| 1 | #include "muscle.h" |
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| 2 | #include <math.h> |
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| 3 | #include "pwpath.h" |
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| 4 | #include "profile.h" |
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| 5 | #include <stdio.h> |
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| 6 | |
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| 7 | // NW small memory |
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| 8 | |
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| 9 | #define TRACE 0 |
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| 10 | |
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| 11 | #if TRACE |
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| 12 | extern bool g_bKeepSimpleDP; |
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| 13 | extern SCORE *g_DPM; |
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| 14 | extern SCORE *g_DPD; |
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| 15 | extern SCORE *g_DPI; |
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| 16 | extern char *g_TBM; |
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| 17 | extern char *g_TBD; |
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| 18 | extern char *g_TBI; |
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| 19 | #endif |
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| 20 | |
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| 21 | #if TRACE |
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| 22 | #define ALLOC_TRACE() \ |
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| 23 | const SCORE UNINIT = MINUS_INFINITY; \ |
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| 24 | const size_t LM = uPrefixCountA*uPrefixCountB; \ |
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| 25 | \ |
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| 26 | SCORE *DPM_ = new SCORE[LM]; \ |
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| 27 | SCORE *DPD_ = new SCORE[LM]; \ |
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| 28 | SCORE *DPI_ = new SCORE[LM]; \ |
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| 29 | \ |
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| 30 | char *TBM_ = new char[LM]; \ |
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| 31 | char *TBD_ = new char[LM]; \ |
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| 32 | char *TBI_ = new char[LM]; \ |
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| 33 | \ |
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| 34 | memset(TBM_, '?', LM); \ |
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| 35 | memset(TBD_, '?', LM); \ |
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| 36 | memset(TBI_, '?', LM); \ |
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| 37 | \ |
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| 38 | for (unsigned i = 0; i <= uLengthA; ++i) \ |
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| 39 | for (unsigned j = 0; j <= uLengthB; ++j) \ |
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| 40 | { \ |
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| 41 | DPM(i, j) = UNINIT; \ |
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| 42 | DPD(i, j) = UNINIT; \ |
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| 43 | DPI(i, j) = UNINIT; \ |
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| 44 | } |
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| 45 | #else |
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| 46 | #define ALLOC_TRACE() |
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| 47 | #endif |
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| 48 | |
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| 49 | #if TRACE |
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| 50 | #define SetDPM(i, j, x) DPM(i, j) = x |
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| 51 | #define SetDPD(i, j, x) DPD(i, j) = x |
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| 52 | #define SetDPI(i, j, x) DPI(i, j) = x |
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| 53 | #define SetTBM(i, j, x) TBM(i, j) = x |
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| 54 | #define SetTBD(i, j, x) TBD(i, j) = x |
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| 55 | #define SetTBI(i, j, x) TBI(i, j) = x |
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| 56 | #else |
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| 57 | #define SetDPM(i, j, x) /* empty */ |
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| 58 | #define SetDPD(i, j, x) /* empty */ |
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| 59 | #define SetDPI(i, j, x) /* empty */ |
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| 60 | #define SetTBM(i, j, x) /* empty */ |
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| 61 | #define SetTBD(i, j, x) /* empty */ |
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| 62 | #define SetTBI(i, j, x) /* empty */ |
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| 63 | #endif |
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| 64 | |
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| 65 | #define RECURSE_D(i, j) \ |
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| 66 | { \ |
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| 67 | SCORE DD = DRow[j] + e; \ |
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| 68 | SCORE MD = MPrev[j] + PA[i-1].m_scoreGapOpen;\ |
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| 69 | if (DD > MD) \ |
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| 70 | { \ |
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| 71 | DRow[j] = DD; \ |
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| 72 | SetTBD(i, j, 'D'); \ |
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| 73 | } \ |
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| 74 | else \ |
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| 75 | { \ |
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| 76 | DRow[j] = MD; \ |
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| 77 | /* SetBitTBD(TB, i, j, 'M'); */ \ |
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| 78 | TBRow[j] &= ~BIT_xD; \ |
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| 79 | TBRow[j] |= BIT_MD; \ |
