source: trunk/arb_CHANGES.txt

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1ARB change log
2
3Ticket references
4
5    Referenced ticket numbers are linked when you view this information
6    at http://help.arb-home.de/changes.html
7
8Major changes for next release:
9
10 - support marking species via selections in merge-tool (#868)
11 - split alignments (#846)
12 - detect poorly aligned helical regions in editor (#854)
13 - tweaked 'Helix settings' in EDIT4
14   - defaults changed for GG ('#'->'='), TT + UU ('+'->'#'), ambiguity codes (''->'%')
15   - added several predefined configs (traditional, two handling ambiguity codes)
16   - display in SECEDIT updates after helix changes
17 - tweaked 'Track alignment changes'
18   - automatically adds generated fields to species info.
19   - enhanced documentation (recommended workflow)
20 - tweaked progress
21   - better estimation for NJ, ConsensusTree, matrix calculation + PVP
22     - uses weighted progresses (#789)
23     - also fixes progress overflow (#807)
24   - support for longer periods (weeks, months, ...)
25   - prefer overestimation
26   - log to console (estimates finish)
27 - include SINA (1.7.2 patched)
28   - interface auto-adapts to sina version (still compatible with 1.3; currently needs patched version for 1.7.2)
29   - added script arb_sina_install_from_fat_tarball.sh (allows to install sina from fat-tarballs provided via arb homepage)
30 - improved macro scriptability
31   - now synchronizes external tools (#869)
32   - properly allows quitting arb (#867)
33   - allow to plan user interaction (#856)
34   - mergetool now also supports macro playback from command line (#870)
35 - append output from external tools to arb logfile.
36 - FastTree
37   - added support for protein sequences.
38   - customizable from GUI (rate categories, NJ, bootstraps).
39   - upgraded to version 2.1.11
40   - arb now provides single+multi processor versions of FastTree
41 - NDS (Node display setup; #841)
42   - specifying a zero WIDTH now means "unlimited" (backward compatible).
43   - avoid unwanted truncation (NDS-export, saved distance matrix).
44   - tree/export (using NDS)
45     - no longer truncates labels.
46     - group-labels are generated by NDS now.
47     - raise an error if non-ASCII characters are used in label (optionally).
48 - import from calcsheet:
49   - support for fuzzy matches (#865)
50   - can handle empty trailing cells
51 - added SAVE button to arb message window (saves pos+size+content)
52 - minor changes:
53   - 'Mark/Unmark listed' buttons in search window
54   - new ACI command 'dupidx' supporting group enumeration (#863)
55 - added
56   - script to analyze database structure (#866; generated reports allow database comparison)
57   - macros to cleanup database ("keep_listed_(trees|SAIs|speciesSelections).amc")
58 - documentation (arb integrated help):
59   - length checked + corrected for preformatted text and titles
60   - minor layout changes
61   - link tickets and URLs (html)
62
63Fixes for arb-7.0.1 (31 Jan 2022):
64
65 - fix perl compatibility for macOS 12
66
67Major changes for arb-7.0 (1 Sep 2021):
68
69 - ARB PARSIMONY
70   * topology optimization
71     - now (by default) strictly restricted to marked/visible parts of the tree (#640)
72     - restriction now customizable (marked/all; visible/all)
73     - tree costs for protein-data were not independent from root-position (as expected by model; #633).
74       Caused infinite running optimization under some circumstances.
75     - optimize-modes now strictly restrict to clicked subtrees. single/repeated optimization possible.
76     - KL-optimizer
77       * static path reduction slightly changed meaning. changed default settings.
78       * removed randomness (was just covering some bugs)
79       * improved general optimization speed
80   * branchlength calculation
81     - "forgot" to recalculate lengths under some conditions. fixed.
82     - is now independent of tree-root position (#641)
83   * adding species
84     - 'add partial species' failed if two partial species had NO overlap (#609). fixed.
85     - in 'add species + NNI' local optimization quality depended on insert position. fixed.
