| 1 | #include "mltaln.h" |
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| 2 | #include "dp.h" |
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| 3 | |
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| 4 | #define MACHIGAI 0 |
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| 5 | #define OUTGAP0TRY 1 |
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| 6 | #define DEBUG 0 |
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| 7 | #define XXXXXXX 0 |
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| 8 | #define USE_PENALTY_EX 0 |
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| 9 | #define FASTMATCHCALC 1 |
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| 10 | |
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| 11 | |
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| 12 | static TLS float **impmtx = NULL; |
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| 13 | #if 1 // tditeration to naiveRscore_imp de tsukawareru. |
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| 14 | float imp_match_out_scR( int i1, int j1 ) |
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| 15 | { |
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| 16 | // fprintf( stderr, "imp+match = %f\n", impmtx[i1][j1] * fastathreshold ); |
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| 17 | // fprintf( stderr, "val = %f\n", impmtx[i1][j1] ); |
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| 18 | return( impmtx[i1][j1] ); |
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| 19 | } |
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| 20 | #endif |
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| 21 | |
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| 22 | static void imp_match_out_veadR( float *imp, int i1, int lgth2 ) |
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| 23 | { |
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| 24 | #if FASTMATCHCALC |
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| 25 | float *pt = impmtx[i1]; |
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| 26 | while( lgth2-- ) |
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| 27 | *imp++ += *pt++; |
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| 28 | #else |
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| 29 | int j; |
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| 30 | float *pt = impmtx[i1]; |
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| 31 | for( j=0; j<lgth2; j++ ) |
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| 32 | *imp++ += pt[j]; |
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| 33 | #endif |
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| 34 | } |
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| 35 | static void imp_match_out_vead_tateR( float *imp, int j1, int lgth1 ) |
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| 36 | { |
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| 37 | int i; |
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| 38 | for( i=0; i<lgth1; i++ ) |
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| 39 | *imp++ += impmtx[i][j1]; |
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| 40 | } |
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| 41 | |
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| 42 | #if 1 // tbfast.c kara yobareru. |
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| 43 | void imp_match_init_strictR( float *imp, int clus1, int clus2, int lgth1, int lgth2, char **seq1, char **seq2, double *eff1, double *eff2, LocalHom ***localhom, int forscore ) |
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| 44 | { |
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| 45 | int i, j, k1, k2, tmpint, start1, start2, end1, end2; |
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| 46 | static TLS int impalloclen = 0; |
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| 47 | float effij; |
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| 48 | double effijx; |
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| 49 | char *pt, *pt1, *pt2; |
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| 50 | static TLS char *nocount1 = NULL; |
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| 51 | static char *nocount2 = NULL; |
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| 52 | LocalHom *tmpptr; |
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| 53 | |
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| 54 | if( impalloclen < lgth1 + 2 || impalloclen < lgth2 + 2 ) |
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| 55 | { |
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| 56 | if( impmtx ) FreeFloatMtx( impmtx ); |
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| 57 | if( nocount1 ) free( nocount1 ); |
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| 58 | if( nocount2 ) free( nocount2 ); |
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| 59 | impalloclen = MAX( lgth1, lgth2 ) + 2; |
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| 60 | impmtx = AllocateFloatMtx( impalloclen, impalloclen ); |
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| 61 | nocount1 = AllocateCharVec( impalloclen ); |
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| 62 | nocount2 = AllocateCharVec( impalloclen ); |
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| 63 | } |
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| 64 | |
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| 65 | for( i=0; i<lgth1; i++ ) |
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| 66 | { |
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| 67 | for( j=0; j<clus1; j++ ) |
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| 68 | if( seq1[j][i] == '-' ) break; |
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| 69 | if( j != clus1 ) nocount1[i] = 1; |
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| 70 | else nocount1[i] = 0; |
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| 71 | } |
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| 72 | for( i=0; i<lgth2; i++ ) |
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| 73 | { |
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| 74 | for( j=0; j<clus2; j++ ) |
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| 75 | if( seq2[j][i] == '-' ) break; |
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| 76 | if( j != clus2 ) nocount2[i] = 1; |
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| 77 | else nocount2[i] = 0; |
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| 78 | } |
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| 79 | |
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| 80 | #if 0 |
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| 81 | fprintf( stderr, "nocount2 =\n" ); |
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| 82 | for( i = 0; i<impalloclen; i++ ) |
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| 83 | { |
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| 84 | fprintf( stderr, "nocount2[%d] = %d (%c)\n", i, nocount2[i], seq2[0][i] ); |
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| 85 | } |
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| 86 | #endif |
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| 87 | |
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| 88 | |
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| 89 | |
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| 90 | #if 0 |
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| 91 | fprintf( stderr, "eff1 in _init_strict = \n" ); |
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| 92 | for( i=0; i<clus1; i++ ) |
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| 93 | fprintf( stderr, "eff1[] = %f\n", eff1[i] ); |
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| 94 | for( i=0; i<clus2; i++ ) |
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| 95 | fprintf( stderr, "eff2[] = %f\n", eff2[i] ); |
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| 96 | #endif |
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| 97 | |
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| 98 | for( i=0; i<lgth1; i++ ) for( j=0; j<lgth2; j++ ) |
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| 99 | impmtx[i][j] = 0.0; |
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| 100 | effijx = fastathreshold; |
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| 101 | for( i=0; i<clus1; i++ ) |
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| 102 | { |
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| 103 | for( j=0; j<clus2; j++ ) |
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| 104 | { |