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| 80 | SetTBD(i, j, 'M'); \ |
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| 81 | } \ |
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| 82 | SetDPD(i, j, DRow[j]); \ |
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| 83 | } |
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| 84 | |
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| 85 | #define RECURSE_D_ATerm(j) RECURSE_D(uLengthA, j) |
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| 86 | #define RECURSE_D_BTerm(j) RECURSE_D(i, uLengthB) |
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| 87 | |
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| 88 | #define RECURSE_I(i, j) \ |
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| 89 | { \ |
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| 90 | Iij += e; \ |
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| 91 | SCORE MI = MCurr[j-1] + PB[j-1].m_scoreGapOpen;\ |
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| 92 | if (MI >= Iij) \ |
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| 93 | { \ |
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| 94 | Iij = MI; \ |
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| 95 | /* SetBitTBI(TB, i, j, 'M'); */ \ |
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| 96 | TBRow[j] &= ~BIT_xI; \ |
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| 97 | TBRow[j] |= BIT_MI; \ |
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| 98 | SetTBI(i, j, 'M'); \ |
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| 99 | } \ |
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| 100 | else \ |
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| 101 | SetTBI(i, j, 'I'); \ |
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| 102 | SetDPI(i, j, Iij); \ |
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| 103 | } |
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| 104 | |
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| 105 | #define RECURSE_I_ATerm(j) RECURSE_I(uLengthA, j) |
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| 106 | #define RECURSE_I_BTerm(j) RECURSE_I(i, uLengthB) |
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| 107 | |
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| 108 | #define RECURSE_M(i, j) \ |
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| 109 | { \ |
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| 110 | SCORE DM = DRow[j] + PA[i-1].m_scoreGapClose; \ |
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| 111 | SCORE IM = Iij + PB[j-1].m_scoreGapClose; \ |
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| 112 | SCORE MM = MCurr[j]; \ |
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| 113 | TB[i+1][j+1] &= ~BIT_xM; \ |
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| 114 | if (MM >= DM && MM >= IM) \ |
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| 115 | { \ |
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| 116 | MNext[j+1] += MM; \ |
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| 117 | SetDPM(i+1, j+1, MNext[j+1]); \ |
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| 118 | SetTBM(i+1, j+1, 'M'); \ |
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| 119 | /* SetBitTBM(TB, i+1, j+1, 'M'); */ \ |
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| 120 | TB[i+1][j+1] |= BIT_MM; \ |
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| 121 | } \ |
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| 122 | else if (DM >= MM && DM >= IM) \ |
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| 123 | { \ |
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| 124 | MNext[j+1] += DM; \ |
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| 125 | SetDPM(i+1, j+1, MNext[j+1]); \ |
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| 126 | SetTBM(i+1, j+1, 'D'); \ |
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| 127 | /* SetBitTBM(TB, i+1, j+1, 'D'); */ \ |
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| 128 | TB[i+1][j+1] |= BIT_DM; \ |
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| 129 | } \ |
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| 130 | else \ |
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| 131 | { \ |
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| 132 | assert(IM >= MM && IM >= DM); \ |
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| 133 | MNext[j+1] += IM; \ |
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| 134 | SetDPM(i+1, j+1, MNext[j+1]); \ |
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| 135 | SetTBM(i+1, j+1, 'I'); \ |
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| 136 | /* SetBitTBM(TB, i+1, j+1, 'I'); */ \ |
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| 137 | TB[i+1][j+1] |= BIT_IM; \ |
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| 138 | } \ |
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| 139 | } |
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| 140 | |
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| 141 | #if TRACE |
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| 142 | static bool LocalEq(BASETYPE b1, BASETYPE b2) |
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| 143 | { |
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| 144 | if (b1 < -100000 && b2 < -100000) |
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| 145 | return true; |
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| 146 | double diff = fabs(b1 - b2); |
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| 147 | if (diff < 0.0001) |
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| 148 | return true; |
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| 149 | double sum = fabs(b1) + fabs(b2); |
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| 150 | return diff/sum < 0.005; |
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| 151 | } |
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| 152 | |
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| 153 | static char Get_M_Char(char Bits) |
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| 154 | { |
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| 155 | switch (Bits & BIT_xM) |
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| 156 | { |
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| 157 | case BIT_MM: |
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| 158 | return 'M'; |
