewer(GBDATA *gb_species, AD_MAP_VIEWER_TYPE vtype) { |
|---|
| 1511 | if (vtype == ADMVT_SELECT && AD_map_viewer_aw_root && gb_species) { |
|---|
| 1512 | AD_map_viewer_aw_root->awar(AWAR_SPECIES_NAME)->write_string(GBT_read_name(gb_species)); |
|---|
| 1513 | } |
|---|
| 1514 | } |
|---|
| 1515 | |
|---|
| 1516 | int ARB_main(int argc, char *argv[]) { |
|---|
| 1517 | aw_initstatus(); |
|---|
| 1518 | |
|---|
| 1519 | GB_shell shell; |
|---|
| 1520 | AW_root *aw_root = AWT_create_root("pars.arb", "ARB_PARS", need_macro_ability(), &argc, &argv); |
|---|
| 1521 | AD_map_viewer_aw_root = aw_root; |
|---|
| 1522 | |
|---|
| 1523 | ap_main = new AP_main; |
|---|
| 1524 | GLOBAL_PARS = new ArbParsimony(); |
|---|
| 1525 | |
|---|
| 1526 | const char *db_server = ":"; |
|---|
| 1527 | |
|---|
| 1528 | PARS_commands cmds; |
|---|
| 1529 | |
|---|
| 1530 | while (argc>=2 && argv[1][0] == '-') { |
|---|
| 1531 | argc--; |
|---|
| 1532 | argv++; |
|---|
| 1533 | if (!strcmp(argv[0], "-quit")) cmds.quit = 1; |
|---|
| 1534 | else if (!strcmp(argv[0], "-add_marked")) cmds.add_marked = 1; |
|---|
| 1535 | else if (!strcmp(argv[0], "-add_selected")) cmds.add_selected = 1; |
|---|
| 1536 | else if (!strcmp(argv[0], "-calc_branchlengths")) cmds.calc_branch_lengths = 1; |
|---|
| 1537 | else if (!strcmp(argv[0], "-calc_bootstrap")) cmds.calc_bootstrap = 1; |
|---|
| 1538 | else { |
|---|
| 1539 | fprintf(stderr, "Unknown option '%s'\n", argv[0]); |
|---|
| 1540 | |
|---|
| 1541 | printf(" Options: Meaning:\n" |
|---|
| 1542 | "\n" |
|---|
| 1543 | " -add_marked add marked species (without changing topology)\n" |
|---|
| 1544 | " -add_selected add selected species (without changing topology)\n" |
|---|
| 1545 | " -calc_branchlengths calculate branch lengths only\n" |
|---|
| 1546 | " -calc_bootstrap estimate bootstrap values\n" |
|---|
| 1547 | " -quit quit after performing operations\n" |
|---|
| 1548 | ); |
|---|
| 1549 | |
|---|
| 1550 | exit(EXIT_FAILURE); |
|---|
| 1551 | } |
|---|
| 1552 | } |
|---|
| 1553 | |
|---|
| 1554 | |
|---|
| 1555 | if (argc==2) db_server = argv[1]; |
|---|
| 1556 | |
|---|
| 1557 | GB_ERROR error = ap_main->open(db_server); |
|---|
| 1558 | if (!error) { |
|---|
| 1559 | GBDATA *gb_main = ap_main->get_gb_main(); |
|---|
| 1560 | error = configure_macro_recording(aw_root, "ARB_PARS", gb_main); |
|---|
| 1561 | |
|---|
| 1562 | if (!error) { |
|---|
| 1563 | #if defined(DEBUG) |
|---|
| 1564 | AWT_announce_db_to_browser(gb_main, GBS_global_string("ARB-database (%s)", db_server)); |
|---|
| 1565 | #endif // DEBUG |
|---|
| 1566 | |
|---|
| 1567 | pars_create_all_awars(aw_root, AW_ROOT_DEFAULT, gb_main); |
|---|
| 1568 | |
|---|
| 1569 | AW_window *aww = create_pars_init_window(aw_root, &cmds); |
|---|
| 1570 | aww->show(); |
|---|
| 1571 | |
|---|
| 1572 | AWT_install_cb_guards(); |
|---|
| 1573 | aw_root->main_loop(); |
|---|
| 1574 | } |
|---|
| 1575 | } |
|---|
| 1576 | |
|---|
| 1577 | if (error) aw_popup_exit(error); |
|---|
| 1578 | return EXIT_SUCCESS; |
|---|
| 1579 | } |
|---|
| 1580 | |
|---|
| 1581 | |
|---|
| 1582 | // -------------------------------------------------------------------------------- |
|---|
| 1583 | |
|---|
| 1584 | #ifdef UNIT_TESTS |
|---|
| 1585 | #include <arb_file.h> |
|---|
| 1586 | #include <arb_diff.h> |
|---|
| 1587 | #include <test_unit.h> |
|---|
| 1588 | #include <AP_seq_dna.hxx> |
|---|
| 1589 | #include <AP_seq_protein.hxx> |
|---|
| 1590 | #include "test_env.h" |
|---|
| 1591 | |
|---|
| 1592 | #if defined(DEVEL_RALF) |
|---|
| 1593 | // #define AUTO_UPDATE_IF_CHANGED // uncomment to auto update expected results |
|---|
| 1594 | #endif |
|---|
| 1595 | |
|---|
| 1596 | arb_test::match_expectation topologyEquals(AP_tree_nlen *root_node, const char *treefile_base) { |
|---|
| 1597 | using namespace arb_test; |
|---|
| 1598 | expectation_group fulfilled; |
|---|
| 1599 | |
|---|
| 1600 | char *outfile = GBS_global_string_copy("pars/%s.tree", treefile_base); |
|---|
| 1601 | char *expected = GBS_global_string_copy("%s.expected", outfile); |
|---|
| 1602 | bool update = false; |
|---|
| 1603 | |
|---|
| 1604 | { |
|---|
| 1605 | FILE *out = fopen(outfile, "wt"); |
|---|
| 1606 | fulfilled.add(that(out).does_differ_from_NULL()); |
|---|
| 1607 | char *newick = GBT_tree_2_newick(root_node, NewickFormat(nLENGTH|nWRAP), false); |
|---|
| 1608 | fputs(newick, out); |
|---|
| 1609 | free(newick); |
|---|
| 1610 | fclose(out); |
|---|
| 1611 | } |
|---|
| 1612 | |
|---|
| 1613 | if (GB_is_regularfile(expected)) { |
|---|
| 1614 | bool match_exp_topo = textfiles_have_difflines(outfile,expected,0); |
|---|
| 1615 | #if defined(AUTO_UPDATE_IF_CHANGED) |
|---|
| 1616 | if (!match_exp_topo) update = true; |
|---|
| 1617 | #endif |
|---|
| 1618 | if (!update) fulfilled.add(that(match_exp_topo).is_equal_to(true)); |
|---|
| 1619 | } |
|---|
| 1620 | else { |
|---|
| 1621 | update = true; |
|---|
| 1622 | } |
|---|
| 1623 | |
|---|
| 1624 | if (update) TEST_COPY_FILE(outfile, expected); |
|---|
| 1625 | TEST_EXPECT_ZERO_OR_SHOW_ERRNO(GB_unlink(outfile)); |
|---|
| 1626 | |
|---|
| 1627 | free(expected); |
|---|
| 1628 | free(outfile); |
|---|
| 1629 | |
|---|
| 1630 | return all().ofgroup(fulfilled); |
|---|
| 1631 | } |
|---|
| 1632 | #define TEST_EXPECT_SAVED_TOPOLOGY(env,exp_topo) TEST_EXPECTATION(topologyEquals(env.root_node(), exp_topo)) |
|---|
| 1633 | |
|---|
| 1634 | #define TEST_EXPECT_PARSVAL(env,exp_pars) TEST_EXPECT_SIMILAR(env.root_node()->costs(), exp_pars, 0.001); |
|---|
| 1635 | |
|---|
| 1636 | enum TopoMod { |
|---|
| 1637 | MOD_REMOVE_MARKED, |
|---|
| 1638 | |
|---|
| 1639 | MOD_QUICK_ADD, |
|---|
| 1640 | MOD_ADD_NNI, |
|---|
| 1641 | |
|---|
| 1642 | MOD_ADD_PARTIAL, |
|---|
| 1643 | |
|---|
