1 | #include "mltaln.h" |
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2 | |
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3 | #define DEBUG 0 |
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4 | |
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5 | |
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6 | static char *comment; |
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7 | static char *orderfile; |
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8 | static int format; |
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9 | static int namelen; |
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10 | |
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11 | static void fillspace( char *seq, int lenmax ) |
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12 | { |
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13 | int len = strlen( seq ); |
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14 | seq += len; |
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15 | lenmax -= len; |
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16 | while( lenmax-- ) *seq++ = ' '; |
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17 | *seq = 0; |
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18 | } |
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19 | |
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20 | void setmark_clustal( int nlen, int nseq, char **seq, char *mark ) |
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21 | { |
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22 | int i, j, k, nalpha; |
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23 | char firstletter; |
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24 | char *strong[9]; |
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25 | char *weaker[11]; |
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26 | int nstrong, nweaker; |
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27 | char s; |
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28 | |
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29 | if( dorp == 'd' ) |
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30 | { |
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31 | strong[0] = "TU"; |
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32 | nstrong = 1; |
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33 | weaker[0] = "AG"; |
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34 | weaker[1] = "CT"; |
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35 | nweaker = 2; |
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36 | nalpha = 10; |
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37 | } |
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38 | else |
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39 | { |
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40 | strong[0] = "STA"; |
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41 | strong[1] = "NEQK"; |
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42 | strong[2] = "NHQK"; |
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43 | strong[3] = "NDEQ"; |
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44 | strong[4] = "QHRK"; |
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45 | strong[5] = "MILV"; |
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46 | strong[6] = "MILF"; |
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47 | strong[7] = "HY"; |
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48 | strong[8] = "FYW"; |
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49 | nstrong = 9; |
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50 | weaker[0] = "CSA"; |
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51 | weaker[1] = "ATV"; |
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52 | weaker[2] = "SAG"; |
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53 | weaker[3] = "STNK"; |
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54 | weaker[4] = "STPA"; |
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55 | weaker[5] = "SGND"; |
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56 | weaker[6] = "SNDEQK"; |
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57 | weaker[7] = "NDEQHK"; |
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58 | weaker[8] = "NEQHRK"; |
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59 | weaker[9] = "FVLIM"; |
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60 | weaker[10] = "HFY"; |
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61 | nweaker = 11; |
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62 | nalpha = 20; |
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63 | } |
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64 | |
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65 | for( i=0; i<nlen; i++ ) |
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66 | { |
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67 | mark[i] = ' '; |
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68 | for( j=0; j<nseq; j++ ) |
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69 | { |
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70 | s = seq[j][i]; |
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71 | if( '-' == s || ' ' == s ) break; |
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72 | } |
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73 | if( j != nseq ) |
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74 | { |
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75 | continue; |
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76 | } |
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77 | firstletter = toupper( seq[0][i] ); |
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78 | if( amino_n[(int)firstletter] >= nalpha || amino_n[(int)firstletter] < 0 ) continue; |
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79 | |
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80 | for( j=0; j<nseq; j++ ) |
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81 | if( toupper( seq[j][i] ) != firstletter ) break; |
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82 | if( j == nseq ) |
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83 | { |
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84 | mark[i] = '*'; |
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85 | continue; |
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86 | } |
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87 | for( k=0; k<nstrong; k++ ) |
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88 | { |
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89 | for( j=0; j<nseq; j++ ) |
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90 | { |
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91 | if( !strchr( strong[k], toupper( seq[j][i] ) ) ) break; |
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92 | } |
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93 | if( j == nseq ) break; |
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94 | } |
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95 | if( k < nstrong ) |
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96 | { |
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97 | mark[i] = ':'; |
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98 | continue; |
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99 | } |
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100 | for( k=0; k<nweaker; k++ ) |
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101 | { |
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102 | for( j=0; j<nseq; j++ ) |
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103 | { |
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104 | if( !strchr( weaker[k], toupper( seq[j][i] ) ) ) break; |
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105 | } |
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106 | if( j == nseq ) break; |
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107 | } |
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108 | if( k < nweaker ) |
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109 | { |
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110 | mark[i] = '.'; |
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111 | continue; |
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112 | } |
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113 | } |
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114 | mark[nlen] = 0; |
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115 | } |
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116 | |
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117 | void setmark( int nlen, int nseq, char **seq, char *mark ) |
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118 | { |
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119 | int i, j; |
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120 | |
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121 | for( i=0; i<nlen; i++ ) |
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122 | { |
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123 | mark[i] = ' '; |
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124 | for( j=0; j<nseq; j++ ) |
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125 | if( '-' == seq[j][i] ) break; |
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126 | if( j != nseq ) |
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127 | { |
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128 | continue; |
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129 | } |
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130 | for( j=0; j<nseq; j++ ) |
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131 | if( seq[0][i] != seq[j][i] ) break; |
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132 | if( j == nseq ) |
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133 | { |
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134 | mark[i] = '*'; |
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135 | continue; |
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136 | } |
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137 | for( j=0; j<nseq; j++ ) |
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138 | if( amino_grp[(int)seq[0][i]] != amino_grp[(int)seq[j][i]] ) break; |
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139 | if( j == nseq ) |
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140 | { |
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141 | mark[i] = '.'; |
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142 | continue; |
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143 | } |
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144 | } |
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145 | mark[nlen] = 0; |
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146 | } |
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147 | |
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148 | void arguments( int argc, char *argv[] ) |
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149 | { |
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150 | int c; |