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| 159 | case BIT_DM: |
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| 160 | return 'D'; |
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| 161 | case BIT_IM: |
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| 162 | return 'I'; |
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| 163 | } |
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| 164 | Quit("Huh?"); |
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| 165 | return '?'; |
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| 166 | } |
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| 167 | |
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| 168 | static char Get_D_Char(char Bits) |
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| 169 | { |
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| 170 | return (Bits & BIT_xD) ? 'M' : 'D'; |
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| 171 | } |
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| 172 | |
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| 173 | static char Get_I_Char(char Bits) |
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| 174 | { |
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| 175 | return (Bits & BIT_xI) ? 'M' : 'I'; |
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| 176 | } |
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| 177 | |
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| 178 | static bool DPEq(char c, SCORE *g_DP, SCORE *DPD_, |
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| 179 | unsigned uPrefixCountA, unsigned uPrefixCountB) |
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| 180 | { |
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| 181 | SCORE *DPM_ = g_DP; |
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| 182 | for (unsigned i = 0; i < uPrefixCountA; ++i) |
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| 183 | for (unsigned j = 0; j < uPrefixCountB; ++j) |
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| 184 | if (!LocalEq(DPM(i, j), DPD(i, j))) |
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| 185 | { |
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| 186 | Log("***DPDIFF*** DP%c(%d, %d) Simple = %.2g, Fast = %.2g\n", |
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| 187 | c, i, j, DPM(i, j), DPD(i, j)); |
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| 188 | return false; |
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| 189 | } |
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| 190 | return true; |
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| 191 | } |
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| 192 | |
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| 193 | static bool CompareTB(char **TB, char *TBM_, char *TBD_, char *TBI_, |
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| 194 | unsigned uPrefixCountA, unsigned uPrefixCountB) |
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| 195 | { |
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| 196 | SCORE *DPM_ = g_DPM; |
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| 197 | bool Eq = true; |
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| 198 | for (unsigned i = 0; i < uPrefixCountA; ++i) |
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| 199 | for (unsigned j = 0; j < uPrefixCountB; ++j) |
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| 200 | { |
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| 201 | char c1 = TBM(i, j); |
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| 202 | char c2 = Get_M_Char(TB[i][j]); |
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| 203 | if (c1 != '?' && c1 != c2 && DPM(i, j) > -100000) |
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| 204 | { |
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| 205 | Log("TBM(%d, %d) Simple = %c, NW = %c\n", i, j, c1, c2); |
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| 206 | Eq = false; |
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| 207 | goto D; |
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| 208 | } |
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| 209 | } |
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| 210 | |
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| 211 | D: |
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| 212 | SCORE *DPD_ = g_DPD; |
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| 213 | for (unsigned i = 0; i < uPrefixCountA; ++i) |
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| 214 | for (unsigned j = 0; j < uPrefixCountB; ++j) |
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| 215 | { |
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| 216 | char c1 = TBD(i, j); |
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| 217 | char c2 = Get_D_Char(TB[i][j]); |
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| 218 | if (c1 != '?' && c1 != c2 && DPD(i, j) > -100000) |
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| 219 | { |
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| 220 | Log("TBD(%d, %d) Simple = %c, NW = %c\n", i, j, c1, c2); |
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| 221 | Eq = false; |
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| 222 | goto I; |
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| 223 | } |
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| 224 | } |
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| 225 | I: |
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| 226 | SCORE *DPI_ = g_DPI; |
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| 227 | for (unsigned i = 0; i < uPrefixCountA; ++i) |
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| 228 | for (unsigned j = 0; j < uPrefixCountB; ++j) |
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| 229 | { |
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| 230 | char c1 = TBI(i, j); |
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| 231 | char c2 = Get_I_Char(TB[i][j]); |
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| 232 | if (c1 != '?' && c1 != c2 && DPI(i, j) > -100000) |
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| 233 | { |
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| 234 | Log("TBI(%d, %d) Simple = %c, NW = %c\n", i, j, c1, c2); |
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| 235 | Eq = false; |