| 1644 | MOD_CALC_LENS, |
|---|
| 1645 | MOD_OPTI_NNI, |
|---|
| 1646 | MOD_OPTI_GLOBAL, |
|---|
| 1647 | }; |
|---|
| 1648 | |
|---|
| 1649 | template <typename SEQ> |
|---|
| 1650 | static void modifyTopology(PARSIMONY_testenv<SEQ>& env, TopoMod mod) { |
|---|
| 1651 | switch (mod) { |
|---|
| 1652 | case MOD_REMOVE_MARKED: |
|---|
| 1653 | env.graphic_tree()->get_tree_root()->remove_leafs(AWT_RemoveType(AWT_REMOVE_BUT_DONT_FREE|AWT_REMOVE_MARKED)); |
|---|
| 1654 | break; |
|---|
| 1655 | |
|---|
| 1656 | case MOD_QUICK_ADD: |
|---|
| 1657 | nt_reAdd(env.graphic_tree(), NT_ADD_MARKED, true); |
|---|
| 1658 | break; |
|---|
| 1659 | |
|---|
| 1660 | case MOD_ADD_NNI: |
|---|
| 1661 | nt_reAdd(env.graphic_tree(), NT_ADD_MARKED, false); |
|---|
| 1662 | break; |
|---|
| 1663 | |
|---|
| 1664 | case MOD_ADD_PARTIAL: |
|---|
| 1665 | nt_add_partial(env.graphic_tree()); |
|---|
| 1666 | break; |
|---|
| 1667 | |
|---|
| 1668 | case MOD_CALC_LENS: |
|---|
| 1669 | calc_branchlengths(env.graphic_tree()); |
|---|
| 1670 | break; |
|---|
| 1671 | |
|---|
| 1672 | case MOD_OPTI_NNI: |
|---|
| 1673 | recursiveNNI(env.graphic_tree()); |
|---|
| 1674 | break; |
|---|
| 1675 | |
|---|
| 1676 | case MOD_OPTI_GLOBAL: |
|---|
| 1677 | optimizeTree(env.graphic_tree()); |
|---|
| 1678 | break; |
|---|
| 1679 | } |
|---|
| 1680 | } |
|---|
| 1681 | |
|---|
| 1682 | template <typename SEQ> |
|---|
| 1683 | static arb_test::match_expectation modifyingTopoResultsIn(TopoMod mod, const char *topo, int pars_expected, PARSIMONY_testenv<SEQ>& env, bool restore) { |
|---|
| 1684 | using namespace arb_test; |
|---|
| 1685 | expectation_group fulfilled; |
|---|
| 1686 | |
|---|
| 1687 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 1688 | |
|---|
| 1689 | Level upc = env.get_user_push_counter(); |
|---|
| 1690 | Level fl = env.get_frame_level(); |
|---|
| 1691 | |
|---|
| 1692 | if (restore) { |
|---|
| 1693 | env.push(); |
|---|
| 1694 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 1695 | } |
|---|
| 1696 | |
|---|
| 1697 | modifyTopology(env, mod); |
|---|
| 1698 | if (topo) fulfilled.add(topologyEquals(env.root_node(), topo)); |
|---|
| 1699 | if (pars_expected != -1) { |
|---|
| 1700 | fulfilled.add(that(env.root_node()->costs()).fulfills(epsilon_similar(0.001), pars_expected)); |
|---|
| 1701 | } |
|---|
| 1702 | |
|---|
| 1703 | if (restore) { |
|---|
| 1704 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 1705 | env.pop(); |
|---|
| 1706 | } |
|---|
| 1707 | |
|---|
| 1708 | TEST_EXPECT_EQUAL(fl, env.get_frame_level()); |
|---|
| 1709 | TEST_EXPECT_EQUAL(upc, env.get_user_push_counter()); |
|---|
| 1710 | |
|---|
| 1711 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 1712 | |
|---|
| 1713 | return all().ofgroup(fulfilled); |
|---|
| 1714 | } |
|---|
| 1715 | |
|---|
| 1716 | static GBDATA *copy_to(GBDATA *gb_species, const char *newShortname) { |
|---|
| 1717 | GBDATA *gb_species_data = GB_get_father(gb_species); |
|---|
| 1718 | GBDATA *gb_new_species = GB_create_container(gb_species_data, "species"); |
|---|
| 1719 | |
|---|
| 1720 | GB_ERROR error = NULL; |
|---|
| 1721 | if (!gb_new_species) { |
|---|
| 1722 | error = GB_await_error(); |
|---|
| 1723 | } |
|---|
| 1724 | else { |
|---|
| 1725 | error = GB_copy(gb_new_species, gb_species); |
|---|
| 1726 | if (!error) error = GBT_write_string(gb_new_species, "name", newShortname); |
|---|
| 1727 | } |
|---|
| 1728 | |
|---|
| 1729 | ap_assert(contradicted(gb_new_species, error)); |
|---|
| 1730 | return gb_new_species; |
|---|
| 1731 | } |
|---|
| 1732 | |
|---|
| 1733 | inline void mark_only(GBDATA *gb_species) { |
|---|
| 1734 | GBDATA *gb_main = GB_get_root(gb_species); |
|---|
| 1735 | GB_transaction ta(gb_main); |
|---|
| 1736 | GBT_mark_all(gb_main, 0); |
|---|
| 1737 | GB_write_flag(gb_species, 1); |
|---|
| 1738 | } |
|---|
| 1739 | inline void mark(GBDATA *gb_species) { |
|---|
| 1740 | GBDATA *gb_main = GB_get_root(gb_species); |
|---|
| 1741 | GB_transaction ta(gb_main); |
|---|
| 1742 | GB_write_flag(gb_species, 1); |
|---|
| 1743 | } |
|---|
| 1744 | inline void mark_all(GBDATA *gb_main) { |
|---|
| 1745 | GB_transaction ta(gb_main); |
|---|
| 1746 | GBT_mark_all(gb_main, 0); |
|---|
| 1747 | } |
|---|
| 1748 | |
|---|
| 1749 | inline int is_partial(GBDATA *gb_species) { |
|---|
| 1750 | GB_transaction ta(gb_species); |
|---|
| 1751 | return GBT_is_partial(gb_species, -1, false); |
|---|
| 1752 | } |
|---|
| 1753 | |
|---|
| 1754 | template <typename SEQ> |
|---|
| 1755 | static arb_test::match_expectation addedAsBrotherOf(const char *name, const char *allowedBrothers, PARSIMONY_testenv<SEQ>& env) { |
|---|
| 1756 | using namespace arb_test; |
|---|
| 1757 | expectation_group fulfilled; |
|---|
| 1758 | |
|---|
| 1759 | AP_tree_nlen *node_in_tree = env.root_node()->findLeafNamed(name); |
|---|
| 1760 | fulfilled.add(that(node_in_tree).does_differ_from(NULL)); |
|---|
| 1761 | |
|---|
| 1762 | const char *brother = node_in_tree->get_brother()->name; |
|---|
| 1763 | fulfilled.add(that(allowedBrothers).does_contain(brother)); |
|---|
| 1764 | |
|---|
| 1765 | return all().ofgroup(fulfilled); |
|---|
| 1766 | } |
|---|
| 1767 | |
|---|
| 1768 | template <typename SEQ> |
|---|
| 1769 | static arb_test::match_expectation addingPartialResultsIn(GBDATA *gb_added_species, const char *allowedBrothers, const char *topo, int pars_expected, PARSIMONY_testenv<SEQ>& env) { |
|---|
| 1770 | using namespace arb_test; |
|---|
| 1771 | expectation_group fulfilled; |
|---|
| 1772 | |
|---|
| 1773 | mark_only(gb_added_species); |
|---|
| 1774 | fulfilled.add(modifyingTopoResultsIn(MOD_ADD_PARTIAL, topo, pars_expected, env, false)); |
|---|
| 1775 | fulfilled.add(that(is_partial(gb_added_species)).is_equal_to(1)); |