86     - insertion of multiple species is now done independently (=unordered; #643)
87     - performance improved (esp. for many added species/big trees; #643)
88   * generally improved combine performance (using SSE)
89   * generally reduced the number of performed combines (skipping many useless)
90   * added function to randomize (parts of) the tree
91   * warns about insufficient sequence data (e.g. as result of too restrictive filtering; #631)
92   * fixed 'RESTORE' (crashed after deleting species from tree; #528)
93   * corrected handling of dots ('.') while combining ancestor sequences
94   * fixed a bunch of internal bugs (#620, #627, #645, ...)
95   * added species-info mode
96 - added missing translation tables (genetic codes 24-31)
97 - added amino acid code Xle(=J), which means Ile(=I) or Leu(=L)
98 - DNA realigner
99   * several unjustified failures will no longer happen (fixes #419 and most likely #145)
100     - correctly re-syncs after 'X' (if possible at all)
101     - no longer fails for 'B', 'J' and 'Z'
102     - accepts 3 or more consecutive IUPAC codes in DNA
103   * added option to cut-off DNA sequence (was done at end of sequence by old version. fixed)
104   * fixed several minor bugs (#563,..)
105 - ARB probeSpec: visualisation of probe set specificity (thanks to Paavo Jumppanen, CSIRO)
106 - species selections (editor configurations):
107   * visualisation of multiple selections in standard tree view (#658; example in database demo.arb)
108   * order can be changed; each configuration has a comment
109 - import/export (species,sequence):
110   * manage/edit/test import-/export-filter-definitions from inside ARB (#691)
111   * import can store configuration of imported species (#607)
112   * field transfer sets (#562) may be used to customize import/export behavior (also usable from arb merge-tool)
113   * corrected EMBL export filter (numbers at seq.data; #638)
114   * detected duplicates no longer abort complete import (#779)
115   * new CLI sequence exporter 'arb_export_seq_filtered' (#743)
116 - Tree shading (#443)
117   * according to values stored in database
118   * according to given topology (useful when comparing topologies)
119   * added customisable color ranges (#682)
120 - support for extra database compression (using gzip, bzip2, xz; #665); databases cannot be opened by versions before arb-7.0
121 - ARB_EDIT4:
122   * display selected database fields as flags (allowing to toggle their value; #261).
123     Example use: easily mark sequence as "curated" after manually checking its alignment.
124   * allow to load missing SAIs
125   * "view differences" to a reference sequence:
126      - customizable:
127        * char used for "equality" (i.e. what is displayed where a sequence is equal to selected sequence)
128        * case-sensitivity
129        * ignore different gap-types
130      - equal data also gets hidden in consensus
131      - refresh differences of all displayed sequences, when data of selected sequences changes
132      - change reference sequence using CTRL-R or automatically let it follow the cursor
133      - added hotkey to toggle mode: CTRL-D
134      - fixed minor bugs
135   * consensus calculation in ARB_EDIT4 and calculation of CONSENSUS SAI
136     - now both calculations are strictly consistent (#663):
137       * gaps are now ignored while deciding whether to simplify using IUPAC ambiguity codes
138       * IUPAC ambiguity codes encountered in sequence data are now counted proportionally (=> fewer 'N's occur in consensus)
139     - added sliders to consensus definition windows
140     - user defined consensus settings exchangable between both consensus setups
141     - fixed and updated documentation
142   * added species-info mode + database save (#52,#362)
143   * predefined SAI color translation for PVP
144 - changes to SAI generation
145   * MAX_FREQUENCY:
146     - considers IUPAC ambiguity codes proportionally
147     - amino acids: if MAX_FREQUENCY is below 10% SAI now shows '1' (prev. it did show '0', i.e. 100%)
148   * POS_VAR_BY_PARSIMONY (PVP):
149     - now (again) works with amino acid data (#782)
150     - added CLI tool 'arb_calc_pvp' (#701)
151   * implemented a SAI calculator (allows to modify or combine multiple SAIs)
152 - expand zombies in tree (unfold groups; #22)
153 - compare taxonomy (and mark differences; #651)
154 - search&query for taxonomic groups (#652)
155   - many search criteria (name, size, marked, nesting-level, ingroup-distance (#653), ...)