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| 236 | goto Done; |
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| 237 | } |
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| 238 | } |
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| 239 | Done: |
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| 240 | if (Eq) |
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| 241 | Log("TB success\n"); |
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| 242 | return Eq; |
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| 243 | } |
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| 244 | |
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| 245 | static const char *LocalScoreToStr(SCORE s) |
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| 246 | { |
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| 247 | static char str[16]; |
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| 248 | if (s < -100000) |
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| 249 | return " *"; |
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| 250 | sprintf(str, "%6.1f", s); |
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| 251 | return str; |
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| 252 | } |
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| 253 | |
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| 254 | static void LogDP(const SCORE *DPM_, const ProfPos *PA, const ProfPos *PB, |
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| 255 | unsigned uPrefixCountA, unsigned uPrefixCountB) |
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| 256 | { |
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| 257 | Log(" "); |
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| 258 | for (unsigned uPrefixLengthB = 0; uPrefixLengthB < uPrefixCountB; ++uPrefixLengthB) |
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| 259 | { |
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| 260 | char c = ' '; |
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| 261 | if (uPrefixLengthB > 0) |
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| 262 | c = ConsensusChar(PB[uPrefixLengthB - 1]); |
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| 263 | Log(" %4u:%c", uPrefixLengthB, c); |
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| 264 | } |
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| 265 | Log("\n"); |
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| 266 | for (unsigned uPrefixLengthA = 0; uPrefixLengthA < uPrefixCountA; ++uPrefixLengthA) |
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| 267 | { |
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| 268 | char c = ' '; |
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| 269 | if (uPrefixLengthA > 0) |
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| 270 | c = ConsensusChar(PA[uPrefixLengthA - 1]); |
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| 271 | Log("%4u:%c ", uPrefixLengthA, c); |
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| 272 | for (unsigned uPrefixLengthB = 0; uPrefixLengthB < uPrefixCountB; ++uPrefixLengthB) |
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| 273 | Log(" %s", LocalScoreToStr(DPM(uPrefixLengthA, uPrefixLengthB))); |
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| 274 | Log("\n"); |
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| 275 | } |
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| 276 | } |
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| 277 | |
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| 278 | static void LogBitTB(char **TB, const ProfPos *PA, const ProfPos *PB, |
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| 279 | unsigned uPrefixCountA, unsigned uPrefixCountB) |
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| 280 | { |
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| 281 | Log(" "); |
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| 282 | for (unsigned uPrefixLengthB = 0; uPrefixLengthB < uPrefixCountB; ++uPrefixLengthB) |
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| 283 | { |
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| 284 | char c = ' '; |
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| 285 | if (uPrefixLengthB > 0) |
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| 286 | c = ConsensusChar(PB[uPrefixLengthB - 1]); |
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| 287 | Log(" %4u:%c", uPrefixLengthB, c); |
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| 288 | } |
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| 289 | Log("\n"); |
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| 290 | Log("Bit TBM:\n"); |
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| 291 | for (unsigned uPrefixLengthA = 0; uPrefixLengthA < uPrefixCountA; ++uPrefixLengthA) |
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| 292 | { |
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| 293 | char c = ' '; |
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| 294 | if (uPrefixLengthA > 0) |
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| 295 | c = ConsensusChar(PA[uPrefixLengthA - 1]); |
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| 296 | Log("%4u:%c ", uPrefixLengthA, c); |
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| 297 | for (unsigned uPrefixLengthB = 0; uPrefixLengthB < uPrefixCountB; ++uPrefixLengthB) |
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| 298 | { |
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| 299 | char c = Get_M_Char(TB[uPrefixLengthA][uPrefixLengthB]); |
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| 300 | Log(" %6c", c); |
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| 301 | } |
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| 302 | Log("\n"); |
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| 303 | } |
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| 304 | |
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| 305 | Log("\n"); |
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| 306 | Log("Bit TBD:\n"); |
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| 307 | for (unsigned uPrefixLengthA = 0; uPrefixLengthA < uPrefixCountA; ++uPrefixLengthA) |
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| 308 | { |
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| 309 | char c = ' '; |