|---|
| 1776 | |
|---|
| 1777 | const char *name = GBT_read_name(gb_added_species); |
|---|
| 1778 | fulfilled.add(addedAsBrotherOf(name, allowedBrothers, env)); |
|---|
| 1779 | |
|---|
| 1780 | return all().ofgroup(fulfilled); |
|---|
| 1781 | } |
|---|
| 1782 | |
|---|
| 1783 | static GBDATA *createPartialSeqFrom(GBDATA *gb_main, const char *aliname, const char *dest_species, const char *source_species, int startPos, int endPos) { |
|---|
| 1784 | GB_transaction ta(gb_main); |
|---|
| 1785 | |
|---|
| 1786 | GBDATA *gb_result = NULL; |
|---|
| 1787 | GBDATA *gb_source_species = GBT_expect_species(gb_main, source_species); |
|---|
| 1788 | |
|---|
| 1789 | if (gb_source_species) { |
|---|
| 1790 | GBDATA *gb_dest_species = copy_to(gb_source_species, dest_species); |
|---|
| 1791 | GBDATA *gb_dest_seq = GBT_find_sequence(gb_dest_species, aliname); // =same as source seq |
|---|
| 1792 | char *seq = GB_read_string(gb_dest_seq); |
|---|
| 1793 | |
|---|
| 1794 | if (seq) { |
|---|
| 1795 | int maxPos = strlen(seq)-1; |
|---|
| 1796 | |
|---|
| 1797 | startPos = std::min(startPos, maxPos); |
|---|
| 1798 | endPos = std::min(endPos, maxPos); |
|---|
| 1799 | |
|---|
| 1800 | if (startPos>0) memset(seq, '.', startPos); |
|---|
| 1801 | if (endPos<maxPos) memset(seq+endPos+1, '.', maxPos-endPos); |
|---|
| 1802 | |
|---|
| 1803 | GB_ERROR error = GB_write_string(gb_dest_seq, seq); |
|---|
| 1804 | if (error) GB_export_error(error); |
|---|
| 1805 | else { |
|---|
| 1806 | gb_result = gb_dest_species; // success |
|---|
| 1807 | #if defined(DEBUG) |
|---|
| 1808 | fprintf(stderr, "created partial '%s' from '%s' (seq='%s')\n", dest_species, source_species, seq); |
|---|
| 1809 | #endif |
|---|
| 1810 | } |
|---|
| 1811 | |
|---|
| 1812 | free(seq); |
|---|
| 1813 | } |
|---|
| 1814 | } |
|---|
| 1815 | |
|---|
| 1816 | return gb_result; |
|---|
| 1817 | } |
|---|
| 1818 | |
|---|
| 1819 | static GB_ERROR modifyOneBase(GBDATA *gb_species, const char *aliname, char cOld, char cNew) { |
|---|
| 1820 | GB_transaction ta(gb_species); |
|---|
| 1821 | GB_ERROR error = "failed to modifyOneBase"; |
|---|
| 1822 | |
|---|
| 1823 | GBDATA *gb_seq = GBT_find_sequence(gb_species, aliname); |
|---|
| 1824 | if (gb_seq) { |
|---|
| 1825 | char *seq = GB_read_string(gb_seq); |
|---|
| 1826 | if (seq) { |
|---|
| 1827 | char *B = strchr(seq, cOld); |
|---|
| 1828 | if (!B) { |
|---|
| 1829 | error = "does not contain base in modifyOneBase"; |
|---|
| 1830 | } |
|---|
| 1831 | else { |
|---|
| 1832 | B[0] = cNew; |
|---|
| 1833 | error = GB_write_string(gb_seq, seq); |
|---|
| 1834 | } |
|---|
| 1835 | free(seq); |
|---|
| 1836 | } |
|---|
| 1837 | } |
|---|
| 1838 | |
|---|
| 1839 | return error; |
|---|
| 1840 | } |
|---|
| 1841 | |
|---|
| 1842 | void TEST_nucl_tree_modifications() { |
|---|
| 1843 | const char *aliname = "ali_5s"; |
|---|
| 1844 | |
|---|
| 1845 | PARSIMONY_testenv<AP_sequence_parsimony> env("TEST_trees.arb", aliname); |
|---|
| 1846 | TEST_EXPECT_NO_ERROR(env.load_tree("tree_test")); |
|---|
| 1847 | TEST_EXPECT_SAVED_TOPOLOGY(env, "nucl-initial"); |
|---|
| 1848 | |
|---|
| 1849 | const int PARSIMONY_ORG = 301; |
|---|
| 1850 | TEST_EXPECT_EQUAL(env.combines_performed(), 0); |
|---|
| 1851 | TEST_EXPECT_PARSVAL(env, PARSIMONY_ORG); |
|---|
| 1852 | TEST_EXPECT_EQUAL(env.combines_performed(), 14); |
|---|
| 1853 | |
|---|
| 1854 | // Note: following code leaks father nodes and edges |
|---|
| 1855 | // suppressed in valgrind via ../SOURCE_TOOLS/arb.supp@TEST_nucl_tree_modifications |
|---|
| 1856 | |
|---|
| 1857 | // [NUCOPTI] opposed to protein tests below the initial tree here is NOT optimized! compare .@PROTOPTI |
|---|
| 1858 | // -> removing and adding species produces a better tree |
|---|
| 1859 | // |
|---|
| 1860 | // diff initial->removed : http://bugs.arb-home.de/changeset/HEAD/branches/pars/UNIT_TESTER/run/pars/nucl-removed.tree.expected?old=HEAD&old_path=branches%2Fpars%2FUNIT_TESTER%2Frun%2Fpars%2Fnucl-initial.tree.expected |
|---|
| 1861 | // diff initial->add-quick: http://bugs.arb-home.de/changeset/HEAD/branches/pars/UNIT_TESTER/run/pars/nucl-add-quick.tree.expected?old=HEAD&old_path=branches%2Fpars%2FUNIT_TESTER%2Frun%2Fpars%2Fnucl-initial.tree.expected |
|---|
| 1862 | // diff initial->add-NNI: http://bugs.arb-home.de/changeset/HEAD/branches/pars/UNIT_TESTER/run/pars/nucl-add-NNI.tree.expected?old=HEAD&old_path=branches%2Fpars%2FUNIT_TESTER%2Frun%2Fpars%2Fnucl-initial.tree.expected |
|---|
| 1863 | |
|---|
| 1864 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_REMOVE_MARKED, "nucl-removed", PARSIMONY_ORG-93, env, true)); // test remove-marked only (same code as part of nt_reAdd) |
|---|
| 1865 | TEST_EXPECT_EQUAL(env.combines_performed(), 3); |
|---|
| 1866 | |
|---|
| 1867 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_QUICK_ADD, "nucl-add-quick", PARSIMONY_ORG-23, env, true)); // test quick-add |
|---|
| 1868 | TEST_EXPECT_EQUAL(env.combines_performed(), 591); |
|---|
| 1869 | |
|---|
| 1870 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_ADD_NNI, "nucl-add-NNI", PARSIMONY_ORG-25, env, true)); // test add + NNI |
|---|
| 1871 | TEST_EXPECT_EQUAL(env.combines_performed(), 925); |
|---|
| 1872 | |
|---|
| 1873 | // @@@ test optimize etc. |
|---|
| 1874 | |
|---|
| 1875 | // test partial-add |
|---|
| 1876 | { |
|---|
| 1877 | GBDATA *gb_main = env.gbmain(); |
|---|
| 1878 | |
|---|
| 1879 | // create 2 non-overlapping partial species |
|---|
| 1880 | const int SPLIT = 55; |
|---|
| 1881 | GBDATA *CorGlutP = createPartialSeqFrom(gb_main, aliname, "CorGlutP", "CorGluta", 0, SPLIT); |
|---|
| 1882 | GBDATA *CloButyP = createPartialSeqFrom(gb_main, aliname, "CloButyP", "CloButyr", SPLIT+1, INT_MAX); |
|---|
