1 | #ifndef tree_h |
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2 | #define tree_h |
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3 | |
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4 | #include <limits.h> |
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5 | |
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6 | class Clust; |
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7 | |
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8 | const unsigned NULL_NEIGHBOR = UINT_MAX; |
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9 | |
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10 | enum NEWICK_TOKEN_TYPE |
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11 | { |
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12 | NTT_Unknown, |
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13 | |
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14 | // Returned from Tree::GetToken: |
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15 | NTT_Lparen, |
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16 | NTT_Rparen, |
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17 | NTT_Colon, |
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18 | NTT_Comma, |
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19 | NTT_Semicolon, |
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20 | NTT_String, |
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21 | |
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22 | // Following are never returned from Tree::GetToken: |
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23 | NTT_SingleQuotedString, |
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24 | NTT_DoubleQuotedString, |
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25 | NTT_Comment |
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26 | }; |
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27 | |
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28 | class Tree |
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29 | { |
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30 | public: |
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31 | Tree() |
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32 | { |
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33 | m_uNodeCount = 0; |
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34 | m_uCacheCount = 0; |
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35 | m_uNeighbor1 = 0; |
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36 | m_uNeighbor2 = 0; |
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37 | m_uNeighbor3 = 0; |
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38 | m_dEdgeLength1 = 0; |
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39 | m_dEdgeLength2 = 0; |
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40 | m_dEdgeLength3 = 0; |
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41 | m_dHeight = 0; |
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42 | m_bHasEdgeLength1 = 0; |
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43 | m_bHasEdgeLength2 = 0; |
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44 | m_bHasEdgeLength3 = 0; |
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45 | m_bHasHeight = 0; |
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46 | m_ptrName = 0; |
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47 | m_Ids = 0; |
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48 | } |
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49 | virtual ~Tree() |
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50 | { |
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51 | Clear(); |
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52 | } |
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53 | |
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54 | void Clear() |
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55 | { |
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56 | for (unsigned n = 0; n < m_uNodeCount; ++n) |
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57 | free(m_ptrName[n]); |
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58 | |
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59 | m_uNodeCount = 0; |
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60 | m_uCacheCount = 0; |
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61 | |
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62 | delete[] m_uNeighbor1; |
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63 | delete[] m_uNeighbor2; |
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64 | delete[] m_uNeighbor3; |
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65 | delete[] m_dEdgeLength1; |
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66 | delete[] m_dEdgeLength2; |
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67 | delete[] m_dEdgeLength3; |
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68 | delete[] m_bHasEdgeLength1; |
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69 | delete[] m_bHasEdgeLength2; |
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70 | delete[] m_bHasEdgeLength3; |
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71 | delete[] m_ptrName; |
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72 | delete[] m_Ids; |
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73 | delete[] m_bHasHeight; |
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74 | delete[] m_dHeight; |
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75 | |
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76 | m_uNeighbor1 = 0; |
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77 | m_uNeighbor2 = 0; |
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78 | m_uNeighbor3 = 0; |
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79 | m_dEdgeLength1 = 0; |
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80 | m_dEdgeLength2 = 0; |
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81 | m_dEdgeLength3 = 0; |
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82 | m_ptrName = 0; |
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83 | m_Ids = 0; |
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84 | m_uRootNodeIndex = 0; |
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85 | m_bHasHeight = 0; |
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86 | m_dHeight = 0; |
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87 | |
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88 | m_bRooted = false; |
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89 | } |
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90 | |
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91 | // Creation and manipulation |
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92 | void CreateRooted(); |
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93 | void CreateUnrooted(double dEdgeLength); |
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94 | |
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95 | void FromFile(TextFile &File); |
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96 | void FromClust(Clust &C); |
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97 | |
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98 | void Copy(const Tree &tree); |