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| 105 | effij = (float)( eff1[i] * eff2[j] * effijx ); |
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| 106 | tmpptr = localhom[i][j]; |
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| 107 | while( tmpptr ) |
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| 108 | { |
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| 109 | // fprintf( stderr, "start1 = %d\n", tmpptr->start1 ); |
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| 110 | // fprintf( stderr, "end1 = %d\n", tmpptr->end1 ); |
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| 111 | // fprintf( stderr, "i = %d, seq1 = \n%s\n", i, seq1[i] ); |
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| 112 | // fprintf( stderr, "j = %d, seq2 = \n%s\n", j, seq2[j] ); |
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| 113 | pt = seq1[i]; |
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| 114 | tmpint = -1; |
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| 115 | while( *pt != 0 ) |
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| 116 | { |
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| 117 | if( *pt++ != '-' ) tmpint++; |
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| 118 | if( tmpint == tmpptr->start1 ) break; |
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| 119 | } |
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| 120 | start1 = pt - seq1[i] - 1; |
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| 121 | |
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| 122 | if( tmpptr->start1 == tmpptr->end1 ) end1 = start1; |
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| 123 | else |
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| 124 | { |
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| 125 | #if MACHIGAI |
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| 126 | while( *pt != 0 ) |
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| 127 | { |
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| 128 | // fprintf( stderr, "tmpint = %d, end1 = %d pos = %d\n", tmpint, tmpptr->end1, pt-seq1[i] ); |
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| 129 | if( tmpint == tmpptr->end1 ) break; |
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| 130 | if( *pt++ != '-' ) tmpint++; |
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| 131 | } |
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| 132 | end1 = pt - seq1[i] - 0; |
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| 133 | #else |
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| 134 | while( *pt != 0 ) |
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| 135 | { |
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| 136 | // fprintf( stderr, "tmpint = %d, end1 = %d pos = %d\n", tmpint, tmpptr->end1, pt-seq1[i] ); |
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| 137 | if( *pt++ != '-' ) tmpint++; |
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| 138 | if( tmpint == tmpptr->end1 ) break; |
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| 139 | } |
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| 140 | end1 = pt - seq1[i] - 1; |
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| 141 | #endif |
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| 142 | } |
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| 143 | |
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| 144 | pt = seq2[j]; |
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| 145 | tmpint = -1; |
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| 146 | while( *pt != 0 ) |
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| 147 | { |
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| 148 | if( *pt++ != '-' ) tmpint++; |
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| 149 | if( tmpint == tmpptr->start2 ) break; |
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| 150 | } |
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| 151 | start2 = pt - seq2[j] - 1; |
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| 152 | if( tmpptr->start2 == tmpptr->end2 ) end2 = start2; |
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| 153 | else |
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| 154 | { |
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| 155 | #if MACHIGAI |
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| 156 | while( *pt != 0 ) |
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| 157 | { |
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| 158 | if( tmpint == tmpptr->end2 ) break; |
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| 159 | if( *pt++ != '-' ) tmpint++; |
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| 160 | } |
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| 161 | end2 = pt - seq2[j] - 0; |
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| 162 | #else |
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| 163 | while( *pt != 0 ) |
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| 164 | { |
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| 165 | if( *pt++ != '-' ) tmpint++; |
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| 166 | if( tmpint == tmpptr->end2 ) break; |
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| 167 | } |
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| 168 | end2 = pt - seq2[j] - 1; |
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| 169 | #endif |
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| 170 | } |
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| 171 | // fprintf( stderr, "start1 = %d (%c), end1 = %d (%c), start2 = %d (%c), end2 = %d (%c)\n", start1, seq1[i][start1], end1, seq1[i][end1], start2, seq2[j][start2], end2, seq2[j][end2] ); |
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| 172 | // fprintf( stderr, "step 0\n" ); |
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| 173 | if( end1 - start1 != end2 - start2 ) |
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| 174 | { |
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| 175 | // fprintf( stderr, "CHUUI!!, start1 = %d, end1 = %d, start2 = %d, end2 = %d\n", start1, end1, start2, end2 ); |
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| 176 | } |
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| 177 | |
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| 178 | #if 1 |
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| 179 | k1 = start1; k2 = start2; |
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| 180 | pt1 = seq1[i] + k1; |
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| 181 | pt2 = seq2[j] + k2; |
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| 182 | while( *pt1 && *pt2 ) |
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| 183 | { |
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| 184 | if( *pt1 != '-' && *pt2 != '-' ) |
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| 185 | { |
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| 186 | // œÅ€ß€òÆóœÅ€Ë€«€±€Ê€€€è€Š€ËÃí°Õ€·€Æ²Œ€µ€€¡£ |
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| 187 | // impmtx[k1][k2] += tmpptr->wimportance * fastathreshold; |
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| 188 | // impmtx[k1][k2] += tmpptr->importance * effij; |
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| 189 | impmtx[k1][k2] += tmpptr->fimportance * effij; |
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| 190 | // fprintf( stderr, "#### impmtx[k1][k2] = %f, tmpptr->fimportance=%f, effij=%f\n", impmtx[k1][k2], tmpptr->fimportance, effij ); |
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| 191 | // fprintf( stderr, "mark, %d (%c) - %d (%c) \n", k1, *pt1, k2, *pt2 ); |
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| 192 | // fprintf( stderr, "%d (%c) - %d (%c) - %f\n", k1, *pt1, k2, *pt2, tmpptr->fimportance * effij ); |
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| 193 | k1++; k2++; |
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| 194 | pt1++; pt2++; |
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| 195 | } |
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| 196 | else if( *pt1 != '-' && *pt2 == '-' ) |
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| 197 | { |
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| 198 | // fprintf( stderr, "skip, %d (%c) - %d (%c) \n", k1, *pt1, k2, *pt2 ); |
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| 199 | k2++; pt2++; |
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| 200 | } |
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| 201 | else if( *pt1 == '-' && *pt2 != '-' ) |
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| 202 | { |