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| 310 | if (uPrefixLengthA > 0) |
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| 311 | c = ConsensusChar(PA[uPrefixLengthA - 1]); |
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| 312 | Log("%4u:%c ", uPrefixLengthA, c); |
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| 313 | for (unsigned uPrefixLengthB = 0; uPrefixLengthB < uPrefixCountB; ++uPrefixLengthB) |
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| 314 | { |
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| 315 | char c = Get_D_Char(TB[uPrefixLengthA][uPrefixLengthB]); |
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| 316 | Log(" %6c", c); |
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| 317 | } |
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| 318 | Log("\n"); |
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| 319 | } |
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| 320 | |
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| 321 | Log("\n"); |
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| 322 | Log("Bit TBI:\n"); |
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| 323 | for (unsigned uPrefixLengthA = 0; uPrefixLengthA < uPrefixCountA; ++uPrefixLengthA) |
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| 324 | { |
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| 325 | char c = ' '; |
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| 326 | if (uPrefixLengthA > 0) |
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| 327 | c = ConsensusChar(PA[uPrefixLengthA - 1]); |
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| 328 | Log("%4u:%c ", uPrefixLengthA, c); |
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| 329 | for (unsigned uPrefixLengthB = 0; uPrefixLengthB < uPrefixCountB; ++uPrefixLengthB) |
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| 330 | { |
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| 331 | char c = Get_I_Char(TB[uPrefixLengthA][uPrefixLengthB]); |
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| 332 | Log(" %6c", c); |
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| 333 | } |
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| 334 | Log("\n"); |
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| 335 | } |
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| 336 | } |
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| 337 | |
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| 338 | static void ListTB(char *TBM_, const ProfPos *PA, const ProfPos *PB, |
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| 339 | unsigned uPrefixCountA, unsigned uPrefixCountB) |
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| 340 | { |
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| 341 | Log(" "); |
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| 342 | for (unsigned uPrefixLengthB = 0; uPrefixLengthB < uPrefixCountB; ++uPrefixLengthB) |
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| 343 | { |
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| 344 | char c = ' '; |
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| 345 | if (uPrefixLengthB > 0) |
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| 346 | c = ConsensusChar(PB[uPrefixLengthB - 1]); |
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| 347 | Log(" %4u:%c", uPrefixLengthB, c); |
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| 348 | } |
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| 349 | Log("\n"); |
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| 350 | for (unsigned uPrefixLengthA = 0; uPrefixLengthA < uPrefixCountA; ++uPrefixLengthA) |
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| 351 | { |
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| 352 | char c = ' '; |
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| 353 | if (uPrefixLengthA > 0) |
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| 354 | c = ConsensusChar(PA[uPrefixLengthA - 1]); |
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| 355 | Log("%4u:%c ", uPrefixLengthA, c); |
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| 356 | for (unsigned uPrefixLengthB = 0; uPrefixLengthB < uPrefixCountB; ++uPrefixLengthB) |
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| 357 | { |
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| 358 | char c = TBM(uPrefixLengthA, uPrefixLengthB); |
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| 359 | Log(" %6c", c); |
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| 360 | } |
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| 361 | Log("\n"); |
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| 362 | } |
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| 363 | } |
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| 364 | |
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| 365 | static const char *BitsToStr(char Bits) |
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| 366 | { |
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| 367 | static char Str[9]; |
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| 368 | |
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| 369 | sprintf(Str, "%cM %cD %cI", |
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| 370 | Get_M_Char(Bits), |
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| 371 | Get_D_Char(Bits), |
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| 372 | Get_I_Char(Bits)); |
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| 373 | } |
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| 374 | #endif // TRACE |
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| 375 | |
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| 376 | static inline void SetBitTBM(char **TB, unsigned i, unsigned j, char c) |
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| 377 | { |
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| 378 | char Bit; |
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| 379 | switch (c) |
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| 380 | { |
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| 381 | case 'M': |
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| 382 | Bit = BIT_MM; |
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| 383 | break; |
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| 384 | case 'D': |
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| 385 | Bit = BIT_DM; |