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99 | |
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100 | void Create(unsigned uLeafCount, unsigned uRoot, const unsigned Left[], |
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101 | const unsigned Right[], const float LeftLength[], const float RightLength[], |
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102 | const unsigned LeafIds[], char *LeafNames[]); |
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103 | unsigned AppendBranch(unsigned uExistingNodeIndex); |
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104 | void SetLeafName(unsigned uNodeIndex, const char *ptrName); |
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105 | void SetLeafId(unsigned uNodeIndex, unsigned uId); |
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106 | void SetEdgeLength(unsigned uNodeIndex1, unsigned uNodeIndex2, |
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107 | double dLength); |
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108 | |
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109 | void RootUnrootedTree(unsigned uNodeIndex1, unsigned uNodeIndex2); |
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110 | void RootUnrootedTree(ROOT Method); |
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111 | void UnrootByDeletingRoot(); |
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112 | |
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113 | // Saving to file |
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114 | void ToFile(TextFile &File) const; |
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115 | |
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116 | // Accessor functions |
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117 | unsigned GetNodeCount() const |
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118 | { |
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119 | return m_uNodeCount; |
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120 | } |
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121 | |
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122 | unsigned GetLeafCount() const |
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123 | { |
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124 | if (m_bRooted) |
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125 | { |
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126 | assert(m_uNodeCount%2 == 1); |
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127 | return (m_uNodeCount + 1)/2; |
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128 | } |
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129 | else |
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130 | { |
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131 | assert(m_uNodeCount%2 == 0); |
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132 | return (m_uNodeCount + 2)/2; |
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133 | } |
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134 | } |
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135 | |
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136 | unsigned GetNeighbor(unsigned uNodeIndex, unsigned uNeighborSubscript) const; |
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137 | |
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138 | unsigned GetNeighbor1(unsigned uNodeIndex) const |
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139 | { |
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140 | assert(uNodeIndex < m_uNodeCount); |
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141 | return m_uNeighbor1[uNodeIndex]; |
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142 | } |
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143 | |
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144 | unsigned GetNeighbor2(unsigned uNodeIndex) const |
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145 | { |
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146 | assert(uNodeIndex < m_uNodeCount); |
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147 | return m_uNeighbor2[uNodeIndex]; |
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148 | } |
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149 | |
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150 | unsigned GetNeighbor3(unsigned uNodeIndex) const |
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151 | { |
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152 | assert(uNodeIndex < m_uNodeCount); |
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153 | return m_uNeighbor3[uNodeIndex]; |
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154 | } |
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155 | |
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156 | unsigned GetParent(unsigned uNodeIndex) const |
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157 | { |
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158 | assert(m_bRooted && uNodeIndex < m_uNodeCount); |
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159 | return m_uNeighbor1[uNodeIndex]; |
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160 | } |
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161 | |
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162 | bool IsRooted() const |
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163 | { |
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164 | return m_bRooted; |
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165 | } |
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166 | |
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167 | unsigned GetLeft(unsigned uNodeIndex) const |
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168 | { |
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169 | assert(m_bRooted && uNodeIndex < m_uNodeCount); |
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170 | return m_uNeighbor2[uNodeIndex]; |
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171 | } |
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172 | |
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173 | unsigned GetRight(unsigned uNodeIndex) const |
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174 | { |
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175 | assert(m_bRooted && uNodeIndex < m_uNodeCount); |
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176 | return m_uNeighbor3[uNodeIndex]; |
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177 | } |
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178 | |
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179 | const char *GetName(unsigned uNodeIndex) const |
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180 | { |
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181 | assert(uNodeIndex < m_uNodeCount); |
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182 | return m_ptrName[uNodeIndex]; |
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183 | } |
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184 | |
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185 | unsigned GetRootNodeIndex() const |
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186 | { |
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187 | assert(m_bRooted); |