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| 203 | // fprintf( stderr, "skip, %d (%c) - %d (%c) \n", k1, *pt1, k2, *pt2 ); |
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| 204 | k1++; pt1++; |
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| 205 | } |
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| 206 | else if( *pt1 == '-' && *pt2 == '-' ) |
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| 207 | { |
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| 208 | // fprintf( stderr, "skip, %d (%c) - %d (%c) \n", k1, *pt1, k2, *pt2 ); |
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| 209 | k1++; pt1++; |
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| 210 | k2++; pt2++; |
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| 211 | } |
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| 212 | if( k1 > end1 || k2 > end2 ) break; |
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| 213 | } |
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| 214 | #else |
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| 215 | while( k1 <= end1 && k2 <= end2 ) |
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| 216 | { |
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| 217 | fprintf( stderr, "k1,k2=%d,%d - ", k1, k2 ); |
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| 218 | if( !nocount1[k1] && !nocount2[k2] ) |
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| 219 | { |
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| 220 | impmtx[k1][k2] += tmpptr->wimportance * eff1[i] * eff2[j] * fastathreshold; |
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| 221 | fprintf( stderr, "marked\n" ); |
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| 222 | } |
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| 223 | else |
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| 224 | fprintf( stderr, "no count\n" ); |
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| 225 | k1++; k2++; |
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| 226 | } |
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| 227 | #endif |
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| 228 | tmpptr = tmpptr->next; |
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| 229 | } |
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| 230 | } |
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| 231 | } |
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| 232 | #if 0 |
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| 233 | if( clus1 == 1 && clus2 == 6 ) |
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| 234 | { |
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| 235 | fprintf( stderr, "\n" ); |
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| 236 | fprintf( stderr, "seq1[0] = %s\n", seq1[0] ); |
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| 237 | fprintf( stderr, "seq2[0] = %s\n", seq2[0] ); |
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| 238 | fprintf( stderr, "impmtx = \n" ); |
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| 239 | for( k2=0; k2<lgth2; k2++ ) |
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| 240 | fprintf( stderr, "%6.3f ", (double)k2 ); |
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| 241 | fprintf( stderr, "\n" ); |
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| 242 | for( k1=0; k1<lgth1; k1++ ) |
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| 243 | { |
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| 244 | fprintf( stderr, "%d ", k1 ); |
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| 245 | for( k2=0; k2<3; k2++ ) |
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| 246 | fprintf( stderr, "%2.1f ", impmtx[k1][k2] ); |
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| 247 | fprintf( stderr, "\n" ); |
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| 248 | } |
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| 249 | exit( 1 ); |
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| 250 | } |
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| 251 | #endif |
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| 252 | } |
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| 253 | #endif |
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| 254 | |
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| 255 | |
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| 256 | static void match_calc( float *match, float **cpmx1, float **cpmx2, int i1, int lgth2, float **floatwork, int **intwork, int initialize ) |
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| 257 | { |
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| 258 | #if FASTMATCHCALC |
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| 259 | int j, l; |
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| 260 | float scarr[26]; |
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| 261 | float **cpmxpd = floatwork; |
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| 262 | int **cpmxpdn = intwork; |
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| 263 | float *matchpt, *cpmxpdpt, **cpmxpdptpt; |
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| 264 | int *cpmxpdnpt, **cpmxpdnptpt; |
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| 265 | if( initialize ) |
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| 266 | { |
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| 267 | int count = 0; |
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| 268 | for( j=0; j<lgth2; j++ ) |
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| 269 | { |
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| 270 | count = 0; |
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| 271 | for( l=0; l<26; l++ ) |
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| 272 | { |
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| 273 | if( cpmx2[l][j] ) |
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| 274 | { |
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| 275 | cpmxpd[j][count] = cpmx2[l][j]; |
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| 276 | cpmxpdn[j][count] = l; |
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| 277 | count++; |
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| 278 | } |
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| 279 | } |
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| 280 | cpmxpdn[j][count] = -1; |
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| 281 | } |
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| 282 | } |
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| 283 | |
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| 284 | { |
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| 285 | for( l=0; l<26; l++ ) |
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| 286 | { |
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| 287 | scarr[l] = 0.0; |
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| 288 | for( j=0; j<26; j++ ) |
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| 289 | scarr[l] += n_dis[j][l] * cpmx1[j][i1]; |
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| 290 | } |
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| 291 | matchpt = match; |
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| 292 | cpmxpdnptpt = cpmxpdn; |
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| 293 | cpmxpdptpt = cpmxpd; |
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| 294 | while( lgth2-- ) |
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| 295 | { |
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| 296 | *matchpt = 0.0; |
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| 297 | cpmxpdnpt = *cpmxpdnptpt++; |
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| 298 | cpmxpdpt = *cpmxpdptpt++; |
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| 299 | while( *cpmxpdnpt>-1 ) |
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| 300 | *matchpt += scarr[*cpmxpdnpt++] * *cpmxpdpt++; |
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| 301 | matchpt++; |
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| 302 | } |
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| 303 | } |
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| 304 | #else |
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| 305 | int j, k, l; |
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| 306 | float scarr[26]; |
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| 307 | float **cpmxpd = floatwork; |
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| 308 | int **cpmxpdn = intwork; |
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| 309 | // simple |