156   - search multiple trees, detect duplicate and missing groups
157   - operations on found groups (delete, rename, fold, mark)
158 - added concept of "inverse groups" (aka "keeled groups"; #735)
159 - group transfer between trees (#780):
160   - penalties can be customized in detail
161   - quality reports (to log and optionally to target name)
162 - synchronize positions of roots of multiple trees (#449)
163 - external (command line) aligners (#504):
164   * fixed incorrect handling of 'T' vs 'U': now all aligned sequences will contain the correct base depending on alignment type
165   * preserve gap-type ('-' vs '.') and upper-/lower-case of original alignment
166   * no longer ask what to do with aligned sequence, just overwrite it
167     - only warn about real sequence changes (so please do NOT ignore from now on!)
168 - config-managers:
169   * possibility to restore factory defaults
170   * added comment field for configurations
171   * added them throughout arb (#647)
172 - added slide controls throughout arb (#656)
173 - tree (display) options:
174   * fine grained scaling
175   * group display (shading, customizable counters (#118,#209), triangle clades, name display position)
176   * bootstrap values (filter by upper/lower limits, display position/styles, on/off toggle; #614)
177   * diagonal branch style (#578)
178   * parent branch position
179   * all options are now also supported by ARB_PARSIMONY
180   * improved auto-jump; now also works for groups
181   * added optional auto-unfolding (to selected group/species)
182   * select group on fold/unfold/create/move/..
183   * draw selected group in cursor-color (#709)
184   * added keys for tree-traversal (moving to selected species or group; #687)
185 - synchronized tree scrolling (#683)
186 - colorsets were invalidated by generating new IDs (#660). fixed.
187 - added alternate RAxML (DNA only; version 8.2.8)
188   - multicore support (automatically activates recommended number of threads)
189   - evaluation, optimization and extension of existing trees with RAxML (#681)
190 - fix performance of
191   * "format sequences" (broken in arb-6.0.x series; #702)
192   * nameserver for huge databases (#646)
193   * closing arb (if database uses fastload file; #649)
194 - ACI
195   - added boolean operators, numeric comparisons, floating point arithmetic and several other new commands
196   - allow access to other species via ID or accession number (findspec, ...)
197   - improved ACI debugging: more verbose tracing (console log accessible from inside ARB)
198 - NDS optionally uses only visible definitions
199 - Search&Query:
200   * sort results numerically (#203)
201   * recursive search through all fields (#773)
202 - Species information window: improved detachment, field selection (#695)
203 - improved macro compatibility:
204   * check compatibility with installed perl version during arb startup (#754)
205   * esp. tweaked compatibility of 'Search&Query' and 'Species information window'
206   * fixed a lot of internal names (missing or duplicated) which are used for macros (#429)
207 - improved OSX compatibility (thx to Jan Gerken)
208 - updated integrated documentation (#409)
209
210
211Fixes for arb-6.0.6 (22 Aug 2016):
212
213 - fixes for gcc 6.1.0
214 - tested gcc 4.9.4 + 5.4.0
215
216Fixes for arb-6.0.5 (4 May 2016):
217
218 - fixes for ubuntu 16.04 build
219
220Fixes for arb-6.0.4 (2 May 2016):
221
222 - fixes for OSX build (SIP, accepted compilers)
223
224Fixes for arb-6.0.3 (19 Nov 2015):
225
226 - fixes permission problems when multiple users share databases or ptservers (thx to Alan McCulloch)
227
228Fixes for arb-6.0.2 (8 Aug 2014):
229
230 - compile issues on Snow Leopard (OSX 10.6)
231 - merge Debian security fix for CVE-2008-5378
232 - small changes to build system for Debian
233 - add desktop integration files
234
235Fixes for arb-6.0.1 (22 Jul 2014):
236
237 - arb_parsimony
238   - skip unwanted automatic branchlength recalculations (e.g. by unfolding a group)
239   - corrected branchlength calculation for "Add marked partial species"
240   - dots were treated as gaps for protein sequences (now treated as 'X'; analog to DNA treating gaps as 'N'; #144). thx to Yan Shi for detecting that problem!