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188 | return m_uRootNodeIndex; |
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189 | } |
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190 | |
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191 | unsigned GetNeighborCount(unsigned uNodeIndex) const |
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192 | { |
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193 | const unsigned n1 = m_uNeighbor1[uNodeIndex]; |
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194 | const unsigned n2 = m_uNeighbor2[uNodeIndex]; |
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195 | const unsigned n3 = m_uNeighbor3[uNodeIndex]; |
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196 | return (NULL_NEIGHBOR != n1) + (NULL_NEIGHBOR != n2) + (NULL_NEIGHBOR != n3); |
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197 | } |
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198 | |
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199 | bool IsLeaf(unsigned uNodeIndex) const |
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200 | { |
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201 | assert(uNodeIndex < m_uNodeCount); |
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202 | if (1 == m_uNodeCount) |
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203 | return true; |
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204 | return 1 == GetNeighborCount(uNodeIndex); |
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205 | } |
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206 | |
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207 | bool IsRoot(unsigned uNodeIndex) const |
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208 | { |
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209 | return IsRooted() && m_uRootNodeIndex == uNodeIndex; |
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210 | } |
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211 | |
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212 | unsigned GetLeafId(unsigned uNodeIndex) const; |
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213 | unsigned GetLeafNodeIndex(const char *ptrName) const; |
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214 | bool IsEdge(unsigned uNodeIndex1, unsigned uNodeIndex2) const; |
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215 | bool HasEdgeLength(unsigned uNodeIndex1, unsigned uNodeIndex2) const; |
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216 | double GetEdgeLength(unsigned uNodeIndex1, unsigned uNodeIndex2) const; |
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217 | const char *GetLeafName(unsigned uNodeIndex) const; |
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218 | unsigned GetNeighborSubscript(unsigned uNodeIndex, unsigned uNeighborIndex) const; |
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219 | double GetNodeHeight(unsigned uNodeIndex) const; |
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220 | |
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221 | // Depth-first traversal |
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222 | unsigned FirstDepthFirstNode() const; |
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223 | unsigned NextDepthFirstNode(unsigned uNodeIndex) const; |
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224 | |
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225 | unsigned FirstDepthFirstNodeR() const; |
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226 | unsigned NextDepthFirstNodeR(unsigned uNodeIndex) const; |
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227 | |
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228 | // Equivalent of GetLeft/Right in unrooted tree, works in rooted tree too. |
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229 | unsigned GetFirstNeighbor(unsigned uNodeIndex, unsigned uNeighborIndex) const; |
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230 | unsigned GetSecondNeighbor(unsigned uNodeIndex, unsigned uNeighborIndex) const; |
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231 | |
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232 | // Getting parent node in unrooted tree defined iff leaf |
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233 | unsigned GetLeafParent(unsigned uNodeIndex) const; |
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234 | |
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235 | // Misc |
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236 | const char *NTTStr(NEWICK_TOKEN_TYPE NTT) const; |
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237 | void FindCenterByLongestSpan(unsigned *ptrNodeIndex1, |
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238 | unsigned *ptrNodeIndex2) const; |
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239 | void PruneTree(const Tree &tree, unsigned Subfams[], |
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240 | unsigned uSubfamCount); |
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241 | unsigned LeafIndexToNodeIndex(unsigned uLeafIndex) const; |
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242 | |
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243 | // Debugging & trouble-shooting support |
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244 | void Validate() const; |
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245 | void ValidateNode(unsigned uNodeIndex) const; |
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246 | void AssertAreNeighbors(unsigned uNodeIndex1, unsigned uNodeIndex2) const; |
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247 | void LogMe() const; |
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248 | |
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249 | private: |
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250 | unsigned UnrootFromFile(); |
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251 | NEWICK_TOKEN_TYPE GetTokenVerbose(TextFile &File, char szToken[], |
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252 | unsigned uBytes) const |
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253 | { |
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254 | NEWICK_TOKEN_TYPE NTT = GetToken(File, szToken, uBytes); |
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255 | Log("GetToken %10.10s %s\n", NTTStr(NTT), szToken); |
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256 | return NTT; |
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257 | } |
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258 | |
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259 | void InitCache(unsigned uCacheCount); |
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260 | void ExpandCache(); |
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261 | NEWICK_TOKEN_TYPE GetToken(TextFile &File, char szToken[], unsigned uBytes) const; |
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262 | bool GetGroupFromFile(TextFile &File, unsigned uNodeIndex, double *ptrdEdgeLength); |
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263 | unsigned GetLeafCountUnrooted(unsigned uNodeIndex1, unsigned uNodeIndex2, |