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| 310 | if( initialize ) |
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| 311 | { |
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| 312 | int count = 0; |
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| 313 | for( j=0; j<lgth2; j++ ) |
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| 314 | { |
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| 315 | count = 0; |
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| 316 | for( l=0; l<26; l++ ) |
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| 317 | { |
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| 318 | if( cpmx2[l][j] ) |
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| 319 | { |
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| 320 | cpmxpd[count][j] = cpmx2[l][j]; |
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| 321 | cpmxpdn[count][j] = l; |
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| 322 | count++; |
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| 323 | } |
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| 324 | } |
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| 325 | cpmxpdn[count][j] = -1; |
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| 326 | } |
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| 327 | } |
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| 328 | for( l=0; l<26; l++ ) |
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| 329 | { |
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| 330 | scarr[l] = 0.0; |
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| 331 | for( k=0; k<26; k++ ) |
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| 332 | scarr[l] += n_dis[k][l] * cpmx1[k][i1]; |
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| 333 | } |
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| 334 | for( j=0; j<lgth2; j++ ) |
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| 335 | { |
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| 336 | match[j] = 0.0; |
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| 337 | for( k=0; cpmxpdn[k][j]>-1; k++ ) |
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| 338 | match[j] += scarr[cpmxpdn[k][j]] * cpmxpd[k][j]; |
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| 339 | } |
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| 340 | #endif |
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| 341 | } |
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| 342 | |
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| 343 | static void Atracking_localhom( float *impwmpt, float *lasthorizontalw, float *lastverticalw, |
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| 344 | char **seq1, char **seq2, |
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| 345 | char **mseq1, char **mseq2, |
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| 346 | float **cpmx1, float **cpmx2, |
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| 347 | int **ijp, int icyc, int jcyc ) |
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| 348 | { |
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| 349 | int i, j, l, iin, jin, ifi, jfi, lgth1, lgth2, k; |
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| 350 | float wm; |
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| 351 | char *gaptable1, *gt1bk; |
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| 352 | char *gaptable2, *gt2bk; |
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| 353 | lgth1 = strlen( seq1[0] ); |
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| 354 | lgth2 = strlen( seq2[0] ); |
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| 355 | gt1bk = AllocateCharVec( lgth1+lgth2+1 ); |
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| 356 | gt2bk = AllocateCharVec( lgth1+lgth2+1 ); |
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| 357 | |
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| 358 | #if 0 |
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| 359 | for( i=0; i<lgth1; i++ ) |
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| 360 | { |
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| 361 | fprintf( stderr, "lastverticalw[%d] = %f\n", i, lastverticalw[i] ); |
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| 362 | } |
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| 363 | #endif |
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| 364 | |
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| 365 | if( outgap == 1 ) |
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| 366 | ; |
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| 367 | else |
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| 368 | { |
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| 369 | wm = lastverticalw[0]; |
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| 370 | for( i=0; i<lgth1; i++ ) |
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| 371 | { |
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| 372 | if( lastverticalw[i] >= wm ) |
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| 373 | { |
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| 374 | wm = lastverticalw[i]; |
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| 375 | iin = i; jin = lgth2-1; |
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| 376 | ijp[lgth1][lgth2] = +( lgth1 - i ); |
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| 377 | } |
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| 378 | } |
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| 379 | for( j=0; j<lgth2; j++ ) |
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| 380 | { |
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| 381 | if( lasthorizontalw[j] >= wm ) |
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| 382 | { |
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| 383 | wm = lasthorizontalw[j]; |
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| 384 | iin = lgth1-1; jin = j; |
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| 385 | ijp[lgth1][lgth2] = -( lgth2 - j ); |
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| 386 | } |
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| 387 | } |
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| 388 | } |
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| 389 | |
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| 390 | for( i=0; i<lgth1+1; i++ ) |
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| 391 | { |
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| 392 | ijp[i][0] = i + 1; |
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| 393 | } |
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| 394 | for( j=0; j<lgth2+1; j++ ) |
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| 395 | { |
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| 396 | ijp[0][j] = -( j + 1 ); |
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| 397 | } |
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| 398 | |
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| 399 | gaptable1 = gt1bk + lgth1+lgth2; |
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| 400 | *gaptable1 = 0; |
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| 401 | gaptable2 = gt2bk + lgth1+lgth2; |
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| 402 | *gaptable2 = 0; |
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| 403 | |
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| 404 | iin = lgth1; jin = lgth2; |
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| 405 | *impwmpt = 0.0; |
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| 406 | for( k=0; k<=lgth1+lgth2; k++ ) |
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| 407 | { |
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| 408 | if( ijp[iin][jin] < 0 ) |
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| 409 | { |
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| 410 | ifi = iin-1; jfi = jin+ijp[iin][jin]; |
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| 411 | } |
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| 412 | else if( ijp[iin][jin] > 0 ) |
|---|
| 413 | { |
|---|
| 414 | ifi = iin-ijp[iin][jin]; jfi = jin-1; |
|---|
| 415 | } |
|---|
| 416 | else |
|---|
| 417 | { |
|---|
| 418 | ifi = iin-1; jfi = jin-1; |
|---|
| 419 | } |
|---|
| 420 | l = iin - ifi; |
|---|
| 421 | while( --l ) |
|---|
| 422 | { |
|---|
| 423 | *--gaptable1 = 'o'; |
|---|
| 424 | *--gaptable2 = '-'; |
|---|
| 425 | k++; |
|---|
| 426 | } |
|---|
| 427 | l= jin - jfi; |
|---|
| 428 | while( --l ) |
|---|
| 429 | { |
|---|
| 430 | *--gaptable1 = '-'; |
|---|
| 431 | *--gaptable2 = 'o'; |
|---|
| 432 | k++; |
|---|
| 433 | } |
|---|