| 1883 | GBDATA *CloButyM = createPartialSeqFrom(gb_main, aliname, "CloButyM", "CloButyr", SPLIT+1, INT_MAX); |
|---|
| 1884 | TEST_EXPECT_NO_ERROR(modifyOneBase(CloButyM, aliname, 'G', 'C')); // change first 'G' into 'C' |
|---|
| 1885 | |
|---|
| 1886 | // add CloButyP (and undo) |
|---|
| 1887 | { |
|---|
| 1888 | env.push(); |
|---|
| 1889 | // CloButyr and CloButy2 do not differ in seq-range of partial -> any of both may be chosen as brother. |
|---|
| 1890 | // behavior should be changed with #605 |
|---|
| 1891 | TEST_EXPECTATION(addingPartialResultsIn(CloButyP, "CloButyr;CloButy2", "nucl-addPart-CloButyP", PARSIMONY_ORG, env)); |
|---|
| 1892 | TEST_EXPECT_EQUAL(env.combines_performed(), 6); |
|---|
| 1893 | env.pop(); |
|---|
| 1894 | } |
|---|
| 1895 | |
|---|
| 1896 | { |
|---|
| 1897 | env.push(); |
|---|
| 1898 | TEST_EXPECTATION(addingPartialResultsIn(CorGlutP, "CorGluta", "nucl-addPart-CorGlutP", PARSIMONY_ORG, env)); // add CorGlutP |
|---|
| 1899 | TEST_EXPECT_EQUAL(env.combines_performed(), 5); // @@@ partial-add should not perform combines at all |
|---|
| 1900 | TEST_EXPECTATION(addingPartialResultsIn(CloButyP, "CloButyr;CloButy2", "nucl-addPart-CorGlutP-CloButyP", PARSIMONY_ORG, env)); // also add CloButyP |
|---|
| 1901 | TEST_EXPECT_EQUAL(env.combines_performed(), 6); |
|---|
| 1902 | env.pop(); |
|---|
| 1903 | } |
|---|
| 1904 | |
|---|
| 1905 | // now add CorGlutP as full, then CloButyP and CloButyM as partials |
|---|
| 1906 | { |
|---|
| 1907 | env.push(); |
|---|
| 1908 | |
|---|
| 1909 | mark_only(CorGlutP); |
|---|
| 1910 | { |
|---|
| 1911 | GB_transaction ta(gb_main); |
|---|
| 1912 | TEST_EXPECT_NO_ERROR(GBT_write_int(CorGlutP, "ARB_partial", 0)); // revert species to "full" |
|---|
| 1913 | } |
|---|
| 1914 | |
|---|
| 1915 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_QUICK_ADD, "nucl-addPartialAsFull-CorGlutP", PARSIMONY_ORG, env, false)); |
|---|
| 1916 | TEST_EXPECT_EQUAL(env.combines_performed(), 254); |
|---|
| 1917 | TEST_EXPECT_EQUAL(is_partial(CorGlutP), 0); // check CorGlutP was added as full sequence |
|---|
| 1918 | TEST_EXPECTATION(addedAsBrotherOf("CorGlutP", "CorGluta", env)); // partial created from CorGluta gets inserted next to CorGluta |
|---|
| 1919 | |
|---|
| 1920 | // add CloButyP as partial. |
|---|
| 1921 | // as expected it is placed next to matching full sequences (does not differ in partial range) |
|---|
| 1922 | TEST_EXPECTATION(addingPartialResultsIn(CloButyP, "CloButyr;CloButy2", NULL, PARSIMONY_ORG, env)); |
|---|
| 1923 | TEST_EXPECT_EQUAL(env.combines_performed(), 6); |
|---|
| 1924 | |
|---|
| 1925 | // CloButyM differs slightly in overlap with CloButyr/CloButy2, but has no overlap with CorGlutP |
|---|
| 1926 | // reproduces bug described in #609 |
|---|
| 1927 | TEST_EXPECTATION(addingPartialResultsIn(CloButyM, "CorGlutP", "nucl-addPart-bug609", |
|---|
| 1928 | PARSIMONY_ORG+9, // @@@ known bug - partial should not affect parsimony value; possibly related to ../HELP_SOURCE/oldhelp/pa_partial.hlp@WARNINGS |
|---|
| 1929 | env)); |
|---|
| 1930 | TEST_EXPECT_EQUAL(env.combines_performed(), 6); |
|---|
| 1931 | env.pop(); |
|---|
| 1932 | } |
|---|
| 1933 | } |
|---|
| 1934 | |
|---|
| 1935 | #if 0 |
|---|
| 1936 | // @@@ crashes here with missing sequence (caused by pop()), but works below in TEST_optimizations |
|---|
| 1937 | |
|---|
| 1938 | // test branchlength calculation |
|---|
| 1939 | // (optimizations below implicitely recalculate branchlengths) |
|---|
| 1940 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_CALC_LENS, "nucl-calclength", PARSIMONY_ORG-17, env, false)); |
|---|
| 1941 | #endif |
|---|
| 1942 | } |
|---|
| 1943 | |
|---|
| 1944 | void TEST_optimizations_some() { |
|---|
| 1945 | const char *aliname = "ali_5s"; |
|---|
| 1946 | |
|---|
| 1947 | PARSIMONY_testenv<AP_sequence_parsimony> env("TEST_trees.arb", aliname); |
|---|
| 1948 | TEST_EXPECT_NO_ERROR(env.load_tree("tree_test")); |
|---|
| 1949 | TEST_EXPECT_SAVED_TOPOLOGY(env, "nucl-initial"); |
|---|
| 1950 | |
|---|
| 1951 | const int PARSIMONY_ORG = 301; |
|---|
| 1952 | TEST_EXPECT_PARSVAL(env, PARSIMONY_ORG); |
|---|
| 1953 | TEST_EXPECT_EQUAL(env.combines_performed(), 14); |
|---|
| 1954 | |
|---|
| 1955 | // test branchlength calculation |
|---|
| 1956 | // (optimizations below implicitely recalculate branchlengths) |
|---|
| 1957 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_CALC_LENS, "nucl-calclength", PARSIMONY_ORG, env, false)); |
|---|
| 1958 | TEST_EXPECT_EQUAL(env.combines_performed(), 142); |
|---|
| 1959 | |
|---|
| 1960 | // test optimize (some) |
|---|
| 1961 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_OPTI_NNI, "nucl-opti-NNI", PARSIMONY_ORG-17, env, true)); // test recursive NNI |
|---|
| 1962 | TEST_EXPECT_EQUAL(env.combines_performed(), 581); |
|---|
| 1963 | |
|---|
| 1964 | const int PARSIMONY_OPTI = 272; // may depend on seed |
|---|
| 1965 | const unsigned seed = 1417001558; |
|---|
| 1966 | GB_random_seed(seed); |
|---|
| 1967 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_OPTI_GLOBAL, "nucl-opti-global", PARSIMONY_OPTI, env, true)); // test recursive NNI+KL |
|---|
| 1968 | TEST_EXPECT_EQUAL(env.combines_performed(), 40074); |
|---|
| 1969 | |
|---|
| 1970 | #if 0 |
|---|
| 1971 | // @@@ test results changed by adding the MOD_OPTI_GLOBAL test above (rel #620) |
|---|
| 1972 | // test optimize (all) |
|---|
| 1973 | mark_all(env.gbmain()); |
|---|
| 1974 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_OPTI_NNI, "nucl-opti-NNI", PARSIMONY_ORG-17, env, true)); // test recursive NNI |
|---|
| 1975 | |
|---|
| 1976 | // in a fresh environment it works as before (see TEST_optimizations_all) |
|---|
| 1977 | #endif |
|---|
| 1978 | } |
|---|
| 1979 | |