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264 | double *ptrdTotalDistance) const; |
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265 | void ToFileNodeRooted(TextFile &File, unsigned uNodeIndex) const; |
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266 | void ToFileNodeUnrooted(TextFile &File, unsigned uNodeIndex, unsigned uParent) const; |
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267 | void OrientParent(unsigned uNodeIndex, unsigned uParentNodeIndex); |
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268 | double FromClustNode(const Clust &C, unsigned uClustNodeIndex, unsigned uPhyNodeIndex); |
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269 | unsigned GetAnyNonLeafNode() const; |
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270 | |
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271 | // Yuck. Data is made public for the convenience of Tree::Copy. |
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272 | // There has to be a better way. |
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273 | public: |
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274 | unsigned m_uNodeCount; |
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275 | unsigned m_uCacheCount; |
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276 | unsigned *m_uNeighbor1; |
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277 | unsigned *m_uNeighbor2; |
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278 | unsigned *m_uNeighbor3; |
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279 | double *m_dEdgeLength1; |
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280 | double *m_dEdgeLength2; |
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281 | double *m_dEdgeLength3; |
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282 | double *m_dHeight; |
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283 | bool *m_bHasEdgeLength1; |
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284 | bool *m_bHasEdgeLength2; |
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285 | bool *m_bHasEdgeLength3; |
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286 | bool *m_bHasHeight; |
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287 | unsigned *m_Ids; |
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288 | char **m_ptrName; |
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289 | bool m_bRooted; |
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290 | unsigned m_uRootNodeIndex; |
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291 | }; |
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292 | |
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293 | struct PhyEnumEdgeState |
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294 | { |
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295 | PhyEnumEdgeState() |
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296 | { |
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297 | m_bInit = false; |
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298 | m_uNodeIndex1 = NULL_NEIGHBOR; |
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299 | m_uNodeIndex2 = NULL_NEIGHBOR; |
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300 | } |
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301 | bool m_bInit; |
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302 | unsigned m_uNodeIndex1; |
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303 | unsigned m_uNodeIndex2; |
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304 | }; |
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305 | |
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306 | const unsigned NODE_CHANGED = (unsigned) (~0); |
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307 | |
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308 | extern bool PhyEnumBiParts(const Tree &tree, PhyEnumEdgeState &ES, |
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309 | unsigned Leaves1[], unsigned *ptruCount1, |
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310 | unsigned Leaves2[], unsigned *ptruCount2); |
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311 | extern bool PhyEnumBiPartsR(const Tree &tree, PhyEnumEdgeState &ES, |
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312 | unsigned Leaves1[], unsigned *ptruCount1, |
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313 | unsigned Leaves2[], unsigned *ptruCount2); |
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314 | extern void ClusterByHeight(const Tree &tree, double dMaxHeight, unsigned Subtrees[], |
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315 | unsigned *ptruSubtreeCount); |
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316 | void ClusterBySubfamCount(const Tree &tree, unsigned uSubfamCount, |
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317 | unsigned Subfams[], unsigned *ptruSubfamCount); |
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318 | void GetLeaves(const Tree &tree, unsigned uNodeIndex, unsigned Leaves[], |
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319 | unsigned *ptruLeafCount); |
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320 | void GetLeavesExcluding(const Tree &tree, unsigned uNodeIndex, |
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321 | unsigned uExclude, unsigned Leaves[], unsigned *ptruCount); |
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322 | void GetInternalNodesInHeightOrder(const Tree &tree, unsigned NodeIndexes[]); |
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323 | void ApplyMinEdgeLength(Tree &tree, double dMinEdgeLength); |
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324 | void LeafIndexesToLeafNames(const Tree &tree, const unsigned Leaves[], unsigned uCount, |
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325 | char *Names[]); |
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326 | void LeafIndexesToIds(const Tree &tree, const unsigned Leaves[], unsigned uCount, |
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327 | unsigned Ids[]); |
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328 | void MSASeqSubset(const MSA &msaIn, char *Names[], unsigned uSeqCount, |
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329 | MSA &msaOut); |
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330 | void DiffTrees(const Tree &Tree1, const Tree &Tree2, Tree &Diffs, |
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331 | unsigned IdToDiffsLeafNodeIndex[]); |
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332 | void DiffTreesE(const Tree &NewTree, const Tree &OldTree, |
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333 | unsigned NewNodeIndexToOldNodeIndex[]); |
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334 | void FindRoot(const Tree &tree, unsigned *ptruNode1, unsigned *ptruNode2, |
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335 | double *ptrdLength1, double *ptrdLength2, |
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336 | ROOT RootMethod); |
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337 | void FixRoot(Tree &tree, ROOT RootMethod); |
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338 | |
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339 | #endif // tree_h |
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