| 434 | if( iin == lgth1 || jin == lgth2 ) |
|---|
| 435 | ; |
|---|
| 436 | else |
|---|
| 437 | { |
|---|
| 438 | *impwmpt += imp_match_out_scR( iin, jin ); |
|---|
| 439 | |
|---|
| 440 | // fprintf( stderr, "impwm = %f (iin=%d, jin=%d) seq1=%c, seq2=%c\n", *impwmpt, iin, jin, seq1[0][iin], seq2[0][jin] ); |
|---|
| 441 | } |
|---|
| 442 | if( iin <= 0 || jin <= 0 ) break; |
|---|
| 443 | *--gaptable1 = 'o'; |
|---|
| 444 | *--gaptable2 = 'o'; |
|---|
| 445 | k++; |
|---|
| 446 | iin = ifi; jin = jfi; |
|---|
| 447 | } |
|---|
| 448 | |
|---|
| 449 | for( i=0; i<icyc; i++ ) gapireru( mseq1[i], seq1[i], gaptable1 ); |
|---|
| 450 | for( j=0; j<jcyc; j++ ) gapireru( mseq2[j], seq2[j], gaptable2 ); |
|---|
| 451 | |
|---|
| 452 | free( gt1bk ); |
|---|
| 453 | free( gt2bk ); |
|---|
| 454 | } |
|---|
| 455 | |
|---|
| 456 | static float Atracking( float *lasthorizontalw, float *lastverticalw, |
|---|
| 457 | char **seq1, char **seq2, |
|---|
| 458 | char **mseq1, char **mseq2, |
|---|
| 459 | float **cpmx1, float **cpmx2, |
|---|
| 460 | int **ijp, int icyc, int jcyc ) |
|---|
| 461 | { |
|---|
| 462 | int i, j, l, iin, jin, ifi, jfi, lgth1, lgth2, k; |
|---|
| 463 | float wm; |
|---|
| 464 | char *gaptable1, *gt1bk; |
|---|
| 465 | char *gaptable2, *gt2bk; |
|---|
| 466 | lgth1 = strlen( seq1[0] ); |
|---|
| 467 | lgth2 = strlen( seq2[0] ); |
|---|
| 468 | |
|---|
| 469 | gt1bk = AllocateCharVec( lgth1+lgth2+1 ); |
|---|
| 470 | gt2bk = AllocateCharVec( lgth1+lgth2+1 ); |
|---|
| 471 | |
|---|
| 472 | #if 0 |
|---|
| 473 | for( i=0; i<lgth1; i++ ) |
|---|
| 474 | { |
|---|
| 475 | fprintf( stderr, "lastverticalw[%d] = %f\n", i, lastverticalw[i] ); |
|---|
| 476 | } |
|---|
| 477 | #endif |
|---|
| 478 | |
|---|
| 479 | if( outgap == 1 ) |
|---|
| 480 | ; |
|---|
| 481 | else |
|---|
| 482 | { |
|---|
| 483 | wm = lastverticalw[0]; |
|---|
| 484 | for( i=0; i<lgth1; i++ ) |
|---|
| 485 | { |
|---|
| 486 | if( lastverticalw[i] >= wm ) |
|---|
| 487 | { |
|---|
| 488 | wm = lastverticalw[i]; |
|---|
| 489 | iin = i; jin = lgth2-1; |
|---|
| 490 | ijp[lgth1][lgth2] = +( lgth1 - i ); |
|---|
| 491 | } |
|---|
| 492 | } |
|---|
| 493 | for( j=0; j<lgth2; j++ ) |
|---|
| 494 | { |
|---|
| 495 | if( lasthorizontalw[j] >= wm ) |
|---|
| 496 | { |
|---|
| 497 | wm = lasthorizontalw[j]; |
|---|
| 498 | iin = lgth1-1; jin = j; |
|---|
| 499 | ijp[lgth1][lgth2] = -( lgth2 - j ); |
|---|
| 500 | } |
|---|
| 501 | } |
|---|
| 502 | } |
|---|
| 503 | |
|---|
| 504 | for( i=0; i<lgth1+1; i++ ) |
|---|
| 505 | { |
|---|
| 506 | ijp[i][0] = i + 1; |
|---|
| 507 | } |
|---|
| 508 | for( j=0; j<lgth2+1; j++ ) |
|---|
| 509 | { |
|---|
| 510 | ijp[0][j] = -( j + 1 ); |
|---|
| 511 | } |
|---|
| 512 | |
|---|
| 513 | gaptable1 = gt1bk + lgth1+lgth2; |
|---|
| 514 | *gaptable1 = 0; |
|---|
| 515 | gaptable2 = gt2bk + lgth1+lgth2; |
|---|
| 516 | *gaptable2 = 0; |
|---|
| 517 | |
|---|
| 518 | iin = lgth1; jin = lgth2; |
|---|
| 519 | for( k=0; k<=lgth1+lgth2; k++ ) |
|---|
| 520 | { |
|---|
| 521 | if( ijp[iin][jin] < 0 ) |
|---|
| 522 | { |
|---|
| 523 | ifi = iin-1; jfi = jin+ijp[iin][jin]; |
|---|
| 524 | } |
|---|
| 525 | else if( ijp[iin][jin] > 0 ) |
|---|
| 526 | { |
|---|
| 527 | ifi = iin-ijp[iin][jin]; jfi = jin-1; |
|---|
| 528 | } |
|---|
| 529 | else |
|---|
| 530 | { |
|---|
| 531 | ifi = iin-1; jfi = jin-1; |
|---|
| 532 | } |
|---|
| 533 | l = iin - ifi; |
|---|
| 534 | while( --l ) |
|---|
| 535 | { |
|---|
| 536 | *--gaptable1 = 'o'; |
|---|
| 537 | *--gaptable2 = '-'; |
|---|
| 538 | k++; |
|---|
| 539 | } |
|---|
| 540 | l= jin - jfi; |
|---|
| 541 | while( --l ) |
|---|
| 542 | { |
|---|
| 543 | *--gaptable1 = '-'; |
|---|
| 544 | *--gaptable2 = 'o'; |
|---|
| 545 | k++; |
|---|
| 546 | } |
|---|
| 547 | if( iin <= 0 || jin <= 0 ) break; |
|---|
| 548 | *--gaptable1 = 'o'; |
|---|
| 549 | *--gaptable2 = 'o'; |
|---|
| 550 | k++; |
|---|
| 551 | iin = ifi; jin = jfi; |
|---|
| 552 | } |
|---|
| 553 | |
|---|
| 554 | for( i=0; i<icyc; i++ ) gapireru( mseq1[i], seq1[i], gaptable1 ); |
|---|
| 555 | for( j=0; j<jcyc; j++ ) gapireru( mseq2[j], seq2[j], gaptable2 ); |
|---|
| 556 | |
|---|
| 557 | free( gt1bk ); |
|---|
| 558 | free( gt2bk ); |
|---|
| 559 | |
|---|
| 560 | return( 0.0 ); |
|---|
| 561 | } |
|---|
| 562 | |
|---|
| 563 | float R__align( char **seq1, char **seq2, double *eff1, double *eff2, int icyc, int jcyc, int alloclen, LocalHom ***localhom, float *impmatch, char *sgap1, char *sgap2, char *egap1, char *egap2 ) |
|---|
| 564 | /* score no keisan no sai motokaraaru gap no atukai ni mondai ga aru */ |
|---|
| 565 | { |
|---|
| 566 | // int k; |
|---|
| 567 | register int i, j; |
|---|
| 568 | int lasti, lastj; /* outgap == 0 -> lgth1, outgap == 1 -> lgth1+1 */ |
|---|
| 569 | int lgth1, lgth2; |
|---|
| 570 | int resultlen; |
|---|
| 571 | float wm = 0.0; /* int ?????? */ |
|---|
| 572 | float g; |
|---|
| 573 | float *currentw, *previousw; |
|---|
| 574 | // float fpenalty = (float)penalty; |
|---|
| 575 | #if USE_PENALTY_EX |
|---|
| 576 | float fpenalty_ex = (float)penalty_ex; |
|---|
| 577 | #endif |
|---|
| 578 | #if 1 |
|---|
| 579 | float *wtmp; |
|---|
| 580 | int *ijppt; |
|---|
| 581 | float *mjpt, *prept, *curpt; |
|---|
| 582 | int *mpjpt; |
|---|
| 583 | #endif |
|---|
| 584 | static TLS float mi, *m; |
|---|
| 585 | static TLS int **ijp; |
|---|
| 586 | static TLS int mpi, *mp; |
|---|
| 587 | static TLS float *w1, *w2; |
|---|
| 588 | static TLS float *match; |
|---|
| 589 | static TLS float *initverticalw; /* kufuu sureba iranai */ |
|---|
| 590 | static TLS float *lastverticalw; /* kufuu sureba iranai */ |
|---|
| 591 | static TLS char **mseq1; |
|---|
| 592 | static TLS char **mseq2; |
|---|
| 593 | static TLS char **mseq; |
|---|
| 594 | static TLS float *digf1; |
|---|
| 595 | static TLS float *digf2; |
|---|
| 596 | static TLS float *diaf1; |
|---|
| 597 | static TLS float *diaf2; |
|---|
| 598 | static TLS float *gapz1; |
|---|
| 599 | static TLS float *gapz2; |
|---|
| 600 | static TLS float *gapf1; |
|---|
| 601 | static TLS float *gapf2; |
|---|
| 602 | static TLS float *ogcp1g; |
|---|
| 603 | static TLS float *ogcp2g; |
|---|
| 604 | static TLS float *fgcp1g; |
|---|
| 605 | static TLS float *fgcp2g; |
|---|
| 606 | static TLS float *ogcp1; |
|---|
| 607 | static TLS float *ogcp2; |
|---|
| 608 | static TLS float *fgcp1; |
|---|
| 609 | static TLS float *fgcp2; |
|---|
| 610 | static TLS float **cpmx1; |
|---|
| 611 | static TLS float **cpmx2; |
|---|
| 612 | static TLS int **intwork; |
|---|
| 613 | static TLS float **floatwork; |
|---|
| 614 | static TLS int orlgth1 = 0, orlgth2 = 0; |
|---|
| 615 | float fpenalty = (float)penalty; |
|---|
| 616 | float tmppenal; |
|---|
| 617 | float cumpenal; |
|---|
| 618 | float *fgcp2pt; |
|---|
| 619 | float *ogcp2pt; |
|---|
| 620 | float fgcp1va; |
|---|
| 621 | float ogcp1va; |
|---|
| 622 | float kyokaipenal; |
|---|
| 623 | |
|---|
| 624 | |
|---|
| 625 | |
|---|
| 626 | #if 0 |
|---|
| 627 | fprintf( stderr, "#### seq1[0] = %s\n", seq1[0] ); |
|---|
| 628 | fprintf( stderr, "#### seq2[0] = %s\n", seq2[0] ); |
|---|
| 629 | #endif |
|---|
| 630 | if( orlgth1 == 0 ) |
|---|
| 631 | { |
|---|
| 632 | mseq1 = AllocateCharMtx( njob, 0 ); |
|---|
| 633 | mseq2 = AllocateCharMtx( njob, 0 ); |
|---|
| 634 | } |
|---|
| 635 | |
|---|
| 636 | |
|---|
| 637 | lgth1 = strlen( seq1[0] ); |
|---|
| 638 | lgth2 = strlen( seq2[0] ); |
|---|
| 639 | #if 0 |
|---|
| 640 | if( lgth1 == 0 || lgth2 == 0 ) |
|---|
| 641 | { |
|---|
| 642 | fprintf( stderr, "WARNING (Aalignmm): lgth1=%d, lgth2=%d\n", lgth1, lgth2 ); |
|---|
| 643 | } |
|---|
| 644 | #endif |
|---|
| 645 | |
|---|
| 646 | if( lgth1 > orlgth1 || lgth2 > orlgth2 ) |
|---|
| 647 | { |
|---|
| 648 | int ll1, ll2; |
|---|
| 649 | |
|---|
| 650 | if( orlgth1 > 0 && orlgth2 > 0 ) |
|---|
| 651 | { |
|---|
| 652 | FreeFloatVec( w1 ); |
|---|
| 653 | FreeFloatVec( w2 ); |
|---|
| 654 | FreeFloatVec( match ); |
|---|
| 655 | FreeFloatVec( initverticalw ); |
|---|
| 656 | FreeFloatVec( lastverticalw ); |
|---|
| 657 | |
|---|
| 658 | FreeFloatVec( m ); |
|---|
| 659 | FreeIntVec( mp ); |
|---|
| 660 | |
|---|
| 661 | FreeCharMtx( mseq ); |
|---|
| 662 | |
|---|
| 663 | FreeFloatVec( digf1 ); |
|---|
| 664 | FreeFloatVec( digf2 ); |
|---|
| 665 | FreeFloatVec( diaf1 ); |
|---|
| 666 | FreeFloatVec( diaf2 ); |
|---|
| 667 | FreeFloatVec( gapz1 ); |
|---|
| 668 | FreeFloatVec( gapz2 ); |
|---|
| 669 | FreeFloatVec( gapf1 ); |
|---|
| 670 | FreeFloatVec( gapf2 ); |
|---|
| 671 | FreeFloatVec( ogcp1 ); |
|---|
| 672 | FreeFloatVec( ogcp2 ); |
|---|
| 673 | FreeFloatVec( fgcp1 ); |
|---|
| 674 | FreeFloatVec( fgcp2 ); |
|---|
| 675 | FreeFloatVec( ogcp1g ); |
|---|
| 676 | FreeFloatVec( ogcp2g ); |
|---|