241 - print
242   - preview failed (showed empty postscript file)
243   - print to file now always saves in user home
244 - raxml (import tree with bootstrap values)
245
246Major changes for arb-6.0 (4 Jun 2014):
247
248 - merge databases allows to
249   - merge from an existing database into the database loaded in ARB
250   - merge to existing databases from the database loaded in ARB
251 - ARB can now
252   - be restarted with another database and
253   - a second instance of ARB can be opened
254 - ARB_DIST
255   - Detect clusters of species with similar sequences (OTUs)
256   - allow automatic recalculation of matrix and/or tree whenever some parameter or
257     data changes (only makes sense for smaller species sets)
258   - extract distance matrix from tree
259 - Rewrote chimera check. Allows filtering
260 - added RNACMA (computes clusters of correlated positions)
261 - PT-Server
262   - changed behavior
263     - no longer report less hits for a part of a probe than for the probe itself (occurred at 3'-end of alignment)
264     - reports previously missing hits in joined genes
265     - reports more hits at 3'-end of alignment (when using mismatches the PT-server now reports possible
266       matches that go beyond the end of the sequence)
267     - dots in the middle of the alignment act like the sequence ends there
268     - minimum probe length reduced to 2 (was 6)
269     - allow up to 50% of probe to mismatch
270   - performance
271     - optimized memory-estimation (will build in fewer passes)
272     - uses any number of passes (not only 1, 5, 25, ...)
273     - allows to define used memory by setting environment variable ARB_MEMORY
274     - reduced memory needed to build/run ptserver (approx. 50%)
275     - reduced size of indexfile (.pt) to ~50%
276     - fast startup of existing ptservers
277   - probe design
278     - faster in many cases
279     - allow to design probes of length 8 (previously 10)
280     - allow to design probes with different lengths (specifying min/max length)
281     - fixed number of outgroup hits reported when decreasing temperature
282       (now each outgroup member only occurs once)
283     - show possible reasons why no probes could be designed
284   - probe match (allow any number of mismatches)
285   - next relative search
286     - can be restricted to column ranges (needs a PT-Server calculated from aligned sequences)
287     - corrected and improved scaling of relative scores
288     - more accurate scores (due to fixes in PT-Server; see below)
289     - faster in many cases
290   - show errors from ptserver build in ARB
291 - fast-aligner
292   - searches next-relatives based on selected column-block
293   - align multiple column-blocks based on SAI
294 - Rewrote alignment adaption during merge
295 - Insert/delete columns using a SAI to define affected columns
296 - ARB_EDIT4
297   - improved support for using multiple edit-windows
298   - smoother refreshes
299   - tweaked ORF display
300 - tree importer/exporter
301   - ARBs extended newick format (with bootstrap values) handled more restrictive now
302   - fixed several bugs; improved errors/warnings
303 - consensus trees
304   - calculate from multiple existing trees (also allows to merge not completely overlapping trees)
305   - fixed NJ-bootstrapping (no longer drops species)
306 - tree display
307   - Show brackets on open groups (dendrogram tree only)
308   - rewrote IRS (folded) display
309   - fixed tree key-bindings (mark, fold, ...)
310   - improved several tree-commands (move, rotate, spread, length, width)
311 - added a branch analysis tool
312   - groups several functions previously available via menuitems (e.g. mark long branches, etc.)
313   - added leaf-distance analysis
314 - other tree functionality
315   - treelist sortable now
316   - new beautify-tree modes (radial tree / according to other tree)
317   - function to remove marked/zombies from ALL trees
318   - create multifurcations (by branchlength/bootstrap limit)
319   - toggle 100% bootstrap values
320 - tweaked printing (interface, overlapping)
321 - if YOU edit a helpfile it will be automatically packed into an archive ready to be sent to ARB developers
322 - probe design:
323   - added LOAD to result window
324 - automation
325   - macro recording works in ARB client applications (ARB_EDIT4, ARB_PARS, ARB_MERGE, ..)