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| 386 | break; |
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| 387 | case 'I': |
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| 388 | Bit = BIT_IM; |
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| 389 | break; |
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| 390 | default: |
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| 391 | Quit("Huh?!"); |
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| 392 | } |
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| 393 | TB[i][j] &= ~BIT_xM; |
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| 394 | TB[i][j] |= Bit; |
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| 395 | } |
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| 396 | |
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| 397 | static inline void SetBitTBD(char **TB, unsigned i, unsigned j, char c) |
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| 398 | { |
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| 399 | char Bit; |
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| 400 | switch (c) |
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| 401 | { |
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| 402 | case 'M': |
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| 403 | Bit = BIT_MD; |
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| 404 | break; |
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| 405 | case 'D': |
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| 406 | Bit = BIT_DD; |
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| 407 | break; |
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| 408 | default: |
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| 409 | Quit("Huh?!"); |
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| 410 | } |
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| 411 | TB[i][j] &= ~BIT_xD; |
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| 412 | TB[i][j] |= Bit; |
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| 413 | } |
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| 414 | |
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| 415 | static inline void SetBitTBI(char **TB, unsigned i, unsigned j, char c) |
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| 416 | { |
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| 417 | char Bit; |
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| 418 | switch (c) |
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| 419 | { |
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| 420 | case 'M': |
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| 421 | Bit = BIT_MI; |
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| 422 | break; |
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| 423 | case 'I': |
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| 424 | Bit = BIT_II; |
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| 425 | break; |
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| 426 | default: |
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| 427 | Quit("Huh?!"); |
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| 428 | } |
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| 429 | TB[i][j] &= ~BIT_xI; |
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| 430 | TB[i][j] |= Bit; |
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| 431 | } |
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| 432 | |
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| 433 | #if TRACE |
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| 434 | #define LogMatrices() \ |
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| 435 | { \ |
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| 436 | Log("Bit DPM:\n"); \ |
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| 437 | LogDP(DPM_, PA, PB, uPrefixCountA, uPrefixCountB); \ |
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| 438 | Log("Bit DPD:\n"); \ |
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| 439 | LogDP(DPD_, PA, PB, uPrefixCountA, uPrefixCountB); \ |
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| 440 | Log("Bit DPI:\n"); \ |
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| 441 | LogDP(DPI_, PA, PB, uPrefixCountA, uPrefixCountB); \ |
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| 442 | Log("Bit TB:\n"); \ |
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| 443 | LogBitTB(TB, PA, PB, uPrefixCountA, uPrefixCountB); \ |
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| 444 | bool Same; \ |
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| 445 | Same = DPEq('M', g_DPM, DPM_, uPrefixCountA, uPrefixCountB);\ |
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| 446 | if (Same) \ |
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| 447 | Log("DPM success\n"); \ |
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| 448 | Same = DPEq('D', g_DPD, DPD_, uPrefixCountA, uPrefixCountB);\ |
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| 449 | if (Same) \ |
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| 450 | Log("DPD success\n"); \ |
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| 451 | Same = DPEq('I', g_DPI, DPI_, uPrefixCountA, uPrefixCountB);\ |
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| 452 | if (Same) \ |
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| 453 | Log("DPI success\n"); \ |
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| 454 | CompareTB(TB, g_TBM, g_TBD, g_TBI, uPrefixCountA, uPrefixCountB);\ |
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| 455 | } |
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| 456 | #else |
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| 457 | #define LogMatrices() /* empty */ |
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| 458 | #endif |
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| 459 | |
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| 460 | static unsigned uCachePrefixCountB; |
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| 461 | static unsigned uCachePrefixCountA; |
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| 462 | static SCORE *CacheMCurr; |
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| 463 | static SCORE *CacheMNext; |
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| 464 | static SCORE *CacheMPrev; |
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| 465 | static SCORE *CacheDRow; |