| 677 | FreeFloatVec( fgcp1g ); |
|---|
| 678 | FreeFloatVec( fgcp2g ); |
|---|
| 679 | |
|---|
| 680 | |
|---|
| 681 | FreeFloatMtx( cpmx1 ); |
|---|
| 682 | FreeFloatMtx( cpmx2 ); |
|---|
| 683 | |
|---|
| 684 | FreeFloatMtx( floatwork ); |
|---|
| 685 | FreeIntMtx( intwork ); |
|---|
| 686 | } |
|---|
| 687 | |
|---|
| 688 | ll1 = MAX( (int)(1.3*lgth1), orlgth1 ) + 100; |
|---|
| 689 | ll2 = MAX( (int)(1.3*lgth2), orlgth2 ) + 100; |
|---|
| 690 | |
|---|
| 691 | #if DEBUG |
|---|
| 692 | fprintf( stderr, "\ntrying to allocate (%d+%d)xn matrices ... ", ll1, ll2 ); |
|---|
| 693 | #endif |
|---|
| 694 | |
|---|
| 695 | w1 = AllocateFloatVec( ll2+2 ); |
|---|
| 696 | w2 = AllocateFloatVec( ll2+2 ); |
|---|
| 697 | match = AllocateFloatVec( ll2+2 ); |
|---|
| 698 | |
|---|
| 699 | initverticalw = AllocateFloatVec( ll1+2 ); |
|---|
| 700 | lastverticalw = AllocateFloatVec( ll1+2 ); |
|---|
| 701 | |
|---|
| 702 | m = AllocateFloatVec( ll2+2 ); |
|---|
| 703 | mp = AllocateIntVec( ll2+2 ); |
|---|
| 704 | |
|---|
| 705 | mseq = AllocateCharMtx( njob, ll1+ll2 ); |
|---|
| 706 | |
|---|
| 707 | digf1 = AllocateFloatVec( ll1+2 ); |
|---|
| 708 | digf2 = AllocateFloatVec( ll2+2 ); |
|---|
| 709 | diaf1 = AllocateFloatVec( ll1+2 ); |
|---|
| 710 | diaf2 = AllocateFloatVec( ll2+2 ); |
|---|
| 711 | gapz1 = AllocateFloatVec( ll1+2 ); |
|---|
| 712 | gapz2 = AllocateFloatVec( ll2+2 ); |
|---|
| 713 | gapf1 = AllocateFloatVec( ll1+2 ); |
|---|
| 714 | gapf2 = AllocateFloatVec( ll2+2 ); |
|---|
| 715 | ogcp1 = AllocateFloatVec( ll1+2 ); |
|---|
| 716 | ogcp2 = AllocateFloatVec( ll2+2 ); |
|---|
| 717 | fgcp1 = AllocateFloatVec( ll1+2 ); |
|---|
| 718 | fgcp2 = AllocateFloatVec( ll2+2 ); |
|---|
| 719 | ogcp1g = AllocateFloatVec( ll1+2 ); |
|---|
| 720 | ogcp2g = AllocateFloatVec( ll2+2 ); |
|---|
| 721 | fgcp1g = AllocateFloatVec( ll1+2 ); |
|---|
| 722 | fgcp2g = AllocateFloatVec( ll2+2 ); |
|---|
| 723 | |
|---|
| 724 | cpmx1 = AllocateFloatMtx( 26, ll1+2 ); |
|---|
| 725 | cpmx2 = AllocateFloatMtx( 26, ll2+2 ); |
|---|
| 726 | |
|---|
| 727 | #if FASTMATCHCALC |
|---|
| 728 | floatwork = AllocateFloatMtx( MAX( ll1, ll2 )+2, 26 ); |
|---|
| 729 | intwork = AllocateIntMtx( MAX( ll1, ll2 )+2, 27 ); |
|---|
| 730 | #else |
|---|
| 731 | floatwork = AllocateFloatMtx( 26, MAX( ll1, ll2 )+2 ); |
|---|
| 732 | intwork = AllocateIntMtx( 26, MAX( ll1, ll2 )+2 ); |
|---|
| 733 | #endif |
|---|
| 734 | |
|---|
| 735 | #if DEBUG |
|---|
| 736 | fprintf( stderr, "succeeded\n" ); |
|---|
| 737 | #endif |
|---|
| 738 | |
|---|
| 739 | orlgth1 = ll1 - 100; |
|---|
| 740 | orlgth2 = ll2 - 100; |
|---|
| 741 | } |
|---|
| 742 | |
|---|
| 743 | |
|---|
| 744 | for( i=0; i<icyc; i++ ) |
|---|
| 745 | { |
|---|
| 746 | mseq1[i] = mseq[i]; |
|---|
| 747 | seq1[i][lgth1] = 0; |
|---|
| 748 | } |
|---|
| 749 | for( j=0; j<jcyc; j++ ) |
|---|
| 750 | { |
|---|
| 751 | mseq2[j] = mseq[icyc+j]; |
|---|
| 752 | seq2[j][lgth2] = 0; |
|---|
| 753 | } |
|---|
| 754 | |
|---|
| 755 | |
|---|
| 756 | if( orlgth1 > commonAlloc1 || orlgth2 > commonAlloc2 ) |
|---|
| 757 | { |
|---|
| 758 | int ll1, ll2; |
|---|
| 759 | |
|---|
| 760 | if( commonAlloc1 && commonAlloc2 ) |
|---|
| 761 | { |
|---|
| 762 | FreeIntMtx( commonIP ); |
|---|
| 763 | } |
|---|
| 764 | |
|---|
| 765 | ll1 = MAX( orlgth1, commonAlloc1 ); |
|---|
| 766 | ll2 = MAX( orlgth2, commonAlloc2 ); |
|---|
| 767 | |
|---|
| 768 | #if DEBUG |
|---|
| 769 | fprintf( stderr, "\n\ntrying to allocate %dx%d matrices ... ", ll1+1, ll2+1 ); |
|---|
| 770 | #endif |
|---|
| 771 | |
|---|
| 772 | commonIP = AllocateIntMtx( ll1+10, ll2+10 ); |
|---|
| 773 | |
|---|
| 774 | #if DEBUG |
|---|
| 775 | fprintf( stderr, "succeeded\n\n" ); |
|---|
| 776 | #endif |
|---|
| 777 | |
|---|
| 778 | commonAlloc1 = ll1; |
|---|
| 779 | commonAlloc2 = ll2; |
|---|
| 780 | } |
|---|
| 781 | ijp = commonIP; |
|---|
| 782 | |
|---|
| 783 | #if 0 |
|---|
| 784 | { |
|---|
| 785 | float t = 0.0; |
|---|
| 786 | for( i=0; i<icyc; i++ ) |
|---|
| 787 | t += eff1[i]; |
|---|
| 788 | fprintf( stderr, "## totaleff = %f\n", t ); |
|---|
| 789 | } |
|---|
| 790 | #endif |
|---|
| 791 | |
|---|
| 792 | cpmx_calc_new( seq1, cpmx1, eff1, lgth1, icyc ); |
|---|
| 793 | cpmx_calc_new( seq2, cpmx2, eff2, lgth2, jcyc ); |
|---|
| 794 | |
|---|
| 795 | if( sgap1 ) |
|---|
| 796 | { |
|---|
| 797 | new_OpeningGapCount_zure( ogcp1g, icyc, seq1, eff1, lgth1, sgap1, egap1 ); |
|---|
| 798 | new_OpeningGapCount_zure( ogcp2g, jcyc, seq2, eff2, lgth2, sgap2, egap2 ); |
|---|
| 799 | new_FinalGapCount_zure( fgcp1g, icyc, seq1, eff1, lgth1, sgap1, egap1 ); |
|---|
| 800 | new_FinalGapCount_zure( fgcp2g, jcyc, seq2, eff2, lgth2, sgap2, egap2 ); |
|---|
| 801 | getdigapfreq_part( digf1, icyc, seq1, eff1, lgth1, sgap1, egap1 ); |
|---|
| 802 | getdigapfreq_part( digf2, jcyc, seq2, eff2, lgth2, sgap2, egap2 ); |
|---|
| 803 | getdiaminofreq_part( diaf1, icyc, seq1, eff1, lgth1, sgap1, egap1 ); |
|---|
| 804 | getdiaminofreq_part( diaf2, jcyc, seq2, eff2, lgth2, sgap2, egap2 ); |
|---|
| 805 | getgapfreq( gapf1, icyc, seq1, eff1, lgth1 ); |
|---|
| 806 | getgapfreq( gapf2, jcyc, seq2, eff2, lgth2 ); |
|---|
| 807 | getgapfreq_zure_part( gapz1, icyc, seq1, eff1, lgth1, sgap1 ); |
|---|
| 808 | getgapfreq_zure_part( gapz2, jcyc, seq2, eff2, lgth2, sgap1 ); |
|---|
| 809 | } |
|---|
| 810 | else |
|---|
| 811 | { |
|---|
| 812 | st_OpeningGapCount( ogcp1g, icyc, seq1, eff1, lgth1 ); |
|---|
| 813 | st_OpeningGapCount( ogcp2g, jcyc, seq2, eff2, lgth2 ); |
|---|
| 814 | st_FinalGapCount_zure( fgcp1g, icyc, seq1, eff1, lgth1 ); |
|---|
| 815 | st_FinalGapCount_zure( fgcp2g, jcyc, seq2, eff2, lgth2 ); |
|---|
| 816 | getdigapfreq_st( digf1, icyc, seq1, eff1, lgth1 ); |
|---|
| 817 | getdigapfreq_st( digf2, jcyc, seq2, eff2, lgth2 ); |
|---|
| 818 | getdiaminofreq_x( diaf1, icyc, seq1, eff1, lgth1 ); |
|---|
| 819 | getdiaminofreq_x( diaf2, jcyc, seq2, eff2, lgth2 ); |
|---|
| 820 | getgapfreq( gapf1, icyc, seq1, eff1, lgth1 ); |
|---|
| 821 | getgapfreq( gapf2, jcyc, seq2, eff2, lgth2 ); |
|---|
| 822 | getgapfreq_zure( gapz1, icyc, seq1, eff1, lgth1 ); |
|---|
| 823 | getgapfreq_zure( gapz2, jcyc, seq2, eff2, lgth2 ); |
|---|
| 824 | } |
|---|
| 825 | |
|---|
| 826 | #if 0 |
|---|
| 827 | for( i=0; i<lgth1; i++ ) |
|---|
| 828 | fprintf( stderr, "ogcp1[%d]=%f\n", i, ogcp1[i] ); |
|---|
| 829 | #endif |
|---|
| 830 | |
|---|
| 831 | currentw = w1; |
|---|
| 832 | previousw = w2; |
|---|
| 833 | |
|---|
| 834 | match_calc( initverticalw, cpmx2, cpmx1, 0, lgth1, floatwork, intwork, 1 ); |
|---|
| 835 | if( localhom ) |
|---|
| 836 | imp_match_out_vead_tateR( initverticalw, 0, lgth1 ); // 060306 |
|---|
| 837 | |
|---|
| 838 | match_calc( currentw, cpmx1, cpmx2, 0, lgth2, floatwork, intwork, 1 ); |
|---|
| 839 | if( localhom ) |
|---|
| 840 | imp_match_out_veadR( currentw, 0, lgth2 ); // 060306 |
|---|
| 841 | |
|---|
| 842 | |
|---|
| 843 | #if 0 // -> tbfast.c |
|---|
| 844 | if( localhom ) |
|---|
| 845 | imp_match_calc( currentw, icyc, jcyc, lgth1, lgth2, seq1, seq2, eff1, eff2, localhom, 1, 0 ); |
|---|
| 846 | |
|---|
| 847 | #endif |
|---|
| 848 | |
|---|
| 849 | |
|---|
| 850 | |
|---|
| 851 | kyokaipenal = 0.0; |
|---|
| 852 | if( outgap == 1 ) |
|---|
| 853 | { |
|---|
| 854 | g = 0.0; |
|---|
| 855 | |
|---|
| 856 | g += ogcp1g[0] * ( 1.0-ogcp2g[0] ) * fpenalty * 0.5; |
|---|
| 857 | // if( g ) fprintf( stderr, "init-match penal1=%f, %c-%c\n", g, seq1[0][0], seq2[0][0] ); |
|---|
| 858 | |
|---|
| 859 | g += ogcp2g[0] * ( 1.0-ogcp1g[0] ) * fpenalty * 0.5; |
|---|
| 860 | // if( g ) fprintf( stderr, "init-match penal2=%f, %c-%c\n", g, seq1[0][0], seq2[0][0] ); |
|---|
| 861 | |
|---|
| 862 | g += fgcp1g[0] * ( 1.0-fgcp2g[0] ) * fpenalty * 0.5; |
|---|
| 863 | // if( g ) fprintf( stderr, "match penal1=%f, %c-%c\n", g, seq1[0][i], seq2[0][j] ); |
|---|
| 864 | |
|---|
| 865 | g += fgcp2g[0] * ( 1.0-fgcp1g[0] ) * fpenalty * 0.5; |
|---|
| 866 | // if( g ) fprintf( stderr, "match penal2=%f, %c-%c\n", g, seq1[0][i], seq2[0][j] ); |
|---|
| 867 | |
|---|
| 868 | kyokaipenal = g; |
|---|
| 869 | initverticalw[0] += g; |
|---|
| 870 | currentw[0] += g; |
|---|
| 871 | |
|---|
| 872 | cumpenal = 0.0; |
|---|
| 873 | for( i=1; i<lgth1+1; i++ ) |
|---|
| 874 | { |
|---|
| 875 | // initverticalw[i] += ( ogcp1[0] + fgcp1[i-1] ) ; |
|---|
| 876 | |
|---|
| 877 | // Q tmppenal = ( (1.0-gapz2[0])*(1.0-ogcp1g[0]+fgcp1g[0]-digf1[0]) ) * 0.5 * fpenalty; // mada |
|---|
| 878 | // tmppenal = ( (1.0-gapf2[j-1])*(1.0-ogcp1g[i]+fgcp1g[i]) + gapf2[j-1]*(1.0-digf1[i]-diaf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 879 | tmppenal = ( (1.0-gapz2[0])*(1.0-ogcp1g[0]+0.0) + gapz2[0]*(1.0-digf1[0] - diaf1[0]) ) * 0.5 * fpenalty; // mada |
|---|
