1 | ID MA32_HUMAN STANDARD; PRT; 282 AA. |
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2 | XX |
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3 | AC Q07021; |
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4 | XX |
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5 | DT 01-FEB-1995 (Rel. 31, Created) |
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6 | DT 01-FEB-1995 (Rel. 31, Last sequence update) |
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7 | XX |
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8 | DE COMPLEMENT COMPONENT 1, Q SUBCOMPONENT BINDING PROTEIN, MITOCHONDRIAL |
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9 | DE PRECURSOR (GLYCOPROTEIN GC1QBP) (GC1Q-R PROTEIN) (HYALURONAN-BINDING |
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10 | DE PROTEIN 1) (PRE-MRNA SPLICING FACTOR SF2, P32 SUBUNIT) (P33). |
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11 | XX |
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12 | KW Mitochondrion; Transit peptide; 3D-structure. |
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13 | XX |
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14 | OS Homo sapiens (Human). |
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15 | OC No information. |
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16 | XX |
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17 | RN [1] |
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18 | RP SEQUENCE FROM N.A., AND SEQUENCE OF 74; 76-93 AND 208-216. |
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19 | RA Honore B., Madsen P., Rasmussen H.H., Vandekerckhove J., Celis J.E., |
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20 | RA Leffers H.; |
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21 | RT "Cloning and expression of a cDNA covering the complete coding region |
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22 | RT of the P32 subunit of human pre-mRNA splicing factor SF2."; |
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23 | RL Gene 134:283-287(1993). |
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24 | XX |
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25 | RN [2] |
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26 | RP SEQUENCE OF 5-282 FROM N.A., AND SEQUENCE OF 74-114. |
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27 | RA Krainer A.R., Mayeda A., Kozak D., Binns G.; |
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28 | RT "Functional expression of cloned human splicing factor SF2: homology |
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29 | RT to RNA-binding proteins, U1 70K, and Drosophila splicing regulators."; |
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30 | RT |
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31 | RL Cell 66:383-394(1991). |
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32 | XX |
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33 | RN [3] |
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34 | RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. |
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35 | RA Ghebrehiwet B., Lim B.L., Peerschke E.I., Willis A.C., Reid K.B.; |
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36 | RT "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface |
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37 | RT glycoprotein that binds to the globular 'heads' of C1q."; |
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38 | RL J. Exp. Med. 179:1809-1821(1994). |
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39 | XX |
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40 | RN [4] |
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41 | RP X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS). |
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42 | RA Jiang J., Zhang Y., Krainer A.R., Xu R.-M.; |
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43 | RT "Crystal structure of human p32, a doughnut-shaped acidic |
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44 | RT mitochondrial matrix protein."; |
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45 | RL Proc. Natl. Acad. Sci. U.S.A. 96:3572-3577(1999). |
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46 | XX |
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47 | DR EMBL; L04636; AAA16315.1; -. EMBL; M69039; AAA73055.1; -. EMBL; |
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48 | DR X75913; CAA53512.1; -. PIR; JT0762; JT0762. PIR; S44104; S44104. PDB; |
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49 | DR 1P32; 06-APR-99. MIM; 601269; -. |
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50 | XX |
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51 | CC -!- FUNCTION: NOT KNOWN. BINDS TO THE GLOBULAR "HEADS" OF C1Q THUS |
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52 | CC INHIBITING C1 ACTIVATION. |
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53 | CC -!- SUBCELLULAR LOCATION: MITOCHONDRIAL MATRIX. |
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54 | CC -!- SIMILARITY: BELONGS TO THE MAM33 FAMILY. |
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55 | CC -!- CAUTION: WAS ORIGINALLY (REF.1 AND REF.2) THOUGHT TO BE A PRE-MRNA |
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56 | CC SPLICING FACTOR THAT PLAYS A ROLE IN PREVENTING EXON SKIPPING, |
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57 | CC ENSURING THE ACCURACY OF SPLICING AND REGULATING ALTERNATIVE |
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58 | CC SPLICING. |
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59 | CC ---------------------------------------------------------------------- |
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60 | CC ---- |
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61 | CC This SWISS-PROT entry is copyright. It is produced through a collabora |
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62 | CC tion |
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63 | CC between the Swiss Institute of Bioinformatics and the EMBL outstati |
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64 | CC on - |
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65 | CC the European Bioinformatics Institute. There are no restrictions on |
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66 | CC its |
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67 | CC use by non-profit institutions as long as its content is in no |
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68 | CC way |
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69 | CC modified and this statement is not removed. Usage by and for commer |
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70 | CC cial |
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71 | CC entities requires a license agreement (See http://www.isb-sib.ch/annou |
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72 | CC nce/ |
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73 | or send an email to license@isb-sib.ch). |
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74 | CC ---------------------------------------------------------------------- |
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75 | CC ---- |
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76 | XX |
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77 | SQ Sequence 282 BP; 17 A; 7 C; 20 G; 16 T; 222 other; |
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78 | MLPLLRCVPR VLGSSVAGLR AAAPASPFRQ LLQPAPRLCT RPFGLLSVRA GSERRPGLLR |
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79 | PRGPCACGCG CGSLHTDGDK AFVDFLSDEI KEERKIQKHK TLPKMSGGWE LELNGTEAKL |
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80 | VRKVAGEKIT VTFNINNSIP PTFDGEEEPS QGQKVEEQEP ELTSTPNFVV EVIKNDDGKK |
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81 | ALVLDCHYPE DEVGQEDEAE SDIFSIREVS FQSTGESEWK DTNYTLNTDS LDWALYDHLM |
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82 | DFLADRGVDN TFADELVELS TALEHQEYIT FLEDLKSFVK SQ |
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83 | // |
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