1 | /* |
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2 | * |
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3 | * Beta.hpp |
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4 | * |
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5 | */ |
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6 | #ifndef BETA_HPP |
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7 | #define BETA_HPP |
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8 | using namespace std; |
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9 | |
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10 | struct Beta { |
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11 | static const int NBASE = 4;// A, C, G, U |
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12 | static const int NBASEG = (NBASE + 1); // A, C, G, U, Gap |
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13 | static const int NBASENG = (NBASE + 2); // A, C, G, U, N, Gap |
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14 | static const int NPBASE = (NBASE * NBASE); |
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15 | static const int NPBASEG = (NBASEG * NBASEG); |
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16 | static const int NPBASENG = (NBASENG * NBASENG); |
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17 | static const int NCODE = 7; |
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18 | static const int BASEBIT = 2; |
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19 | // static const int BASEMSK = ~(~0 << BASEBIT); |
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20 | static const int BASEMSK = ~(INT_MAX >> BASEBIT << BASEBIT); |
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21 | enum BaseCode { |
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22 | A_CODE = 0, |
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23 | C_CODE = 1, |
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24 | G_CODE = 2, |
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25 | U_CODE = 3, |
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26 | N_CODE = 4, |
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27 | GAP_CODE = 5, |
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28 | INVALID_CODE = 16 |
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29 | }; |
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30 | enum PairCode { |
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31 | AA_CODE = 0, AC_CODE = 1, AG_CODE = 2, AU_CODE = 3, |
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32 | CA_CODE = 4, CC_CODE = 5, CG_CODE = 6, CU_CODE = 7, |
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33 | GA_CODE = 8, GC_CODE = 9, GG_CODE = 10, GU_CODE = 11, |
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34 | UA_CODE = 12, UC_CODE = 13, UG_CODE = 14, UU_CODE = 15, |
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35 | INVALID_PAIR_CODE = 16 |
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36 | }; |
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37 | enum ReducedPairCode { |
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38 | REDUCED_NPBASE = 7, |
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39 | REDUCED_AU_CODE = 0, |
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40 | REDUCED_CG_CODE = 1, |
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41 | REDUCED_GC_CODE = 2, |
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42 | REDUCED_GU_CODE = 3, |
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43 | REDUCED_UA_CODE = 4, |
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44 | REDUCED_UG_CODE = 5, |
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45 | REDUCED_MM_CODE = 6, |
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46 | REDUCED_INVALID_PAIR_CODE = 16 |
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47 | }; |
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48 | |
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49 | static const int N_CANONICAL = 6; |
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50 | static const int canonicalPairs[N_CANONICAL]; |
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51 | static const int N_NON_CANONICAL = 10; |
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52 | static const int nonCanonicalPairs[N_NON_CANONICAL]; |
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53 | static const int i2nt[NCODE]; |
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54 | static const int nt2i[256]; |
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55 | static const bool isCanonicalBasePair[NPBASE]; |
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56 | |
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57 | static bool IsValidCode(const int& c) {return A_CODE <= c && c <= GAP_CODE;} |
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58 | static bool IsBaseCode(const int& c) {return (A_CODE <= c && c <= U_CODE);} |
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59 | static bool IsBasePairCode(const int& c){return (AA_CODE <= c && c <= UU_CODE);} |
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60 | static bool IsReducedBasePairCode(const int& c) { |
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61 | return (REDUCED_AU_CODE <= c && c <= REDUCED_MM_CODE); |
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62 | } |
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63 | static bool IsAmbiguousCode(const int& c) {return c == N_CODE;} |
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64 | static bool IsGapCode(const int& c) {return c == GAP_CODE;} |
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65 | static bool IsValidChar(const unsigned char& c) { |
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66 | return IsValidCode(nt2i[c]); |
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67 | } |
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68 | static bool IsBaseChar(const int& c) {return IsBaseCode(nt2i[c]);} |
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69 | static bool IsAmbiguousChar(const int& c) {return IsAmbiguousCode(nt2i[c]);} |
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70 | static bool IsGapChar(const int& c) {return IsGapCode(nt2i[c]);} |
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71 | static int nt2code(const int& nt) { |
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72 | if (0 <= nt && nt < 256) { |
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73 | return nt2i[nt]; |
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74 | } else { |
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75 | return INVALID_CODE; |
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76 | } |
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77 | } |
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78 | static int getPairCode(const int& c, const int& c1) { |
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79 | return (IsBaseCode(c) && IsBaseCode(c1) |
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80 | ? ((c << BASEBIT) | c1) |
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81 | : INVALID_PAIR_CODE); |
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82 | } |
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83 | static bool isValidPairCode(const int& pairCode) { |
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84 | return (0 <= pairCode && pairCode < NPBASE); |
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85 | } |
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86 | static void pair2Bases(const int& pairCode, int& c, int& c1) { |
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87 | //Assert(IsBasePairCode(pairCode)); |
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88 | c1 = pairCode & BASEMSK; |
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89 | c = (pairCode >> BASEBIT) & BASEMSK; |
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90 | } |
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91 | static int getReducedPairCode(const int& c, const int& c1) { |
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92 | return reducePairCode(getPairCode(c, c1)); |
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93 | } |
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94 | static int reducePairCode(const int& pairCode) { |
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95 | static const int table[NPBASE] = { |
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96 | REDUCED_MM_CODE, REDUCED_MM_CODE, REDUCED_MM_CODE, REDUCED_AU_CODE, |
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97 | REDUCED_MM_CODE, REDUCED_MM_CODE, REDUCED_CG_CODE, REDUCED_MM_CODE, |
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98 | REDUCED_MM_CODE, REDUCED_GC_CODE, REDUCED_MM_CODE, REDUCED_GU_CODE, |
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99 | REDUCED_UA_CODE, REDUCED_MM_CODE, REDUCED_UG_CODE, REDUCED_MM_CODE, |
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100 | }; |