|---|
| 1980 | void TEST_optimizations_all() { |
|---|
| 1981 | const char *aliname = "ali_5s"; |
|---|
| 1982 | |
|---|
| 1983 | PARSIMONY_testenv<AP_sequence_parsimony> env("TEST_trees.arb", aliname); |
|---|
| 1984 | TEST_EXPECT_NO_ERROR(env.load_tree("tree_test")); |
|---|
| 1985 | TEST_EXPECT_SAVED_TOPOLOGY(env, "nucl-initial"); |
|---|
| 1986 | |
|---|
| 1987 | const int PARSIMONY_ORG = 301; |
|---|
| 1988 | TEST_EXPECT_PARSVAL(env, PARSIMONY_ORG); |
|---|
| 1989 | TEST_EXPECT_EQUAL(env.combines_performed(), 14); |
|---|
| 1990 | |
|---|
| 1991 | // test optimize (all) |
|---|
| 1992 | mark_all(env.gbmain()); |
|---|
| 1993 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_OPTI_NNI, "nucl-opti-NNI", PARSIMONY_ORG-17, env, true)); // test recursive NNI |
|---|
| 1994 | TEST_EXPECT_EQUAL(env.combines_performed(), 581); |
|---|
| 1995 | |
|---|
| 1996 | const int PARSIMONY_OPTI = 272; // may depend on seed |
|---|
| 1997 | const unsigned seed = 1417001558; |
|---|
| 1998 | GB_random_seed(seed); |
|---|
| 1999 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_OPTI_GLOBAL, "nucl-opti-global", PARSIMONY_OPTI, env, true)); // test recursive NNI+KL |
|---|
| 2000 | TEST_EXPECT_EQUAL(env.combines_performed(), 40074); // @@@ there is no difference in number of combines between TEST_optimizations_some and TEST_optimizations_all. why not? |
|---|
| 2001 | } |
|---|
| 2002 | |
|---|
| 2003 | void TEST_prot_tree_modifications() { |
|---|
| 2004 | const char *aliname = "ali_tuf_pro"; |
|---|
| 2005 | |
|---|
| 2006 | PARSIMONY_testenv<AP_sequence_protein> env("TEST_prot.arb", aliname); |
|---|
| 2007 | TEST_EXPECT_NO_ERROR(env.load_tree("tree_prot_opti")); |
|---|
| 2008 | TEST_EXPECT_SAVED_TOPOLOGY(env, "prot-initial"); |
|---|
| 2009 | |
|---|
| 2010 | const int PARSIMONY_ORG = 917; |
|---|
| 2011 | TEST_EXPECT_PARSVAL(env, PARSIMONY_ORG); |
|---|
| 2012 | TEST_EXPECT_EQUAL(env.combines_performed(), 10); |
|---|
| 2013 | |
|---|
| 2014 | // Note: following code leaks father nodes and edges |
|---|
| 2015 | // suppressed in valgrind via ../SOURCE_TOOLS/arb.supp@TEST_prot_tree_modifications |
|---|
| 2016 | |
|---|
| 2017 | // [PROTOPTI] opposed to nucleid tests above the initial tree here is already optimized! compare .@NUCOPTI |
|---|
| 2018 | // -> adding species approximately reproduces initial topology |
|---|
| 2019 | // |
|---|
| 2020 | // diff initial->add-quick: http://bugs.arb-home.de/changeset/HEAD/branches/pars/UNIT_TESTER/run/pars/prot-add-quick.tree.expected?old=HEAD&old_path=branches%2Fpars%2FUNIT_TESTER%2Frun%2Fpars%2Fprot-initial.tree.expected |
|---|
| 2021 | // diff initial->add-NNI: http://bugs.arb-home.de/changeset/HEAD/branches/pars/UNIT_TESTER/run/pars/prot-add-NNI.tree.expected?old=HEAD&old_path=branches%2Fpars%2FUNIT_TESTER%2Frun%2Fpars%2Fprot-initial.tree.expected |
|---|
| 2022 | // |
|---|
| 2023 | // Note: comparing these two diffs also demonstrates why quick-adding w/o NNI suffers |
|---|
| 2024 | |
|---|
| 2025 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_REMOVE_MARKED, "prot-removed", PARSIMONY_ORG-123, env, true)); // test remove-marked only (same code as part of nt_reAdd) |
|---|
| 2026 | TEST_EXPECT_EQUAL(env.combines_performed(), 5); |
|---|
| 2027 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_QUICK_ADD, "prot-add-quick", PARSIMONY_ORG+1, env, true)); // test quick-add |
|---|
| 2028 | TEST_EXPECT_EQUAL(env.combines_performed(), 302); |
|---|
| 2029 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_ADD_NNI, "prot-add-NNI", PARSIMONY_ORG, env, true)); // test add + NNI |
|---|
| 2030 | TEST_EXPECT_EQUAL(env.combines_performed(), 471); |
|---|
| 2031 | |
|---|
| 2032 | // @@@ test optimize etc. |
|---|
| 2033 | |
|---|
| 2034 | // test partial-add |
|---|
| 2035 | { |
|---|
| 2036 | GBDATA *gb_main = env.gbmain(); |
|---|
| 2037 | |
|---|
| 2038 | // create 2 non-overlapping partial species |
|---|
| 2039 | GBDATA *MucRaceP = createPartialSeqFrom(gb_main, aliname, "MucRaceP", "MucRacem", 0, 60); |
|---|
| 2040 | GBDATA *StrCoelP = createPartialSeqFrom(gb_main, aliname, "StrCoelP", "StrCoel9", 66-1, 184-1); |
|---|
| 2041 | GBDATA *StrCoelM = createPartialSeqFrom(gb_main, aliname, "StrCoelM", "StrCoel9", 66-1, 184-1); |
|---|
| 2042 | TEST_EXPECT_NO_ERROR(modifyOneBase(StrCoelM, aliname, 'Y', 'H')); // change first 'Y' into 'H' |
|---|
| 2043 | |
|---|
| 2044 | // add StrCoelP (and undo) |
|---|
| 2045 | { |
|---|
| 2046 | env.push(); |
|---|
| 2047 | // StrCoel9 and StrRamo3 do not differ in seq-range of partial -> any of both may be chosen as brother. |
|---|
| 2048 | // behavior should be changed with #605 |
|---|
| 2049 | // TEST_EXPECTATION(addingPartialResultsIn(StrCoelP, "StrCoel9;StrRamo3", "prot-addPart-StrCoelP", PARSIMONY_ORG+114, env)); |
|---|
| 2050 | TEST_EXPECTATION(addingPartialResultsIn(StrCoelP, "AbdGlauc", "prot-addPart-StrCoelP", PARSIMONY_ORG+114, env)); // @@@ inserted completely wrong? |
|---|
| 2051 | TEST_EXPECT_EQUAL(env.combines_performed(), 4); |
|---|
| 2052 | env.pop(); |
|---|
| 2053 | } |
|---|
| 2054 | |
|---|
| 2055 | { |
|---|
| 2056 | env.push(); |
|---|
| 2057 | TEST_EXPECTATION(addingPartialResultsIn(MucRaceP, "MucRacem", "prot-addPart-MucRaceP", PARSIMONY_ORG+7, env)); // add MucRaceP |
|---|
| 2058 | TEST_EXPECT_EQUAL(env.combines_performed(), 6); |
|---|
| 2059 | // TEST_EXPECTATION(addingPartialResultsIn(StrCoelP, "StrCoel9;StrRamo3", "prot-addPart-MucRaceP-StrCoelP", PARSIMONY_ORG+114, env)); // also add StrCoelP |
|---|
| 2060 | TEST_EXPECTATION(addingPartialResultsIn(StrCoelP, "AbdGlauc", "prot-addPart-MucRaceP-StrCoelP", PARSIMONY_ORG+114+7, env)); // also add StrCoelP // @@@ same misplacement as above |
|---|
| 2061 | TEST_EXPECT_EQUAL(env.combines_performed(), 4); |