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| 466 | static char **CacheTB; |
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| 467 | |
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| 468 | static void AllocCache(unsigned uPrefixCountA, unsigned uPrefixCountB) |
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| 469 | { |
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| 470 | if (uPrefixCountA <= uCachePrefixCountA && uPrefixCountB <= uCachePrefixCountB) |
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| 471 | return; |
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| 472 | |
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| 473 | delete[] CacheMCurr; |
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| 474 | delete[] CacheMNext; |
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| 475 | delete[] CacheMPrev; |
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| 476 | delete[] CacheDRow; |
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| 477 | for (unsigned i = 0; i < uCachePrefixCountA; ++i) |
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| 478 | delete[] CacheTB[i]; |
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| 479 | delete[] CacheTB; |
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| 480 | |
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| 481 | uCachePrefixCountA = uPrefixCountA + 1024; |
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| 482 | uCachePrefixCountB = uPrefixCountB + 1024; |
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| 483 | |
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| 484 | CacheMCurr = new SCORE[uCachePrefixCountB]; |
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| 485 | CacheMNext = new SCORE[uCachePrefixCountB]; |
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| 486 | CacheMPrev = new SCORE[uCachePrefixCountB]; |
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| 487 | CacheDRow = new SCORE[uCachePrefixCountB]; |
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| 488 | |
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| 489 | CacheTB = new char *[uCachePrefixCountA]; |
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| 490 | for (unsigned i = 0; i < uCachePrefixCountA; ++i) |
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| 491 | CacheTB[i] = new char [uCachePrefixCountB]; |
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| 492 | } |
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| 493 | |
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| 494 | SCORE NWSmall(const ProfPos *PA, unsigned uLengthA, const ProfPos *PB, |
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| 495 | unsigned uLengthB, PWPath &Path) |
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| 496 | { |
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| 497 | if (0 == uLengthB || 0 == uLengthA ) |
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| 498 | Quit("Internal error, NWSmall: length=0"); |
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| 499 | |
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| 500 | SetTermGaps(PA, uLengthA); |
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| 501 | SetTermGaps(PB, uLengthB); |
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| 502 | |
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| 503 | const unsigned uPrefixCountA = uLengthA + 1; |
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| 504 | const unsigned uPrefixCountB = uLengthB + 1; |
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| 505 | const SCORE e = g_scoreGapExtend; |
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| 506 | |
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| 507 | ALLOC_TRACE() |
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| 508 | |
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| 509 | AllocCache(uPrefixCountA, uPrefixCountB); |
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| 510 | |
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| 511 | SCORE *MCurr = CacheMCurr; |
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| 512 | SCORE *MNext = CacheMNext; |
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| 513 | SCORE *MPrev = CacheMPrev; |
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| 514 | SCORE *DRow = CacheDRow; |
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| 515 | |
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| 516 | char **TB = CacheTB; |
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| 517 | for (unsigned i = 0; i < uPrefixCountA; ++i) |
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| 518 | memset(TB[i], 0, uPrefixCountB); |
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| 519 | |
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| 520 | SCORE Iij = MINUS_INFINITY; |
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| 521 | SetDPI(0, 0, Iij); |
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| 522 | |
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| 523 | Iij = PB[0].m_scoreGapOpen; |
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| 524 | SetDPI(0, 1, Iij); |
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| 525 | |
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| 526 | for (unsigned j = 2; j <= uLengthB; ++j) |
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| 527 | { |
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| 528 | Iij += e; |
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| 529 | SetDPI(0, j, Iij); |
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| 530 | SetTBI(0, j, 'I'); |
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| 531 | } |
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| 532 | |
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| 533 | for (unsigned j = 0; j <= uLengthB; ++j) |
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| 534 | { |
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| 535 | DRow[j] = MINUS_INFINITY; |
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| 536 | SetDPD(0, j, DRow[j]); |
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| 537 | SetTBD(0, j, 'D'); |
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| 538 | } |
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| 539 | |
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| 540 | MPrev[0] = 0; |