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151 | namelen = -1; |
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152 | scoremtx = 1; |
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153 | nblosum = 62; |
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154 | dorp = NOTSPECIFIED; |
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155 | kimuraR = NOTSPECIFIED; |
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156 | pamN = NOTSPECIFIED; |
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157 | inputfile = NULL; |
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158 | comment = NULL; |
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159 | orderfile = NULL; |
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160 | format = 'c'; |
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161 | |
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162 | while( --argc > 0 && (*++argv)[0] == '-' ) |
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163 | { |
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164 | while ( (c = *++argv[0]) ) |
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165 | { |
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166 | switch( c ) |
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167 | { |
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168 | case 'i': |
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169 | inputfile = *++argv; |
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170 | fprintf( stderr, "inputfile = %s\n", inputfile ); |
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171 | --argc; |
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172 | goto nextoption; |
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173 | case 'c': |
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174 | comment = *++argv; |
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175 | fprintf( stderr, "comment = %s\n", comment ); |
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176 | --argc; |
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177 | goto nextoption; |
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178 | case 'r': |
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179 | orderfile = *++argv; |
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180 | fprintf( stderr, "orderfile = %s\n", orderfile ); |
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181 | --argc; |
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182 | goto nextoption; |
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183 | case 'n': |
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184 | namelen = atoi( *++argv ); |
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185 | fprintf( stderr, "namelen = %d\n", namelen ); |
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186 | --argc; |
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187 | goto nextoption; |
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188 | case 'f': |
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189 | format = 'f'; |
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190 | break; |
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191 | case 'y': |
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192 | format = 'y'; |
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193 | break; |
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194 | default: |
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195 | fprintf( stderr, "illegal option %c\n", c ); |
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196 | argc = 0; |
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197 | break; |
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198 | } |
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199 | } |
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200 | nextoption: |
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201 | ; |
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202 | } |
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203 | if( argc != 0 ) |
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204 | { |
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205 | fprintf( stderr, "options: Check source file !\n" ); |
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206 | exit( 1 ); |
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207 | } |
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208 | } |
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209 | |
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210 | |
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211 | int main( int argc, char *argv[] ) |
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212 | { |
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213 | static int *nlen; |
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214 | static char **name, **seq, *mark; |
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215 | static int *order; |
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216 | int i; |
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217 | FILE *infp; |
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218 | FILE *orderfp; |
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219 | char gett[B]; |
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220 | int nlenmin; |
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221 | |
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222 | arguments( argc, argv ); |
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223 | |
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224 | |
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225 | if( inputfile ) |
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226 | { |
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227 | infp = fopen( inputfile, "r" ); |
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228 | if( !infp ) |
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229 | { |
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230 | fprintf( stderr, "Cannot open %s\n", inputfile ); |
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231 | exit( 1 ); |
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232 | } |
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233 | } |
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234 | else |
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235 | infp = stdin; |
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236 | |
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237 | getnumlen_casepreserve( infp, &nlenmin ); |
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238 | rewind( infp ); |
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239 | |
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240 | seq = AllocateCharMtx( njob, nlenmax*2+1 ); |
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241 | mark = AllocateCharVec( nlenmax*2+1 ); |
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242 | order = AllocateIntVec( njob ); |
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243 | name = AllocateCharMtx( njob, B+1 ); |
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244 | nlen = AllocateIntVec( njob ); |
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245 | |
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246 | |
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247 | if( orderfile ) |
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248 | { |
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249 | orderfp = fopen( orderfile, "r" ); |
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250 | if( !orderfp ) |
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251 | { |
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252 | fprintf( stderr, "Cannot open %s\n", orderfile ); |
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253 | exit( 1 ); |
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254 | } |
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255 | for( i=0; i<njob; i++ ) |
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256 | { |
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257 | fgets( gett, B-1, orderfp ); |
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258 | order[i] = atoi( gett ); |
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259 | } |
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260 | fclose( orderfp ); |
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261 | } |
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262 | else |
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263 | { |
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264 | for( i=0; i<njob; i++ ) order[i] = i; |
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265 | } |
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266 | |
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267 | readData_pointer_casepreserve( infp, name, nlen, seq ); |
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268 | fclose( infp ); |
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269 | |
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270 | if( format == 'c' || format == 'y' ) for( i=0; i<njob; i++ ) fillspace( seq[i], nlenmax ); |
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271 | constants( njob, seq ); |
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272 | |
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273 | // initSignalSM(); |
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274 | |
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275 | // initFiles(); |
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276 | |
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277 | |
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278 | |
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279 | // setmark( nlenmax, njob, seq, mark ); |
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280 | setmark_clustal( nlenmax, njob, seq, mark ); |
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281 | |
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282 | if( format == 'f' ) |
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283 | writeData_reorder_pointer( stdout, njob, name, nlen, seq, order ); |
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284 | else if( format == 'c' ) |
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285 | clustalout_pointer( stdout, njob, nlenmax, seq, name, mark, comment, order, namelen ); |
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286 | else if( format == 'y' ) |
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287 | phylipout_pointer( stdout, njob, nlenmax, seq, name, order, namelen ); |
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288 | else |
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289 | fprintf( stderr, "Unknown format\n" ); |
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290 | |
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291 | // SHOWVERSION; |
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292 | return( 0 ); |
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293 | } |
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