|---|
| 2062 | env.pop(); |
|---|
| 2063 | } |
|---|
| 2064 | |
|---|
| 2065 | // now add MucRaceP as full, then StrCoelP and StrCoelM as partials |
|---|
| 2066 | { |
|---|
| 2067 | env.push(); |
|---|
| 2068 | |
|---|
| 2069 | mark_only(MucRaceP); |
|---|
| 2070 | { |
|---|
| 2071 | GB_transaction ta(gb_main); |
|---|
| 2072 | TEST_EXPECT_NO_ERROR(GBT_write_int(MucRaceP, "ARB_partial", 0)); // revert species to "full" |
|---|
| 2073 | } |
|---|
| 2074 | |
|---|
| 2075 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_QUICK_ADD, "prot-addPartialAsFull-MucRaceP", PARSIMONY_ORG+7, env, false)); |
|---|
| 2076 | TEST_EXPECT_EQUAL(env.combines_performed(), 177); |
|---|
| 2077 | TEST_EXPECT_EQUAL(is_partial(MucRaceP), 0); // check CorGlutP was added as full sequence |
|---|
| 2078 | // TEST_EXPECTATION(addedAsBrotherOf("MucRaceP", "MucRacem", env)); // partial created from MucRacem gets inserted next to MucRacem |
|---|
| 2079 | TEST_EXPECTATION(addedAsBrotherOf("MucRaceP", "AbdGlauc", env)); // partial created from MucRacem gets inserted next to MucRacem // @@@ misplacement if added as full sequence (as partial placement is ok) |
|---|
| 2080 | |
|---|
| 2081 | // add StrCoelP as partial. |
|---|
| 2082 | // as expected it is placed next to matching full sequences (does not differ in partial range) |
|---|
| 2083 | // TEST_EXPECTATION(addingPartialResultsIn(StrCoelP, "StrCoel9;StrRamo3", NULL, PARSIMONY_ORG, env)); |
|---|
| 2084 | TEST_EXPECTATION(addingPartialResultsIn(StrCoelP, "MucRaceP", NULL, PARSIMONY_ORG+114+2, env)); // @@@ same position as when adding it partial |
|---|
| 2085 | TEST_EXPECT_EQUAL(env.combines_performed(), 5); |
|---|
| 2086 | |
|---|
| 2087 | // StrCoelM differs slightly in overlap with StrCoel9/StrRamo3, but has no overlap with MucRaceP |
|---|
| 2088 | // reproduces bug described in #609 |
|---|
| 2089 | // @@@ does not demonstrate anything atm (because StrCoelP already is placed next to MucRaceP above) |
|---|
| 2090 | TEST_EXPECTATION(addingPartialResultsIn(StrCoelM, "StrCoelP", "prot-addPart-bug609", |
|---|
| 2091 | PARSIMONY_ORG+114+3, // @@@ known bug - partial should not affect parsimony value; possibly related to ../HELP_SOURCE/oldhelp/pa_partial.hlp@WARNINGS |
|---|
| 2092 | env)); |
|---|
| 2093 | TEST_EXPECT_EQUAL(env.combines_performed(), 6); |
|---|
| 2094 | env.pop(); |
|---|
| 2095 | } |
|---|
| 2096 | } |
|---|
| 2097 | } |
|---|
| 2098 | |
|---|
| 2099 | void TEST_node_stack() { |
|---|
| 2100 | // test was used to fix #620 |
|---|
| 2101 | |
|---|
| 2102 | const char *aliname = "ali_5s"; |
|---|
| 2103 | |
|---|
| 2104 | // Note: following code leaks father nodes and edges |
|---|
| 2105 | // suppressed in valgrind via ../SOURCE_TOOLS/arb.supp@TEST_node_stack |
|---|
| 2106 | |
|---|
| 2107 | PARSIMONY_testenv<AP_sequence_parsimony> env("TEST_trees.arb", aliname); |
|---|
| 2108 | TEST_EXPECT_NO_ERROR(env.load_tree("tree_test")); |
|---|
| 2109 | TEST_EXPECT_SAVED_TOPOLOGY(env, "nucl-initial"); |
|---|
| 2110 | |
|---|
| 2111 | const int PARSIMONY_ORG = 301; |
|---|
| 2112 | TEST_EXPECT_PARSVAL(env, PARSIMONY_ORG); |
|---|
| 2113 | TEST_EXPECT_EQUAL(env.combines_performed(), 14); |
|---|
| 2114 | |
|---|
| 2115 | TEST_EXPECT(env.graphic_tree()->get_root_node()->sequence_state_valid()); |
|---|
| 2116 | |
|---|
| 2117 | // test set root to CytAquat + pop (works) |
|---|
| 2118 | { |
|---|
| 2119 | env.push(); |
|---|
| 2120 | env.root_node()->findLeafNamed("CytAquat")->set_root(); |
|---|
| 2121 | TEST_EXPECT(env.graphic_tree()->get_root_node()->sequence_state_valid()); |
|---|
| 2122 | env.pop(); |
|---|
| 2123 | TEST_EXPECT(env.graphic_tree()->get_root_node()->sequence_state_valid()); |
|---|
| 2124 | } |
|---|
| 2125 | |
|---|
| 2126 | // test set root to CloButyr + pop (works) |
|---|
| 2127 | { |
|---|
| 2128 | env.push(); |
|---|
| 2129 | env.root_node()->findLeafNamed("CloButyr")->set_root(); |
|---|
| 2130 | TEST_EXPECT(env.graphic_tree()->get_root_node()->sequence_state_valid()); |
|---|
| 2131 | env.pop(); |
|---|
| 2132 | TEST_EXPECT(env.graphic_tree()->get_root_node()->sequence_state_valid()); |
|---|
| 2133 | } |
|---|
| 2134 | |
|---|
| 2135 | // test set root to CloBifer + set root to CloTyrob + pop (works) |
|---|
| 2136 | // Note: both species are in same subtree (of root) |
|---|
| 2137 | { |
|---|
| 2138 | env.push(); |
|---|
| 2139 | |
|---|
| 2140 | env.root_node()->findLeafNamed("CloBifer")->set_root(); |
|---|
| 2141 | env.root_node()->findLeafNamed("CloTyrob")->set_root(); |
|---|
| 2142 | |
|---|
| 2143 | TEST_EXPECT(env.graphic_tree()->get_root_node()->sequence_state_valid()); |
|---|
| 2144 | env.pop(); |
|---|
| 2145 | TEST_EXPECT(env.graphic_tree()->get_root_node()->sequence_state_valid()); |
|---|
| 2146 | } |
|---|
| 2147 | |
|---|
| 2148 | // test set root to CytAquat + set root to CloButyr + pop (failed, fixed by [13138]) |
|---|
| 2149 | TEST_EXPECT_EQUAL(env.combines_performed(), 0); |
|---|
| 2150 | for (int calcCostsBetween = 0; calcCostsBetween<2; ++calcCostsBetween) { |
|---|
| 2151 | TEST_ANNOTATE(GBS_global_string("calcCostsBetween=%i", calcCostsBetween)); |
|---|
| 2152 | |
|---|
| 2153 | TEST_EXPECT_PARSVAL(env, PARSIMONY_ORG); |
|---|
| 2154 | |
|---|
| 2155 | env.push(); |
|---|
| 2156 | |
|---|
| 2157 | env.root_node()->findLeafNamed("CytAquat")->set_root(); |
|---|
| 2158 | |
|---|
| 2159 | if (calcCostsBetween) { |
|---|
| 2160 | TEST_EXPECT_PARSVAL(env, PARSIMONY_ORG); |
|---|
| 2161 | TEST_EXPECT_EQUAL(env.combines_performed(), 2); |
|---|
| 2162 | } |
|---|
| 2163 | |
|---|
| 2164 | env.root_node()->findLeafNamed("CloButyr")->set_root(); |
|---|
| 2165 | |
|---|
| 2166 | TEST_EXPECT(env.graphic_tree()->get_root_node()->sequence_state_valid()); |