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| 541 | SetDPM(0, 0, MPrev[0]); |
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| 542 | for (unsigned j = 1; j <= uLengthB; ++j) |
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| 543 | { |
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| 544 | MPrev[j] = MINUS_INFINITY; |
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| 545 | SetDPM(0, j, MPrev[j]); |
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| 546 | } |
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| 547 | |
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| 548 | MCurr[0] = MINUS_INFINITY; |
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| 549 | SetDPM(1, 0, MCurr[0]); |
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| 550 | |
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| 551 | MCurr[1] = ScoreProfPos2(PA[0], PB[0]); |
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| 552 | SetDPM(1, 1, MCurr[1]); |
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| 553 | SetBitTBM(TB, 1, 1, 'M'); |
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| 554 | SetTBM(1, 1, 'M'); |
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| 555 | |
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| 556 | for (unsigned j = 2; j <= uLengthB; ++j) |
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| 557 | { |
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| 558 | MCurr[j] = ScoreProfPos2(PA[0], PB[j-1]) + PB[0].m_scoreGapOpen + |
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| 559 | (j - 2)*e + PB[j-2].m_scoreGapClose; |
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| 560 | SetDPM(1, j, MCurr[j]); |
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| 561 | SetBitTBM(TB, 1, j, 'I'); |
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| 562 | SetTBM(1, j, 'I'); |
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| 563 | } |
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| 564 | |
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| 565 | // Main DP loop |
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| 566 | for (unsigned i = 1; i < uLengthA; ++i) |
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| 567 | { |
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| 568 | char *TBRow = TB[i]; |
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| 569 | |
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| 570 | Iij = MINUS_INFINITY; |
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| 571 | SetDPI(i, 0, Iij); |
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| 572 | |
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| 573 | DRow[0] = PA[0].m_scoreGapOpen + (i - 1)*e; |
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| 574 | SetDPD(i, 0, DRow[0]); |
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| 575 | |
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| 576 | MCurr[0] = MINUS_INFINITY; |
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| 577 | if (i == 1) |
|---|
| 578 | { |
|---|
| 579 | MCurr[1] = ScoreProfPos2(PA[0], PB[0]); |
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| 580 | SetBitTBM(TB, i, 1, 'M'); |
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| 581 | SetTBM(i, 1, 'M'); |
|---|
| 582 | } |
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| 583 | else |
|---|
| 584 | { |
|---|
| 585 | MCurr[1] = ScoreProfPos2(PA[i-1], PB[0]) + PA[0].m_scoreGapOpen + |
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| 586 | (i - 2)*e + PA[i-2].m_scoreGapClose; |
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| 587 | SetBitTBM(TB, i, 1, 'D'); |
|---|
| 588 | SetTBM(i, 1, 'D'); |
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| 589 | } |
|---|
| 590 | SetDPM(i, 0, MCurr[0]); |
|---|
| 591 | SetDPM(i, 1, MCurr[1]); |
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| 592 | |
|---|
| 593 | for (unsigned j = 1; j < uLengthB; ++j) |
|---|
| 594 | MNext[j+1] = ScoreProfPos2(PA[i], PB[j]); |
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| 595 | |
|---|
| 596 | for (unsigned j = 1; j < uLengthB; ++j) |
|---|
| 597 | { |
|---|
| 598 | RECURSE_D(i, j) |
|---|
| 599 | RECURSE_I(i, j) |
|---|
| 600 | RECURSE_M(i, j) |
|---|
| 601 | } |
|---|
| 602 | // Special case for j=uLengthB |
|---|
| 603 | RECURSE_D_BTerm(i) |
|---|
| 604 | RECURSE_I_BTerm(i) |
|---|
| 605 | |
|---|
| 606 | // Prev := Curr, Curr := Next, Next := Prev |
|---|
| 607 | Rotate(MPrev, MCurr, MNext); |
|---|
| 608 | } |
|---|
| 609 | |
|---|
| 610 | // Special case for i=uLengthA |
|---|
| 611 | char *TBRow = TB[uLengthA]; |
|---|
| 612 | MCurr[0] = MINUS_INFINITY; |
|---|
| 613 | if (uLengthA > 1) |
|---|
| 614 | MCurr[1] = ScoreProfPos2(PA[uLengthA-1], PB[0]) + (uLengthA - 2)*e + |
|---|
| 615 | PA[0].m_scoreGapOpen + PA[uLengthA-2].m_scoreGapClose; |
|---|
| 616 | else |
|---|
| 617 | MCurr[1] = ScoreProfPos2(PA[uLengthA-1], PB[0]) + PA[0].m_scoreGapOpen + |
|---|
| 618 | PA[0].m_scoreGapClose; |
|---|
| 619 | SetBitTBM(TB, uLengthA, 1, 'D'); |
|---|
| 620 | SetTBM(uLengthA, 1, 'D'); |
|---|
| 621 | SetDPM(uLengthA, 0, MCurr[0]); |
|---|
| 622 | SetDPM(uLengthA, 1, MCurr[1]); |
|---|
| 623 | |
|---|
| 624 | DRow[0] = MINUS_INFINITY; |
|---|
| 625 | SetDPD(uLengthA, 0, DRow[0]); |
|---|
| 626 | for (unsigned j = 1; j <= uLengthB; ++j) |
|---|
| 627 | RECURSE_D_ATerm(j); |
|---|
| 628 | |
|---|
| 629 | Iij = MINUS_INFINITY; |
|---|
| 630 | for (unsigned j = 1; j <= uLengthB; ++j) |
|---|
| 631 | RECURSE_I_ATerm(j) |
|---|
| 632 | |
|---|
| 633 | LogMatrices(); |
|---|
| 634 | |
|---|
| 635 | SCORE MAB = MCurr[uLengthB]; |
|---|
| 636 | SCORE DAB = DRow[uLengthB]; |
|---|
| 637 | SCORE IAB = Iij; |
|---|
| 638 | |
|---|
| 639 | SCORE Score = MAB; |
|---|
| 640 | char cEdgeType = 'M'; |
|---|
| 641 | if (DAB > Score) |
|---|
| 642 | { |
|---|
| 643 | Score = DAB; |
|---|
| 644 | cEdgeType = 'D'; |
|---|
| 645 | } |
|---|
| 646 | if (IAB > Score) |
|---|
| 647 | { |
|---|
| 648 | Score = IAB; |
|---|
| 649 | cEdgeType = 'I'; |
|---|
| 650 | } |
|---|
| 651 | |
|---|
| 652 | #if TRACE |
|---|
| 653 | Log(" Fast: MAB=%.4g DAB=%.4g IAB=%.4g best=%c\n", |
|---|
| 654 | MAB, DAB, IAB, cEdgeType); |
|---|
| 655 | #endif |
|---|
| 656 | |
|---|
| 657 | BitTraceBack(TB, uLengthA, uLengthB, cEdgeType, Path); |
|---|
| 658 | |
|---|
| 659 | #if DBEUG |
|---|
| 660 | Path.Validate(); |
|---|
| 661 | #endif |
|---|
| 662 | |
|---|
| 663 | return 0; |
|---|
| 664 | } |
|---|