| 880 | // tmppenal = ( (1.0-0.0)*(1.0-ogcp1g[0]+0.0) + 0.0*(1.0-0.0-0.0) ) * 0.5 * fpenalty; // mada |
|---|
| 881 | // tmppenal = 0.5 * fpenalty; |
|---|
| 882 | // tmppenal -= ( (1.0-0.0) * (1.0-diaf1[0]) + 0.0 ) * 0.5 * fpenalty; // 0. |
|---|
| 883 | // tmppenal -= ( (1.0-gapf2[j-1]) * ogcp1g[i] + gapf2[j-1] ) * 0.5 * fpenalty; |
|---|
| 884 | // fprintf( stderr, "0,0<-%d,%d, tmppenal 1 = %f\n", i, 0, tmppenal ); |
|---|
| 885 | initverticalw[i] += tmppenal; |
|---|
| 886 | |
|---|
| 887 | // Q tmppenal = ( (1.0-gapz2[1])*(1.0-fgcp1g[i]+ogcp1g[i]-digf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 888 | // tmppenal = ( (1.0-gapf2[j])*(1.0-fgcp1g[i]+ogcp1g[i]) + gapf2[j]*(1.0-digf1[i]-diaf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 889 | tmppenal = ( (1.0-gapz2[1])*(1.0-fgcp1g[i]+ogcp1g[i]) + gapz2[1]*(1.0-digf1[i]-diaf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 890 | // tmppenal = ( (1.0-gapf2[0])*(1.0-fgcp1g[i]+ogcp1g[i]) + gapf2[0]*(1.0-digf1[i]-diaf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 891 | // tmppenal = 0.5 * fpenalty; |
|---|
| 892 | // tmppenal -= ( (1.0-gapf2[0]) * (1.0-diaf1[i]) + gapf2[0] ) * 0.5 * fpenalty; |
|---|
| 893 | // tmppenal -= ( (1.0-gapf2[j]) * fgcp1g[i] + gapf2[j] ) * 0.5 * fpenalty; |
|---|
| 894 | initverticalw[i] += tmppenal; |
|---|
| 895 | cumpenal += ( ogcp1g[i-0] + fgcp1g[i] ) * fpenalty * 0.5; |
|---|
| 896 | initverticalw[i] += cumpenal - fgcp1g[i] * fpenalty * 0.5; // honto ha iru |
|---|
| 897 | // fprintf( stderr, "0,0<-%d,%d, tmppenal 2 = %f, cumpenal=%f, fgcp1g[i]=%f, ogcp1g[i]=%f\n", i, 0, tmppenal, cumpenal, fgcp1g[i], ogcp1g[i] ); |
|---|
| 898 | |
|---|
| 899 | } |
|---|
| 900 | cumpenal = 0.0; |
|---|
| 901 | for( j=1; j<lgth2+1; j++ ) |
|---|
| 902 | { |
|---|
| 903 | // currentw[j] += ( ogcp2[0] + fgcp2[j-1] ) ; |
|---|
| 904 | |
|---|
| 905 | // tmppenal = ( (1.0-gapz1[0])*(1.0-ogcp2g[0]+fgcp2g[0]-digf2[0]) ) * 0.5 * fpenalty; // mada |
|---|
| 906 | // tmppenal = ( (1.0-gapf1[i-1])*(1.0-ogcp2g[j]+fgcp2g[j]) + gapf1[i-1]*(1.0-digf2[j]-diaf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 907 | tmppenal = ( (1.0-gapz1[0])*(1.0-ogcp2g[0]+0.0) + gapz1[0]*(1.0-digf2[j]-diaf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 908 | // tmppenal = ( (1.0-0.0)*(1.0-ogcp2g[0]+0.0) + 0.0*(1.0-0.0-0.0) ) * 0.5 * fpenalty; // mada |
|---|
| 909 | // tmppenal = 0.5 * fpenalty; |
|---|
| 910 | // tmppenal -= ( (1.0-0.0) * (1.0-diaf2[0]) + 0.0 ) * 0.5 * fpenalty; // 0. |
|---|
| 911 | // tmppenal -= ( (1.0-gapf1[0]) * fgcp2g[j] + gapf1[0] ) * 0.5 * fpenalty; |
|---|
| 912 | // fprintf( stderr, "0,0<-%d,%d, tmppenal 3 = %f\n", 0, j, tmppenal ); |
|---|
| 913 | currentw[j] += tmppenal; |
|---|
| 914 | |
|---|
| 915 | // tmppenal = ( (1.0-gapz1[1])*(1.0-fgcp2g[j]+ogcp2g[j]-digf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 916 | // tmppenal = ( (1.0-gapf1[i])*(1.0-fgcp2g[j]+ogcp2g[j]) + gapf1[i]*(1.0-digf2[j]-diaf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 917 | tmppenal = ( (1.0-gapz1[1])*(1.0-fgcp2g[j]+ogcp2g[j]) + gapz1[1]*(1.0-digf2[j]-diaf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 918 | // tmppenal = ( (1.0-gapf1[0])*(1.0-fgcp2g[j]+ogcp2g[j]) + gapf1[0]*(1.0-digf2[j]-diaf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 919 | // tmppenal = 0.5 * fpenalty; |
|---|
| 920 | // tmppenal -= ( (1.0-gapf1[0]) * (1.0-diaf2[j]) + gapf1[0] ) * 0.5 * fpenalty; |
|---|
| 921 | // tmppenal -= ( (1.0-gapf1[0]) * ogcp2g[j] + gapf1[i-1] ) * 0.5 * fpenalty; |
|---|
| 922 | // fprintf( stderr, "0,0<-%d,%d, tmppenal 4 = %f\n", 0, j, tmppenal ); |
|---|
| 923 | currentw[j] += tmppenal; |
|---|
| 924 | cumpenal += ( ogcp2g[j-0] + fgcp2g[j] ) * fpenalty * 0.5; |
|---|
| 925 | currentw[j] += cumpenal - fgcp2g[j] * fpenalty * 0.5; // honto ha iru |
|---|
| 926 | } |
|---|
| 927 | } |
|---|
| 928 | #if OUTGAP0TRY |
|---|
| 929 | else |
|---|
| 930 | { |
|---|
| 931 | for( j=1; j<lgth2+1; j++ ) |
|---|
| 932 | currentw[j] -= offset * j / 2.0; |
|---|
| 933 | for( i=1; i<lgth1+1; i++ ) |
|---|
| 934 | initverticalw[i] -= offset * i / 2.0; |
|---|
| 935 | } |
|---|
| 936 | #endif |
|---|
| 937 | |
|---|
| 938 | m[0] = 0.0; // iranai |
|---|
| 939 | for( j=1; j<lgth2+1; ++j ) |
|---|
| 940 | { |
|---|
| 941 | mp[j] = 0; |
|---|
| 942 | m[j] = currentw[j-1] + 10000 * fpenalty; //iinoka? |
|---|
| 943 | } |
|---|
| 944 | if( lgth2 == 0 ) |
|---|
| 945 | lastverticalw[0] = 0.0; // Falign kara yobaretatoki kounarukanousei ari |
|---|
| 946 | else |
|---|
| 947 | lastverticalw[0] = currentw[lgth2-1]; |
|---|
| 948 | |
|---|
| 949 | if( outgap ) lasti = lgth1+1; else lasti = lgth1; |
|---|
| 950 | |
|---|
| 951 | #if XXXXXXX |
|---|
| 952 | fprintf( stderr, "currentw = \n" ); |
|---|
| 953 | for( i=0; i<lgth1+1; i++ ) |
|---|
| 954 | { |
|---|
| 955 | fprintf( stderr, "%5.2f ", currentw[i] ); |
|---|
| 956 | } |
|---|
| 957 | fprintf( stderr, "\n" ); |
|---|
| 958 | fprintf( stderr, "initverticalw = \n" ); |
|---|
| 959 | for( i=0; i<lgth2+1; i++ ) |
|---|
| 960 | { |
|---|
| 961 | fprintf( stderr, "%5.2f ", initverticalw[i] ); |
|---|
| 962 | } |
|---|
| 963 | fprintf( stderr, "\n" ); |
|---|
| 964 | fprintf( stderr, "fcgp\n" ); |
|---|
| 965 | for( i=0; i<lgth1; i++ ) |
|---|
| 966 | fprintf( stderr, "fgcp1[%d]=%f\n", i, ogcp1[i] ); |
|---|
| 967 | for( i=0; i<lgth2; i++ ) |
|---|
| 968 | fprintf( stderr, "fgcp2[%d]=%f\n", i, ogcp2[i] ); |
|---|
| 969 | #endif |
|---|
| 970 | |
|---|
| 971 | for( i=1; i<lasti; i++ ) |
|---|
| 972 | { |
|---|
| 973 | wtmp = previousw; |
|---|
| 974 | previousw = currentw; |
|---|
| 975 | currentw = wtmp; |
|---|
| 976 | |
|---|
| 977 | previousw[0] = initverticalw[i-1]; |
|---|
| 978 | |
|---|
| 979 | match_calc( currentw, cpmx1, cpmx2, i, lgth2, floatwork, intwork, 0 ); |
|---|
| 980 | #if XXXXXXX |
|---|
| 981 | fprintf( stderr, "\n" ); |
|---|
| 982 | fprintf( stderr, "i=%d\n", i ); |
|---|
| 983 | fprintf( stderr, "currentw = \n" ); |
|---|
| 984 | for( j=0; j<lgth2; j++ ) |
|---|
| 985 | { |
|---|
| 986 | fprintf( stderr, "%5.2f ", currentw[j] ); |
|---|
| 987 | } |
|---|
| 988 | fprintf( stderr, "\n" ); |
|---|
| 989 | #endif |
|---|
| 990 | if( localhom ) |
|---|
| 991 | { |
|---|
| 992 | // fprintf( stderr, "Calling imp_match_calc (o) lgth = %d, i = %d\n", lgth1, i ); |
|---|
| 993 | #if 0 |
|---|
| 994 | imp_match_out_veadR( currentw, i, lgth2 ); |
|---|
| 995 | #else |
|---|
| 996 | imp_match_out_veadR( currentw, i, lgth2 ); |
|---|
| 997 | #endif |
|---|
| 998 | } |
|---|
| 999 | #if XXXXXXX |
|---|
| 1000 | fprintf( stderr, "\n" ); |
|---|
| 1001 | fprintf( stderr, "i=%d\n", i ); |
|---|
| 1002 | fprintf( stderr, "currentw = \n" ); |
|---|
| 1003 | for( j=0; j<lgth2; j++ ) |
|---|
| 1004 | { |
|---|
| 1005 | fprintf( stderr, "%5.2f ", currentw[j] ); |
|---|
| 1006 | } |
|---|
| 1007 | fprintf( stderr, "\n" ); |
|---|
| 1008 | #endif |
|---|
| 1009 | currentw[0] = initverticalw[i]; |
|---|
| 1010 | |
|---|
| 1011 | mpi = 0; |
|---|
| 1012 | mi = previousw[0] + 10000 * fpenalty; |
|---|
| 1013 | |
|---|
| 1014 | ijppt = ijp[i] + 1; |
|---|
| 1015 | mjpt = m + 1; |
|---|
| 1016 | prept = previousw; |
|---|
| 1017 | curpt = currentw + 1; |
|---|
| 1018 | mpjpt = mp + 1; |
|---|
| 1019 | fgcp2pt = fgcp2; |
|---|
| 1020 | ogcp2pt = ogcp2 + 1; |
|---|
| 1021 | fgcp1va = fgcp1[i-1]; |
|---|
| 1022 | ogcp1va = ogcp1[i]; |
|---|
| 1023 | lastj = lgth2+1; |
|---|
| 1024 | for( j=1; j<lastj; j++ ) |
|---|
| 1025 | { |
|---|
| 1026 | wm = *prept; |
|---|
| 1027 | |
|---|
| 1028 | g = ogcp1g[i] * ( 1.0-ogcp2g[j] ) * fpenalty * 0.5; |
|---|
| 1029 | // if( g && i==j ) fprintf( stderr, "match penal1=%f, %c-%c\n", g, seq1[0][i], seq2[0][j] ); |
|---|
| 1030 | wm += g; |
|---|
| 1031 | |
|---|
| 1032 | g = ogcp2g[j] * ( 1.0-ogcp1g[i] ) * fpenalty * 0.5; |
|---|
| 1033 | // if( g && i==j ) fprintf( stderr, "match penal2=%f, %c-%c\n", g, seq1[0][i], seq2[0][j] ); |
|---|
| 1034 | wm += g; |
|---|
| 1035 | |
|---|
| 1036 | g = fgcp1g[i] * ( 1.0-fgcp2g[j] ) * fpenalty * 0.5; |
|---|
| 1037 | // if( g && i==j ) fprintf( stderr, "match penal3=%f, %c-%c\n", g, seq1[0][i], seq2[0][j] ); |
|---|
| 1038 | wm += g; |
|---|
| 1039 | |
|---|
| 1040 | g = fgcp2g[j] * ( 1.0-fgcp1g[i] ) * fpenalty * 0.5; |
|---|
| 1041 | // if( g && i==j ) fprintf( stderr, "match penal4=%f, %c-%c\n", g, seq1[0][i], seq2[0][j] ); |
|---|
| 1042 | wm += g; |
|---|
| 1043 | |
|---|
| 1044 | #if 0 |
|---|
| 1045 | g = fgcp2g[j] * ogcp1g[i] * fpenalty * 0.5; |
|---|
| 1046 | if( g ) fprintf( stderr, "match m-penal5=%f, %c-%c\n", g, seq1[0][i], seq2[0][j] ); |
|---|
| 1047 | wm -= g; |
|---|
| 1048 | |
|---|
| 1049 | g = fgcp1g[i] * ogcp2g[j] * fpenalty * 0.5; |
|---|
| 1050 | if( g ) fprintf( stderr, "match m-penal6=%f, %c-%c\n", g, seq1[0][i], seq2[0][j] ); |
|---|
| 1051 | wm -= g; |