326   - arb can execute macro from command line
327   - added "Never ask again" to modal question boxes (for better compatibility with macros)
328   - a macro can be called for all marked species (once for each)
329   - macros can be nested (i.e. can call other macros)
330 - support for user-specific customization:
331   - of GDE menus (in ~/.arb_prop/gde)
332   - of import/export filters (in ~/.arb_prop/filter)
333 - ACI (some new commands, bugfixes)
334 - updated/added external tools:
335   - added FastTree (version 2.1.7)
336   - added MAFFT (version 7.055)
337   - added MrBayes (version 3.2.1)
338   - added MUSCLE (version 3.8.31)
339   - added PHYML (2013/07/08; also kept old version 2.4.5)
340   - added PROBCONS (version 1.12)
341   - updated RAxML (version 7.7.2)
342 - load/save for window specific settings (e.g. allows to share parts of configuration with other users)
343 - Support for mouse-wheel
344 - many unlisted bugfixes
345 - many internal refactorings
346
347
348Fixes for arb_5.5 (15 Nov 2012):
349
350 * arb_5.4 was broken (several external tools missing)
351
352
353Fixes for arb_5.4 (14 Nov 2012):
354
355 * make it obvious when probe matches are truncated. Truncate all hits beyond 1 million (was 100000)
356 * fixed realigner (better interaction with fields 'transl_table' and 'codon_start'; improved error handling)
357 * fixed several compilation issues (OSX; recent distro releases)
358
359
360Fixes for arb_5.3 (10 Nov 2011):
361
362 - bugfixes
363   - fixed wrong absolute/ecoli position reported for some designed probes
364   - decompression error handling (pt-server build issues)
365   - fixed 'codon_start' generated with wrong type
366   - fixed a buffer overflow in ACI
367   - report failures to write to /tmp
368 - changes
369   - markSpecies.pl:
370     mark by accession number
371     partial/ambiguous matches
372 - internal fixes
373   - compilation fixes for OSX
374   - some patches for debian version (removed refs to xview, textedit, removed molphy(protml))
375   - removed obsolete dependency from libXp
376
377
378Fixes for arb_5.2 (5 Sep 2010):
379
380 - bugfixes
381   - quicksave did silently do nothing (especially not save anything) if an error occurred
382   - ARB_EDIT4: crashed when using config with MANY unknown species
383   - ARB_SECEDIT: crashed when trying to paint strand w/o any base
384   - ARB tree display: crashed when clicking on inner tree node w/o groupinfo
385 - changes
386   - ARB uses xdg-open to display web-pages
387 - internal fixes
388   - karmic koala (gcc 4.4.1)
389   - installation script
390   - arb build process uses xsltproc instead of sablotron
391
392
393Fixes for arb_5.1 (1 Oct 2009):
394
395 - fixed a bug in 'Create species from consensus' (created sequence was corrupted)
396 - fixed 2 bugs in optimize DB (alignment w/o data, missing transaction)
397 - updated installation instructions, fixed install script, added OSX instruction (thx to Matt Cottrell)
398 - fixed broken demo.arb
399
400
401Major changes for arb_5.00 (4 Sep 2009):
402
403 - ARB 64bit version
404 - new genome importer
405 - search for next relatives improved (normal search and fast-aligner)
406   - new parameters to precise search
407   - improved speed
408   - partial sequence reach normal scores
409 - search&query
410   - supports regular expressions and ACI
411   - track hit information
412   - result sorting
413 - Nameservers with add.field have to be started with default value
414   You need to correct parameter -f in lib/arb_tcp.dat (according to lib/arb_tcp_org.dat)
415 - multiple PT-servers may be used in parallel
416 - fixed multiprobe
417 - type-conversion for DB fields
418 - SILVA compatible import filters
419 - Newick tree export:
420   - optionally save in human-readable format (big)
421   - closer to newick standard format (quoting style, comment, special chars in data)
422 - Upgraded RAxML to 7.0.3 (many features now usable from ARB interface)
423 - Fixed sequence quality calculation
424 - Secondary structures for proteins (DSSP)
425 - Distance matrix (arb_dist): mark by distance to selected
426 - ARB core
427   - many bugfixes and improvements to reliability
428   - faster sorting (general speedup)
429   - improved sequence compression (avoid worse trees, better ratio)
430   - improved handling of temporary files (permission/removal)
431   - prints backtraces in userland
432   - regular expression are POSIX standard now
433 - macro record/playback
434   - fixed several bugs
435   - you need to re-record your old macros!