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101 | return (IsBasePairCode(pairCode) |
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102 | ? table[pairCode] |
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103 | : REDUCED_INVALID_PAIR_CODE); |
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104 | } |
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105 | static bool isValidReducedPairCode(const int& pairCode) { |
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106 | return (0 <= pairCode && pairCode < REDUCED_NPBASE); |
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107 | } |
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108 | static bool isCanonicalReducedPairCode(const int& pairCode) { |
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109 | return (REDUCED_AU_CODE <= pairCode |
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110 | && pairCode <= REDUCED_UG_CODE); |
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111 | } |
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112 | static int flipReducedPairCode(const int& reducedPairCode) { |
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113 | static const int table[REDUCED_NPBASE + 1] = { |
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114 | REDUCED_UA_CODE, |
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115 | REDUCED_GC_CODE, |
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116 | REDUCED_CG_CODE, |
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117 | REDUCED_UG_CODE, |
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118 | REDUCED_AU_CODE, |
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119 | REDUCED_GU_CODE, |
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120 | REDUCED_MM_CODE, |
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121 | REDUCED_INVALID_PAIR_CODE |
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122 | }; |
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123 | return (IsReducedBasePairCode(reducedPairCode) |
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124 | ? table[reducedPairCode] : table[REDUCED_NPBASE]); |
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125 | } |
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126 | static void seq2i(char* s, const char* t, int len) { |
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127 | const char* const s_end = s + len; |
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128 | while (s < s_end) *s++ = nt2i[(unsigned) (*t++)]; |
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129 | } |
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130 | static void i2seq(char* s, const char* t, int len) { |
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131 | const char* const s_end = s + len; |
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132 | while (s < s_end) *s++ = i2nt[(unsigned) (*t++)]; |
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133 | } |
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134 | static void i2seq(ostream& fo, const char* t, int len) { |
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135 | const char* const t_end = t + len; |
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136 | while (t < t_end) fo << (char) i2nt[(unsigned) (*t++)]; |
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137 | } |
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138 | static char* wd2str(unsigned int wdSize, unsigned int wd) { |
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139 | const unsigned int MAX_WD_SIZE = (sizeof(unsigned int) * 8 / BASEBIT); |
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140 | static char buf[MAX_WD_SIZE + 1] = {}; |
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141 | //Assert(wdSize <= MAX_WD_SIZE); |
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142 | |
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143 | char* s = buf + wdSize; |
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144 | *s = '\0'; |
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145 | do { |
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146 | *(--s) = Beta::i2nt[wd & BASEMSK]; |
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147 | wd >>= BASEBIT; |
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148 | } while (s > buf); |
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149 | return buf; |
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150 | } |
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151 | static void printWd(ostream& fo, unsigned int wdSize, unsigned int wd) { |
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152 | fo << wd2str(wdSize, wd); |
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153 | } |
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154 | static const char* code2str(const int& code) { |
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155 | static const char table[NBASENG+1][2] = { |
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156 | "A", "C", "G", "U", "N", ".", "?" |
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157 | }; |
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158 | return ((A_CODE <= code && code <= GAP_CODE) |
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159 | ? table[code] : table[NBASENG]); |
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160 | } |
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161 | static const char* pairCode2str(const int& pairCode) { |
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162 | static const char table[NPBASE+1][3] = { |
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163 | "AA", "AC", "AG", "AU", |
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164 | "CA", "CC", "CG", "CU", |
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165 | "GA", "GC", "GG", "GU", |
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166 | "UA", "UC", "UG", "UU", |
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167 | "??" |
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168 | }; |
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169 | return (IsBasePairCode(pairCode) ? table[pairCode] : table[NPBASE]); |
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170 | } |
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171 | static const char* reducedPairCode2str(const int& reducedPairCode) { |
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172 | static const char table[REDUCED_NPBASE+1][3] = { |
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173 | "AU", "CG", "GC", "GU", "UA", "UG", "MM", "??" |
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174 | }; |
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175 | return (IsReducedBasePairCode(reducedPairCode) |
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176 | ? table[reducedPairCode] : table[REDUCED_NPBASE]); |
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177 | } |
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178 | static char nt2Code(const char& c){ |
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179 | if (!IsValidChar(c)) { cerr << "character " << c << " is not valid"; } |
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180 | |
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181 | return (char) nt2i[(int) c]; |
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182 | } |
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183 | static char code2char(const int& c) { |
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184 | static const char table[NBASENG+1] = { |
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185 | 'A', 'C', 'G', 'U', 'N', '.', '?' |
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186 | }; |
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187 | return ((A_CODE <= c && c <= GAP_CODE) |
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188 | ? table[(int) c] : table[NBASENG]); |
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189 | } |
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190 | /* |
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191 | static string generateRandomRNA(const int& len) { |
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192 | static const char nt[5] = "ACGU"; |
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193 | string rna(len, '\0'); |
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194 | for (int i = 0; i < len; i++) { |
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195 | rna[i] = nt[Rand(4)]; |
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196 | } |
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197 | return rna; |
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198 | } |
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199 | */ |
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200 | }; |
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201 | |
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202 | #endif |
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