|---|
| 2167 | TEST_EXPECT_PARSVAL(env, PARSIMONY_ORG); |
|---|
| 2168 | TEST_EXPECT_EQUAL(env.combines_performed(), 6); |
|---|
| 2169 | |
|---|
| 2170 | env.pop(); |
|---|
| 2171 | |
|---|
| 2172 | TEST_EXPECT(env.graphic_tree()->get_root_node()->sequence_state_valid()); |
|---|
| 2173 | TEST_EXPECT_PARSVAL(env, PARSIMONY_ORG); |
|---|
| 2174 | TEST_EXPECT_EQUAL(env.combines_performed(), 0); |
|---|
| 2175 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2176 | } |
|---|
| 2177 | { |
|---|
| 2178 | env.push(); |
|---|
| 2179 | { |
|---|
| 2180 | env.push(); |
|---|
| 2181 | |
|---|
| 2182 | env.root_node()->findLeafNamed("CloInnoc")->moveNextTo(env.root_node()->findLeafNamed("CytAquat"), 0.5); |
|---|
| 2183 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2184 | env.root_node()->findLeafNamed("CloInnoc")->set_root(); |
|---|
| 2185 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2186 | env.root_node()->findLeafNamed("CytAquat")->moveNextTo(env.root_node()->findLeafNamed("CloPaste"), 0.5); |
|---|
| 2187 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2188 | env.root_node()->findLeafNamed("CloPaste")->set_root(); |
|---|
| 2189 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2190 | env.root_node()->findLeafNamed("CloPaste")->moveNextTo(env.root_node()->findLeafNamed("CloInnoc"), 0.5); |
|---|
| 2191 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2192 | { |
|---|
| 2193 | AP_tree_nlen *son_of_brother; |
|---|
| 2194 | AP_tree_nlen *brother_of_father; |
|---|
| 2195 | |
|---|
| 2196 | // COVER1: son of root -> grandson of root |
|---|
| 2197 | { |
|---|
| 2198 | AP_tree_nlen *son_of_root = env.graphic_tree()->get_root_node()->get_leftson(); |
|---|
| 2199 | ap_assert(son_of_root); |
|---|
| 2200 | |
|---|
| 2201 | son_of_brother = son_of_root->get_brother()->get_leftson(); |
|---|
| 2202 | son_of_root->moveNextTo(son_of_brother, 0.5); |
|---|
| 2203 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2204 | } |
|---|
| 2205 | |
|---|
| 2206 | // COVER2: grandson of root -> son of brother |
|---|
| 2207 | { |
|---|
| 2208 | AP_tree_nlen *son_of_root = env.graphic_tree()->get_root_node()->get_leftson(); |
|---|
| 2209 | AP_tree_nlen *grandson_of_root = son_of_root->get_brother()->get_rightson(); |
|---|
| 2210 | ap_assert(grandson_of_root); |
|---|
| 2211 | |
|---|
| 2212 | son_of_brother = grandson_of_root->get_brother()->get_leftson(); |
|---|
| 2213 | grandson_of_root->moveNextTo(son_of_brother, 0.5); |
|---|
| 2214 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2215 | } |
|---|
| 2216 | |
|---|
| 2217 | AP_tree_nlen *some_leaf = env.root_node()->findLeafNamed("CloBifer"); |
|---|
| 2218 | ap_assert(some_leaf); |
|---|
| 2219 | |
|---|
| 2220 | // COVER3: some leaf -> son of brother |
|---|
| 2221 | son_of_brother = some_leaf->get_brother()->get_leftson(); |
|---|
| 2222 | some_leaf->moveNextTo(son_of_brother, 0.5); |
|---|
| 2223 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2224 | |
|---|
| 2225 | // COVER4: some leaf -> son of brother |
|---|
| 2226 | brother_of_father = some_leaf->get_father()->get_brother(); |
|---|
| 2227 | some_leaf->moveNextTo(brother_of_father, 0.5); |
|---|
| 2228 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2229 | |
|---|
| 2230 | // COVER5: move to father |
|---|
| 2231 | some_leaf->moveNextTo(some_leaf->get_father(), 0.5); |
|---|
| 2232 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2233 | |
|---|
| 2234 | #if 0 |
|---|
| 2235 | // fails assert in AP_tree::moveNextTo ("already there"). ok! |
|---|
| 2236 | some_leaf->moveNextTo(some_leaf->get_brother(), 0.5); |
|---|
| 2237 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2238 | #endif |
|---|
| 2239 | } |
|---|
| 2240 | |
|---|
| 2241 | env.pop(); |
|---|
| 2242 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2243 | } |
|---|
| 2244 | env.pop(); |
|---|
| 2245 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2246 | } |
|---|
| 2247 | |
|---|
| 2248 | // remove + quick add marked + pop() both works |
|---|
| 2249 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_QUICK_ADD, "nucl-add-quick", PARSIMONY_ORG-23, env, true)); // test quick-add |
|---|
| 2250 | |
|---|
| 2251 | // remove + quick-add marked + pop() quick-add -> corrupts tree |
|---|
| 2252 | // (root-edge is lost) |
|---|
| 2253 | { |
|---|
| 2254 | env.push(); |
|---|
| 2255 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2256 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_REMOVE_MARKED, NULL, -1, env, false)); // test remove-marked only (same code as part of nt_reAdd) |
|---|
| 2257 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2258 | |
|---|
| 2259 | env.push(); |
|---|
| 2260 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2261 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_QUICK_ADD, NULL, -1, env, false)); // test quick-add (same code as part of nt_reAdd) |
|---|
| 2262 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2263 | env.pop(); |
|---|
| 2264 | TEST_EXPECT__BROKEN(env.graphic_tree()->get_root_node()->has_valid_edges()); // @@@ doing pop() after quick-adding produces an invalid tree (root-edge missing) |
|---|
| 2265 | |
|---|
| 2266 | env.pop(); |
|---|
| 2267 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2268 | } |
|---|
| 2269 | |
|---|
| 2270 | // same as above, but with only 1 species marked |
|---|
| 2271 | struct { |
|---|
| 2272 | const char *name; |
|---|
| 2273 | bool correct[2]; |
|---|
| 2274 | bool correct_after_2nd_pop[2]; |
|---|
| 2275 | |
|---|
| 2276 | } testSingle[] = { |
|---|
| 2277 | { "CytAquat", { false, true }, { true, true } }, // CytAquat is the only grandson of root (CytAquat located in lower subtree) |
|---|