436 - GUI:
437   - disabled auto-focus, you need to click now
438   - auto-raise windows on access
439 - Minor things:
440   - Ubuntu: packet installation for ARB
441   - Fixed novice/expert mode
442   - Mark deep/degenerated branches
443   - Increased NDS entries
444 - up-to-date Mac port (thx to Matt Cottrell)
445
446Major changes in ARB 07.12.07org (7 Dec 2007):
447
448 - rewrote secondary structure editor
449 - Sequence quality check
450 - Nameserver may use one field additional to 'acc' (useful to keep multiple species with same acc)
451 - tweaked base frequency filter generation
452 - Normal export (not using readseq) improved:
453   - supports filters and gap removal
454   - optimized for big amount of data
455   - reworked export filters
456 - Display translation with different ORFs in EDIT4
457 - ARB exports in FIG 3.2 format (optionally in colors). Thanks to Elmar Pruesse.
458 - added PHYML 2.4.5 (thanks to Stephane Guidon for the permission to distribute that great tool)
459 - more compact display in EDIT4
460 - capable to use iso10646 fonts
461 - supports various gcc versions (2.95.3 - 4.1.1)
462 - fixed a bug in DB optimization (occurred when fields had bigger protection than current)
463 - Bootstrap circles may be displayed as ellipses; upper size limit configurable; uses
464   different color for size-limited circles; fixed xfig-export-bug
465 - Allows Branchlength <-> Bootstrap value transfer (lossy!)
466 - fixed several scaling bugs in "folded tree"-mode
467 - improved import-filter error-messages
468 - NDS-display of groups (e.g. in tree) is now handled by ACI-command 'taxonomy'. This gives
469   several new possibilities:
470   - export taxonomy via 'Export NDS list'
471   - display taxonomy in Editor etc.
472   - display of cascaded taxonomies
473   - display taxonomy of tree_1 in tree_2
474   - allows to write taxonomy into database field of species
475   - compare taxonomies of two trees
476   - ...
477 - ACI:
478   - many new ACI commands
479   - unified handling of binary ACI-operators
480   - tracing of ACI actions for debugging purpose
481 - ARB Neighbour joining:
482   - bootstrap limit configurable
483   - bugfix: when aborting bootstrap calculation, sometimes no tree was generated
484 - EDIT4:
485   - added unalign right (block-op)
486   - added 'Save loaded properties'
487 - GENE MAP:
488   - multiple views possible at the same time
489   - origin now at "12 o'clock"
490   - implemented 'jump to gene'
491 - tweaked file selection
492 - Enhanced Search Depth for Probe Match --> max 20 MM
493 - CLUSTALW:
494   - separated menus for fast and slow alignment
495   - most parameters accessible from inside ARB now
496 - upgraded to PHYLIP 3.6 (adds PROML)
497 - external programs may be called parallel (e.g. several treeing programs)
498 - fixed bugs in protml and integration of protml
499 - rewrote ASCII database import
500 - arb_repair for databases of any size (script for database repair)
501 - fixed bug in data compression
502 - increased internal cache size (alignments up to 400.000bp possible w/o performance collapse)
503 - ARBparsimony: increase hardcoded species limit (50.000 -> 250.000)
504 - GDE menus cleanup
505 - translation/re-alignment tweaked
506 - unalign right (EDIT4)
507 - visualization of SAIs in Probe Match Results
508 - changed formatting of probe match results; increase # of allowed matches to 100.000;
509   warn if results are truncated
510 - PT server for genes
511 - Probe design performance optimized
512 - fixed NEXUS export format
513 - exports group names into Newick format
514 - import XML tree files
515 - help for external tools now properly shown inside ARB
516
517Major changes in Beta 2003_08_22 (22 Aug 2003):
518
519 - automatic formatting of alignments
520 - SECEDIT may use EDIT4 colors
521 - fixed bootstrapping (DNAPARS, PROTPARS, PROTML(experimental!))