|---|
| 1052 | #endif |
|---|
| 1053 | |
|---|
| 1054 | *ijppt = 0; |
|---|
| 1055 | |
|---|
| 1056 | #if 0 |
|---|
| 1057 | fprintf( stderr, "%5.0f->", wm ); |
|---|
| 1058 | #endif |
|---|
| 1059 | #if 0 |
|---|
| 1060 | fprintf( stderr, "%5.0f?", g ); |
|---|
| 1061 | #endif |
|---|
| 1062 | // tmppenal = ( (1.0-gapz1[i+1])*(1.0-fgcp2g[j]+ogcp2g[j]-digf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 1063 | // tmppenal = ( (1.0-gapf1[i])*(1.0-fgcp2g[j]) + gapf1[i]*(1.0-digf2[j]-diaf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 1064 | tmppenal = ( (1.0-gapz1[i+1])*(1.0-fgcp2g[j]+ogcp2g[j]) + gapz1[i+1]*(1.0-digf2[j]-diaf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 1065 | // tmppenal = ( (1.0-gapf1[i])*(1.0-fgcp2g[j]+ogcp2g[j]) + gapf1[i]*(1.0-digf2[j]-diaf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 1066 | // tmppenal = 0.5 * fpenalty; |
|---|
| 1067 | // tmppenal -= ( (1.0-gapf1[i])*(1.0-diaf2[j]) + gapf1[i] ) * 0.5 * fpenalty; |
|---|
| 1068 | // tmppenal -= ( (1.0-gapf1[i])*fgcp2g[j] + gapf1[i] ) * 0.5 * fpenalty; |
|---|
| 1069 | // tmppenal = *fgcp2pt-fpenalty*0.5*gapf1[i]; |
|---|
| 1070 | // tmppenal = *fgcp2pt; |
|---|
| 1071 | if( (g=mi+tmppenal) > wm ) |
|---|
| 1072 | { |
|---|
| 1073 | // fprintf( stderr, "jump i start=%f (j=%d, fgcp2g[j]=%f, digf2[j]=%f, diaf2[j]=%f), %c-%c\n", g-mi, j, fgcp2g[j], digf2[j], diaf2[j], seq1[0][i], seq2[0][j] ); |
|---|
| 1074 | wm = g; |
|---|
| 1075 | *ijppt = -( j - mpi ); |
|---|
| 1076 | } |
|---|
| 1077 | // tmppenal = ( (1.0-gapz1[i])*(1.0-ogcp2g[j]+fgcp2g[j]-digf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 1078 | tmppenal = ( (1.0-gapz1[i])*(1.0-ogcp2g[j]+fgcp2g[j]) + gapz1[i]*(1.0-digf2[j]-diaf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 1079 | // tmppenal = ( (1.0-gapf1[i-1])*(1.0-ogcp2g[j]+fgcp2g[j]) + gapf1[i-1]*(1.0-digf2[j]-diaf2[j]) ) * 0.5 * fpenalty; // mada |
|---|
| 1080 | // tmppenal = *ogcp2pt-fpenalty*0.5*(gapf2[j-1]+gapf1[i-1]); |
|---|
| 1081 | // tmppenal = 0.5 * fpenalty; |
|---|
| 1082 | // tmppenal -= ( (1.0-gapf1[i-1])*(1.0-diaf2[j]) + gapf1[i-1] ) * 0.5 * fpenalty; |
|---|
| 1083 | // tmppenal -= ( (1.0-gapf1[i-1])*ogcp2g[j] + gapf1[i-1] ) * 0.5 * fpenalty; |
|---|
| 1084 | // tmppenal = *prept+*ogcp2pt; |
|---|
| 1085 | if( (g=*prept+tmppenal) >= mi ) |
|---|
| 1086 | { |
|---|
| 1087 | // fprintf( stderr, "jump i end=%f, %c-%c\n", g-*prept, seq1[0][i-1], seq2[0][j-1] ); |
|---|
| 1088 | mi = g; |
|---|
| 1089 | mpi = j-1; |
|---|
| 1090 | } |
|---|
| 1091 | else if( j != 1 ) |
|---|
| 1092 | { |
|---|
| 1093 | mi += ( ogcp2g[j-0] + fgcp2g[j] ) * fpenalty * 0.5; // CHUUI honto ha iru |
|---|
| 1094 | // fprintf( stderr, "%c%c/%c%c exp, og=%f,fg=%f\n", '=', '=', seq2[0][j-1], seq2[0][j], ogcp2g[j-0] * fpenalty*0.5, fgcp2g[j] * fpenalty*0.5 ); |
|---|
| 1095 | } |
|---|
| 1096 | #if USE_PENALTY_EX |
|---|
| 1097 | mi += fpenalty_ex; |
|---|
| 1098 | #endif |
|---|
| 1099 | |
|---|
| 1100 | #if 0 |
|---|
| 1101 | fprintf( stderr, "%5.0f?", g ); |
|---|
| 1102 | #endif |
|---|
| 1103 | // tmppenal = ( (1.0-gapz2[j+1])*(1.0-fgcp1g[i]+ogcp1g[i]-digf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 1104 | tmppenal = ( (1.0-gapz2[j+1])*(1.0-fgcp1g[i]+ogcp1g[i]) + gapz2[j+1]*(1.0-digf1[i]-diaf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 1105 | // tmppenal = ( (1.0-gapf2[j])*(1.0-fgcp1g[i]+ogcp1g[i]) + gapf2[j]*(1.0-digf1[i]-diaf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 1106 | // tmppenal = ( (1.0-gapf2[j])*(1.0-fgcp1g[i]) + gapf2[j]*(1.0-digf1[i]-diaf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 1107 | // tmppenal = 0.5 * fpenalty; |
|---|
| 1108 | // tmppenal -= ( (1.0-gapf2[j])*(1.0-diaf1[i]) + gapf2[j] ) * 0.5 * fpenalty; |
|---|
| 1109 | // tmppenal -= ( (1.0-gapf2[j])*fgcp1g[i] + gapf2[j] ) * 0.5 * fpenalty; |
|---|
| 1110 | // tmppenal = fgcp1va-fpenalty*0.5*gapf2[j]; |
|---|
| 1111 | // tmppenal = fgcp1va; |
|---|
| 1112 | if( (g=*mjpt+tmppenal) > wm ) |
|---|
| 1113 | { |
|---|
| 1114 | // if( seq1[0][i] == 'Y' && seq2[0][j] == 'B' ) |
|---|
| 1115 | // fprintf( stderr, "jump j start=%f, %c-%c\n", g-*mjpt, seq1[0][i], seq2[0][j] ); |
|---|
| 1116 | wm = g; |
|---|
| 1117 | *ijppt = +( i - *mpjpt ); |
|---|
| 1118 | } |
|---|
| 1119 | // tmppenal = ( (1.0-gapz2[j])*(1.0-ogcp1g[i]+fgcp1g[i]-digf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 1120 | tmppenal = ( (1.0-gapz2[j])*(1.0-ogcp1g[i]+fgcp1g[i]) + gapz2[j]*(1.0-digf1[i]-diaf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 1121 | // tmppenal = ( (1.0-gapf2[j-1])*(1.0-ogcp1g[i]+fgcp1g[i]) + gapf2[j-1]*(1.0-digf1[i]-diaf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 1122 | // tmppenal = ( (1.0-gapf2[j-1])*(1.0-ogcp1g[i]) + gapf2[j-1]*(1.0-digf1[i]-diaf1[i]) ) * 0.5 * fpenalty; // mada |
|---|
| 1123 | // tmppenal = ogcp1va-fpenalty*0.5*(gapf1[i-1]+gapf2[j-1]); |
|---|
| 1124 | // tmppenal = 0.5 * fpenalty; |
|---|
| 1125 | // tmppenal -= ( (1.0-gapf2[j-1]) * (1.0-diaf1[i]) + gapf2[j-1] ) * 0.5 * fpenalty; |
|---|
| 1126 | // tmppenal -= ( (1.0-gapf2[j-1]) * ogcp1g[i] + gapf2[j-1] ) * 0.5 * fpenalty; |
|---|
| 1127 | // tmppenal = 0.5 * fpenalty - ( (1.0-gapf2[j-1]) * (ogcp1g[i]) + gapf2[j-1] ) * ( 0.5 * fpenalty ); |
|---|
| 1128 | // tmppenal = ogcp1va-fpenalty*0.5*gapf2[j-1]; |
|---|
| 1129 | // tmppenal = ogcp1va; |
|---|
| 1130 | if( (g=*prept+tmppenal) >= *mjpt ) |
|---|
| 1131 | { |
|---|
| 1132 | // if( seq1[0][i] == 'T' && seq2[0][j] == 'T' ) |
|---|
| 1133 | // fprintf( stderr, "jump j end=%f, %c-%c\n", g-*prept, seq1[0][i-1], seq2[0][j-1] ); |
|---|
| 1134 | *mjpt = g; |
|---|
| 1135 | *mpjpt = i-1; |
|---|
| 1136 | } |
|---|
| 1137 | else if( i != 1 ) |
|---|
| 1138 | { |
|---|
| 1139 | m[j] += ( ogcp1g[i-0] + fgcp1g[i] ) * fpenalty * 0.5; // CHUUI honto ha iru |
|---|
| 1140 | // fprintf( stderr, "%c%c/%c%c exp, og=%f,fg=%f\n", seq1[0][i-1], seq1[0][i], '=', '=', ogcp1g[i-0] * fpenalty*0.5, fgcp1g[i] * fpenalty*0.5 ); |
|---|
| 1141 | } |
|---|
| 1142 | #if USE_PENALTY_EX |
|---|
| 1143 | m[j] += fpenalty_ex; |
|---|
| 1144 | #endif |
|---|
| 1145 | |
|---|
| 1146 | #if 0 |
|---|
| 1147 | fprintf( stderr, "%5.0f ", wm ); |
|---|
| 1148 | #endif |
|---|
| 1149 | *curpt++ += wm; |
|---|
| 1150 | ijppt++; |
|---|
| 1151 | mjpt++; |
|---|
| 1152 | prept++; |
|---|
| 1153 | mpjpt++; |
|---|
| 1154 | fgcp2pt++; |
|---|
| 1155 | ogcp2pt++; |
|---|
| 1156 | } |
|---|
| 1157 | lastverticalw[i] = currentw[lgth2-1]; |
|---|
| 1158 | } |
|---|
| 1159 | |
|---|
| 1160 | // fprintf( stderr, "wm = %f\n", wm ); |
|---|
| 1161 | |
|---|
| 1162 | #if OUTGAP0TRY |
|---|
| 1163 | if( !outgap ) |
|---|
| 1164 | { |
|---|
| 1165 | for( j=1; j<lgth2+1; j++ ) |
|---|
| 1166 | currentw[j] -= offset * ( lgth2 - j ) / 2.0; |
|---|
| 1167 | for( i=1; i<lgth1+1; i++ ) |
|---|
| 1168 | lastverticalw[i] -= offset * ( lgth1 - i / 2.0); |
|---|
| 1169 | } |
|---|
| 1170 | #endif |
|---|
| 1171 | |
|---|
| 1172 | /* |
|---|
| 1173 | fprintf( stderr, "\n" ); |
|---|
| 1174 | for( i=0; i<icyc; i++ ) fprintf( stderr,"%s\n", seq1[i] ); |
|---|
| 1175 | fprintf( stderr, "#####\n" ); |
|---|
| 1176 | for( j=0; j<jcyc; j++ ) fprintf( stderr,"%s\n", seq2[j] ); |
|---|
| 1177 | fprintf( stderr, "====>" ); |
|---|
| 1178 | for( i=0; i<icyc; i++ ) strcpy( mseq1[i], seq1[i] ); |
|---|
| 1179 | for( j=0; j<jcyc; j++ ) strcpy( mseq2[j], seq2[j] ); |
|---|
| 1180 | */ |
|---|
| 1181 | if( localhom ) |
|---|
| 1182 | { |
|---|
| 1183 | Atracking_localhom( impmatch, currentw, lastverticalw, seq1, seq2, mseq1, mseq2, cpmx1, cpmx2, ijp, icyc, jcyc ); |
|---|
| 1184 | } |
|---|
| 1185 | else |
|---|
| 1186 | Atracking( currentw, lastverticalw, seq1, seq2, mseq1, mseq2, cpmx1, cpmx2, ijp, icyc, jcyc ); |
|---|
| 1187 | |
|---|
| 1188 | // fprintf( stderr, "### impmatch = %f\n", *impmatch ); |
|---|
| 1189 | |
|---|
| 1190 | resultlen = strlen( mseq1[0] ); |
|---|
| 1191 | if( alloclen < resultlen || resultlen > N ) |
|---|
| 1192 | { |
|---|
| 1193 | fprintf( stderr, "alloclen=%d, resultlen=%d, N=%d\n", alloclen, resultlen, N ); |
|---|
| 1194 | ErrorExit( "LENGTH OVER!\n" ); |
|---|
| 1195 | } |
|---|
| 1196 | |
|---|
| 1197 | |
|---|
| 1198 | for( i=0; i<icyc; i++ ) strcpy( seq1[i], mseq1[i] ); |
|---|
| 1199 | for( j=0; j<jcyc; j++ ) strcpy( seq2[j], mseq2[j] ); |
|---|
| 1200 | /* |
|---|
| 1201 | fprintf( stderr, "\n" ); |
|---|
| 1202 | for( i=0; i<icyc; i++ ) fprintf( stderr, "%s\n", mseq1[i] ); |
|---|
| 1203 | fprintf( stderr, "#####\n" ); |
|---|
| 1204 | for( j=0; j<jcyc; j++ ) fprintf( stderr, "%s\n", mseq2[j] ); |
|---|
| 1205 | */ |
|---|
| 1206 | |
|---|
| 1207 | fprintf( stderr, "wm = %f\n", wm ); |
|---|
| 1208 | |
|---|
| 1209 | |
|---|
| 1210 | return( wm ); |
|---|
| 1211 | } |
|---|
| 1212 | |
|---|
| 1213 | |
|---|