| 2278 | { "CloBifer", { false, true }, { false, true } }, // two father nodes between CloBifer and root (CloBifer located in upper subtree) |
|---|
| 2279 | { "CloPaste", { false, true }, { false, true } }, // two father nodes between CloPaste and root (CloPaste located in upper subtree) |
|---|
| 2280 | { "CorGluta", { false, true }, { false, true } }, // three father nodes between CorGluta and root (CorGluta located in lower subtree); @@@ might be a different problem |
|---|
| 2281 | { "CelBiazo", { true, false }, { true, true } }, // two father nodes between CelBiazo and root; @@@ might be a different problem |
|---|
| 2282 | |
|---|
| 2283 | { NULL, { true, true }, { true, true } } |
|---|
| 2284 | }; |
|---|
| 2285 | |
|---|
| 2286 | for (int i = 0; testSingle[i].name; ++i) { |
|---|
| 2287 | for (int swapped = 0; swapped<2; ++swapped) { |
|---|
| 2288 | TEST_ANNOTATE(GBS_global_string("single=%s swapped=%i", testSingle[i].name, swapped)); |
|---|
| 2289 | |
|---|
| 2290 | env.push(); |
|---|
| 2291 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2292 | { |
|---|
| 2293 | AP_tree_nlen *old_rightson = env.root_node()->get_rightson(); |
|---|
| 2294 | env.root_node()->get_leftson()->get_rightson()->set_root(); |
|---|
| 2295 | old_rightson->get_leftson()->set_root(); |
|---|
| 2296 | old_rightson->set_root(); |
|---|
| 2297 | |
|---|
| 2298 | ap_assert(env.root_node()->get_rightson() == old_rightson); |
|---|
| 2299 | } |
|---|
| 2300 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2301 | |
|---|
| 2302 | mark_only(env.root_node()->findLeafNamed(testSingle[i].name)->gb_node); |
|---|
| 2303 | |
|---|
| 2304 | env.push(); |
|---|
| 2305 | if (swapped) { |
|---|
| 2306 | env.root_node()->swap_sons(); |
|---|
| 2307 | } |
|---|
| 2308 | |
|---|
| 2309 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2310 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_REMOVE_MARKED, NULL, -1, env, false)); // test remove-marked only (same code as part of nt_reAdd) |
|---|
| 2311 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2312 | |
|---|
| 2313 | env.push(); |
|---|
| 2314 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2315 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_QUICK_ADD, NULL, -1, env, false)); // test quick-add (same code as part of nt_reAdd) |
|---|
| 2316 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2317 | env.pop(); |
|---|
| 2318 | |
|---|
| 2319 | if (testSingle[i].correct[swapped]) { |
|---|
| 2320 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2321 | } |
|---|
| 2322 | else { |
|---|
| 2323 | TEST_EXPECT__BROKEN(env.graphic_tree()->get_root_node()->has_valid_edges()); // @@@ doing pop() after quick-adding produces an invalid tree (root-edge missing) |
|---|
| 2324 | } |
|---|
| 2325 | |
|---|
| 2326 | env.pop(); |
|---|
| 2327 | |
|---|
| 2328 | if (testSingle[i].correct_after_2nd_pop[swapped]) { |
|---|
| 2329 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2330 | } |
|---|
| 2331 | else { |
|---|
| 2332 | TEST_EXPECT__BROKEN(env.graphic_tree()->get_root_node()->has_valid_edges()); // @@@ doing 2nd pop() (=undo remove) produces an invalid tree |
|---|
| 2333 | } |
|---|
| 2334 | |
|---|
| 2335 | env.pop(); |
|---|
| 2336 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2337 | } |
|---|
| 2338 | } |
|---|
| 2339 | |
|---|
| 2340 | // similar to above (remove+add a grandson of root; here grandson is a subtree with 4 species) |
|---|
| 2341 | |
|---|
| 2342 | for (int remove_from_lower_subtree = 0; remove_from_lower_subtree<2; ++remove_from_lower_subtree) { |
|---|
| 2343 | TEST_ANNOTATE(GBS_global_string("remove_from_lower_subtree=%i", remove_from_lower_subtree)); |
|---|
| 2344 | |
|---|
| 2345 | // mark a complete subtree (which - as a whole - forms a grandson of root). subtree is located in upper part of the tree |
|---|
| 2346 | mark_only(env.root_node()->findLeafNamed("CloButy2")->gb_node); |
|---|
| 2347 | mark(env.root_node()->findLeafNamed("CloButyr")->gb_node); |
|---|
| 2348 | mark(env.root_node()->findLeafNamed("CloCarni")->gb_node); |
|---|
| 2349 | mark(env.root_node()->findLeafNamed("CloPaste")->gb_node); |
|---|
| 2350 | |
|---|
| 2351 | env.push(); |
|---|
| 2352 | if (remove_from_lower_subtree) { |
|---|
| 2353 | env.root_node()->swap_sons(); |
|---|
| 2354 | } |
|---|
| 2355 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2356 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_REMOVE_MARKED, NULL, -1, env, false)); // test remove-marked only (same code as part of nt_reAdd) |
|---|
| 2357 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2358 | |
|---|
| 2359 | env.push(); |
|---|
| 2360 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2361 | TEST_EXPECTATION(modifyingTopoResultsIn(MOD_QUICK_ADD, NULL, -1, env, false)); // test quick-add (same code as part of nt_reAdd) |
|---|
| 2362 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2363 | env.pop(); |
|---|
| 2364 | |
|---|
| 2365 | if (remove_from_lower_subtree) { |
|---|
| 2366 | TEST_EXPECT__BROKEN(env.graphic_tree()->get_root_node()->has_valid_edges()); // @@@ broken if removed from lower part of tree |
|---|
| 2367 | } |
|---|
| 2368 | else { |
|---|
| 2369 | TEST_EXPECT(env.graphic_tree()->get_root_node()->has_valid_edges()); // @@@ NOT broken if removed from upper part of tree |
|---|
| 2370 | } |
|---|
| 2371 | |
|---|
| 2372 | env.pop(); |
|---|
| 2373 | TEST_ASSERT_VALID_TREE(env.graphic_tree()->get_root_node()); |
|---|
| 2374 | } |
|---|
| 2375 | |
|---|
| 2376 | TEST_EXPECT_EQUAL(env.combines_performed(), 4438); // @@@ distribute |
|---|
| 2377 | } |
|---|
| 2378 | |
|---|
| 2379 | #endif // UNIT_TESTS |
|---|
| 2380 | |
|---|
| 2381 | // -------------------------------------------------------------------------------- |
|---|
| 2382 | |
|---|