522 - updated clustalw to version 1.83
523 - Restore window sizes for ALL windows (too small sizes are ignored)
524 - new algorithm to add partial sequences to an existing tree
525 - PROT-parsimony was completely redesigned and works now most similar to DNA/RNA-parsimony
526 - ARB_EDIT4 top area may be reduced to maximize display area
527 - All arb menus may be detached (click dashed line at top of menu)
528 - visualization of SAIs (as background color behind Sequences)
529 - ARB_EDIT4 may save/use alignment-specific and alignment-type-specific properties
530 - PT-server occupies more memory => does less passes; more diagnostic output
531 - small changes to status window (unhide behavior/time estimation)
532 - menus and menu-hotkeys reorganized
533 - colored buttons in color config windows
534 - alignment concatenation (e.g. several different genes)
535 - merging data of similar species (according selected database field)
536 - keyboard commands for tree display (mark/unmark/invert, collapse/expand)
537 - expanded sellists
538 - save/load fixed for multi probes
539 - Binary SAIs are editable in ARB_EDIT4
540 - Information windows are detachable (allows to have multiple windows showing different items)
541 - Scanning for hidden/unknown database fields improved and separated;
542   possibility to remove unused fields.
543 - new tabbed format in 'Export NDS' and 'Export matrix' (useful for star-calc/excel/etc.)
544 - updated fastDNAml to 1.2.2
545 - added AxML (accelerated fastDNAml 1.2.2)
546 - Field transfer definitions for exporting gene-species
547 - File Selection: - recursive search available
548 - macro recording/execution has been fixed
549 - Colorize species (see demo.arb)
550 - Fixed missing-character-bug in Xfig, Print and Edit4-Info-Display
551 - 'IslandHopper' -- a new integrated aligner (beta)
552 - Many improvements and bugfixes to secondary structure editor:
553   - highlighting of search (i.e for probes) like in EDIT4
554   - interactive constraint editing (stretch/compress)
555   - probe info
556   - editing secondary structure in XFIG now possible
557   - visualization of SAIs
558 - import reads Unix, DOS, and MAC linefeeds
559 - NTREE/SAI/Etc/GnuPlot: calls gnuplot directly; more plotting features; basic help
560 - tree and sequence export to XML ( DTDs are provided in ./lib/dtd )
561   (reloading of these XML files is planned for the future)
562 - fixed problems with phylip-tree import/export (bootstrap values,comments,...)
563 - search in all database fields possible ('[all fields]')
564 - up to 10 quicksaves are kept
565 - new ACI functions: upper, lower, caps, eval
566 - variables for import filter programming
567 - extract gene-species: creates acc; extraction to existing alignments
568 - sequence of selected gene is mirrored in ARB_EDIT4/local_signature
569   (=> selected gene can be highlighted in primary editor)
570 - PCR primer-design for single genes
571 - when selecting a gene, the corresponding gene-species is selected (if found)
572 - save configuration for several windows (e.g. Search&Query, WWW, NDS, ...)
573 - file selection box in import window
574 - mark item with double click works in all search&query windows
575 - User masks: create new; 'edit enable' and 'marked' toggles (like in info window)
576 - Fixed command line help for all Arb-modules
577 - Fixed problem parsing fonts (should fix display problems with default fonts)
578 - Mark mode now also works in list-view of tree-display
579 - Fixed appearance of 'tiny little boxes' (everywhere)
580 - Redesign of ARB help:
581     - a HTML version is in $ARBHOME/lib/help_html
582     - a text version is in $ARBHOME/lib/help (like before, but now generated)
583
584Major changes in Beta 2001_11_07 (7 Nov 2001):
585
586 - design probes to maximum length of 60 nucleotides
587 - fastAligner1.03 bug fixed (chooses best match now in 'auto search' mode)
588 - import default changed to foreign data format, ali name '16s'
589 - printing of multi-page-trees works again
590 - implemented user defineable masks to access database fields
591 - fixed bugs in pt-server (lockup, unknown species just after building pt-server)
592 - improved performance during pt-server-build
593 - several programs coming along with ARB where updated (PHYLIP,...)
594 - reads EMBL genom files
595 - support for experiments (genom databases only)
596
597Major changes in Beta 2001_07_24 (24 Jul 2001):
598
599 - basic support for genoms (Gene Map, reads Genebank files)
600 - ported to libc6
601
602Changes in ancient versions (last century):
603
604 - see http://help.arb-home.de/version.html
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